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P52867

- PMT5_YEAST

UniProt

P52867 - PMT5_YEAST

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Protein
Dolichyl-phosphate-mannose--protein mannosyltransferase 5
Gene
PMT5, YDL093W, D2399
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins By similarity.

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: SGD
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. protein O-linked mannosylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:YDL093W-MONOMER.
BRENDAi2.4.1.109. 984.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 5 (EC:2.4.1.109)
Gene namesi
Name:PMT5
Ordered Locus Names:YDL093W
ORF Names:D2399
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL093w.
SGDiS000002251. PMT5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646Lumenal Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Reviewed prediction
Add
BLAST
Topological domaini68 – 12962Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei130 – 15021Helical; Reviewed prediction
Add
BLAST
Topological domaini151 – 1588Lumenal Reviewed prediction
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Topological domaini180 – 1801Cytoplasmic Reviewed prediction
Transmembranei181 – 20121Helical; Reviewed prediction
Add
BLAST
Topological domaini202 – 23130Lumenal Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Topological domaini253 – 26412Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Topological domaini286 – 583298Lumenal Reviewed prediction
Add
BLAST
Transmembranei584 – 60421Helical; Reviewed prediction
Add
BLAST
Topological domaini605 – 62319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei624 – 64421Helical; Reviewed prediction
Add
BLAST
Topological domaini645 – 6462Lumenal Reviewed prediction
Transmembranei647 – 66721Helical; Reviewed prediction
Add
BLAST
Topological domaini668 – 68316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei684 – 70421Helical; Reviewed prediction
Add
BLAST
Topological domaini705 – 74339Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex Source: SGD
  2. dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex Source: SGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Dolichyl-phosphate-mannose--protein mannosyltransferase 5
PRO_0000121495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi380 – 3801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP52867.
PeptideAtlasiP52867.

Expressioni

Gene expression databases

GenevestigatoriP52867.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PMT2P313822EBI-13591,EBI-13573

Protein-protein interaction databases

BioGridi31967. 25 interactions.
DIPiDIP-5025N.
IntActiP52867. 4 interactions.
MINTiMINT-563573.
STRINGi4932.YDL093W.

Structurei

3D structure databases

ProteinModelPortaliP52867.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini320 – 37455MIR 1
Add
BLAST
Domaini384 – 44461MIR 2
Add
BLAST
Domaini454 – 51057MIR 3
Add
BLAST

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
GeneTreeiENSGT00740000116239.
HOGENOMiHOG000157526.
KOiK00728.
OMAiMEFANDI.
OrthoDBiEOG7BP89X.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
IPR027004. PMT1/PTM5.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PTHR10050:SF28. PTHR10050:SF28. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52867-1 [UniParc]FASTAAdd to Basket

« Hide

MNKEHLLKVD PIPDVTIKRG PLRSFLITKP CDNLSSLRTV TSSKEKLLVG    50
CLLIFTAIVR LHNISLPNSV VFGENEVGTF VSQYVNNIFF TDVHPPLVAM 100
LYATVSSVFG YKGLFNYGNI GTEYTANVPY VAMRFFSATL GIVSVLVLYL 150
TLRVSGVKIA VAAICAVCFA IENSFVTLSR FTLIEGPFVF FMACAVYFFR 200
RSELYLPNSC KANKSLLAAS IALGFAVSSK WAGLFTIAWA GIIVLWRVWF 250
MIGDLSRPIG SSIKYMAFQF TCLLAIPAFI YFLIFSVHIK TLNVNGISSS 300
FFPAEFRKTL KYNNVIKETV AEVAVGSAVS LNHVGTAGGY LHSHLHNYPA 350
GSMQQQVTLY PHIDQNNKWI IELAEHPNEN VTSFQNLTDG TIIKLRQLKN 400
GCRLHSHDHK PPVSQNADWQ KEVSCYGYEG FEGDINDDWI IEIDKKRSEP 450
GPAQEHIRAI ETKFRLKHYL TGCYLFSHPE KLPEWGFGQQ EVTCAYFARE 500
DLTSWYIEEN ENEISLPNPE KVSYKKMSFW QKFVAIHKFM FYLNNYMDTS 550
HAYSSEPKTW PLMLRGIDFW NENGREVYFL GNAVLWWSVT AFICTFIIGV 600
AVELLAWKLG VNILRDKHII NFHYQVFQYL LGFAAHYFPY FFVGQKLFLY 650
DYLPAYYFGI LAFGHALDLI STYISNKRNN TGYIVVAIFM VVCFYFFSEH 700
SPLIYATGWS SNLCKRSKWL GSWDFYCNSL LLSDSHYELN AES 743
Length:743
Mass (Da):84,776
Last modified:October 1, 1996 - v1
Checksum:iE75625C236AC6A68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92759 Genomic DNA. Translation: CAA63414.1.
X95644 Genomic DNA. Translation: CAA64918.1.
Z74142 Genomic DNA. Translation: CAA98661.1.
BK006938 Genomic DNA. Translation: DAA11765.1.
PIRiS67635.
RefSeqiNP_010190.1. NM_001180152.1.

Genome annotation databases

EnsemblFungiiYDL093W; YDL093W; YDL093W.
GeneIDi851464.
KEGGisce:YDL093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92759 Genomic DNA. Translation: CAA63414.1 .
X95644 Genomic DNA. Translation: CAA64918.1 .
Z74142 Genomic DNA. Translation: CAA98661.1 .
BK006938 Genomic DNA. Translation: DAA11765.1 .
PIRi S67635.
RefSeqi NP_010190.1. NM_001180152.1.

3D structure databases

ProteinModelPortali P52867.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31967. 25 interactions.
DIPi DIP-5025N.
IntActi P52867. 4 interactions.
MINTi MINT-563573.
STRINGi 4932.YDL093W.

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

Proteomic databases

MaxQBi P52867.
PeptideAtlasi P52867.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL093W ; YDL093W ; YDL093W .
GeneIDi 851464.
KEGGi sce:YDL093W.

Organism-specific databases

CYGDi YDL093w.
SGDi S000002251. PMT5.

Phylogenomic databases

eggNOGi COG1928.
GeneTreei ENSGT00740000116239.
HOGENOMi HOG000157526.
KOi K00728.
OMAi MEFANDI.
OrthoDBi EOG7BP89X.

Enzyme and pathway databases

BioCyci YEAST:YDL093W-MONOMER.
BRENDAi 2.4.1.109. 984.

Miscellaneous databases

NextBioi 968747.

Gene expression databases

Genevestigatori P52867.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
IPR027004. PMT1/PTM5.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
PTHR10050:SF28. PTHR10050:SF28. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Dommaschk U.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames."
    Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G., Jimenez A., Remacha M.A.
    Yeast 12:1377-1384(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiPMT5_YEAST
AccessioniPrimary (citable) accession number: P52867
Secondary accession number(s): D6VRQ5, Q92181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi