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P52840

- ST1A1_MOUSE

UniProt

P52840 - ST1A1_MOUSE

Protein

Sulfotransferase 1A1

Gene

Sult1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Proton acceptorBy similarity
    Binding sitei126 – 1261PAPSBy similarity
    Binding sitei134 – 1341PAPSBy similarity
    Binding sitei189 – 1891PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 496PAPSBy similarity
    Nucleotide bindingi223 – 2286PAPSBy similarity
    Nucleotide bindingi251 – 2555PAPSBy similarity

    GO - Molecular functioni

    1. aryl sulfotransferase activity Source: UniProtKB-EC
    2. nucleotide binding Source: MGI
    3. sulfotransferase activity Source: MGI

    GO - Biological processi

    1. steroid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfotransferase 1A1 (EC:2.8.2.1)
    Short name:
    ST1A1
    Alternative name(s):
    Aryl sulfotransferase
    Phenol sulfotransferase
    Phenol/aryl sulfotransferase
    Short name:
    mSTp1
    ST1A4
    Sulfokinase
    Gene namesi
    Name:Sult1a1
    Synonyms:St1a1, Stp, Stp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:102896. Sult1a1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Sulfotransferase 1A1PRO_0000085130Add
    BLAST

    Proteomic databases

    MaxQBiP52840.
    PaxDbiP52840.
    PRIDEiP52840.

    2D gel databases

    REPRODUCTION-2DPAGEP52840.

    PTM databases

    PhosphoSiteiP52840.

    Expressioni

    Gene expression databases

    GenevestigatoriP52840.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiP52840. 2 interactions.
    MINTiMINT-1869624.

    Structurei

    3D structure databases

    ProteinModelPortaliP52840.
    SMRiP52840. Positions 5-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni102 – 1043Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the sulfotransferase 1 family.Curated

    Phylogenomic databases

    eggNOGiNOG260792.
    HOGENOMiHOG000037209.
    HOVERGENiHBG001195.
    InParanoidiP52840.
    PhylomeDBiP52840.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P52840-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLRKPLVP VKGIPLIKYF AETMEQLQNF TAWPDDVLIS TYPKSGTNWM    50
    SEIMDMIYQG GKLDKCGRAP VYARIPFLEF SCPGVPPGLE TLKETPAPRI 100
    IKTHLPLSLL PQSLLDQKIK VIYVARNAKD VVVSYYNFYK MAKLHPDPGT 150
    WESFLENFMD GKVSYGSWYQ HVKEWWELRR THPVLYLFYE DMKENPKREI 200
    KKILEFLGRS LPEETVDLIV HHTSFKKMKE NPMANYTTIP TEVMDHTIYP 250
    FMRKGTIGDW KNTFTVAQSE HFDAHYAKLM TGCDFTFRCQ I 291
    Length:291
    Mass (Da):33,974
    Last modified:October 1, 1996 - v1
    Checksum:iADC07187DFA51D96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02331 mRNA. No translation available.
    UniGeneiMm.368982.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02331 mRNA. No translation available.
    UniGenei Mm.368982.

    3D structure databases

    ProteinModelPortali P52840.
    SMRi P52840. Positions 5-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P52840. 2 interactions.
    MINTi MINT-1869624.

    PTM databases

    PhosphoSitei P52840.

    2D gel databases

    REPRODUCTION-2DPAGE P52840.

    Proteomic databases

    MaxQBi P52840.
    PaxDbi P52840.
    PRIDEi P52840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:102896. Sult1a1.

    Phylogenomic databases

    eggNOGi NOG260792.
    HOGENOMi HOG000037209.
    HOVERGENi HBG001195.
    InParanoidi P52840.
    PhylomeDBi P52840.

    Miscellaneous databases

    PROi P52840.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P52840.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver."
      Kong A.-N.T., Ma M., Tao D., Yang L.
      Biochim. Biophys. Acta 1171:315-318(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.

    Entry informationi

    Entry nameiST1A1_MOUSE
    AccessioniPrimary (citable) accession number: P52840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3