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Protein

Trypsin iota

Gene

iotaTry

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Charge relay systemBy similarity1
Active sitei113Charge relay systemBy similarity1
Sitei200Required for specificityBy similarity1
Active sitei206Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.115.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin iota (EC:3.4.21.4)
Gene namesi
Name:iotaTry
Synonyms:Tryiota
ORF Names:CG7754
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0015001. iotaTry.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002827520 – 27Activation peptide8
ChainiPRO_000002827628 – 252Trypsin iotaAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 69PROSITE-ProRule annotation
Disulfide bondi175 ↔ 193PROSITE-ProRule annotation
Disulfide bondi202 ↔ 226PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP52905.
PRIDEiP52905.

Expressioni

Gene expression databases

BgeeiFBgn0015001.
ExpressionAtlasiP52905. differential.
GenevisibleiP52905. DM.

Interactioni

Protein-protein interaction databases

BioGridi62014. 1 interactor.
STRINGi7227.FBpp0087226.

Structurei

3D structure databases

ProteinModelPortaliP52905.
SMRiP52905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 250Peptidase S1PROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00880000138081.
InParanoidiP52905.
KOiK01312.
OMAiIHNAPWQ.
OrthoDBiEOG091G0AH5.
PhylomeDBiP52905.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYGIVATV LVLLLLGDAS DVEATGRIIG GSDQLIRNAP WQVSIQISAR
60 70 80 90 100
HECGGVIYSK EIIITAGHCL HERSVTLMKV RVGAQNHNYG GTLVPVAAYK
110 120 130 140 150
VHEQFDSRFL HYDIAVLRLS TPLTFGLSTR AINLASTSPS GGTTVTVTGW
160 170 180 190 200
GHTDNGALSD SLQKAQLQII DRGECASQKF GYGADFVGEE TICAASTDAD
210 220 230 240 250
ACTGDSGGPL VASSQLVGIV SWGYRCADDN YPGVYADVAI LRPWIVKAAN

AI
Length:252
Mass (Da):26,612
Last modified:October 1, 1996 - v1
Checksum:i044DEDA4700910C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04853 Genomic DNA. Translation: AAA84377.1.
AE013599 Genomic DNA. Translation: AAF58655.1.
AY113550 mRNA. Translation: AAM29555.1.
RefSeqiNP_523695.1. NM_078971.4.
UniGeneiDm.5695.

Genome annotation databases

EnsemblMetazoaiFBtr0088125; FBpp0087226; FBgn0015001.
GeneIDi36223.
KEGGidme:Dmel_CG7754.

Similar proteinsi

Entry informationi

Entry nameiTRYI_DROME
AccessioniPrimary (citable) accession number: P52905
Secondary accession number(s): Q540Z6, Q9V5Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families