Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52843

- ST2A1_MOUSE

UniProt

P52843 - ST2A1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bile salt sulfotransferase 1

Gene

Sult2a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721SubstrateBy similarity
Binding sitei77 – 771SubstrateBy similarity
Active sitei99 – 991Proton acceptorBy similarity
Binding sitei121 – 1211PAPSBy similarity
Binding sitei129 – 1291PAPSBy similarity
Binding sitei184 – 1841PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 496PAPSBy similarity
Nucleotide bindingi218 – 2236PAPSBy similarity
Nucleotide bindingi247 – 2493PAPSBy similarity

GO - Molecular functioni

  1. bile-salt sulfotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt sulfotransferase 1 (EC:2.8.2.14)
Alternative name(s):
Hydroxysteroid sulfotransferase
Short name:
ST
Sulfotransferase 2A1
Short name:
ST2A1
Gene namesi
Name:Sult2a1
Synonyms:Sta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98430. Sult2a1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Bile salt sulfotransferase 1PRO_0000085147Add
BLAST

Proteomic databases

MaxQBiP52843.
PaxDbiP52843.
PRIDEiP52843.

PTM databases

PhosphoSiteiP52843.

Expressioni

Gene expression databases

BgeeiP52843.
GenevestigatoriP52843.

Interactioni

Protein-protein interaction databases

IntActiP52843. 1 interaction.
MINTiMINT-4135640.
STRINGi10090.ENSMUSP00000104162.

Structurei

3D structure databases

ProteinModelPortaliP52843.
SMRiP52843. Positions 4-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG274515.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP52843.
KOiK11822.
OMAiAKVIYLV.
OrthoDBiEOG7V49ZK.
PhylomeDBiP52843.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P52843-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSDYNWFEG IPFPAISYQR EILEDIRNKF VVKEEDLLIL TYPKSGTNWL
60 70 80 90 100
IEIVCLIQTK GDPKWIQTVP IWNRSPWIET DIGYSALINK EGPRLITSHL
110 120 130 140 150
PIHLFSKSFF SSKAKAIYLV RNPRDILVSG YFFWGNTNLV KNPGSLGTYF
160 170 180 190 200
EWFLKGNVLF GSWFEHVRGW LSMREWDNFL VLYYEDIKKD TKGTIKKICD
210 220 230 240 250
FLGKNLGPDE LDLVLKYSSF QAMKENNMSN FSLIKEDQVT NGLKLMRKGT
260 270 280
IGDWKNHFTV AQAEAFDKVF QEKMAGFPPG IFPWE
Length:285
Mass (Da):33,213
Last modified:October 1, 1996 - v1
Checksum:iFB71D587A2F4F4A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02335 mRNA. No translation available.
CCDSiCCDS52031.1.
RefSeqiNP_001104766.1. NM_001111296.2.
UniGeneiMm.260026.

Genome annotation databases

EnsembliENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798.
GeneIDi20859.
KEGGimmu:20859.
UCSCiuc009ffz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02335 mRNA. No translation available.
CCDSi CCDS52031.1.
RefSeqi NP_001104766.1. NM_001111296.2.
UniGenei Mm.260026.

3D structure databases

ProteinModelPortali P52843.
SMRi P52843. Positions 4-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P52843. 1 interaction.
MINTi MINT-4135640.
STRINGi 10090.ENSMUSP00000104162.

PTM databases

PhosphoSitei P52843.

Proteomic databases

MaxQBi P52843.
PaxDbi P52843.
PRIDEi P52843.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108522 ; ENSMUSP00000104162 ; ENSMUSG00000078798 .
GeneIDi 20859.
KEGGi mmu:20859.
UCSCi uc009ffz.2. mouse.

Organism-specific databases

CTDi 6822.
MGIi MGI:98430. Sult2a1.

Phylogenomic databases

eggNOGi NOG274515.
GeneTreei ENSGT00760000118932.
HOGENOMi HOG000037209.
HOVERGENi HBG001195.
InParanoidi P52843.
KOi K11822.
OMAi AKVIYLV.
OrthoDBi EOG7V49ZK.
PhylomeDBi P52843.
TreeFami TF321745.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi 299661.
PROi P52843.
SOURCEi Search...

Gene expression databases

Bgeei P52843.
Genevestigatori P52843.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver."
    Kong A.-N.T., Tao D., Ma M., Yang L.
    Pharm. Res. 10:627-630(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.

Entry informationi

Entry nameiST2A1_MOUSE
AccessioniPrimary (citable) accession number: P52843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3