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P52892

- ALAT_YEAST

UniProt

P52892 - ALAT_YEAST

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Protein

Probable alanine aminotransferase

Gene

ALT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. transaminase activity Source: SGD

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. L-alanine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:YDR111C-MONOMER.
UniPathwayiUPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alanine aminotransferase (EC:2.6.1.2)
Alternative name(s):
Glutamate pyruvate transaminase
Short name:
GPT
Glutamic--alanine transaminase
Glutamic--pyruvic transaminase
Gene namesi
Name:ALT2
Ordered Locus Names:YDR111C
ORF Names:YD9727.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR111c.
SGDiS000002518. ALT2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Probable alanine aminotransferasePRO_0000123937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei327 – 3271N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiP52892.
PaxDbiP52892.

Expressioni

Gene expression databases

GenevestigatoriP52892.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi32169. 31 interactions.
DIPiDIP-4931N.
IntActiP52892. 2 interactions.
MINTiMINT-550889.
STRINGi4932.YDR111C.

Structurei

3D structure databases

ProteinModelPortaliP52892.
SMRiP52892. Positions 30-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
GeneTreeiENSGT00650000093331.
HOGENOMiHOG000215020.
InParanoidiP52892.
KOiK00814.
OMAiEESNWST.
OrthoDBiEOG7GXPMR.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P52892-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMTHQQDLK GVFTAKDLDF KPAGKITKKD LNTGVTKAEY AVRGAIPTRA
60 70 80 90 100
DELKEELKKN PEVLPFDDII NANIGNPQQL DQKPLTFTRQ VLAILEYPEI
110 120 130 140 150
LRVGHNELAS LNLFSRDALE RAERLLNDIG GSIGAYSHSQ GVPGIRQTVA
160 170 180 190 200
DFITRRDGGE PATPEDIYLT TGASSAATSL LSLLCKDSQT GLLIPIPQYP
210 220 230 240 250
LYTASASLFN AQVLPYYLDE ESNWSTNSDE IEKVVQDALK KQIRPSVLIV
260 270 280 290 300
INPGNPTGAV LSEETIARIC LIAAKYGITI ISDEVYQENI FNDVKFHSMK
310 320 330 340 350
KVLRKLQHLY PGKFDNVQLA SLHSISKGFM DECGQRGGYM EIIGFSQEIR
360 370 380 390 400
DALFKLMSIS ICSVVTGQAV VDLMVKPPQP GDESYEQDHD ERLKIFHEMR
410 420 430 440 450
TRANLLYETF KELEGIECQK PQGAMYLFPR LVLPKKALCE SERLGIEPDE
460 470 480 490 500
FYCTSLLEST GICTVPGSGF GQRPGTYHVR TTFLAPGTKW IQDWKEFHQD

FFSKYRN
Length:507
Mass (Da):56,770
Last modified:October 1, 1996 - v1
Checksum:iCB4DCD137CF26085
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti420 – 4201K → E in AAU09694. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48758 Genomic DNA. Translation: CAA88665.1.
AY723777 Genomic DNA. Translation: AAU09694.1.
BK006938 Genomic DNA. Translation: DAA11957.1.
PIRiS52677.
RefSeqiNP_010396.1. NM_001180419.1.

Genome annotation databases

EnsemblFungiiYDR111C; YDR111C; YDR111C.
GeneIDi851690.
KEGGisce:YDR111C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48758 Genomic DNA. Translation: CAA88665.1 .
AY723777 Genomic DNA. Translation: AAU09694.1 .
BK006938 Genomic DNA. Translation: DAA11957.1 .
PIRi S52677.
RefSeqi NP_010396.1. NM_001180419.1.

3D structure databases

ProteinModelPortali P52892.
SMRi P52892. Positions 30-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32169. 31 interactions.
DIPi DIP-4931N.
IntActi P52892. 2 interactions.
MINTi MINT-550889.
STRINGi 4932.YDR111C.

Proteomic databases

MaxQBi P52892.
PaxDbi P52892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR111C ; YDR111C ; YDR111C .
GeneIDi 851690.
KEGGi sce:YDR111C.

Organism-specific databases

CYGDi YDR111c.
SGDi S000002518. ALT2.

Phylogenomic databases

eggNOGi COG0436.
GeneTreei ENSGT00650000093331.
HOGENOMi HOG000215020.
InParanoidi P52892.
KOi K00814.
OMAi EESNWST.
OrthoDBi EOG7GXPMR.

Enzyme and pathway databases

UniPathwayi UPA00528 ; UER00586 .
BioCyci YEAST:YDR111C-MONOMER.

Miscellaneous databases

NextBioi 969341.

Gene expression databases

Genevestigatori P52892.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiALAT_YEAST
AccessioniPrimary (citable) accession number: P52892
Secondary accession number(s): D6VS97, Q66RF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3480 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3