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P52843

- ST2A1_MOUSE

UniProt

P52843 - ST2A1_MOUSE

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Protein

Bile salt sulfotransferase 1

Gene
Sult2a1, Sta1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics By similarity.

Catalytic activityi

3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721Substrate By similarity
Binding sitei77 – 771Substrate By similarity
Active sitei99 – 991Proton acceptor By similarity
Binding sitei121 – 1211PAPS By similarity
Binding sitei129 – 1291PAPS By similarity
Binding sitei184 – 1841PAPS By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 496PAPS By similarity
Nucleotide bindingi218 – 2236PAPS By similarity
Nucleotide bindingi247 – 2493PAPS By similarity

GO - Molecular functioni

  1. bile-salt sulfotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt sulfotransferase 1 (EC:2.8.2.14)
Alternative name(s):
Hydroxysteroid sulfotransferase
Short name:
ST
Sulfotransferase 2A1
Short name:
ST2A1
Gene namesi
Name:Sult2a1
Synonyms:Sta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98430. Sult2a1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Bile salt sulfotransferase 1PRO_0000085147Add
BLAST

Proteomic databases

MaxQBiP52843.
PaxDbiP52843.
PRIDEiP52843.

PTM databases

PhosphoSiteiP52843.

Expressioni

Gene expression databases

BgeeiP52843.
GenevestigatoriP52843.

Interactioni

Protein-protein interaction databases

IntActiP52843. 1 interaction.
MINTiMINT-4135640.
STRINGi10090.ENSMUSP00000104162.

Structurei

3D structure databases

ProteinModelPortaliP52843.
SMRiP52843. Positions 4-285.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274515.
GeneTreeiENSGT00670000097842.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP52843.
KOiK11822.
OMAiAKVIYLV.
OrthoDBiEOG7V49ZK.
PhylomeDBiP52843.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P52843-1 [UniParc]FASTAAdd to Basket

« Hide

MMSDYNWFEG IPFPAISYQR EILEDIRNKF VVKEEDLLIL TYPKSGTNWL    50
IEIVCLIQTK GDPKWIQTVP IWNRSPWIET DIGYSALINK EGPRLITSHL 100
PIHLFSKSFF SSKAKAIYLV RNPRDILVSG YFFWGNTNLV KNPGSLGTYF 150
EWFLKGNVLF GSWFEHVRGW LSMREWDNFL VLYYEDIKKD TKGTIKKICD 200
FLGKNLGPDE LDLVLKYSSF QAMKENNMSN FSLIKEDQVT NGLKLMRKGT 250
IGDWKNHFTV AQAEAFDKVF QEKMAGFPPG IFPWE 285
Length:285
Mass (Da):33,213
Last modified:October 1, 1996 - v1
Checksum:iFB71D587A2F4F4A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02335 mRNA. No translation available.
CCDSiCCDS52031.1.
RefSeqiNP_001104766.1. NM_001111296.2.
UniGeneiMm.260026.

Genome annotation databases

EnsembliENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798.
GeneIDi20859.
KEGGimmu:20859.
UCSCiuc009ffz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02335 mRNA. No translation available.
CCDSi CCDS52031.1.
RefSeqi NP_001104766.1. NM_001111296.2.
UniGenei Mm.260026.

3D structure databases

ProteinModelPortali P52843.
SMRi P52843. Positions 4-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P52843. 1 interaction.
MINTi MINT-4135640.
STRINGi 10090.ENSMUSP00000104162.

PTM databases

PhosphoSitei P52843.

Proteomic databases

MaxQBi P52843.
PaxDbi P52843.
PRIDEi P52843.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108522 ; ENSMUSP00000104162 ; ENSMUSG00000078798 .
GeneIDi 20859.
KEGGi mmu:20859.
UCSCi uc009ffz.2. mouse.

Organism-specific databases

CTDi 6822.
MGIi MGI:98430. Sult2a1.

Phylogenomic databases

eggNOGi NOG274515.
GeneTreei ENSGT00670000097842.
HOGENOMi HOG000037209.
HOVERGENi HBG001195.
InParanoidi P52843.
KOi K11822.
OMAi AKVIYLV.
OrthoDBi EOG7V49ZK.
PhylomeDBi P52843.
TreeFami TF321745.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi 299661.
PROi P52843.
SOURCEi Search...

Gene expression databases

Bgeei P52843.
Genevestigatori P52843.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver."
    Kong A.-N.T., Tao D., Ma M., Yang L.
    Pharm. Res. 10:627-630(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.

Entry informationi

Entry nameiST2A1_MOUSE
AccessioniPrimary (citable) accession number: P52843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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