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P52871

- SC6B2_YEAST

UniProt

P52871 - SC6B2_YEAST

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Protein

Protein transport protein SBH2

Gene

SBH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.

GO - Molecular functioni

  1. ARF guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. SRP-dependent cotranslational protein targeting to membrane Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30348-MONOMER.

Protein family/group databases

TCDBi3.A.5.8.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SBH2
Alternative name(s):
Ssh1 complex subunit SBH2
Ssh1 complex subunit beta
Gene namesi
Name:SBH2
Synonyms:SEB2
Ordered Locus Names:YER019C-A
ORF Names:YER019BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER019c-a.
SGDiS000002127. SBH2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. Ssh1 translocon complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Protein transport protein SBH2PRO_0000157262Add
BLAST

Proteomic databases

MaxQBiP52871.
PaxDbiP52871.

Expressioni

Gene expression databases

GenevestigatoriP52871.

Interactioni

Subunit structurei

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

Protein-protein interaction databases

BioGridi36753. 56 interactions.
DIPiDIP-1708N.
IntActiP52871. 6 interactions.
MINTiMINT-396359.
STRINGi4932.YER019C-A.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60C1-87[»]
2WWAelectron microscopy8.90C1-87[»]
ProteinModelPortaliP52871.
SMRiP52871. Positions 52-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52871.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330120.
GeneTreeiENSGT00390000015774.
HOGENOMiHOG000211109.
InParanoidiP52871.
KOiK09481.
OMAiNAMPLST.
OrthoDBiEOG7WQ85T.

Family and domain databases

InterProiIPR016482. SecG/Sec61-beta/Sbh1.
[Graphical view]
PANTHERiPTHR13509. PTHR13509. 1 hit.
PfamiPF03911. Sec61_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF006398. Sec61_beta_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

P52871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASVPPGGQ RILQKRRQAQ SIKEKQAKQT PTSTRQAGYG GSSSSILKLY
60 70 80
TDEANGFRVD SLVVLFLSVG FIFSVIALHL LTKFTHII
Length:88
Mass (Da):9,606
Last modified:October 1, 1996 - v1
Checksum:i5A4F5B9184202E88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50012 mRNA. Translation: CAA90305.1.
L38891 mRNA. Translation: AAT01101.1.
U18778 Genomic DNA. Translation: AAB64567.1.
AY693199 Genomic DNA. Translation: AAT93218.1.
BK006939 Genomic DNA. Translation: DAA07672.1.
PIRiS68163.
RefSeqiNP_010936.1. NM_001180031.1.

Genome annotation databases

EnsemblFungiiYER019C-A; YER019C-A; YER019C-A.
GeneIDi856740.
KEGGisce:YER019C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50012 mRNA. Translation: CAA90305.1 .
L38891 mRNA. Translation: AAT01101.1 .
U18778 Genomic DNA. Translation: AAB64567.1 .
AY693199 Genomic DNA. Translation: AAT93218.1 .
BK006939 Genomic DNA. Translation: DAA07672.1 .
PIRi S68163.
RefSeqi NP_010936.1. NM_001180031.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WW9 electron microscopy 8.60 C 1-87 [» ]
2WWA electron microscopy 8.90 C 1-87 [» ]
ProteinModelPortali P52871.
SMRi P52871. Positions 52-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36753. 56 interactions.
DIPi DIP-1708N.
IntActi P52871. 6 interactions.
MINTi MINT-396359.
STRINGi 4932.YER019C-A.

Protein family/group databases

TCDBi 3.A.5.8.1. the general secretory pathway (sec) family.

Proteomic databases

MaxQBi P52871.
PaxDbi P52871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER019C-A ; YER019C-A ; YER019C-A .
GeneIDi 856740.
KEGGi sce:YER019C-A.

Organism-specific databases

CYGDi YER019c-a.
SGDi S000002127. SBH2.

Phylogenomic databases

eggNOGi NOG330120.
GeneTreei ENSGT00390000015774.
HOGENOMi HOG000211109.
InParanoidi P52871.
KOi K09481.
OMAi NAMPLST.
OrthoDBi EOG7WQ85T.

Enzyme and pathway databases

BioCyci YEAST:G3O-30348-MONOMER.

Miscellaneous databases

EvolutionaryTracei P52871.
NextBioi 982870.
PROi P52871.

Gene expression databases

Genevestigatori P52871.

Family and domain databases

InterProi IPR016482. SecG/Sec61-beta/Sbh1.
[Graphical view ]
PANTHERi PTHR13509. PTHR13509. 1 hit.
Pfami PF03911. Sec61_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF006398. Sec61_beta_euk. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit."
    Toikkanen J., Gatti E., Takei K., Saloheimo M., Olkkonen V.M., Soederlund H., de Camilli P., Keraenen S.
    Yeast 12:425-438(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Yeast Sec61 beta subunit."
    Finke K., Panzner S., Sommer T., Hartmann E., Rapoport T.A.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae."
    Finke K., Plath K., Panzner S., Prehn S., Rapoport T.A., Hartmann E., Sommer T.
    EMBO J. 15:1482-1494(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-32.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC6B2_YEAST
AccessioniPrimary (citable) accession number: P52871
Secondary accession number(s): D3DLR8, Q53X22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3