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P52846

- ST1A1_MACFA

UniProt

P52846 - ST1A1_MACFA

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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Proton acceptorBy similarity
Binding sitei130 – 1301PAPSBy similarity
Binding sitei138 – 1381PAPSBy similarity
Binding sitei193 – 1931PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 536PAPSBy similarity
Nucleotide bindingi227 – 2326PAPSBy similarity
Nucleotide bindingi255 – 2595PAPSBy similarity

GO - Molecular functioni

  1. aryl sulfotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1. 3121.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name:
P-PST
Gene namesi
Name:SULT1A1
Synonyms:STP
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Sulfotransferase 1A1PRO_0000085129Add
BLAST

Proteomic databases

PRIDEiP52846.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP52846.
SMRiP52846. Positions 7-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1083Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

HOVERGENiHBG001195.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P52846 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFRARPDD LLISTYPKSG
60 70 80 90 100
TTWVSQILDM IYQGGDLEKC RRAPIFMRVP FLEFKVPGIP SGMETLKDTP
110 120 130 140 150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP
160 170 180 190 200
EPGTWDSFLE KFMAGEVSYG SWYQHVQEWW ELSHTHPVLY LFYEDMKENP
210 220 230 240 250
KREIWKILEF VGRSLPEETV DLMVQHTSFK EMKKNPMANY TTIPQELMDH
260 270 280 290
SISPFMRKGM TGDWKTTFTV AQNEHFDVDY AEKMAGCSLS FRSEL
Length:295
Mass (Da):34,239
Last modified:October 1, 1996 - v1
Checksum:iBD51639D1570A841
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85514 mRNA. Translation: BAA12822.1.
PIRiG02924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85514 mRNA. Translation: BAA12822.1 .
PIRi G02924.

3D structure databases

ProteinModelPortali P52846.
SMRi P52846. Positions 7-295.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P52846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG001195.

Enzyme and pathway databases

BRENDAi 2.8.2.1. 3121.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and bacterial expression of monkey liver phenol sulfotransferase."
    Ogura K., Satsukawa M., Okuda H., Watabe T.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiST1A1_MACFA
AccessioniPrimary (citable) accession number: P52846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3