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Protein

Carnitine O-palmitoyltransferase 2, mitochondrial

Gene

Cpt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei372Proton acceptorBy similarity1
Binding sitei486CarnitineBy similarity1
Binding sitei488CarnitineBy similarity1
Binding sitei499CarnitineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

ReactomeiR-MMU-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial (EC:2.3.1.21)
Alternative name(s):
Carnitine palmitoyltransferase II
Short name:
CPT II
Gene namesi
Name:Cpt2
Synonyms:Cpt-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109176. Cpt2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 178Mitochondrial matrixBy similarityAdd BLAST153
Intramembranei179 – 208Note=Mitochondrial inner membraneBy similarityAdd BLAST30
Topological domaini209 – 658Mitochondrial matrixBy similarityAdd BLAST450

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000000442626 – 658Carnitine O-palmitoyltransferase 2, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-succinyllysineCombined sources1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei85N6-succinyllysineCombined sources1
Modified residuei239N6-acetyllysine; alternateCombined sources1
Modified residuei239N6-succinyllysine; alternateCombined sources1
Modified residuei305N6-acetyllysineCombined sources1
Modified residuei418N6-acetyllysine; alternateCombined sources1
Modified residuei418N6-succinyllysine; alternateCombined sources1
Modified residuei424N6-succinyllysineCombined sources1
Modified residuei439N6-succinyllysineCombined sources1
Modified residuei510N6-acetyllysine; alternateCombined sources1
Modified residuei510N6-succinyllysine; alternateCombined sources1
Modified residuei544N6-acetyllysine; alternateCombined sources1
Modified residuei544N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52825.
MaxQBiP52825.
PaxDbiP52825.
PeptideAtlasiP52825.
PRIDEiP52825.

PTM databases

iPTMnetiP52825.
PhosphoSitePlusiP52825.
SwissPalmiP52825.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028607.
CleanExiMM_CPT2.
ExpressionAtlasiP52825. baseline and differential.
GenevisibleiP52825. MM.

Interactioni

Protein-protein interaction databases

BioGridi198865. 1 interactor.
IntActiP52825. 2 interactors.
MINTiMINT-1845154.
STRINGi10090.ENSMUSP00000030345.

Structurei

3D structure databases

ProteinModelPortaliP52825.
SMRiP52825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni452 – 464Coenzyme A bindingBy similarityAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3719. Eukaryota.
ENOG410XNZ9. LUCA.
GeneTreeiENSGT00550000074786.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiP52825.
KOiK08766.
OMAiFNPFMAF.
OrthoDBiEOG091G0697.
TreeFamiTF315202.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 2 hits.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPRLLLRDW PRCPSLVLGA PSRPLSAVSG PAEYLQHSIV PTMHYQDSLP
60 70 80 90 100
RLPIPKLEDT MKRYLSAQKP LLNDSQFRKT EVLCKDFENG IGKELHAHLL
110 120 130 140 150
AQDKQNKHTS YISGPWFDMY LTARDSVVLN FNPFMAFNPD PKSEYNDQLT
160 170 180 190 200
RATNLTVSAV RFLKTLRAGL LEPEVFHLNP ARSDTDAFKR LIRFVPSSLS
210 220 230 240 250
WYGAYLVNAY PLDMSQYFRL FNSTRIPKPS RDELFTDTKA RHLLVLRKGH
260 270 280 290 300
FYVFDVLDQD GNIVNPSEIQ AHLKYILSDS SPVPEFPLAY LTSENRDVWA
310 320 330 340 350
ELRQKLIHGG NEETLRKVDS AVFCLCLDDF PMKDLVHLSH TMLHGDGTNR
360 370 380 390 400
WFDKSFNLIV AKDGTAAVHF EHAWGDGVAV LRFFNEVFRD STQTPAIAPQ
410 420 430 440 450
SQPAATDSSV SVQKLSFKLS SALKAGVTAA KEKFDATMKT LTIDAIQFQR
460 470 480 490 500
GGKEFLKKKK LSPDAVAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE
510 520 530 540 550
TIRPASIFTK RCSEAFVREP SKHSVGELQH MMAECSKYHG QLTKEAAMGQ
560 570 580 590 600
GFDRHLFALR YLAAARGVTL PELYQDPAYQ RINHNILSTS TLSSPAVSLG
610 620 630 640 650
GFAPVVPDGF GIAYAVHDDW IGCNVSSYSG RNAREFLHCV QKCLEDMFDA

LEGKAIKT
Length:658
Mass (Da):73,981
Last modified:July 27, 2011 - v2
Checksum:i3A02DA887DF1D3A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503R → C in AAA18921 (PubMed:8307575).Curated1
Sequence conflicti503R → C in AAA18922 (PubMed:8307575).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01170
, U01166, U01167, U01168, U01169 Unassigned DNA. Translation: AAA18922.1.
U01163 mRNA. Translation: AAA18921.1.
AK169038 mRNA. Translation: BAE40828.1.
AL611936 Genomic DNA. Translation: CAM23589.1.
CH466527 Genomic DNA. Translation: EDL30761.1.
BC138514 mRNA. Translation: AAI38515.1.
BC145859 mRNA. Translation: AAI45860.1.
CCDSiCCDS18443.1.
PIRiA49362.
RefSeqiNP_034079.2. NM_009949.2.
UniGeneiMm.307620.

Genome annotation databases

EnsembliENSMUST00000030345; ENSMUSP00000030345; ENSMUSG00000028607.
GeneIDi12896.
KEGGimmu:12896.
UCSCiuc008uan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01170
, U01166, U01167, U01168, U01169 Unassigned DNA. Translation: AAA18922.1.
U01163 mRNA. Translation: AAA18921.1.
AK169038 mRNA. Translation: BAE40828.1.
AL611936 Genomic DNA. Translation: CAM23589.1.
CH466527 Genomic DNA. Translation: EDL30761.1.
BC138514 mRNA. Translation: AAI38515.1.
BC145859 mRNA. Translation: AAI45860.1.
CCDSiCCDS18443.1.
PIRiA49362.
RefSeqiNP_034079.2. NM_009949.2.
UniGeneiMm.307620.

3D structure databases

ProteinModelPortaliP52825.
SMRiP52825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198865. 1 interactor.
IntActiP52825. 2 interactors.
MINTiMINT-1845154.
STRINGi10090.ENSMUSP00000030345.

PTM databases

iPTMnetiP52825.
PhosphoSitePlusiP52825.
SwissPalmiP52825.

Proteomic databases

EPDiP52825.
MaxQBiP52825.
PaxDbiP52825.
PeptideAtlasiP52825.
PRIDEiP52825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030345; ENSMUSP00000030345; ENSMUSG00000028607.
GeneIDi12896.
KEGGimmu:12896.
UCSCiuc008uan.2. mouse.

Organism-specific databases

CTDi1376.
MGIiMGI:109176. Cpt2.

Phylogenomic databases

eggNOGiKOG3719. Eukaryota.
ENOG410XNZ9. LUCA.
GeneTreeiENSGT00550000074786.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiP52825.
KOiK08766.
OMAiFNPFMAF.
OrthoDBiEOG091G0697.
TreeFamiTF315202.

Enzyme and pathway databases

ReactomeiR-MMU-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

PROiP52825.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028607.
CleanExiMM_CPT2.
ExpressionAtlasiP52825. baseline and differential.
GenevisibleiP52825. MM.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 2 hits.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPT2_MOUSE
AccessioniPrimary (citable) accession number: P52825
Secondary accession number(s): Q3TFS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.