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Protein

Nucleolysin TIA-1

Gene

Tia1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity).By similarity

GO - Molecular functioni

  • AU-rich element binding Source: MGI
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolysin TIA-1
Alternative name(s):
RNA-binding protein TIA-1
T-cell-restricted intracellular antigen-1
Short name:
TIA-1
Gene namesi
Name:Tia1
Synonyms:Tia
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107914. Tia1.

Subcellular locationi

  • Cytoplasmic granule By similarity
  • Nucleus By similarity

  • Note: Accumulates in cytoplasmic stress granules (SG) following cellular damage.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoplasmic stress granule Source: MGI
  • nuclear stress granule Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819771 – 386Nucleolysin TIA-1Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52912.
PaxDbiP52912.
PRIDEiP52912.

PTM databases

iPTMnetiP52912.
PhosphoSitePlusiP52912.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071337.
ExpressionAtlasiP52912. baseline and differential.
GenevisibleiP52912. MM.

Interactioni

Protein-protein interaction databases

BioGridi204190. 1 interactor.
IntActiP52912. 1 interactor.
MINTiMINT-4593011.
STRINGi10090.ENSMUSP00000093425.

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi106 – 112Combined sources7
Helixi119 – 126Combined sources8
Helixi127 – 129Combined sources3
Beta strandi132 – 139Combined sources8
Turni141 – 143Combined sources3
Beta strandi146 – 156Combined sources11
Helixi157 – 166Combined sources10
Turni167 – 169Combined sources3
Beta strandi178 – 183Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGONMR-A87-199[»]
2RNENMR-A87-224[»]
ProteinModelPortaliP52912.
SMRiP52912.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52912.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 83RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini106 – 184RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini214 – 286RRM 3PROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0148. Eukaryota.
ENOG410XQ8U. LUCA.
GeneTreeiENSGT00860000133749.
HOGENOMiHOG000206748.
HOVERGENiHBG105006.
InParanoidiP52912.
KOiK13201.
OMAiFGTMGPV.
OrthoDBiEOG091G0FH8.
PhylomeDBiP52912.
TreeFamiTF312915.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DTAGNDPYCF
60 70 80 90 100
VEFHEHRHAA AALAAMNGRK IMGKEVKVNW ATTPSSQKKD TSSSTVVSTQ
110 120 130 140 150
RSQDHFHVFV GDLSPEITTE DIKAAFAPFG RISDARVVKD MATGKSKGYG
160 170 180 190 200
FVSFFNKWDA ENAIQQMGGQ WLGGRQIRTN WATRKPPAPK STYESNTKQL
210 220 230 240 250
SYDEVVSQSS PNNCTVYCGG VTSGLTEQLM RQTFSPFGQI MEIRVFPDKG
260 270 280 290 300
YSFVRFSSHE SAAHAIVSVN GTTIEGHVVK CYWGKETLDM INPVQQQNQI
310 320 330 340 350
GYPPTYGQWG QWYGNAQQIG QYVPNGWQVP AYGVYGQPWS QQGFNQTQSS
360 370 380
APWMGPNYSV PPPQGQNGSM LPSQPAGYRV AGYETQ
Length:386
Mass (Da):42,800
Last modified:October 1, 1996 - v1
Checksum:i51BFFE90E046D3AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00689 mRNA. Translation: AAA03711.1.
U55862 mRNA. Translation: AAC52871.1.
CCDSiCCDS20312.1.
PIRiS72435.
RefSeqiNP_035715.1. NM_011585.4.
UniGeneiMm.333219.

Genome annotation databases

EnsembliENSMUST00000095753; ENSMUSP00000093425; ENSMUSG00000071337.
GeneIDi21841.
KEGGimmu:21841.
UCSCiuc009crp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00689 mRNA. Translation: AAA03711.1.
U55862 mRNA. Translation: AAC52871.1.
CCDSiCCDS20312.1.
PIRiS72435.
RefSeqiNP_035715.1. NM_011585.4.
UniGeneiMm.333219.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGONMR-A87-199[»]
2RNENMR-A87-224[»]
ProteinModelPortaliP52912.
SMRiP52912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204190. 1 interactor.
IntActiP52912. 1 interactor.
MINTiMINT-4593011.
STRINGi10090.ENSMUSP00000093425.

PTM databases

iPTMnetiP52912.
PhosphoSitePlusiP52912.

Proteomic databases

EPDiP52912.
PaxDbiP52912.
PRIDEiP52912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095753; ENSMUSP00000093425; ENSMUSG00000071337.
GeneIDi21841.
KEGGimmu:21841.
UCSCiuc009crp.2. mouse.

Organism-specific databases

CTDi7072.
MGIiMGI:107914. Tia1.

Phylogenomic databases

eggNOGiKOG0148. Eukaryota.
ENOG410XQ8U. LUCA.
GeneTreeiENSGT00860000133749.
HOGENOMiHOG000206748.
HOVERGENiHBG105006.
InParanoidiP52912.
KOiK13201.
OMAiFGTMGPV.
OrthoDBiEOG091G0FH8.
PhylomeDBiP52912.
TreeFamiTF312915.

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.

Miscellaneous databases

EvolutionaryTraceiP52912.
PROiP52912.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071337.
ExpressionAtlasiP52912. baseline and differential.
GenevisibleiP52912. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIA1_MOUSE
AccessioniPrimary (citable) accession number: P52912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.