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Protein

Pre-mRNA-splicing factor CWC23

Gene

CWC23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures.3 Publications

GO - Biological processi

  • spliceosomal complex disassembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-30624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC23
Alternative name(s):
Complexed with CEF1 protein 23
Gene namesi
Name:CWC23
Ordered Locus Names:YGL128C
ORF Names:G2861
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL128C.
SGDiS000003096. CWC23.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • U2-type spliceosomal complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000711291 – 283Pre-mRNA-splicing factor CWC23Add BLAST283

Proteomic databases

MaxQBiP52868.
PRIDEiP52868.
TopDownProteomicsiP52868.

Interactioni

Subunit structurei

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.1 Publication

Protein-protein interaction databases

BioGridi33123. 29 interactors.
DIPiDIP-6831N.
IntActiP52868. 16 interactors.
MINTiMINT-636455.

Structurei

3D structure databases

ProteinModelPortaliP52868.
SMRiP52868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 87JPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the DnaJ family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP52868.
OMAiMPGHELE.
OrthoDBiEOG092C3AF6.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHELEDVI NQRLNLYDVL ELPTPLDVHT IYDDLPQIKR KYRTLALKYH
60 70 80 90 100
PDKHPDNPSI IHKFHLLSTA TNILTNADVR PHYDRWLIEF LRKTNDIERN
110 120 130 140 150
KLIQKLEESE SSTIPTTTPH PDLLQIQRHG ELLRKLKHFN LPYGDWKHLN
160 170 180 190 200
TQDQENASQH PYYDCSTLRI VLDNFLQSNN KSNCLSHLRN QVFITLSANE
210 220 230 240 250
IYDIYFSERN NYSKDDSIII YTVFDTPITA QHVFRNWSSG NLIPTVKDIS
260 270 280
PLIPLHYYSD FNLETELNDD IARLVSNEPI LLD
Length:283
Mass (Da):33,237
Last modified:August 30, 2005 - v2
Checksum:iAA1D0894328CAEA5
GO

Sequence cautioni

The sequence AAT93027 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA60703 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA96837 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87252 Genomic DNA. Translation: CAA60703.1. Different initiation.
Z72650 Genomic DNA. Translation: CAA96837.1. Different initiation.
AY693008 Genomic DNA. Translation: AAT93027.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA07981.1.
PIRiS64139.
RefSeqiNP_011387.2. NM_001180993.1.

Genome annotation databases

EnsemblFungiiYGL128C; YGL128C; YGL128C.
GeneIDi852749.
KEGGisce:YGL128C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87252 Genomic DNA. Translation: CAA60703.1. Different initiation.
Z72650 Genomic DNA. Translation: CAA96837.1. Different initiation.
AY693008 Genomic DNA. Translation: AAT93027.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA07981.1.
PIRiS64139.
RefSeqiNP_011387.2. NM_001180993.1.

3D structure databases

ProteinModelPortaliP52868.
SMRiP52868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33123. 29 interactors.
DIPiDIP-6831N.
IntActiP52868. 16 interactors.
MINTiMINT-636455.

Proteomic databases

MaxQBiP52868.
PRIDEiP52868.
TopDownProteomicsiP52868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL128C; YGL128C; YGL128C.
GeneIDi852749.
KEGGisce:YGL128C.

Organism-specific databases

EuPathDBiFungiDB:YGL128C.
SGDiS000003096. CWC23.

Phylogenomic databases

InParanoidiP52868.
OMAiMPGHELE.
OrthoDBiEOG092C3AF6.

Enzyme and pathway databases

BioCyciYEAST:G3O-30624-MONOMER.

Miscellaneous databases

PROiP52868.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCWC23_YEAST
AccessioniPrimary (citable) accession number: P52868
Secondary accession number(s): D6VU20, Q6B1S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.