P52840 (ST1A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfotransferase 1A1
Short name=ST1A1
EC=2.8.2.1

Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol/aryl sulfotransferase
Short name=mSTp1
ST1A4
Sulfokinase

Gene names

Name:	Sult1a1
Synonyms:	St1a1, Stp, Stp1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.
Catalytic activity	3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the sulfotransferase 1 family.

Ontologies

Keywords
Biological process	Lipid metabolism Steroid metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	steroid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aryl sulfotransferase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from direct assay PubMed 12390022. Source: MGI sulfotransferase activity Inferred from direct assay PubMed 12390022. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Sulfotransferase 1A1		PRO_0000085130
Regions
	Nucleotide binding	44 – 49	6	PAPS By similarity
	Nucleotide binding	223 – 228	6	PAPS By similarity
	Nucleotide binding	251 – 255	5	PAPS By similarity
	Region	102 – 104	3	Substrate binding By similarity
Sites
	Active site	104	1	Proton acceptor By similarity
	Binding site	126	1	PAPS By similarity
	Binding site	134	1	PAPS By similarity
	Binding site	189	1	PAPS By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52840 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: ADC07187DFA51D96	FASTA	291	33,974
	10 20 30 40 50 60 MEPLRKPLVP VKGIPLIKYF AETMEQLQNF TAWPDDVLIS TYPKSGTNWM SEIMDMIYQG 70 80 90 100 110 120 GKLDKCGRAP VYARIPFLEF SCPGVPPGLE TLKETPAPRI IKTHLPLSLL PQSLLDQKIK 130 140 150 160 170 180 VIYVARNAKD VVVSYYNFYK MAKLHPDPGT WESFLENFMD GKVSYGSWYQ HVKEWWELRR 190 200 210 220 230 240 THPVLYLFYE DMKENPKREI KKILEFLGRS LPEETVDLIV HHTSFKKMKE NPMANYTTIP 250 260 270 280 290 TEVMDHTIYP FMRKGTIGDW KNTFTVAQSE HFDAHYAKLM TGCDFTFRCQ I

References

[1]	"Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver." Kong A.-N.T., Ma M., Tao D., Yang L. Biochim. Biophys. Acta 1171:315-318(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L02331 mRNA. No translation available.
IPI	IPI01007896.
UniGene	Mm.368982.
3D structure databases
ProteinModelPortal	P52840.
SMR	P52840. Positions 5-291.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1869624.
PTM databases
PhosphoSite	P52840.
2D gel databases
REPRODUCTION-2DPAGE	P52840.
Proteomic databases
PaxDb	P52840.
PRIDE	P52840.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:102896. Sult1a1.
Phylogenomic databases
eggNOG	NOG260792.
HOGENOM	HOG000037209.
HOVERGEN	HBG001195.
InParanoid	P52840.
OrthoDB	EOG4255T9.
Gene expression databases
Genevestigator	P52840.
GermOnline	ENSMUSG00000030711. Mus musculus.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR000863. Sulfotransferase_dom. [Graphical view]
Pfam	PF00685. Sulfotransfer_1. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ST1A1_MOUSE

Accession

Primary (citable) accession number: P52840

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program