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P52871 (SC6B2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein SBH2
Alternative name(s):
Ssh1 complex subunit SBH2
Ssh1 complex subunit beta
Gene names
Name:SBH2
Synonyms:SEB2
Ordered Locus Names:YER019C-A
ORF Names:YER019BC
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length88 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.

Subunit structure

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein.

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SEC61-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8888Protein transport protein SBH2
PRO_0000157262

Regions

Topological domain1 – 6161Cytoplasmic Potential
Transmembrane62 – 8221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P52871 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5A4F5B9184202E88

FASTA889,606
        10         20         30         40         50         60 
MAASVPPGGQ RILQKRRQAQ SIKEKQAKQT PTSTRQAGYG GSSSSILKLY TDEANGFRVD 

        70         80 
SLVVLFLSVG FIFSVIALHL LTKFTHII 

« Hide

References

« Hide 'large scale' references
[1]"Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit."
Toikkanen J., Gatti E., Takei K., Saloheimo M., Olkkonen V.M., Soederlund H., de Camilli P., Keraenen S.
Yeast 12:425-438(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Yeast Sec61 beta subunit."
Finke K., Panzner S., Sommer T., Hartmann E., Rapoport T.A.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae."
Finke K., Plath K., Panzner S., Prehn S., Rapoport T.A., Hartmann E., Sommer T.
EMBO J. 15:1482-1494(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 16-32.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z50012 mRNA. Translation: CAA90305.1.
L38891 mRNA. Translation: AAT01101.1.
U18778 Genomic DNA. Translation: AAB64567.1.
AY693199 Genomic DNA. Translation: AAT93218.1.
BK006939 Genomic DNA. Translation: DAA07672.1.
PIRS68163.
RefSeqNP_010936.1. NM_001180031.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60C1-87[»]
2WWAelectron microscopy8.90C1-87[»]
ProteinModelPortalP52871.
SMRP52871. Positions 52-86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36753. 56 interactions.
DIPDIP-1708N.
IntActP52871. 6 interactions.
MINTMINT-396359.
STRING4932.YER019C-A.

Protein family/group databases

TCDB3.A.5.8.1. the general secretory pathway (sec) family.

Proteomic databases

MaxQBP52871.
PaxDbP52871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER019C-A; YER019C-A; YER019C-A.
GeneID856740.
KEGGsce:YER019C-A.

Organism-specific databases

CYGDYER019c-a.
SGDS000002127. SBH2.

Phylogenomic databases

eggNOGNOG330120.
GeneTreeENSGT00390000015774.
HOGENOMHOG000211109.
KOK09481.
OMANAMPLST.
OrthoDBEOG7WQ85T.

Enzyme and pathway databases

BioCycYEAST:G3O-30348-MONOMER.

Gene expression databases

GenevestigatorP52871.

Family and domain databases

InterProIPR016482. SecG/Sec61-beta/Sbh1.
[Graphical view]
PANTHERPTHR13509. PTHR13509. 1 hit.
PfamPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFPIRSF006398. Sec61_beta_euk. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP52871.
NextBio982870.
PROP52871.

Entry information

Entry nameSC6B2_YEAST
AccessionPrimary (citable) accession number: P52871
Secondary accession number(s): D3DLR8, Q53X22
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references