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P52894

- ALA2_HORVU

UniProt

P52894 - ALA2_HORVU

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Protein

Alanine aminotransferase 2

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transfer of C3 units between the cytosol of mesophyll and bundle sheath cells to maintain a nitrogen-carbon balance in the C4-dicarboxylic pathway.

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. L-alanine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00322.
UPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine aminotransferase 2 (EC:2.6.1.2)
Short name:
ALAAT-2
Alternative name(s):
Glutamate pyruvate transaminase 2
Short name:
GPT
Glutamic--alanine transaminase 2
Glutamic--pyruvic transaminase 2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiP52894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Alanine aminotransferase 2PRO_0000123939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991N6-(pyridoxal phosphate)lysine By similarity

Expressioni

Gene expression databases

GenevestigatoriP52894.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

Secondary structure

1
482
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93
Helixi12 – 165
Helixi20 – 223
Helixi24 – 3815
Beta strandi42 – 476
Helixi56 – 583
Helixi65 – 7511
Helixi77 – 815
Helixi85 – 884
Helixi91 – 10111
Beta strandi109 – 1113
Helixi119 – 13315
Helixi139 – 1413
Beta strandi142 – 1487
Helixi149 – 15911
Beta strandi165 – 1728
Helixi176 – 1838
Beta strandi187 – 1926
Turni195 – 1984
Helixi203 – 21513
Beta strandi219 – 22810
Turni230 – 2323
Helixi238 – 25114
Beta strandi254 – 2585
Turni260 – 2634
Helixi275 – 2817
Beta strandi285 – 2873
Beta strandi291 – 2999
Turni300 – 3023
Helixi305 – 3073
Beta strandi310 – 3167
Helixi321 – 33010
Helixi337 – 34711
Beta strandi352 – 3543
Helixi356 – 38328
Beta strandi395 – 3995
Helixi407 – 41610
Helixi420 – 43213
Beta strandi437 – 4393
Turni440 – 4423
Beta strandi450 – 4556
Turni459 – 4613
Helixi462 – 48019

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TCMX-ray2.71A/B1-482[»]
ProteinModelPortaliP52894.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P52894-1 [UniParc]FASTAAdd to Basket

« Hide

MAATVAVDNL NPKVLKCEYA VRGEIVIHAQ RLQEQLKTQP GSLPFDEILY    50
CNIGNPQSLG QQPVTFFREV LALCDHPDLL QREEIKTLFS ADSISRAKQI 100
LAMIPGRATG AYSHSQGIKG LRDAIASGIA SRDGFPANAD DIFLTDGASP 150
GVHLMMQLLI RNEKDGILVP IPQYPLYSAS IALHGGALVP YYLNESTGWG 200
LETSDVKKQL EDARSRGINV RALVVINPGN PTGQVLAEEN QYDIVKFCKN 250
EGLVLLADEV YQENIYVDNK KFHSFKKIVR SLGYGEEDLP LVSYQSVSKG 300
YYGECGKRGG YFEITGFSAP VREQIYKIAS VNLCSNITGQ ILASLVMNPP 350
KASDESYASY KAEKDGILAS LARRAKALEH AFNKLEGITC NEAEGAMYVF 400
PQICLPQKAI EAAKAANKAP DAFYALRLLE STGIVVVPGS GFGQVPGTWH 450
FRCTILPQED KIPAVISRFT VFHEAFMSEY RD 482
Length:482
Mass (Da):52,877
Last modified:October 1, 1996 - v1
Checksum:iE84176F7DFB6B2FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26322 mRNA. Translation: CAA81231.1.
PIRiS42535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26322 mRNA. Translation: CAA81231.1 .
PIRi S42535.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TCM X-ray 2.71 A/B 1-482 [» ]
ProteinModelPortali P52894.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P52894.

Enzyme and pathway databases

UniPathwayi UPA00322 .
UPA00528 ; UER00586 .

Gene expression databases

Genevestigatori P52894.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Hypoxically inducible barley alanine aminotransferase: cDNA cloning and expression analysis."
    Muench D.G., Good A.G.
    Plant Mol. Biol. 24:417-427(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Himalaya.
    Tissue: Root.

Entry informationi

Entry nameiALA2_HORVU
AccessioniPrimary (citable) accession number: P52894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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