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P52840 (ST1A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfotransferase 1A1

Short name=ST1A1
EC=2.8.2.1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol/aryl sulfotransferase
Short name=mSTp1
ST1A4
Sulfokinase
Gene names
Name:Sult1a1
Synonyms:St1a1, Stp, Stp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.

Catalytic activity

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
   Biological processLipid metabolism
Steroid metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsteroid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaryl sulfotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

nucleotide binding

Inferred from direct assay PubMed 12390022. Source: MGI

sulfotransferase activity

Inferred from direct assay PubMed 12390022. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Sulfotransferase 1A1
PRO_0000085130

Regions

Nucleotide binding44 – 496PAPS By similarity
Nucleotide binding223 – 2286PAPS By similarity
Nucleotide binding251 – 2555PAPS By similarity
Region102 – 1043Substrate binding By similarity

Sites

Active site1041Proton acceptor By similarity
Binding site1261PAPS By similarity
Binding site1341PAPS By similarity
Binding site1891PAPS By similarity

Sequences

Sequence LengthMass (Da)Tools
P52840 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: ADC07187DFA51D96

FASTA29133,974
        10         20         30         40         50         60 
MEPLRKPLVP VKGIPLIKYF AETMEQLQNF TAWPDDVLIS TYPKSGTNWM SEIMDMIYQG 

        70         80         90        100        110        120 
GKLDKCGRAP VYARIPFLEF SCPGVPPGLE TLKETPAPRI IKTHLPLSLL PQSLLDQKIK 

       130        140        150        160        170        180 
VIYVARNAKD VVVSYYNFYK MAKLHPDPGT WESFLENFMD GKVSYGSWYQ HVKEWWELRR 

       190        200        210        220        230        240 
THPVLYLFYE DMKENPKREI KKILEFLGRS LPEETVDLIV HHTSFKKMKE NPMANYTTIP 

       250        260        270        280        290 
TEVMDHTIYP FMRKGTIGDW KNTFTVAQSE HFDAHYAKLM TGCDFTFRCQ I 

« Hide

References

[1]"Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver."
Kong A.-N.T., Ma M., Tao D., Yang L.
Biochim. Biophys. Acta 1171:315-318(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L02331 mRNA. No translation available.
UniGeneMm.368982.

3D structure databases

ProteinModelPortalP52840.
SMRP52840. Positions 5-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP52840. 2 interactions.
MINTMINT-1869624.

PTM databases

PhosphoSiteP52840.

2D gel databases

REPRODUCTION-2DPAGEP52840.

Proteomic databases

PaxDbP52840.
PRIDEP52840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:102896. Sult1a1.

Phylogenomic databases

eggNOGNOG260792.
HOGENOMHOG000037209.
HOVERGENHBG001195.
InParanoidP52840.
PhylomeDBP52840.

Gene expression databases

GenevestigatorP52840.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

PROP52840.
SOURCESearch...

Entry information

Entry nameST1A1_MOUSE
AccessionPrimary (citable) accession number: P52840
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot