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P52843

- ST2A1_MOUSE

UniProt

P52843 - ST2A1_MOUSE

Protein

Bile salt sulfotransferase 1

Gene

Sult2a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.
    3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721SubstrateBy similarity
    Binding sitei77 – 771SubstrateBy similarity
    Active sitei99 – 991Proton acceptorBy similarity
    Binding sitei121 – 1211PAPSBy similarity
    Binding sitei129 – 1291PAPSBy similarity
    Binding sitei184 – 1841PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 496PAPSBy similarity
    Nucleotide bindingi218 – 2236PAPSBy similarity
    Nucleotide bindingi247 – 2493PAPSBy similarity

    GO - Molecular functioni

    1. bile-salt sulfotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. steroid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bile salt sulfotransferase 1 (EC:2.8.2.14)
    Alternative name(s):
    Hydroxysteroid sulfotransferase
    Short name:
    ST
    Sulfotransferase 2A1
    Short name:
    ST2A1
    Gene namesi
    Name:Sult2a1
    Synonyms:Sta1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98430. Sult2a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Bile salt sulfotransferase 1PRO_0000085147Add
    BLAST

    Proteomic databases

    MaxQBiP52843.
    PaxDbiP52843.
    PRIDEiP52843.

    PTM databases

    PhosphoSiteiP52843.

    Expressioni

    Gene expression databases

    BgeeiP52843.
    GenevestigatoriP52843.

    Interactioni

    Protein-protein interaction databases

    IntActiP52843. 1 interaction.
    MINTiMINT-4135640.
    STRINGi10090.ENSMUSP00000104162.

    Structurei

    3D structure databases

    ProteinModelPortaliP52843.
    SMRiP52843. Positions 4-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sulfotransferase 1 family.Curated

    Phylogenomic databases

    eggNOGiNOG274515.
    GeneTreeiENSGT00670000097842.
    HOGENOMiHOG000037209.
    HOVERGENiHBG001195.
    InParanoidiP52843.
    KOiK11822.
    OMAiAKVIYLV.
    OrthoDBiEOG7V49ZK.
    PhylomeDBiP52843.
    TreeFamiTF321745.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P52843-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSDYNWFEG IPFPAISYQR EILEDIRNKF VVKEEDLLIL TYPKSGTNWL    50
    IEIVCLIQTK GDPKWIQTVP IWNRSPWIET DIGYSALINK EGPRLITSHL 100
    PIHLFSKSFF SSKAKAIYLV RNPRDILVSG YFFWGNTNLV KNPGSLGTYF 150
    EWFLKGNVLF GSWFEHVRGW LSMREWDNFL VLYYEDIKKD TKGTIKKICD 200
    FLGKNLGPDE LDLVLKYSSF QAMKENNMSN FSLIKEDQVT NGLKLMRKGT 250
    IGDWKNHFTV AQAEAFDKVF QEKMAGFPPG IFPWE 285
    Length:285
    Mass (Da):33,213
    Last modified:October 1, 1996 - v1
    Checksum:iFB71D587A2F4F4A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02335 mRNA. No translation available.
    CCDSiCCDS52031.1.
    RefSeqiNP_001104766.1. NM_001111296.2.
    UniGeneiMm.260026.

    Genome annotation databases

    EnsembliENSMUST00000108522; ENSMUSP00000104162; ENSMUSG00000078798.
    GeneIDi20859.
    KEGGimmu:20859.
    UCSCiuc009ffz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02335 mRNA. No translation available.
    CCDSi CCDS52031.1.
    RefSeqi NP_001104766.1. NM_001111296.2.
    UniGenei Mm.260026.

    3D structure databases

    ProteinModelPortali P52843.
    SMRi P52843. Positions 4-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P52843. 1 interaction.
    MINTi MINT-4135640.
    STRINGi 10090.ENSMUSP00000104162.

    PTM databases

    PhosphoSitei P52843.

    Proteomic databases

    MaxQBi P52843.
    PaxDbi P52843.
    PRIDEi P52843.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108522 ; ENSMUSP00000104162 ; ENSMUSG00000078798 .
    GeneIDi 20859.
    KEGGi mmu:20859.
    UCSCi uc009ffz.2. mouse.

    Organism-specific databases

    CTDi 6822.
    MGIi MGI:98430. Sult2a1.

    Phylogenomic databases

    eggNOGi NOG274515.
    GeneTreei ENSGT00670000097842.
    HOGENOMi HOG000037209.
    HOVERGENi HBG001195.
    InParanoidi P52843.
    KOi K11822.
    OMAi AKVIYLV.
    OrthoDBi EOG7V49ZK.
    PhylomeDBi P52843.
    TreeFami TF321745.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 299661.
    PROi P52843.
    SOURCEi Search...

    Gene expression databases

    Bgeei P52843.
    Genevestigatori P52843.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver."
      Kong A.-N.T., Tao D., Ma M., Yang L.
      Pharm. Res. 10:627-630(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.

    Entry informationi

    Entry nameiST2A1_MOUSE
    AccessioniPrimary (citable) accession number: P52843
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3