Reviewed, UniProtKB/Swiss-Prot P52824 (DGKQ_HUMAN)

Names and origin

Protein names

Recommended name:
    Diacylglycerol kinase theta
      Short name=DAG kinase theta
    EC=2.7.1.107
Alternative name(s):
    Diglyceride kinase theta
      Short name=DGK-theta

Gene names

Name:	DGKQ
Synonyms:	DAGK4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	942 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
Sequence similarities	Belongs to the eukaryotic diacylglycerol kinase family. Contains 1 DAGKc domain. Contains 3 phorbol-ester/DAG-type zinc fingers. Contains 1 Ras-associating domain.

Ontologies

Keywords
Domain	Phorbol-ester binding Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	activation of protein kinase C activity Inferred from electronic annotation. Source: InterPro
Molecular function	diacylglycerol binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol kinase activity Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 942	942	Diacylglycerol kinase theta		PRO_0000218467
Regions
	Domain	395 – 494	100	Ras-associating
	Domain	588 – 715	128	DAGKc
	Zinc finger	60 – 108	49	Phorbol-ester/DAG-type 1
	Zinc finger	121 – 168	48	Phorbol-ester/DAG-type 2
	Zinc finger	183 – 234	52	Phorbol-ester/DAG-type 3

Sequences

	Sequence		Length	Mass (Da)
	P52824-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 26F8D135B248477E	FASTA	942	101,403
	10 20 30 40 50 60 MAAAAEPGAR AWLGGGSPRP GSPACSPVLG SGGRARPGPG PGPGRDRAGG VRARARAAPG 70 80 90 100 110 120 HSFRKVTLTK PTFCHLCSDF IWGLAGFLCD VCNFMSHEKC LKHVRIPCTS VAPSLVRVPV 130 140 150 160 170 180 AHCFGPRGLH KRKFCAVCRK VLEAPALHCE VCELHLHPDC VPFACSDCRQ CHQDGHQDHD 190 200 210 220 230 240 THHHHWREGN LPSGARCEVC RKTCGSSDVL AGVRCEWCGV QAHSLCSAAL APECGFGRLR 250 260 270 280 290 300 SLVLPPACVR LLPGGFSKTQ SFRIVEAAEP GEGGDGADGS AAVGPGRETQ ATPESGKQTL 310 320 330 340 350 360 KIFDGDDAVR RSQFRLVTVS RLAGAEEVLE AALRAHHIPE DPGHLELCRL PPSSQACDAW 370 380 390 400 410 420 AGGKAGSAVI SEEGRSPGSG EATPEAWVIR ALPRAQEVLK IYPGWLKVGV AYVSVRVTPK 430 440 450 460 470 480 STARSVVLEV LPLLGRQAES PESFQLVEVA MGCRHVQRTM LMDEQPLLDR LQDIRQMSVR 490 500 510 520 530 540 QVSQTRFYVA ESRDVAPHVS LFVGGLPPGL SPEEYSSLLH EAGATKATVV SVSHIYSSQG 550 560 570 580 590 600 AVVLDVACFA EAERLYMLLK DMAVRGRLLT ALVLPDLLHA KLPPDSCPLL VFVNPKSGGL 610 620 630 640 650 660 KGRDLLCSFR KLLNPHQVFD LTNGGPLPGL HLFSQVPCFR VLVCGGDGTV GWVLGALEET 670 680 690 700 710 720 RYRLACPEPS VAILPLGTGN DLGRVLRWGA GYSGEDPFSV LLSVDEADAV LMDRWTILLD 730 740 750 760 770 780 AHEAGSAEND TADAEPPKIV QMSNYCGIGI DAELSLDFHQ AREEEPGKFT SRLHNKGVYV 790 800 810 820 830 840 RVGLQKISHS RSLHKQIRLQ VERQEVELPS IEGLIFINIP SWGSGADLWG SDSDTRFEKP 850 860 870 880 890 900 RMDDGLLEVV GVTGVVHMGQ VQGGLRSGIR IAQGSYFRVT LLKATPVQVD GEPWVQAPGH 910 920 930 940 MIISAAGPKV HMLRKAKQKP RRAGTTRDAR ADRAPAPESD PR

References

[1]	"Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene." Pilz A., Schaap D., Hunt D., Fitzgibbon J. Genomics 26:599-601(1995) [PubMed: 7607687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L38707 mRNA. Translation: AAA98749.1.
UniGene	Hs.584858
3D structure databases
HSSP	HSSP built from PDB template 1FAR based on UniProtKB P04049.
ModBase	Search...
PTM databases
PhosphoSite	P52824.
Genome annotation databases
Ensembl	ENSG00000145214. Homo sapiens. [Contig view]
Organism-specific databases
H-InvDB	HIX0031472.
HGNC	HGNC:2856. DGKQ.
MIM	601207. gene.
PharmGKB	PA27317.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P52824.
HOVERGEN	P52824.
Gene expression databases
ArrayExpress	P52824.
CleanEx	HS_DGKQ.
GermOnline	ENSG00000145214. Homo sapiens.
Family and domain databases
InterPro	IPR011424. C1_3. IPR002219. DAG_PE_bd. IPR000756. DAGKa. IPR001206. DAGKc. IPR000159. Ras-assoc. [Graphical view]
Pfam	PF00130. C1_1. 2 hits. PF07649. C1_3. 1 hit. PF00609. DAGK_acc. 1 hit. PF00781. DAGK_cat. 1 hit. PF00788. RA. 2 hits. [Graphical view]
PRINTS	PR00008. DAGPEDOMAIN.
ProDom	PD002939. DAGKa. 1 hit. PD005043. DAGKc. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00109. C1. 3 hits. SM00045. DAGKa. 1 hit. SM00046. DAGKc. 1 hit. SM00314. RA. 1 hit. [Graphical view]
PROSITE	PS50200. RA. 1 hit. PS00479. ZF_DAG_PE_1. 3 hits. PS50081. ZF_DAG_PE_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

DGKQ_HUMAN

Accession

Primary (citable) accession number: P52824

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)