SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52903

- ODPA_SOLTU

UniProt

P52903 - ODPA_SOLTU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.

Enzyme regulationi

E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit By similarity.

GO - Molecular functioni

  1. cobalt ion binding Source: EnsemblPlants/Gramene
  2. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
  3. zinc ion binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. response to salt stress Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-A
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. nucleus Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626Mitochondrion1 PublicationAdd
BLAST
Chaini27 – 391365Pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPRO_0000020455Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

ProMEXiP52903.

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits By similarity.

Protein-protein interaction databases

IntActiP52903. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP52903.
SMRiP52903. Positions 32-379.

Family & Domainsi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52903-1 [UniParc]FASTAAdd to Basket

« Hide

MALSTSRAIN HIMKPLSAAV CATRRLSSDS TATITVETSL PFTSHNIDPP    50
SRSVETSPKE LMTFFKDMTE MRRMEIAADS LYKAKLIRGF CHLYDGQEAV 100
AVGMEAAITK KDCIITAYRD HCIFLGRGGT LVEAFAELMG RRDGCSRGKG 150
GSMHFYKKES GFYGGHGIVG AQVPLGIGLA FAQKYKKEDY VTFAMYGDGA 200
ANQGQLFEAL NMAALWDLPA ILVCENNHYG MGTAEWRAAK SPAYYKRGDY 250
VPGLRVDGMD VFAVKQACTF AKQHALKNGP IILEMDTYRY HGHSMSDPGS 300
TYRTRDEISG VRQERDPVER IRSLILAHNI ATEAELKDIE KENRKVVDEA 350
IAKAKESPMP DPSELFTNVY VKGFGVEAYG ADRKELRATL P 391
Length:391
Mass (Da):43,228
Last modified:October 1, 1996 - v1
Checksum:iF9110B374B022F0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26949 mRNA. Translation: CAA81558.1.
PIRiT07372.
UniGeneiStu.18026.

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400058223; PGSC0003DMT400058223; PGSC0003DMG400022607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26949 mRNA. Translation: CAA81558.1 .
PIRi T07372.
UniGenei Stu.18026.

3D structure databases

ProteinModelPortali P52903.
SMRi P52903. Positions 32-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P52903. 1 interaction.

Proteomic databases

ProMEXi P52903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi PGSC0003DMT400058223 ; PGSC0003DMT400058223 ; PGSC0003DMG400022607 .

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mitochondrial pyruvate dehydrogenase. Molecular cloning of the E1 alpha subunit and expression analysis."
    Grof C.P., Winning B.M., Scaysbrook T.P., Hill S.A., Leaver C.J.
    Plant Physiol. 108:1623-1629(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Desiree.
    Tissue: Leaf.
  2. "Genome sequence and analysis of the tuber crop potato."
    The Potato Genome Sequencing Consortium
    Nature 475:189-195(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. DM1-3 516 R44.
  3. "Plant mitochondrial pyruvate dehydrogenase complex: purification and identification of catalytic components in potato."
    Millar A.H., Knorpp C., Leaver C.J., Hill S.A.
    Biochem. J. 334:571-576(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-42.
    Strain: cv. Romano.
    Tissue: Tuber.

Entry informationi

Entry nameiODPA_SOLTU
AccessioniPrimary (citable) accession number: P52903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

Similar proteinsi