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P52843 (ST2A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bile salt sulfotransferase 1

EC=2.8.2.14
Alternative name(s):
Hydroxysteroid sulfotransferase
Short name=ST
Sulfotransferase 2A1
Short name=ST2A1
Gene names
Name:Sult2a1
Synonyms:Sta1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics By similarity.

Catalytic activity

3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.

3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
   Biological processLipid metabolism
Steroid metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsteroid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbile-salt sulfotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Bile salt sulfotransferase 1
PRO_0000085147

Regions

Nucleotide binding44 – 496PAPS By similarity
Nucleotide binding218 – 2236PAPS By similarity
Nucleotide binding247 – 2493PAPS By similarity

Sites

Active site991Proton acceptor By similarity
Binding site721Substrate By similarity
Binding site771Substrate By similarity
Binding site1211PAPS By similarity
Binding site1291PAPS By similarity
Binding site1841PAPS By similarity

Sequences

Sequence LengthMass (Da)Tools
P52843 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FB71D587A2F4F4A4

FASTA28533,213
        10         20         30         40         50         60 
MMSDYNWFEG IPFPAISYQR EILEDIRNKF VVKEEDLLIL TYPKSGTNWL IEIVCLIQTK 

        70         80         90        100        110        120 
GDPKWIQTVP IWNRSPWIET DIGYSALINK EGPRLITSHL PIHLFSKSFF SSKAKAIYLV 

       130        140        150        160        170        180 
RNPRDILVSG YFFWGNTNLV KNPGSLGTYF EWFLKGNVLF GSWFEHVRGW LSMREWDNFL 

       190        200        210        220        230        240 
VLYYEDIKKD TKGTIKKICD FLGKNLGPDE LDLVLKYSSF QAMKENNMSN FSLIKEDQVT 

       250        260        270        280 
NGLKLMRKGT IGDWKNHFTV AQAEAFDKVF QEKMAGFPPG IFPWE 

« Hide

References

[1]"Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver."
Kong A.-N.T., Tao D., Ma M., Yang L.
Pharm. Res. 10:627-630(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L02335 mRNA. No translation available.
CCDSCCDS52031.1.
RefSeqNP_001104766.1. NM_001111296.2.
UniGeneMm.260026.

3D structure databases

ProteinModelPortalP52843.
SMRP52843. Positions 4-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP52843. 1 interaction.
MINTMINT-4135640.
STRING10090.ENSMUSP00000104162.

PTM databases

PhosphoSiteP52843.

Proteomic databases

MaxQBP52843.
PaxDbP52843.
PRIDEP52843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798.
GeneID20859.
KEGGmmu:20859.
UCSCuc009ffz.2. mouse.

Organism-specific databases

CTD6822.
MGIMGI:98430. Sult2a1.

Phylogenomic databases

eggNOGNOG274515.
GeneTreeENSGT00670000097842.
HOGENOMHOG000037209.
HOVERGENHBG001195.
InParanoidP52843.
KOK11822.
OMAAKVIYLV.
OrthoDBEOG7V49ZK.
PhylomeDBP52843.
TreeFamTF321745.

Gene expression databases

BgeeP52843.
GenevestigatorP52843.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio299661.
PROP52843.
SOURCESearch...

Entry information

Entry nameST2A1_MOUSE
AccessionPrimary (citable) accession number: P52843
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot