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Protein

Transmembrane protein 165

Gene

Tmem165

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation (By similarity).By similarity

GO - Biological processi

Protein family/group databases

TCDBi2.A.106.2.1 the ca(2+):h(+) antiporter-2 (caca2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 165
Alternative name(s):
TPA-regulated locus protein
Transmembrane protein PFT27
Transmembrane protein TPARL
Gene namesi
Name:Tmem165
Synonyms:Tparl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:894407 Tmem165

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 89LumenalSequence analysisAdd BLAST56
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 126CytoplasmicSequence analysisAdd BLAST16
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 151LumenalSequence analysis4
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 227CytoplasmicSequence analysisAdd BLAST55
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 266LumenalSequence analysisAdd BLAST18
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 298CytoplasmicSequence analysisAdd BLAST11
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 323LumenalSequence analysis4

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000021246934 – 323Transmembrane protein 165Add BLAST290

Proteomic databases

EPDiP52875
MaxQBiP52875
PaxDbiP52875
PeptideAtlasiP52875
PRIDEiP52875

PTM databases

iPTMnetiP52875
PhosphoSitePlusiP52875

Expressioni

Developmental stagei

Expressed in undifferentiated mouse F9 teratocarcinoma stem cells but disappearing rapidly after treatment with a tumor-promoting phorbol ester.

Gene expression databases

BgeeiENSMUSG00000029234
CleanExiMM_TMEM165
ExpressionAtlasiP52875 baseline and differential
GenevisibleiP52875 MM

Interactioni

Protein-protein interaction databases

BioGridi204284, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP52875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili184 – 211Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the GDT1 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2881 Eukaryota
COG2119 LUCA
GeneTreeiENSGT00390000005261
HOGENOMiHOG000224541
HOVERGENiHBG002358
InParanoidiP52875
OMAiPIFVQAF
OrthoDBiEOG091G0LRI
PhylomeDBiP52875
TreeFamiTF105960

Family and domain databases

InterProiView protein in InterPro
IPR001727 Gdt1
PANTHERiPTHR12608 PTHR12608, 1 hit
PfamiView protein in Pfam
PF01169 UPF0016, 2 hits
PROSITEiView protein in PROSITE
PS01214 UPF0016, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAARGSGR APTRRLLVLL LLQLLWAPAG VRAGPEEDLS HRNQEPPAPA
60 70 80 90 100
QQLQPQPAAV QGLEPARAEK GLTPVAPVHT NKEDAAAQTN LGFIHAFVAA
110 120 130 140 150
ISVIIVSELG DKTFFIAAIM AMRYNRLTVL AGAMLALALM TCLSVLFGYA
160 170 180 190 200
TTVIPRVYTY YVSTALFAIF GIRMLREGLK MSPDEGQEEL EEVQAELKKK
210 220 230 240 250
DEEFQRTKLL NGPDVETGTS TAIPQKKWLH FISPIFVQAL TLTFLAEWGD
260 270 280 290 300
RSQLTTIVLA AREDPYGVAV GGTVGHCLCT GLAVIGGRMI AQKISVRTVT
310 320
IIGGIVFLAF AFSALFISPE SGF
Length:323
Mass (Da):34,791
Last modified:July 25, 2006 - v2
Checksum:i3CBE4348A5B70563
GO

Sequence cautioni

The sequence AAA40456 differs from that shown. Reason: Frameshift at positions 49 and 55.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23568 mRNA Translation: AAA40456.1 Frameshift.
AF146793 Genomic DNA Translation: AAD30566.2
CCDSiCCDS19359.1
PIRiA31351
RefSeqiNP_035756.2, NM_011626.2
UniGeneiMm.790

Genome annotation databases

EnsembliENSMUST00000031144; ENSMUSP00000031144; ENSMUSG00000029234
GeneIDi21982
KEGGimmu:21982
UCSCiuc008xup.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTM165_MOUSE
AccessioniPrimary (citable) accession number: P52875
Secondary accession number(s): Q9R292
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 25, 2006
Last modified: December 20, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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