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Protein

Bile salt sulfotransferase 1

Gene

Sult2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72SubstrateBy similarity1
Binding sitei77SubstrateBy similarity1
Active sitei99Proton acceptorBy similarity1
Binding sitei121PAPSBy similarity1
Binding sitei129PAPSBy similarity1
Binding sitei184PAPSBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 49PAPSBy similarity6
Nucleotide bindingi218 – 223PAPSBy similarity6
Nucleotide bindingi247 – 249PAPSBy similarity3

GO - Molecular functioni

GO - Biological processi

  • steroid metabolic process Source: UniProtKB-KW
  • sulfation Source: MGI

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-156584 Cytosolic sulfonation of small molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt sulfotransferase 1 (EC:2.8.2.14)
Alternative name(s):
Hydroxysteroid sulfotransferase
Short name:
ST
Sulfotransferase 2A1
Short name:
ST2A1
Gene namesi
Name:Sult2a1
Synonyms:Sta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98430 Sult2a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851471 – 285Bile salt sulfotransferase 1Add BLAST285

Proteomic databases

MaxQBiP52843
PaxDbiP52843
PRIDEiP52843

PTM databases

iPTMnetiP52843
PhosphoSitePlusiP52843

Expressioni

Gene expression databases

BgeeiENSMUSG00000078798
GenevisibleiP52843 MM

Interactioni

Protein-protein interaction databases

IntActiP52843, 1 interactor
MINTiP52843
STRINGi10090.ENSMUSP00000104162

Structurei

3D structure databases

ProteinModelPortaliP52843
SMRiP52843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiP52843
KOiK11822
OMAiHILAYWK
OrthoDBiEOG091G0D5F
PhylomeDBiP52843
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P52843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSDYNWFEG IPFPAISYQR EILEDIRNKF VVKEEDLLIL TYPKSGTNWL
60 70 80 90 100
IEIVCLIQTK GDPKWIQTVP IWNRSPWIET DIGYSALINK EGPRLITSHL
110 120 130 140 150
PIHLFSKSFF SSKAKAIYLV RNPRDILVSG YFFWGNTNLV KNPGSLGTYF
160 170 180 190 200
EWFLKGNVLF GSWFEHVRGW LSMREWDNFL VLYYEDIKKD TKGTIKKICD
210 220 230 240 250
FLGKNLGPDE LDLVLKYSSF QAMKENNMSN FSLIKEDQVT NGLKLMRKGT
260 270 280
IGDWKNHFTV AQAEAFDKVF QEKMAGFPPG IFPWE
Length:285
Mass (Da):33,213
Last modified:October 1, 1996 - v1
Checksum:iFB71D587A2F4F4A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02335 mRNA No translation available.
CCDSiCCDS52031.1
RefSeqiNP_001104766.1, NM_001111296.2
UniGeneiMm.260026

Genome annotation databases

EnsembliENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798
GeneIDi20859
KEGGimmu:20859
UCSCiuc009ffz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiST2A1_MOUSE
AccessioniPrimary (citable) accession number: P52843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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