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Protein

Glucan 1,3-beta-glucosidase 2

Gene

EXG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 2410 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei254Proton donorBy similarity1
Active sitei334NucleophileBy similarity1

GO - Molecular functioni

  • glucan exo-1,3-beta-glucosidase activity Source: SGD

GO - Biological processi

  • cellular glucan metabolic process Source: GO_Central
  • fungal-type cell wall organization Source: SGD
  • glucan catabolic process Source: GO_Central

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:YDR261C-MONOMER.

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase 2 (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 2
Gene namesi
Name:EXG2
Ordered Locus Names:YDR261C
ORF Names:YD9320A.12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR261C.
SGDiS000002669. EXG2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000789423 – 562Glucan 1,3-beta-glucosidase 2Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi539N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP52911.
PRIDEiP52911.

Interactioni

Protein-protein interaction databases

BioGridi32311. 50 interactors.
IntActiP52911. 3 interactors.
STRINGi4932.YDR261C.

Structurei

3D structure databases

ProteinModelPortaliP52911.
SMRiP52911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000009809.
HOGENOMiHOG000114462.
InParanoidiP52911.
KOiK01210.
OMAiPLDNYKY.
OrthoDBiEOG092C22A6.

Family and domain databases

InterProiView protein in InterPro
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00150. Cellulase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKSFFFSA FLVLCLSKFT QGVGTTEKEE SLSPLELNIL QNKFASYYAN
60 70 80 90 100
DTITVKGITI GGWLVTEPYI TPSLYRNATS LAKQQNSSSN ISIVDEFTLC
110 120 130 140 150
KTLGYNTSLT LLDNHFKTWI TEDDFEQIKT NGFNLVRIPI GYWAWKQNTD
160 170 180 190 200
KNLYIDNITF NDPYVSDGLQ LKYLNNALEW AQKYELNVWL DLHGAPGSQN
210 220 230 240 250
GFDNSGERIL YGDLGWLRLN NTKELTLAIW RDMFQTFLNK GDKSPVVGIQ
260 270 280 290 300
IVNEPLGGKI DVSDITEMYY EAFDLLKKNQ NSSDNTTFVI HDGFQGIGHW
310 320 330 340 350
NLELNPTYQN VSHHYFNLTG ANYSSQDILV DHHHYEVFTD AQLAETQFAR
360 370 380 390 400
IENIINYGDS IHKELSFHPA VVGEWSGAIT DCATWLNGVG VGARYDGSYY
410 420 430 440 450
NTTLFTTNDK PVGTCISQNS LADWTQDYRD RVRQFIEAQL ATYSSKTTGW
460 470 480 490 500
IFWNWKTEDA VEWDYLKLKE ANLFPSPFDN YTYFKADGSI EEKFSSSLSA
510 520 530 540 550
QAFPRTTSSV LSSTTTSRKS KNAAISNKLT TSQLLPIKNM SLTWKASVCA
560
LAITIAALCA SL
Length:562
Mass (Da):63,508
Last modified:October 1, 1996 - v1
Checksum:i5814509CC3D93F73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46870 Genomic DNA. Translation: CAA86950.1.
Z70202 Genomic DNA. Translation: CAA94100.1.
Z68329 Genomic DNA. Translation: CAA92719.1.
BK006938 Genomic DNA. Translation: DAA12101.1.
PIRiS55516.
RefSeqiNP_010547.1. NM_001180569.1.

Genome annotation databases

EnsemblFungiiYDR261C; YDR261C; YDR261C.
GeneIDi851848.
KEGGisce:YDR261C.

Similar proteinsi

Entry informationi

Entry nameiEXG2_YEAST
AccessioniPrimary (citable) accession number: P52911
Secondary accession number(s): D6VSP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names