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P52867 (PMT5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 5

EC=2.4.1.109
Gene names
Name:PMT5
Ordered Locus Names:YDL093W
ORF Names:D2399
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins By similarity.

Catalytic activity

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 39 family.

Contains 3 MIR domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 743743Dolichyl-phosphate-mannose--protein mannosyltransferase 5
PRO_0000121495

Regions

Topological domain1 – 4646Lumenal Potential
Transmembrane47 – 6721Helical; Potential
Topological domain68 – 12962Cytoplasmic Potential
Transmembrane130 – 15021Helical; Potential
Topological domain151 – 1588Lumenal Potential
Transmembrane159 – 17921Helical; Potential
Topological domain1801Cytoplasmic Potential
Transmembrane181 – 20121Helical; Potential
Topological domain202 – 23130Lumenal Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 26412Cytoplasmic Potential
Transmembrane265 – 28521Helical; Potential
Topological domain286 – 583298Lumenal Potential
Transmembrane584 – 60421Helical; Potential
Topological domain605 – 62319Cytoplasmic Potential
Transmembrane624 – 64421Helical; Potential
Topological domain645 – 6462Lumenal Potential
Transmembrane647 – 66721Helical; Potential
Topological domain668 – 68316Cytoplasmic Potential
Transmembrane684 – 70421Helical; Potential
Topological domain705 – 74339Lumenal Potential
Domain320 – 37455MIR 1
Domain384 – 44461MIR 2
Domain454 – 51057MIR 3

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation3801N-linked (GlcNAc...) Potential
Glycosylation3861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P52867 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E75625C236AC6A68

FASTA74384,776
        10         20         30         40         50         60 
MNKEHLLKVD PIPDVTIKRG PLRSFLITKP CDNLSSLRTV TSSKEKLLVG CLLIFTAIVR 

        70         80         90        100        110        120 
LHNISLPNSV VFGENEVGTF VSQYVNNIFF TDVHPPLVAM LYATVSSVFG YKGLFNYGNI 

       130        140        150        160        170        180 
GTEYTANVPY VAMRFFSATL GIVSVLVLYL TLRVSGVKIA VAAICAVCFA IENSFVTLSR 

       190        200        210        220        230        240 
FTLIEGPFVF FMACAVYFFR RSELYLPNSC KANKSLLAAS IALGFAVSSK WAGLFTIAWA 

       250        260        270        280        290        300 
GIIVLWRVWF MIGDLSRPIG SSIKYMAFQF TCLLAIPAFI YFLIFSVHIK TLNVNGISSS 

       310        320        330        340        350        360 
FFPAEFRKTL KYNNVIKETV AEVAVGSAVS LNHVGTAGGY LHSHLHNYPA GSMQQQVTLY 

       370        380        390        400        410        420 
PHIDQNNKWI IELAEHPNEN VTSFQNLTDG TIIKLRQLKN GCRLHSHDHK PPVSQNADWQ 

       430        440        450        460        470        480 
KEVSCYGYEG FEGDINDDWI IEIDKKRSEP GPAQEHIRAI ETKFRLKHYL TGCYLFSHPE 

       490        500        510        520        530        540 
KLPEWGFGQQ EVTCAYFARE DLTSWYIEEN ENEISLPNPE KVSYKKMSFW QKFVAIHKFM 

       550        560        570        580        590        600 
FYLNNYMDTS HAYSSEPKTW PLMLRGIDFW NENGREVYFL GNAVLWWSVT AFICTFIIGV 

       610        620        630        640        650        660 
AVELLAWKLG VNILRDKHII NFHYQVFQYL LGFAAHYFPY FFVGQKLFLY DYLPAYYFGI 

       670        680        690        700        710        720 
LAFGHALDLI STYISNKRNN TGYIVVAIFM VVCFYFFSEH SPLIYATGWS SNLCKRSKWL 

       730        740 
GSWDFYCNSL LLSDSHYELN AES 

« Hide

References

« Hide 'large scale' references
[1]Dommaschk U.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames."
Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G., Jimenez A., Remacha M.A.
Yeast 12:1377-1384(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92759 Genomic DNA. Translation: CAA63414.1.
X95644 Genomic DNA. Translation: CAA64918.1.
Z74142 Genomic DNA. Translation: CAA98661.1.
BK006938 Genomic DNA. Translation: DAA11765.1.
PIRS67635.
RefSeqNP_010190.1. NM_001180152.1.

3D structure databases

ProteinModelPortalP52867.
SMRP52867. Positions 321-514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31967. 25 interactions.
DIPDIP-5025N.
IntActP52867. 4 interactions.
MINTMINT-563573.
STRING4932.YDL093W.

Protein family/group databases

CAZyGT39. Glycosyltransferase Family 39.

Proteomic databases

PeptideAtlasP52867.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDL093W; YDL093W; YDL093W.
GeneID851464.
KEGGsce:YDL093W.

Organism-specific databases

CYGDYDL093w.
SGDS000002251. PMT5.

Phylogenomic databases

eggNOGCOG1928.
GeneTreeENSGT00740000116239.
HOGENOMHOG000157526.
KOK00728.
OMAMEFANDI.
OrthoDBEOG7BP89X.

Enzyme and pathway databases

BioCycYEAST:YDL093W-MONOMER.
BRENDA2.4.1.109. 984.

Gene expression databases

GenevestigatorP52867.

Family and domain databases

InterProIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
[Graphical view]
PANTHERPTHR10050. PTHR10050. 1 hit.
PfamPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMSSF82109. SSF82109. 1 hit.
PROSITEPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio968747.

Entry information

Entry namePMT5_YEAST
AccessionPrimary (citable) accession number: P52867
Secondary accession number(s): D6VRQ5, Q92181
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families