Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P52899

- ODPA_CAEEL

UniProt

P52899 - ODPA_CAEEL

Protein

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Gene

T05H10.6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Enzyme regulationi

    E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC:1.2.4.1)
    Short name:
    PDHE1-A
    Gene namesi
    ORF Names:T05H10.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiT05H10.6a; CE01643; WBGene00011510.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 397Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPRO_0000020439
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP52899.
    PRIDEiP52899.

    Interactioni

    Subunit structurei

    Tetramer of 2 alpha and 2 beta subunits.By similarity

    Protein-protein interaction databases

    DIPiDIP-24909N.
    STRINGi6239.T05H10.6b.

    Structurei

    3D structure databases

    ProteinModelPortaliP52899.
    SMRiP52899. Positions 25-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1071.
    GeneTreeiENSGT00530000063174.
    HOGENOMiHOG000281336.
    KOiK00161.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52899-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLFARQLQS LTASGIRTQQ VRLASTEVSF HTKPCKLHKL DNGPNTSVTL    50
    NREDALKYYR DMQVIRRMES AAGNLYKEKK IRGFCHLYSG QEACAVGMKA 100
    AMTEGDAVIT AYRCHGWTWL LGATVTEVLA ELTGRVAGNV HGKGGSMHMY 150
    TKNFYGGNGI VGAQQPLGAG VALAMKYREQ KNVCVTLYGD GAANQGQLFE 200
    ATNMAKLWDL PVLFVCENNG FGMGTTAERS SASTEYYTRG DYVPGIWVDG 250
    MDILAVREAT KWAKEYCDSG KGPLMMEMAT YRYHGHSMSD PGTSYRTREE 300
    IQEVRKTRDP ITGFKDRIIT SSLATEEELK AIDKEVRKEV DEALKIATSD 350
    GVLPPEALYA DIYHNTPAQE IRGATIDETI VQPFKTSADV LKSIGRA 397
    Length:397
    Mass (Da):43,792
    Last modified:October 1, 1996 - v1
    Checksum:i27FB6410B0EA8513
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47812 Genomic DNA. Translation: CAA87793.1.
    PIRiT24557.
    RefSeqiNP_495693.1. NM_063292.4.
    UniGeneiCel.38645.

    Genome annotation databases

    EnsemblMetazoaiT05H10.6a.1; T05H10.6a.1; WBGene00011510.
    T05H10.6a.2; T05H10.6a.2; WBGene00011510.
    T05H10.6a.3; T05H10.6a.3; WBGene00011510.
    GeneIDi3565996.
    KEGGicel:CELE_T05H10.6.
    UCSCiT05H10.6b. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47812 Genomic DNA. Translation: CAA87793.1 .
    PIRi T24557.
    RefSeqi NP_495693.1. NM_063292.4.
    UniGenei Cel.38645.

    3D structure databases

    ProteinModelPortali P52899.
    SMRi P52899. Positions 25-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-24909N.
    STRINGi 6239.T05H10.6b.

    Proteomic databases

    PaxDbi P52899.
    PRIDEi P52899.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T05H10.6a.1 ; T05H10.6a.1 ; WBGene00011510 .
    T05H10.6a.2 ; T05H10.6a.2 ; WBGene00011510 .
    T05H10.6a.3 ; T05H10.6a.3 ; WBGene00011510 .
    GeneIDi 3565996.
    KEGGi cel:CELE_T05H10.6.
    UCSCi T05H10.6b. c. elegans.

    Organism-specific databases

    CTDi 3565996.
    WormBasei T05H10.6a ; CE01643 ; WBGene00011510 .

    Phylogenomic databases

    eggNOGi COG1071.
    GeneTreei ENSGT00530000063174.
    HOGENOMi HOG000281336.
    KOi K00161.

    Miscellaneous databases

    NextBioi 958671.
    PROi P52899.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiODPA_CAEEL
    AccessioniPrimary (citable) accession number: P52899
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase

    External Data

    Dasty 3