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Protein

Transmembrane protein 165

Gene

Tmem165

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.106.2.1. the ca(2+):h(+) antiporter-2 (caca2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 165
Alternative name(s):
TPA-regulated locus protein
Transmembrane protein PFT27
Transmembrane protein TPARL
Gene namesi
Name:Tmem165
Synonyms:Tparl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:894407. Tmem165.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 8956LumenalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 12616CytoplasmicSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 1514LumenalSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 22755CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST
Topological domaini249 – 26618LumenalSequence analysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST
Topological domaini288 – 29811CytoplasmicSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Topological domaini320 – 3234LumenalSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 323290Transmembrane protein 165PRO_0000212469Add
BLAST

Proteomic databases

EPDiP52875.
MaxQBiP52875.
PaxDbiP52875.
PeptideAtlasiP52875.
PRIDEiP52875.

PTM databases

iPTMnetiP52875.
PhosphoSiteiP52875.

Expressioni

Developmental stagei

Expressed in undifferentiated mouse F9 teratocarcinoma stem cells but disappearing rapidly after treatment with a tumor-promoting phorbol ester.

Gene expression databases

BgeeiENSMUSG00000029234.
CleanExiMM_TMEM165.
ExpressionAtlasiP52875. baseline and differential.
GenevisibleiP52875. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031144.

Structurei

3D structure databases

ProteinModelPortaliP52875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili184 – 21128Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GDT1 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2881. Eukaryota.
COG2119. LUCA.
GeneTreeiENSGT00390000005261.
HOGENOMiHOG000224541.
HOVERGENiHBG002358.
InParanoidiP52875.
OMAiPIFVQAF.
OrthoDBiEOG091G0LRI.
PhylomeDBiP52875.
TreeFamiTF105960.

Family and domain databases

InterProiIPR001727. Gdt1.
[Graphical view]
PANTHERiPTHR12608. PTHR12608. 1 hit.
PfamiPF01169. UPF0016. 2 hits.
[Graphical view]
PROSITEiPS01214. UPF0016. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAARGSGR APTRRLLVLL LLQLLWAPAG VRAGPEEDLS HRNQEPPAPA
60 70 80 90 100
QQLQPQPAAV QGLEPARAEK GLTPVAPVHT NKEDAAAQTN LGFIHAFVAA
110 120 130 140 150
ISVIIVSELG DKTFFIAAIM AMRYNRLTVL AGAMLALALM TCLSVLFGYA
160 170 180 190 200
TTVIPRVYTY YVSTALFAIF GIRMLREGLK MSPDEGQEEL EEVQAELKKK
210 220 230 240 250
DEEFQRTKLL NGPDVETGTS TAIPQKKWLH FISPIFVQAL TLTFLAEWGD
260 270 280 290 300
RSQLTTIVLA AREDPYGVAV GGTVGHCLCT GLAVIGGRMI AQKISVRTVT
310 320
IIGGIVFLAF AFSALFISPE SGF
Length:323
Mass (Da):34,791
Last modified:July 25, 2006 - v2
Checksum:i3CBE4348A5B70563
GO

Sequence cautioni

The sequence AAA40456 differs from that shown. Reason: Frameshift at positions 49 and 55. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23568 mRNA. Translation: AAA40456.1. Frameshift.
AF146793 Genomic DNA. Translation: AAD30566.2.
CCDSiCCDS19359.1.
PIRiA31351.
RefSeqiNP_035756.2. NM_011626.2.
UniGeneiMm.790.

Genome annotation databases

EnsembliENSMUST00000031144; ENSMUSP00000031144; ENSMUSG00000029234.
GeneIDi21982.
KEGGimmu:21982.
UCSCiuc008xup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23568 mRNA. Translation: AAA40456.1. Frameshift.
AF146793 Genomic DNA. Translation: AAD30566.2.
CCDSiCCDS19359.1.
PIRiA31351.
RefSeqiNP_035756.2. NM_011626.2.
UniGeneiMm.790.

3D structure databases

ProteinModelPortaliP52875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031144.

Protein family/group databases

TCDBi2.A.106.2.1. the ca(2+):h(+) antiporter-2 (caca2) family.

PTM databases

iPTMnetiP52875.
PhosphoSiteiP52875.

Proteomic databases

EPDiP52875.
MaxQBiP52875.
PaxDbiP52875.
PeptideAtlasiP52875.
PRIDEiP52875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031144; ENSMUSP00000031144; ENSMUSG00000029234.
GeneIDi21982.
KEGGimmu:21982.
UCSCiuc008xup.1. mouse.

Organism-specific databases

CTDi55858.
MGIiMGI:894407. Tmem165.

Phylogenomic databases

eggNOGiKOG2881. Eukaryota.
COG2119. LUCA.
GeneTreeiENSGT00390000005261.
HOGENOMiHOG000224541.
HOVERGENiHBG002358.
InParanoidiP52875.
OMAiPIFVQAF.
OrthoDBiEOG091G0LRI.
PhylomeDBiP52875.
TreeFamiTF105960.

Miscellaneous databases

ChiTaRSiTmem165. mouse.
PROiP52875.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029234.
CleanExiMM_TMEM165.
ExpressionAtlasiP52875. baseline and differential.
GenevisibleiP52875. MM.

Family and domain databases

InterProiIPR001727. Gdt1.
[Graphical view]
PANTHERiPTHR12608. PTHR12608. 1 hit.
PfamiPF01169. UPF0016. 2 hits.
[Graphical view]
PROSITEiPS01214. UPF0016. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM165_MOUSE
AccessioniPrimary (citable) accession number: P52875
Secondary accession number(s): Q9R292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.