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Protein

Pre-mRNA-splicing factor CWC23

Gene

CWC23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures.3 Publications

GO - Biological processi

  • spliceosomal complex disassembly Source: SGD

Keywordsi

Molecular functionChaperone
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-30624-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC23
Alternative name(s):
Complexed with CEF1 protein 23
Gene namesi
Name:CWC23
Ordered Locus Names:YGL128C
ORF Names:G2861
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL128C
SGDiS000003096 CWC23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000711291 – 283Pre-mRNA-splicing factor CWC23Add BLAST283

Proteomic databases

MaxQBiP52868
PaxDbiP52868
PRIDEiP52868
TopDownProteomicsiP52868

Interactioni

Subunit structurei

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPP382Q064116EBI-560,EBI-576

Protein-protein interaction databases

BioGridi33123, 31 interactors
DIPiDIP-6831N
IntActiP52868, 16 interactors
MINTiP52868
STRINGi4932.YGL128C

Structurei

3D structure databases

ProteinModelPortaliP52868
SMRiP52868
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 87JPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the DnaJ family.Curated

Phylogenomic databases

InParanoidiP52868
OMAiQPRIPIS
OrthoDBiEOG092C3AF6

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHELEDVI NQRLNLYDVL ELPTPLDVHT IYDDLPQIKR KYRTLALKYH
60 70 80 90 100
PDKHPDNPSI IHKFHLLSTA TNILTNADVR PHYDRWLIEF LRKTNDIERN
110 120 130 140 150
KLIQKLEESE SSTIPTTTPH PDLLQIQRHG ELLRKLKHFN LPYGDWKHLN
160 170 180 190 200
TQDQENASQH PYYDCSTLRI VLDNFLQSNN KSNCLSHLRN QVFITLSANE
210 220 230 240 250
IYDIYFSERN NYSKDDSIII YTVFDTPITA QHVFRNWSSG NLIPTVKDIS
260 270 280
PLIPLHYYSD FNLETELNDD IARLVSNEPI LLD
Length:283
Mass (Da):33,237
Last modified:August 30, 2005 - v2
Checksum:iAA1D0894328CAEA5
GO

Sequence cautioni

The sequence AAT93027 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA60703 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA96837 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87252 Genomic DNA Translation: CAA60703.1 Different initiation.
Z72650 Genomic DNA Translation: CAA96837.1 Different initiation.
AY693008 Genomic DNA Translation: AAT93027.1 Different initiation.
BK006941 Genomic DNA Translation: DAA07981.1
PIRiS64139
RefSeqiNP_011387.2, NM_001180993.1

Genome annotation databases

EnsemblFungiiYGL128C; YGL128C; YGL128C
GeneIDi852749
KEGGisce:YGL128C

Similar proteinsi

Entry informationi

Entry nameiCWC23_YEAST
AccessioniPrimary (citable) accession number: P52868
Secondary accession number(s): D6VU20, Q6B1S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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