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P52899

- ODPA_CAEEL

UniProt

P52899 - ODPA_CAEEL

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Protein

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Gene

T05H10.6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

Enzyme regulationi

E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-A
Gene namesi
ORF Names:T05H10.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiT05H10.6a; CE01643; WBGene00011510.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 397Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPRO_0000020439
Transit peptidei1 – ?MitochondrionSequence Analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52899.
PRIDEiP52899.

Expressioni

Gene expression databases

ExpressionAtlasiP52899. baseline.

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

DIPiDIP-24909N.
STRINGi6239.T05H10.6b.

Structurei

3D structure databases

ProteinModelPortaliP52899.
SMRiP52899. Positions 25-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1071.
GeneTreeiENSGT00530000063174.
HOGENOMiHOG000281336.
InParanoidiP52899.
KOiK00161.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52899-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLFARQLQS LTASGIRTQQ VRLASTEVSF HTKPCKLHKL DNGPNTSVTL
60 70 80 90 100
NREDALKYYR DMQVIRRMES AAGNLYKEKK IRGFCHLYSG QEACAVGMKA
110 120 130 140 150
AMTEGDAVIT AYRCHGWTWL LGATVTEVLA ELTGRVAGNV HGKGGSMHMY
160 170 180 190 200
TKNFYGGNGI VGAQQPLGAG VALAMKYREQ KNVCVTLYGD GAANQGQLFE
210 220 230 240 250
ATNMAKLWDL PVLFVCENNG FGMGTTAERS SASTEYYTRG DYVPGIWVDG
260 270 280 290 300
MDILAVREAT KWAKEYCDSG KGPLMMEMAT YRYHGHSMSD PGTSYRTREE
310 320 330 340 350
IQEVRKTRDP ITGFKDRIIT SSLATEEELK AIDKEVRKEV DEALKIATSD
360 370 380 390
GVLPPEALYA DIYHNTPAQE IRGATIDETI VQPFKTSADV LKSIGRA
Length:397
Mass (Da):43,792
Last modified:October 1, 1996 - v1
Checksum:i27FB6410B0EA8513
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47812 Genomic DNA. Translation: CAA87793.1.
PIRiT24557.
RefSeqiNP_495693.1. NM_063292.4.
UniGeneiCel.38645.

Genome annotation databases

EnsemblMetazoaiT05H10.6a.1; T05H10.6a.1; WBGene00011510.
T05H10.6a.2; T05H10.6a.2; WBGene00011510.
T05H10.6a.3; T05H10.6a.3; WBGene00011510.
GeneIDi3565996.
KEGGicel:CELE_T05H10.6.
UCSCiT05H10.6b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47812 Genomic DNA. Translation: CAA87793.1 .
PIRi T24557.
RefSeqi NP_495693.1. NM_063292.4.
UniGenei Cel.38645.

3D structure databases

ProteinModelPortali P52899.
SMRi P52899. Positions 25-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-24909N.
STRINGi 6239.T05H10.6b.

Proteomic databases

PaxDbi P52899.
PRIDEi P52899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T05H10.6a.1 ; T05H10.6a.1 ; WBGene00011510 .
T05H10.6a.2 ; T05H10.6a.2 ; WBGene00011510 .
T05H10.6a.3 ; T05H10.6a.3 ; WBGene00011510 .
GeneIDi 3565996.
KEGGi cel:CELE_T05H10.6.
UCSCi T05H10.6b. c. elegans.

Organism-specific databases

CTDi 3565996.
WormBasei T05H10.6a ; CE01643 ; WBGene00011510 .

Phylogenomic databases

eggNOGi COG1071.
GeneTreei ENSGT00530000063174.
HOGENOMi HOG000281336.
InParanoidi P52899.
KOi K00161.

Miscellaneous databases

NextBioi 958671.
PROi P52899.

Gene expression databases

ExpressionAtlasi P52899. baseline.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiODPA_CAEEL
AccessioniPrimary (citable) accession number: P52899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

External Data

Dasty 3