Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P52846 (ST1A1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfotransferase 1A1

Short name=ST1A1
EC=2.8.2.1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name=P-PST
Gene names
Name:SULT1A1
Synonyms:STP
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.

Catalytic activity

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
   Biological processCatecholamine metabolism
Lipid metabolism
Steroid metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processcatecholamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

steroid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaryl sulfotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Sulfotransferase 1A1
PRO_0000085129

Regions

Nucleotide binding48 – 536PAPS By similarity
Nucleotide binding227 – 2326PAPS By similarity
Nucleotide binding255 – 2595PAPS By similarity
Region106 – 1083Substrate binding By similarity

Sites

Active site1081Proton acceptor By similarity
Binding site1301PAPS By similarity
Binding site1381PAPS By similarity
Binding site1931PAPS By similarity

Sequences

Sequence LengthMass (Da)Tools
P52846 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: BD51639D1570A841

FASTA29534,239
        10         20         30         40         50         60 
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFRARPDD LLISTYPKSG TTWVSQILDM 

        70         80         90        100        110        120 
IYQGGDLEKC RRAPIFMRVP FLEFKVPGIP SGMETLKDTP APRLLKTHLP LALLPQTLLD 

       130        140        150        160        170        180 
QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP EPGTWDSFLE KFMAGEVSYG SWYQHVQEWW 

       190        200        210        220        230        240 
ELSHTHPVLY LFYEDMKENP KREIWKILEF VGRSLPEETV DLMVQHTSFK EMKKNPMANY 

       250        260        270        280        290 
TTIPQELMDH SISPFMRKGM TGDWKTTFTV AQNEHFDVDY AEKMAGCSLS FRSEL 

« Hide

References

[1]"cDNA cloning and bacterial expression of monkey liver phenol sulfotransferase."
Ogura K., Satsukawa M., Okuda H., Watabe T.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D85514 mRNA. Translation: BAA12822.1.
PIRG02924.

3D structure databases

ProteinModelPortalP52846.
SMRP52846. Positions 7-295.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP52846.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001195.

Enzyme and pathway databases

BRENDA2.8.2.1. 3121.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameST1A1_MACFA
AccessionPrimary (citable) accession number: P52846
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families