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P52911

- EXG2_YEAST

UniProt

P52911 - EXG2_YEAST

Protein

Glucan 1,3-beta-glucosidase 2

Gene

EXG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei254 – 2541Proton donorBy similarity
    Active sitei334 – 3341NucleophileBy similarity

    GO - Molecular functioni

    1. glucan exo-1,3-beta-glucosidase activity Source: SGD

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. fungal-type cell wall organization Source: SGD

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Enzyme and pathway databases

    BioCyciYEAST:YDR261C-MONOMER.

    Protein family/group databases

    CAZyiGH5. Glycoside Hydrolase Family 5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucan 1,3-beta-glucosidase 2 (EC:3.2.1.58)
    Alternative name(s):
    Exo-1,3-beta-glucanase 2
    Gene namesi
    Name:EXG2
    Ordered Locus Names:YDR261C
    ORF Names:YD9320A.12C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR261c.
    SGDiS000002669. EXG2.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. fungal-type cell wall Source: SGD
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 562540Glucan 1,3-beta-glucosidase 2PRO_0000007894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiP52911.
    PaxDbiP52911.

    Expressioni

    Gene expression databases

    GenevestigatoriP52911.

    Interactioni

    Protein-protein interaction databases

    BioGridi32311. 19 interactions.
    IntActiP52911. 1 interaction.
    STRINGi4932.YDR261C.

    Structurei

    3D structure databases

    ProteinModelPortaliP52911.
    SMRiP52911. Positions 51-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2730.
    GeneTreeiENSGT00390000009809.
    HOGENOMiHOG000114462.
    KOiK01210.
    OMAiSAQGVLM.
    OrthoDBiEOG7JT75H.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52911-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLKSFFFSA FLVLCLSKFT QGVGTTEKEE SLSPLELNIL QNKFASYYAN    50
    DTITVKGITI GGWLVTEPYI TPSLYRNATS LAKQQNSSSN ISIVDEFTLC 100
    KTLGYNTSLT LLDNHFKTWI TEDDFEQIKT NGFNLVRIPI GYWAWKQNTD 150
    KNLYIDNITF NDPYVSDGLQ LKYLNNALEW AQKYELNVWL DLHGAPGSQN 200
    GFDNSGERIL YGDLGWLRLN NTKELTLAIW RDMFQTFLNK GDKSPVVGIQ 250
    IVNEPLGGKI DVSDITEMYY EAFDLLKKNQ NSSDNTTFVI HDGFQGIGHW 300
    NLELNPTYQN VSHHYFNLTG ANYSSQDILV DHHHYEVFTD AQLAETQFAR 350
    IENIINYGDS IHKELSFHPA VVGEWSGAIT DCATWLNGVG VGARYDGSYY 400
    NTTLFTTNDK PVGTCISQNS LADWTQDYRD RVRQFIEAQL ATYSSKTTGW 450
    IFWNWKTEDA VEWDYLKLKE ANLFPSPFDN YTYFKADGSI EEKFSSSLSA 500
    QAFPRTTSSV LSSTTTSRKS KNAAISNKLT TSQLLPIKNM SLTWKASVCA 550
    LAITIAALCA SL 562
    Length:562
    Mass (Da):63,508
    Last modified:October 1, 1996 - v1
    Checksum:i5814509CC3D93F73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46870 Genomic DNA. Translation: CAA86950.1.
    Z70202 Genomic DNA. Translation: CAA94100.1.
    Z68329 Genomic DNA. Translation: CAA92719.1.
    BK006938 Genomic DNA. Translation: DAA12101.1.
    PIRiS55516.
    RefSeqiNP_010547.1. NM_001180569.1.

    Genome annotation databases

    EnsemblFungiiYDR261C; YDR261C; YDR261C.
    GeneIDi851848.
    KEGGisce:YDR261C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46870 Genomic DNA. Translation: CAA86950.1 .
    Z70202 Genomic DNA. Translation: CAA94100.1 .
    Z68329 Genomic DNA. Translation: CAA92719.1 .
    BK006938 Genomic DNA. Translation: DAA12101.1 .
    PIRi S55516.
    RefSeqi NP_010547.1. NM_001180569.1.

    3D structure databases

    ProteinModelPortali P52911.
    SMRi P52911. Positions 51-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32311. 19 interactions.
    IntActi P52911. 1 interaction.
    STRINGi 4932.YDR261C.

    Protein family/group databases

    CAZyi GH5. Glycoside Hydrolase Family 5.

    Proteomic databases

    MaxQBi P52911.
    PaxDbi P52911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR261C ; YDR261C ; YDR261C .
    GeneIDi 851848.
    KEGGi sce:YDR261C.

    Organism-specific databases

    CYGDi YDR261c.
    SGDi S000002669. EXG2.

    Phylogenomic databases

    eggNOGi COG2730.
    GeneTreei ENSGT00390000009809.
    HOGENOMi HOG000114462.
    KOi K01210.
    OMAi SAQGVLM.
    OrthoDBi EOG7JT75H.

    Enzyme and pathway databases

    BioCyci YEAST:YDR261C-MONOMER.

    Miscellaneous databases

    NextBioi 969766.

    Gene expression databases

    Genevestigatori P52911.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "EXG2, a gene coding for a exo-1,3-B-glucanase with a GPI anchor attachment site in the carboxy terminus."
      Correa J., Vazquez de Aldana C., San Segundo P., del Rey F.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204510 / AB320.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEXG2_YEAST
    AccessioniPrimary (citable) accession number: P52911
    Secondary accession number(s): D6VSP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2410 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3