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Protein

Nucleoporin NUP84

Gene

NUP84

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP84 is involved in nuclear poly(A)+ RNA export, in NPC assembly and distribution, as well as in nuclear envelope organization.2 Publications

GO - Molecular functioni

  • nucleocytoplasmic transporter activity Source: GO_Central
  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • chromatin silencing at silent mating-type cassette Source: SGD
  • double-strand break repair Source: SGD
  • maintenance of chromatin silencing at telomere Source: SGD
  • mRNA export from nucleus Source: SGD
  • mRNA export from nucleus in response to heat stress Source: SGD
  • nuclear pore distribution Source: SGD
  • positive regulation of transcription, DNA-templated Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: SGD
  • protein import into nucleus Source: SGD
  • telomere tethering at nuclear periphery Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29516-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP84
Alternative name(s):
Nuclear pore protein NUP84
Gene namesi
Name:NUP84
Ordered Locus Names:YDL116W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL116W.
SGDiS000002274. NUP84.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: GOC
  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: SGD
  • nuclear pore outer ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048841 – 726Nucleoporin NUP84Add BLAST726

Proteomic databases

MaxQBiP52891.
PRIDEiP52891.

PTM databases

iPTMnetiP52891.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP84 is part of the heptameric 0.5 MDa autoassembling NUP84 NPC subcomplex (NUP84, NUP85, NUP120, NUP133, NUP145C, SEC13 and SEH1).

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP100Q026292EBI-12337,EBI-11698
NUP120P357296EBI-12337,EBI-11713
NUP133P361613EBI-12337,EBI-11722
NUP145P4968710EBI-12337,EBI-11730

Protein-protein interaction databases

BioGridi31946. 247 interactors.
DIPiDIP-2430N.
IntActiP52891. 22 interactors.
MINTiMINT-426746.

Structurei

Secondary structure

1726
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 11Combined sources4
Helixi12 – 23Combined sources12
Helixi36 – 55Combined sources20
Helixi61 – 87Combined sources27
Helixi102 – 112Combined sources11
Helixi114 – 128Combined sources15
Helixi145 – 149Combined sources5
Helixi160 – 163Combined sources4
Helixi166 – 168Combined sources3
Helixi171 – 189Combined sources19
Helixi193 – 202Combined sources10
Helixi206 – 213Combined sources8
Turni221 – 223Combined sources3
Helixi225 – 227Combined sources3
Turni228 – 230Combined sources3
Beta strandi235 – 237Combined sources3
Helixi240 – 252Combined sources13
Beta strandi254 – 256Combined sources3
Helixi258 – 268Combined sources11
Helixi274 – 277Combined sources4
Helixi282 – 304Combined sources23
Helixi310 – 312Combined sources3
Helixi324 – 334Combined sources11
Helixi336 – 340Combined sources5
Helixi344 – 351Combined sources8
Helixi356 – 364Combined sources9
Helixi383 – 399Combined sources17
Helixi406 – 422Combined sources17
Helixi426 – 428Combined sources3
Helixi429 – 433Combined sources5
Helixi437 – 441Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IKOX-ray3.20C/F/I1-460[»]
3JROX-ray4.00C1-424[»]
4XMMX-ray7.38F1-451[»]
4XMNX-ray7.60F2-451[»]
ProteinModelPortaliP52891.
SMRiP52891.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52891.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili563 – 583Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the Nup84/Nup107 nucleoporin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000012080.
HOGENOMiHOG000113892.
InParanoidiP52891.
KOiK14301.
OMAiEENAYNE.
OrthoDBiEOG092C0NZM.

Family and domain databases

InterProiIPR007252. Nup84_Nup100.
[Graphical view]
PANTHERiPTHR13003. PTHR13003. 1 hit.
PfamiPF04121. Nup84_Nup100. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSPTYQTE RFTKFSDTLK EFKIEQNNEQ NPIDPFNIIR EFRSAAGQLA
60 70 80 90 100
LDLANSGDES NVISSKDWEL EARFWHLVEL LLVFRNADLD LDEMELHPYN
110 120 130 140 150
SRGLFEKKLM QDNKQLYQIW IVMVWLKENT YVMERPKNVP TSKWLNSITS
160 170 180 190 200
GGLKSCDLDF PLRENTNVLD VKDKEEDHIF FKYIYELILA GAIDEALEEA
210 220 230 240 250
KLSDNISICM ILCGIQEYLN PVIDTQIANE FNTQQGIKKH SLWRRTVYSL
260 270 280 290 300
SQQAGLDPYE RAIYSYLSGA IPNQEVLQYS DWESDLHIHL NQILQTEIEN
310 320 330 340 350
YLLENNQVGT DELILPLPSH ALTVQEVLNR VASRHPSESE HPIRVLMASV
360 370 380 390 400
ILDSLPSVIH SSVEMLLDVV KGTEASNDII DKPYLLRIVT HLAICLDIIN
410 420 430 440 450
PGSVEEVDKS KLITTYISLL KLQGLYENIP IYATFLNESD CLEACSFILS
460 470 480 490 500
SLEDPQVRKK QIETINFLRL PASNILRRTT QRVFDETEQE YSPSNEISIS
510 520 530 540 550
FDVNNIDMHL IYGVEWLIEG KLYVDAVHSI IALSRRFLLN GRVKALEQFM
560 570 580 590 600
ERNNIGEICK NYELEKIADN ISKDENEDQF LEEITQYEHL IKGIREYEEW
610 620 630 640 650
QKSVSLLSSE SNIPTLIEKL QGFSKDTFEL IKTFLVDLTS SNFADSADYE
660 670 680 690 700
ILYEIRALYT PFLLMELHKK LVEAAKLLKI PKFISEALAF TSLVANENDK
710 720
IYLLFQSSGK LKEYLDLVAR TATLSN
Length:726
Mass (Da):83,635
Last modified:October 1, 1996 - v1
Checksum:iF45BAAF9B976EEFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90993 Genomic DNA. Translation: CAA62479.1.
Z74164 Genomic DNA. Translation: CAA98684.1.
BK006938 Genomic DNA. Translation: DAA11744.1.
PIRiS62180.
RefSeqiNP_010167.1. NM_001180175.1.

Genome annotation databases

EnsemblFungiiYDL116W; YDL116W; YDL116W.
GeneIDi851441.
KEGGisce:YDL116W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90993 Genomic DNA. Translation: CAA62479.1.
Z74164 Genomic DNA. Translation: CAA98684.1.
BK006938 Genomic DNA. Translation: DAA11744.1.
PIRiS62180.
RefSeqiNP_010167.1. NM_001180175.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IKOX-ray3.20C/F/I1-460[»]
3JROX-ray4.00C1-424[»]
4XMMX-ray7.38F1-451[»]
4XMNX-ray7.60F2-451[»]
ProteinModelPortaliP52891.
SMRiP52891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31946. 247 interactors.
DIPiDIP-2430N.
IntActiP52891. 22 interactors.
MINTiMINT-426746.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP52891.

Proteomic databases

MaxQBiP52891.
PRIDEiP52891.

Protocols and materials databases

DNASUi851441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL116W; YDL116W; YDL116W.
GeneIDi851441.
KEGGisce:YDL116W.

Organism-specific databases

EuPathDBiFungiDB:YDL116W.
SGDiS000002274. NUP84.

Phylogenomic databases

GeneTreeiENSGT00390000012080.
HOGENOMiHOG000113892.
InParanoidiP52891.
KOiK14301.
OMAiEENAYNE.
OrthoDBiEOG092C0NZM.

Enzyme and pathway databases

BioCyciYEAST:G3O-29516-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP52891.
PROiP52891.

Family and domain databases

InterProiIPR007252. Nup84_Nup100.
[Graphical view]
PANTHERiPTHR13003. PTHR13003. 1 hit.
PfamiPF04121. Nup84_Nup100. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUP84_YEAST
AccessioniPrimary (citable) accession number: P52891
Secondary accession number(s): D6VRN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8580 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.