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Protein

Protein transport protein SBH2

Gene

SBH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30348-MONOMER

Protein family/group databases

TCDBi3.A.5.8.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SBH2
Alternative name(s):
Ssh1 complex subunit SBH2
Ssh1 complex subunit beta
Gene namesi
Name:SBH2
Synonyms:SEB2
Ordered Locus Names:YER019C-A
ORF Names:YER019BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER019C-A
SGDiS000002127 SBH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001572621 – 88Protein transport protein SBH2Add BLAST88

Proteomic databases

MaxQBiP52871
PaxDbiP52871
PRIDEiP52871
TopDownProteomicsiP52871

Interactioni

Subunit structurei

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: SGD

Protein-protein interaction databases

BioGridi3675368 interactors.
DIPiDIP-1708N
IntActiP52871 6 interactors.
MINTiP52871
STRINGi4932.YER019C-A

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60C1-87[»]
2WWAelectron microscopy8.90C1-87[»]
ProteinModelPortaliP52871
SMRiP52871
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52871

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000211109
InParanoidiP52871
KOiK09481
OMAiNSGGMWR
OrthoDBiEOG092C5YZH

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit

Sequencei

Sequence statusi: Complete.

P52871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVPPGGQ RILQKRRQAQ SIKEKQAKQT PTSTRQAGYG GSSSSILKLY
60 70 80
TDEANGFRVD SLVVLFLSVG FIFSVIALHL LTKFTHII
Length:88
Mass (Da):9,606
Last modified:October 1, 1996 - v1
Checksum:i5A4F5B9184202E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50012 mRNA Translation: CAA90305.1
L38891 mRNA Translation: AAT01101.1
U18778 Genomic DNA Translation: AAB64567.1
AY693199 Genomic DNA Translation: AAT93218.1
BK006939 Genomic DNA Translation: DAA07672.1
PIRiS68163
RefSeqiNP_010936.1, NM_001180031.1

Genome annotation databases

EnsemblFungiiYER019C-A; YER019C-A; YER019C-A
GeneIDi856740
KEGGisce:YER019C-A

Similar proteinsi

Entry informationi

Entry nameiSC6B2_YEAST
AccessioniPrimary (citable) accession number: P52871
Secondary accession number(s): D3DLR8, Q53X22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome