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Reviewed, UniProtKB/Swiss-Prot P52898 (DDBX_BOVIN)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Dihydrodiol dehydrogenase 3
    EC=1.-.-.-
Alternative name(s):
    Prostaglandin F synthase
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the aldo/keto reductase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Dihydrodiol dehydrogenase 3
PRO_0000124648

Regions

Nucleotide binding13 – 2210NADP Potential
Nucleotide binding217 – 28064NADP By similarity

Sites

Active site551Proton donor By similarity
Binding site1171Substrate By similarity
Site841Lowers pKa of active site Tyr By similarity

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Sequences

Sequence LengthMass (Da)Tools
P52898-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B7FCC6F8EE09A010

FASTA32336,784
        10         20         30         40         50         60 
MDPKGQRVKL NDGHFIPVLG FGTFAPREVP KSEALEVTKF AIEAGFRHID SAHLYQNEEQ 

        70         80         90        100        110        120 
VGQAIRSKIA DGTVKREDIF YTSKLWSTSL RPELVRPALE KSLNNLQLDY VDLYIIHFPV 

       130        140        150        160        170        180 
ALKPGETLFP TDENGKPIFD SVDLCRTWEA LEKCKDAGLT KSIGVSNFNH KQLEKILNKP 

       190        200        210        220        230        240 
GLKYKPVCNQ VECHPYFNQS KLLDFCKSHD IVLVAYGALG SQRLKEWVNP NLPFLLEDPV 

       250        260        270        280        290        300 
LSAIAKKHRQ TPALVALRYQ IQRGVVVLAK SYNKKRIKEN IQVFDFELTP EDMKAIDGLN 

       310        320 
SNMRYNELLL GVGHPEYPFV EEY

« Hide

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References

« Hide 'large scale' references
[1]Terada T., Hirofumi N., Hideki A.
Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]Suzuki T., Watanabe K., Fujii Y., Chen L., Hayaishi O.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

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Cross-references

Sequence databases

D49542 mRNA. Translation: BAA08493.1.
D88749 mRNA. Translation: BAA13690.1.
BC112519 mRNA. Translation: AAI12520.1.
IPIIPI00704078.
RefSeqNP_851370.1.
UniGeneBt.64820
Bt.66508
Bt.67184
Bt.91770

3D structure databases

HSSPHSSP built from PDB template 1J96 based on UniProtKB P52895.
SMRP52898. Positions 2-323.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000022564. Bos taurus. [Contig view]
GeneID282138.
KEGGbta:282138.

Phylogenomic databases

HOVERGENP52898.
OMAP52898. KRECLEA.

Family and domain databases

InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHERPTHR11732. Aldo/ket_red. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
ProDomPD000288. Aldo/ket_red. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDDBX_BOVIN
AccessionPrimary (citable) accession number: P52898
Secondary accession number(s): Q2KIT3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents