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Protein

Bile salt sulfotransferase 1

Gene

Sult2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721SubstrateBy similarity
Binding sitei77 – 771SubstrateBy similarity
Active sitei99 – 991Proton acceptorBy similarity
Binding sitei121 – 1211PAPSBy similarity
Binding sitei129 – 1291PAPSBy similarity
Binding sitei184 – 1841PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 496PAPSBy similarity
Nucleotide bindingi218 – 2236PAPSBy similarity
Nucleotide bindingi247 – 2493PAPSBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

ReactomeiREACT_309610. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt sulfotransferase 1 (EC:2.8.2.14)
Alternative name(s):
Hydroxysteroid sulfotransferase
Short name:
ST
Sulfotransferase 2A1
Short name:
ST2A1
Gene namesi
Name:Sult2a1
Synonyms:Sta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98430. Sult2a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Bile salt sulfotransferase 1PRO_0000085147Add
BLAST

Proteomic databases

MaxQBiP52843.
PaxDbiP52843.
PRIDEiP52843.

PTM databases

PhosphoSiteiP52843.

Expressioni

Gene expression databases

BgeeiP52843.

Interactioni

Protein-protein interaction databases

IntActiP52843. 1 interaction.
MINTiMINT-4135640.
STRINGi10090.ENSMUSP00000104162.

Structurei

3D structure databases

ProteinModelPortaliP52843.
SMRiP52843. Positions 4-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG274515.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP52843.
KOiK11822.
OMAiPWIENEV.
OrthoDBiEOG7V49ZK.
PhylomeDBiP52843.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P52843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSDYNWFEG IPFPAISYQR EILEDIRNKF VVKEEDLLIL TYPKSGTNWL
60 70 80 90 100
IEIVCLIQTK GDPKWIQTVP IWNRSPWIET DIGYSALINK EGPRLITSHL
110 120 130 140 150
PIHLFSKSFF SSKAKAIYLV RNPRDILVSG YFFWGNTNLV KNPGSLGTYF
160 170 180 190 200
EWFLKGNVLF GSWFEHVRGW LSMREWDNFL VLYYEDIKKD TKGTIKKICD
210 220 230 240 250
FLGKNLGPDE LDLVLKYSSF QAMKENNMSN FSLIKEDQVT NGLKLMRKGT
260 270 280
IGDWKNHFTV AQAEAFDKVF QEKMAGFPPG IFPWE
Length:285
Mass (Da):33,213
Last modified:October 1, 1996 - v1
Checksum:iFB71D587A2F4F4A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02335 mRNA. No translation available.
CCDSiCCDS52031.1.
RefSeqiNP_001104766.1. NM_001111296.2.
UniGeneiMm.260026.

Genome annotation databases

EnsembliENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798.
GeneIDi20859.
KEGGimmu:20859.
UCSCiuc009ffz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02335 mRNA. No translation available.
CCDSiCCDS52031.1.
RefSeqiNP_001104766.1. NM_001111296.2.
UniGeneiMm.260026.

3D structure databases

ProteinModelPortaliP52843.
SMRiP52843. Positions 4-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52843. 1 interaction.
MINTiMINT-4135640.
STRINGi10090.ENSMUSP00000104162.

PTM databases

PhosphoSiteiP52843.

Proteomic databases

MaxQBiP52843.
PaxDbiP52843.
PRIDEiP52843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798.
GeneIDi20859.
KEGGimmu:20859.
UCSCiuc009ffz.2. mouse.

Organism-specific databases

CTDi6822.
MGIiMGI:98430. Sult2a1.

Phylogenomic databases

eggNOGiNOG274515.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP52843.
KOiK11822.
OMAiPWIENEV.
OrthoDBiEOG7V49ZK.
PhylomeDBiP52843.
TreeFamiTF321745.

Enzyme and pathway databases

ReactomeiREACT_309610. Cytosolic sulfonation of small molecules.

Miscellaneous databases

NextBioi299661.
PROiP52843.
SOURCEiSearch...

Gene expression databases

BgeeiP52843.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver."
    Kong A.-N.T., Tao D., Ma M., Yang L.
    Pharm. Res. 10:627-630(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.

Entry informationi

Entry nameiST2A1_MOUSE
AccessioniPrimary (citable) accession number: P52843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.