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Protein

Protein transport protein SBH2

Gene

SBH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

  • positive regulation of GTPase activity Source: GOC
  • SRP-dependent cotranslational protein targeting to membrane Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30348-MONOMER.

Protein family/group databases

TCDBi3.A.5.8.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SBH2
Alternative name(s):
Ssh1 complex subunit SBH2
Ssh1 complex subunit beta
Gene namesi
Name:SBH2
Synonyms:SEB2
Ordered Locus Names:YER019C-A
ORF Names:YER019BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYER019c-a.
EuPathDBiFungiDB:YER019C-A.
SGDiS000002127. SBH2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • Sec61 translocon complex Source: InterPro
  • Ssh1 translocon complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Protein transport protein SBH2PRO_0000157262Add
BLAST

Proteomic databases

MaxQBiP52871.
PaxDbiP52871.

Interactioni

Subunit structurei

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

Protein-protein interaction databases

BioGridi36753. 55 interactions.
DIPiDIP-1708N.
IntActiP52871. 6 interactions.
MINTiMINT-396359.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60C1-87[»]
2WWAelectron microscopy8.90C1-87[»]
ProteinModelPortaliP52871.
SMRiP52871. Positions 52-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52871.

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330120.
GeneTreeiENSGT00390000015774.
HOGENOMiHOG000211109.
InParanoidiP52871.
KOiK09481.
OMAiIANARPN.
OrthoDBiEOG7WQ85T.

Family and domain databases

InterProiIPR030671. Sec61-beta/Sbh.
IPR016482. SecG/Sec61-beta/Sbh.
[Graphical view]
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

P52871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVPPGGQ RILQKRRQAQ SIKEKQAKQT PTSTRQAGYG GSSSSILKLY
60 70 80
TDEANGFRVD SLVVLFLSVG FIFSVIALHL LTKFTHII
Length:88
Mass (Da):9,606
Last modified:October 1, 1996 - v1
Checksum:i5A4F5B9184202E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50012 mRNA. Translation: CAA90305.1.
L38891 mRNA. Translation: AAT01101.1.
U18778 Genomic DNA. Translation: AAB64567.1.
AY693199 Genomic DNA. Translation: AAT93218.1.
BK006939 Genomic DNA. Translation: DAA07672.1.
PIRiS68163.
RefSeqiNP_010936.1. NM_001180031.1.

Genome annotation databases

EnsemblFungiiYER019C-A; YER019C-A; YER019C-A.
GeneIDi856740.
KEGGisce:YER019C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50012 mRNA. Translation: CAA90305.1.
L38891 mRNA. Translation: AAT01101.1.
U18778 Genomic DNA. Translation: AAB64567.1.
AY693199 Genomic DNA. Translation: AAT93218.1.
BK006939 Genomic DNA. Translation: DAA07672.1.
PIRiS68163.
RefSeqiNP_010936.1. NM_001180031.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60C1-87[»]
2WWAelectron microscopy8.90C1-87[»]
ProteinModelPortaliP52871.
SMRiP52871. Positions 52-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36753. 55 interactions.
DIPiDIP-1708N.
IntActiP52871. 6 interactions.
MINTiMINT-396359.

Protein family/group databases

TCDBi3.A.5.8.1. the general secretory pathway (sec) family.

Proteomic databases

MaxQBiP52871.
PaxDbiP52871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER019C-A; YER019C-A; YER019C-A.
GeneIDi856740.
KEGGisce:YER019C-A.

Organism-specific databases

CYGDiYER019c-a.
EuPathDBiFungiDB:YER019C-A.
SGDiS000002127. SBH2.

Phylogenomic databases

eggNOGiNOG330120.
GeneTreeiENSGT00390000015774.
HOGENOMiHOG000211109.
InParanoidiP52871.
KOiK09481.
OMAiIANARPN.
OrthoDBiEOG7WQ85T.

Enzyme and pathway databases

BioCyciYEAST:G3O-30348-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP52871.
NextBioi982870.
PROiP52871.

Family and domain databases

InterProiIPR030671. Sec61-beta/Sbh.
IPR016482. SecG/Sec61-beta/Sbh.
[Graphical view]
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit."
    Toikkanen J., Gatti E., Takei K., Saloheimo M., Olkkonen V.M., Soederlund H., de Camilli P., Keraenen S.
    Yeast 12:425-438(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Yeast Sec61 beta subunit."
    Finke K., Panzner S., Sommer T., Hartmann E., Rapoport T.A.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae."
    Finke K., Plath K., Panzner S., Prehn S., Rapoport T.A., Hartmann E., Sommer T.
    EMBO J. 15:1482-1494(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-32.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC6B2_YEAST
AccessioniPrimary (citable) accession number: P52871
Secondary accession number(s): D3DLR8, Q53X22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.