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Protein

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Gene

T05H10.6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Enzyme regulationi

E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiREACT_319260. Regulation of pyruvate dehydrogenase (PDH) complex.
REACT_348544. Pyruvate metabolism.
REACT_351896. Signaling by Retinoic Acid.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-A
Gene namesi
ORF Names:T05H10.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT05H10.6a; CE01643; WBGene00011510.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 397Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrialPRO_0000020439
Transit peptidei1 – ?MitochondrionSequence Analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52899.
PRIDEiP52899.

Expressioni

Gene expression databases

ExpressionAtlasiP52899. baseline.

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

DIPiDIP-24909N.
STRINGi6239.T05H10.6b.

Structurei

3D structure databases

ProteinModelPortaliP52899.
SMRiP52899. Positions 25-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1071.
GeneTreeiENSGT00530000063174.
HOGENOMiHOG000281336.
InParanoidiP52899.
KOiK00161.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFARQLQS LTASGIRTQQ VRLASTEVSF HTKPCKLHKL DNGPNTSVTL
60 70 80 90 100
NREDALKYYR DMQVIRRMES AAGNLYKEKK IRGFCHLYSG QEACAVGMKA
110 120 130 140 150
AMTEGDAVIT AYRCHGWTWL LGATVTEVLA ELTGRVAGNV HGKGGSMHMY
160 170 180 190 200
TKNFYGGNGI VGAQQPLGAG VALAMKYREQ KNVCVTLYGD GAANQGQLFE
210 220 230 240 250
ATNMAKLWDL PVLFVCENNG FGMGTTAERS SASTEYYTRG DYVPGIWVDG
260 270 280 290 300
MDILAVREAT KWAKEYCDSG KGPLMMEMAT YRYHGHSMSD PGTSYRTREE
310 320 330 340 350
IQEVRKTRDP ITGFKDRIIT SSLATEEELK AIDKEVRKEV DEALKIATSD
360 370 380 390
GVLPPEALYA DIYHNTPAQE IRGATIDETI VQPFKTSADV LKSIGRA
Length:397
Mass (Da):43,792
Last modified:October 1, 1996 - v1
Checksum:i27FB6410B0EA8513
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47812 Genomic DNA. Translation: CAA87793.1.
PIRiT24557.
RefSeqiNP_495693.1. NM_063292.4.
UniGeneiCel.38645.

Genome annotation databases

EnsemblMetazoaiT05H10.6a.1; T05H10.6a.1; WBGene00011510.
T05H10.6a.2; T05H10.6a.2; WBGene00011510.
T05H10.6a.3; T05H10.6a.3; WBGene00011510.
GeneIDi3565996.
KEGGicel:CELE_T05H10.6.
UCSCiT05H10.6b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47812 Genomic DNA. Translation: CAA87793.1.
PIRiT24557.
RefSeqiNP_495693.1. NM_063292.4.
UniGeneiCel.38645.

3D structure databases

ProteinModelPortaliP52899.
SMRiP52899. Positions 25-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24909N.
STRINGi6239.T05H10.6b.

Proteomic databases

PaxDbiP52899.
PRIDEiP52899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT05H10.6a.1; T05H10.6a.1; WBGene00011510.
T05H10.6a.2; T05H10.6a.2; WBGene00011510.
T05H10.6a.3; T05H10.6a.3; WBGene00011510.
GeneIDi3565996.
KEGGicel:CELE_T05H10.6.
UCSCiT05H10.6b. c. elegans.

Organism-specific databases

CTDi3565996.
WormBaseiT05H10.6a; CE01643; WBGene00011510.

Phylogenomic databases

eggNOGiCOG1071.
GeneTreeiENSGT00530000063174.
HOGENOMiHOG000281336.
InParanoidiP52899.
KOiK00161.

Enzyme and pathway databases

ReactomeiREACT_319260. Regulation of pyruvate dehydrogenase (PDH) complex.
REACT_348544. Pyruvate metabolism.
REACT_351896. Signaling by Retinoic Acid.

Miscellaneous databases

NextBioi958671.
PROiP52899.

Gene expression databases

ExpressionAtlasiP52899. baseline.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiODPA_CAEEL
AccessioniPrimary (citable) accession number: P52899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.