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Protein

Apoptosis-inducing factor 1

Gene

AIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis.3 Publications

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51FADSequence analysis1
Binding sitei56FADSequence analysis1
Binding sitei283FADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 16FADSequence analysis5

GO - Molecular functioni

GO - Biological processi

  • aerobic electron transport chain Source: GO_Central
  • apoptotic process Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: SGD
  • response to singlet oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciYEAST:G3O-33378-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-inducing factor 1 (EC:1.-.-.-)
Alternative name(s):
Cercosporin and photosensitizer-detoxification protein 1
Gene namesi
Name:AIF1
Synonyms:CPD1
Ordered Locus Names:YNR074C
ORF Names:N3815
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR074C.
SGDiS000005357. AIF1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 25HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
  • nucleus Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034861 – 378Apoptosis-inducing factor 1Add BLAST378

Proteomic databases

MaxQBiP52923.
PRIDEiP52923.

PTM databases

iPTMnetiP52923.

Interactioni

Protein-protein interaction databases

BioGridi35900. 18 interactors.
DIPiDIP-4250N.
IntActiP52923. 4 interactors.
MINTiMINT-517181.

Structurei

3D structure databases

ProteinModelPortaliP52923.
SMRiP52923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP52923.
OMAiYENLATE.
OrthoDBiEOG092C2TP2.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

P52923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTINTKNIVV VGAGVFGVSV ANHLYRELGG TYAIKLVTAS NYVYFLPSAV
60 70 80 90 100
RLTVSKDYTK SILPLKNVLD SGIEVIKDTA ASFDDKEVVL GSDRAIKFDI
110 120 130 140 150
LVLATGSKWA DPIGSTYTFG DNYKEYFERE ASRISDADHI LFLGGGFVNC
160 170 180 190 200
ELAGELLFKY LEEIRSGKKR ISIIHNSDKL LPDSGLYNDT LRKNVTDYLS
210 220 230 240 250
KNGITLYLNT VGASLDTSPK RIFLGEGSSK YIDADLIYRG VGISPNVPVN
260 270 280 290 300
SISDLCDKKG FIQVEKNFRV KAVEAGNVFA IGDVTNFRYH GLVKRDNWVD
310 320 330 340 350
VLTRNVISSL QEGTEASLVD ADCLETGHAP SGVSLGPNAG FGQFPLPLLG
360 370
TINIPSFLIS RAKSKNLFSD KMEPLFKK
Length:378
Mass (Da):41,335
Last modified:October 1, 1996 - v1
Checksum:iC0E078B3B0072C1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86790 Genomic DNA. Translation: CAA60487.1.
Z71689 Genomic DNA. Translation: CAA96357.1.
BK006947 Genomic DNA. Translation: DAA10615.1.
PIRiS54056.
RefSeqiNP_014472.1. NM_001183251.1.

Genome annotation databases

EnsemblFungiiYNR074C; YNR074C; YNR074C.
GeneIDi855811.
KEGGisce:YNR074C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86790 Genomic DNA. Translation: CAA60487.1.
Z71689 Genomic DNA. Translation: CAA96357.1.
BK006947 Genomic DNA. Translation: DAA10615.1.
PIRiS54056.
RefSeqiNP_014472.1. NM_001183251.1.

3D structure databases

ProteinModelPortaliP52923.
SMRiP52923.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35900. 18 interactors.
DIPiDIP-4250N.
IntActiP52923. 4 interactors.
MINTiMINT-517181.

PTM databases

iPTMnetiP52923.

Proteomic databases

MaxQBiP52923.
PRIDEiP52923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR074C; YNR074C; YNR074C.
GeneIDi855811.
KEGGisce:YNR074C.

Organism-specific databases

EuPathDBiFungiDB:YNR074C.
SGDiS000005357. AIF1.

Phylogenomic databases

InParanoidiP52923.
OMAiYENLATE.
OrthoDBiEOG092C2TP2.

Enzyme and pathway databases

BioCyciYEAST:G3O-33378-MONOMER.

Miscellaneous databases

PROiP52923.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAIF1_YEAST
AccessioniPrimary (citable) accession number: P52923
Secondary accession number(s): D6W1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.