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Protein

Sulfotransferase 1A1

Gene

Sult1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptorBy similarity
Binding sitei126 – 1261PAPSBy similarity
Binding sitei134 – 1341PAPSBy similarity
Binding sitei189 – 1891PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 496PAPSBy similarity
Nucleotide bindingi223 – 2286PAPSBy similarity
Nucleotide bindingi251 – 2555PAPSBy similarity

GO - Molecular functioni

  1. aryl sulfotransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: MGI
  3. sulfotransferase activity Source: MGI

GO - Biological processi

  1. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol/aryl sulfotransferase
Short name:
mSTp1
ST1A4
Sulfokinase
Gene namesi
Name:Sult1a1
Synonyms:St1a1, Stp, Stp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:102896. Sult1a1.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Sulfotransferase 1A1PRO_0000085130Add
BLAST

Proteomic databases

MaxQBiP52840.
PaxDbiP52840.
PRIDEiP52840.

2D gel databases

REPRODUCTION-2DPAGEP52840.

PTM databases

PhosphoSiteiP52840.

Expressioni

Gene expression databases

GenevestigatoriP52840.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP52840. 2 interactions.
MINTiMINT-1869624.

Structurei

3D structure databases

ProteinModelPortaliP52840.
SMRiP52840. Positions 5-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 1043Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG260792.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP52840.
PhylomeDBiP52840.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P52840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLRKPLVP VKGIPLIKYF AETMEQLQNF TAWPDDVLIS TYPKSGTNWM
60 70 80 90 100
SEIMDMIYQG GKLDKCGRAP VYARIPFLEF SCPGVPPGLE TLKETPAPRI
110 120 130 140 150
IKTHLPLSLL PQSLLDQKIK VIYVARNAKD VVVSYYNFYK MAKLHPDPGT
160 170 180 190 200
WESFLENFMD GKVSYGSWYQ HVKEWWELRR THPVLYLFYE DMKENPKREI
210 220 230 240 250
KKILEFLGRS LPEETVDLIV HHTSFKKMKE NPMANYTTIP TEVMDHTIYP
260 270 280 290
FMRKGTIGDW KNTFTVAQSE HFDAHYAKLM TGCDFTFRCQ I
Length:291
Mass (Da):33,974
Last modified:October 1, 1996 - v1
Checksum:iADC07187DFA51D96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02331 mRNA. No translation available.
UniGeneiMm.368982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02331 mRNA. No translation available.
UniGeneiMm.368982.

3D structure databases

ProteinModelPortaliP52840.
SMRiP52840. Positions 5-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52840. 2 interactions.
MINTiMINT-1869624.

PTM databases

PhosphoSiteiP52840.

2D gel databases

REPRODUCTION-2DPAGEP52840.

Proteomic databases

MaxQBiP52840.
PaxDbiP52840.
PRIDEiP52840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:102896. Sult1a1.

Phylogenomic databases

eggNOGiNOG260792.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP52840.
PhylomeDBiP52840.

Miscellaneous databases

PROiP52840.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP52840.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver."
    Kong A.-N.T., Ma M., Tao D., Yang L.
    Biochim. Biophys. Acta 1171:315-318(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.

Entry informationi

Entry nameiST1A1_MOUSE
AccessioniPrimary (citable) accession number: P52840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.