Reviewed,
UniProtKB/Swiss-Prot P52824 (DGKQ_HUMAN)
Last modified
November 25, 2008.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Diacylglycerol kinase theta Short name=DAG kinase theta EC=2.7.1.107 Alternative name(s): Diglyceride kinase theta Short name=DGK-theta | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 942 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Sequence similarities | Belongs to the eukaryotic diacylglycerol kinase family. Contains 1 DAGKc domain. Contains 3 phorbol-ester/DAG-type zinc fingers. Contains 1 Ras-associating domain. |
Ontologies
Keywords | |
|---|---|
| Domain | Phorbol-ester binding Repeat Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Kinase Transferase |
Gene Ontology (GO) | |
| Biological process | activation of protein kinase C activity Inferred from electronic annotation. Source: InterPro |
| Molecular function | diacylglycerol binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol kinase activityTraceable author statement. Source: ProtInc zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 942 | 942 | Diacylglycerol kinase theta | PRO_0000218467 | |||||
Regions | |||||||||
| Domain | 395 – 494 | 100 | Ras-associating | ||||||
| Domain | 588 – 715 | 128 | DAGKc | ||||||
| Zinc finger | 60 – 108 | 49 | Phorbol-ester/DAG-type 1 | ||||||
| Zinc finger | 121 – 168 | 48 | Phorbol-ester/DAG-type 2 | ||||||
| Zinc finger | 183 – 234 | 52 | Phorbol-ester/DAG-type 3 | ||||||
Sequences
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References
| [1] | "Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene." Pilz A., Schaap D., Hunt D., Fitzgibbon J. Genomics 26:599-601(1995) [PubMed: 7607687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L38707 mRNA. Translation: AAA98749.1. | |
| UniGene | Hs.584858 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FAR based on UniProtKB P04049. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P52824. |
Genome annotation databases | |
| Ensembl | ENSG00000145214. Homo sapiens. [Contig view] |
Organism-specific databases | |
| H-InvDB | HIX0031472. |
| HGNC | HGNC:2856. DGKQ. |
| MIM | 601207. gene. |
| PharmGKB | PA27317. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P52824. |
| HOVERGEN | P52824. |
Gene expression databases | |
| ArrayExpress | P52824. |
| CleanEx | HS_DGKQ. |
| GermOnline | ENSG00000145214. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011424. C1_3. IPR002219. DAG_PE_bd. IPR000756. DAGKa. IPR001206. DAGKc. IPR000159. Ras-assoc. [Graphical view] |
| Pfam | PF00130. C1_1. 2 hits. PF07649. C1_3. 1 hit. PF00609. DAGK_acc. 1 hit. PF00781. DAGK_cat. 1 hit. PF00788. RA. 2 hits. [Graphical view] |
| PRINTS | PR00008. DAGPEDOMAIN. |
| ProDom | PD002939. DAGKa. 1 hit. PD005043. DAGKc. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00109. C1. 3 hits. SM00045. DAGKa. 1 hit. SM00046. DAGKc. 1 hit. SM00314. RA. 1 hit. [Graphical view] |
| PROSITE | PS50200. RA. 1 hit. PS00479. ZF_DAG_PE_1. 3 hits. PS50081. ZF_DAG_PE_2. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | DGKQ_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P52824 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


