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P52825

- CPT2_MOUSE

UniProt

P52825 - CPT2_MOUSE

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Protein

Carnitine O-palmitoyltransferase 2, mitochondrial

Gene

Cpt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei372 – 3721Proton acceptorBy similarity
Binding sitei486 – 4861CarnitineBy similarity
Binding sitei488 – 4881CarnitineBy similarity
Binding sitei499 – 4991CarnitineBy similarity

GO - Molecular functioni

  1. carnitine O-palmitoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_257268. Import of palmitoyl-CoA into the mitochondrial matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial (EC:2.3.1.21)
Alternative name(s):
Carnitine palmitoyltransferase II
Short name:
CPT II
Gene namesi
Name:Cpt2
Synonyms:Cpt-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:109176. Cpt2.

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 178153Mitochondrial matrixBy similarityAdd
BLAST
Intramembranei179 – 20830Note=Mitochondrial inner membraneBy similarityAdd
BLAST
Topological domaini209 – 658450Mitochondrial matrixBy similarityAdd
BLAST

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
  3. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionBy similarityAdd
BLAST
Chaini26 – 658633Carnitine O-palmitoyltransferase 2, mitochondrialPRO_0000004426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-succinyllysine1 Publication
Modified residuei79 – 791N6-acetyllysine1 Publication
Modified residuei85 – 851N6-succinyllysine1 Publication
Modified residuei239 – 2391N6-acetyllysine; alternate1 Publication
Modified residuei239 – 2391N6-succinyllysine; alternate1 Publication
Modified residuei305 – 3051N6-acetyllysine1 Publication
Modified residuei418 – 4181N6-acetyllysine; alternate1 Publication
Modified residuei418 – 4181N6-succinyllysine; alternate1 Publication
Modified residuei424 – 4241N6-succinyllysine1 Publication
Modified residuei439 – 4391N6-succinyllysine1 Publication
Modified residuei510 – 5101N6-acetyllysine; alternate1 Publication
Modified residuei510 – 5101N6-succinyllysine; alternate1 Publication
Modified residuei544 – 5441N6-acetyllysine; alternate1 Publication
Modified residuei544 – 5441N6-succinyllysine; alternate1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP52825.
PaxDbiP52825.
PRIDEiP52825.

PTM databases

PhosphoSiteiP52825.

Expressioni

Gene expression databases

BgeeiP52825.
CleanExiMM_CPT2.
ExpressionAtlasiP52825. baseline and differential.
GenevestigatoriP52825.

Interactioni

Protein-protein interaction databases

IntActiP52825. 2 interactions.
MINTiMINT-1845154.

Structurei

3D structure databases

ProteinModelPortaliP52825.
SMRiP52825. Positions 33-658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni452 – 46413Coenzyme A bindingBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG70127.
GeneTreeiENSGT00550000074786.
HOGENOMiHOG000007446.
HOVERGENiHBG098001.
InParanoidiP52825.
KOiK08766.
OMAiRCSEAFV.
OrthoDBiEOG776SPG.
TreeFamiTF315202.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52825-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMPRLLLRDW PRCPSLVLGA PSRPLSAVSG PAEYLQHSIV PTMHYQDSLP
60 70 80 90 100
RLPIPKLEDT MKRYLSAQKP LLNDSQFRKT EVLCKDFENG IGKELHAHLL
110 120 130 140 150
AQDKQNKHTS YISGPWFDMY LTARDSVVLN FNPFMAFNPD PKSEYNDQLT
160 170 180 190 200
RATNLTVSAV RFLKTLRAGL LEPEVFHLNP ARSDTDAFKR LIRFVPSSLS
210 220 230 240 250
WYGAYLVNAY PLDMSQYFRL FNSTRIPKPS RDELFTDTKA RHLLVLRKGH
260 270 280 290 300
FYVFDVLDQD GNIVNPSEIQ AHLKYILSDS SPVPEFPLAY LTSENRDVWA
310 320 330 340 350
ELRQKLIHGG NEETLRKVDS AVFCLCLDDF PMKDLVHLSH TMLHGDGTNR
360 370 380 390 400
WFDKSFNLIV AKDGTAAVHF EHAWGDGVAV LRFFNEVFRD STQTPAIAPQ
410 420 430 440 450
SQPAATDSSV SVQKLSFKLS SALKAGVTAA KEKFDATMKT LTIDAIQFQR
460 470 480 490 500
GGKEFLKKKK LSPDAVAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE
510 520 530 540 550
TIRPASIFTK RCSEAFVREP SKHSVGELQH MMAECSKYHG QLTKEAAMGQ
560 570 580 590 600
GFDRHLFALR YLAAARGVTL PELYQDPAYQ RINHNILSTS TLSSPAVSLG
610 620 630 640 650
GFAPVVPDGF GIAYAVHDDW IGCNVSSYSG RNAREFLHCV QKCLEDMFDA

LEGKAIKT
Length:658
Mass (Da):73,981
Last modified:July 27, 2011 - v2
Checksum:i3A02DA887DF1D3A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti503 – 5031R → C in AAA18921. (PubMed:8307575)Curated
Sequence conflicti503 – 5031R → C in AAA18922. (PubMed:8307575)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01170
, U01166, U01167, U01168, U01169 Unassigned DNA. Translation: AAA18922.1.
U01163 mRNA. Translation: AAA18921.1.
AK169038 mRNA. Translation: BAE40828.1.
AL611936 Genomic DNA. Translation: CAM23589.1.
CH466527 Genomic DNA. Translation: EDL30761.1.
BC138514 mRNA. Translation: AAI38515.1.
BC145859 mRNA. Translation: AAI45860.1.
CCDSiCCDS18443.1.
PIRiA49362.
RefSeqiNP_034079.2. NM_009949.2.
UniGeneiMm.307620.

Genome annotation databases

EnsembliENSMUST00000030345; ENSMUSP00000030345; ENSMUSG00000028607.
GeneIDi12896.
KEGGimmu:12896.
UCSCiuc008uan.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01170
, U01166 , U01167 , U01168 , U01169 Unassigned DNA. Translation: AAA18922.1 .
U01163 mRNA. Translation: AAA18921.1 .
AK169038 mRNA. Translation: BAE40828.1 .
AL611936 Genomic DNA. Translation: CAM23589.1 .
CH466527 Genomic DNA. Translation: EDL30761.1 .
BC138514 mRNA. Translation: AAI38515.1 .
BC145859 mRNA. Translation: AAI45860.1 .
CCDSi CCDS18443.1.
PIRi A49362.
RefSeqi NP_034079.2. NM_009949.2.
UniGenei Mm.307620.

3D structure databases

ProteinModelPortali P52825.
SMRi P52825. Positions 33-658.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P52825. 2 interactions.
MINTi MINT-1845154.

PTM databases

PhosphoSitei P52825.

Proteomic databases

MaxQBi P52825.
PaxDbi P52825.
PRIDEi P52825.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030345 ; ENSMUSP00000030345 ; ENSMUSG00000028607 .
GeneIDi 12896.
KEGGi mmu:12896.
UCSCi uc008uan.2. mouse.

Organism-specific databases

CTDi 1376.
MGIi MGI:109176. Cpt2.

Phylogenomic databases

eggNOGi NOG70127.
GeneTreei ENSGT00550000074786.
HOGENOMi HOG000007446.
HOVERGENi HBG098001.
InParanoidi P52825.
KOi K08766.
OMAi RCSEAFV.
OrthoDBi EOG776SPG.
TreeFami TF315202.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_257268. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

NextBioi 282510.
PROi P52825.
SOURCEi Search...

Gene expression databases

Bgeei P52825.
CleanExi MM_CPT2.
ExpressionAtlasi P52825. baseline and differential.
Genevestigatori P52825.

Family and domain databases

InterProi IPR000542. Carn_acyl_trans.
[Graphical view ]
PANTHERi PTHR22589. PTHR22589. 1 hit.
Pfami PF00755. Carn_acyltransf. 1 hit.
[Graphical view ]
PROSITEi PS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene."
    Gelb B.D.
    Genomics 18:651-655(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-69; LYS-85; LYS-239; LYS-418; LYS-424; LYS-439; LYS-510 AND LYS-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast and Liver.
  7. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-79; LYS-239; LYS-305; LYS-418; LYS-510 AND LYS-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCPT2_MOUSE
AccessioniPrimary (citable) accession number: P52825
Secondary accession number(s): Q3TFS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3