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P52846

- ST1A1_MACFA

UniProt

P52846 - ST1A1_MACFA

Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Proton acceptorBy similarity
    Binding sitei130 – 1301PAPSBy similarity
    Binding sitei138 – 1381PAPSBy similarity
    Binding sitei193 – 1931PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi48 – 536PAPSBy similarity
    Nucleotide bindingi227 – 2326PAPSBy similarity
    Nucleotide bindingi255 – 2595PAPSBy similarity

    GO - Molecular functioni

    1. aryl sulfotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. steroid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Lipid metabolism, Steroid metabolism

    Enzyme and pathway databases

    BRENDAi2.8.2.1. 3121.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfotransferase 1A1 (EC:2.8.2.1)
    Short name:
    ST1A1
    Alternative name(s):
    Aryl sulfotransferase
    Phenol sulfotransferase
    Phenol-sulfating phenol sulfotransferase
    Short name:
    P-PST
    Gene namesi
    Name:SULT1A1
    Synonyms:STP
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Sulfotransferase 1A1PRO_0000085129Add
    BLAST

    Proteomic databases

    PRIDEiP52846.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP52846.
    SMRiP52846. Positions 7-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 1083Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the sulfotransferase 1 family.Curated

    Phylogenomic databases

    HOVERGENiHBG001195.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P52846-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFRARPDD LLISTYPKSG    50
    TTWVSQILDM IYQGGDLEKC RRAPIFMRVP FLEFKVPGIP SGMETLKDTP 100
    APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP 150
    EPGTWDSFLE KFMAGEVSYG SWYQHVQEWW ELSHTHPVLY LFYEDMKENP 200
    KREIWKILEF VGRSLPEETV DLMVQHTSFK EMKKNPMANY TTIPQELMDH 250
    SISPFMRKGM TGDWKTTFTV AQNEHFDVDY AEKMAGCSLS FRSEL 295
    Length:295
    Mass (Da):34,239
    Last modified:October 1, 1996 - v1
    Checksum:iBD51639D1570A841
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85514 mRNA. Translation: BAA12822.1.
    PIRiG02924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85514 mRNA. Translation: BAA12822.1 .
    PIRi G02924.

    3D structure databases

    ProteinModelPortali P52846.
    SMRi P52846. Positions 7-295.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P52846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG001195.

    Enzyme and pathway databases

    BRENDAi 2.8.2.1. 3121.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and bacterial expression of monkey liver phenol sulfotransferase."
      Ogura K., Satsukawa M., Okuda H., Watabe T.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiST1A1_MACFA
    AccessioniPrimary (citable) accession number: P52846
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3