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Protein

Transcription factor jun-D

Gene

Jund

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.By similarity

GO - Molecular functioni

  • double-stranded DNA binding Source: RGD
  • ligand-dependent nuclear receptor binding Source: RGD
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  • sequence-specific DNA binding Source: RGD
  • transcription factor activity, sequence-specific DNA binding Source: RGD
  • transcription regulatory region DNA binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • aging Source: RGD
  • cellular response to calcium ion Source: Ensembl
  • circadian rhythm Source: RGD
  • osteoblast development Source: Ensembl
  • positive regulation of osteoblast differentiation Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of transcription, DNA-templated Source: RGD
  • response to light stimulus Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:Jund
Synonyms:Jun-d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2945. Jund.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ParkinsonsUK-UCL
  • protein complex Source: RGD
  • protein-DNA complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Transcription factor jun-DPRO_0000076444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451PhosphoserineBy similarity
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei253 – 2531PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52909.

PTM databases

iPTMnetiP52909.
PhosphoSiteiP52909.

Expressioni

Gene expression databases

GenevisibleiP52909. RN.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with MEN1.By similarity

GO - Molecular functioni

  • ligand-dependent nuclear receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026470.

Structurei

3D structure databases

ProteinModelPortaliP52909.
SMRiP52909. Positions 263-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 32564bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 28928Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni290 – 31829Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
GeneTreeiENSGT00390000009929.
HOVERGENiHBG001722.
InParanoidiP52909.
KOiK04449.
OMAiAPVYANL.
OrthoDBiEOG75MVXV.
PhylomeDBiP52909.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029823. JunD.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF7. PTHR11462:SF7. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPFYGEEA LSGLAAGASS VAGAAGAPGG GGFAPPGRAF PGAPPTSSML
60 70 80 90 100
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA
210 220 230 240 250
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP
260 270 280 290 300
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ
310 320 330 340
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y
Length:341
Mass (Da):34,875
Last modified:October 1, 1996 - v1
Checksum:i2D9BF82313101988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26307 Genomic DNA. Translation: BAA05369.1.
BC062053 mRNA. Translation: AAH62053.1.
PIRiJC4051.
RefSeqiNP_001273895.1. NM_001286966.1.
NP_620230.1. NM_138875.4.
UniGeneiRn.46225.

Genome annotation databases

EnsembliENSRNOT00000026470; ENSRNOP00000026470; ENSRNOG00000019568.
GeneIDi24518.
KEGGirno:24518.
UCSCiRGD:2945. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26307 Genomic DNA. Translation: BAA05369.1.
BC062053 mRNA. Translation: AAH62053.1.
PIRiJC4051.
RefSeqiNP_001273895.1. NM_001286966.1.
NP_620230.1. NM_138875.4.
UniGeneiRn.46225.

3D structure databases

ProteinModelPortaliP52909.
SMRiP52909. Positions 263-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026470.

PTM databases

iPTMnetiP52909.
PhosphoSiteiP52909.

Proteomic databases

PaxDbiP52909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026470; ENSRNOP00000026470; ENSRNOG00000019568.
GeneIDi24518.
KEGGirno:24518.
UCSCiRGD:2945. rat.

Organism-specific databases

CTDi3727.
RGDi2945. Jund.

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
GeneTreeiENSGT00390000009929.
HOVERGENiHBG001722.
InParanoidiP52909.
KOiK04449.
OMAiAPVYANL.
OrthoDBiEOG75MVXV.
PhylomeDBiP52909.

Miscellaneous databases

PROiP52909.

Gene expression databases

GenevisibleiP52909. RN.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029823. JunD.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF7. PTHR11462:SF7. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249 AND SER-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJUND_RAT
AccessioniPrimary (citable) accession number: P52909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.