P52898 (DDBX_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Dihydrodiol dehydrogenase 3 EC=1.-.-.- Alternative name(s): Prostaglandin F synthase
Organism	Bos taurus (Bovine)
Taxonomic identifier	9913 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Dihydrodiol dehydrogenase 3		PRO_0000124648
Regions
	Nucleotide binding	13 – 22	10	NADP Potential
	Nucleotide binding	217 – 280	64	NADP By similarity
Sites
	Active site	55	1	Proton donor By similarity
	Binding site	117	1	Substrate By similarity
	Site	84	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52898 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: B7FCC6F8EE09A010	FASTA	323	36,784
	10 20 30 40 50 60 MDPKGQRVKL NDGHFIPVLG FGTFAPREVP KSEALEVTKF AIEAGFRHID SAHLYQNEEQ 70 80 90 100 110 120 VGQAIRSKIA DGTVKREDIF YTSKLWSTSL RPELVRPALE KSLNNLQLDY VDLYIIHFPV 130 140 150 160 170 180 ALKPGETLFP TDENGKPIFD SVDLCRTWEA LEKCKDAGLT KSIGVSNFNH KQLEKILNKP 190 200 210 220 230 240 GLKYKPVCNQ VECHPYFNQS KLLDFCKSHD IVLVAYGALG SQRLKEWVNP NLPFLLEDPV 250 260 270 280 290 300 LSAIAKKHRQ TPALVALRYQ IQRGVVVLAK SYNKKRIKEN IQVFDFELTP EDMKAIDGLN 310 320 SNMRYNELLL GVGHPEYPFV EEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Terada T., Hirofumi N., Hideki A. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	Suzuki T., Watanabe K., Fujii Y., Chen L., Hayaishi O. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49542 mRNA. Translation: BAA08493.1. D88749 mRNA. Translation: BAA13690.1. BC112519 mRNA. Translation: AAI12520.1.
IPI	IPI00704078.
RefSeq	NP_851370.1. NM_181027.2.
UniGene	Bt.91770.
3D structure databases
ProteinModelPortal	P52898.
SMR	P52898. Positions 2-323.
ModBase	Search...
Protein-protein interaction databases
STRING	P52898.
Proteomic databases
PRIDE	P52898.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000014044; ENSBTAP00000014044; ENSBTAG00000022564.
GeneID	282138.
KEGG	bta:282138.
Organism-specific databases
CTD	1109.
Phylogenomic databases
eggNOG	maNOG12158.
HOVERGEN	HBG000020.
InParanoid	P52898.
OMA	PSETILP.
OrthoDB	EOG434W6N.
PhylomeDB	P52898.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DDBX_BOVIN

Accession

Primary (citable) accession number: P52898
Secondary accession number(s): Q2KIT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program