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Protein

Stanniocalcin-1

Gene

STC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

GO - Biological processi

  • bone development Source: UniProtKB
  • cellular calcium ion homeostasis Source: UniProtKB
  • cellular response to cAMP Source: Ensembl
  • cellular response to glucocorticoid stimulus Source: Ensembl
  • cellular response to hypoxia Source: Ensembl
  • chondrocyte proliferation Source: UniProtKB
  • decidualization Source: Ensembl
  • embryo implantation Source: Ensembl
  • endothelial cell morphogenesis Source: UniProtKB
  • growth plate cartilage axis specification Source: UniProtKB
  • negative regulation of calcium ion transport Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of endothelial cell migration Source: UniProtKB
  • negative regulation of renal phosphate excretion Source: UniProtKB
  • ossification Source: Ensembl
  • positive regulation of calcium ion import Source: UniProtKB
  • regulation of anion transport Source: UniProtKB
  • regulation of cardiac muscle cell contraction Source: UniProtKB
  • response to vitamin D Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-1
Short name:
STC-1
Gene namesi
Name:STC1
Synonyms:STC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11373. STC1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • cytoplasm Source: UniProtKB
  • extracellular space Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36190.

Polymorphism and mutation databases

BioMutaiSTC1.
DMDMi1706175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Propeptidei18 – 3316Sequence analysisPRO_0000033297Add
BLAST
Chaini34 – 247214Stanniocalcin-1PRO_0000033298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 59By similarity
Disulfide bondi54 ↔ 74By similarity
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi65 ↔ 114By similarity
Disulfide bondi98 ↔ 128By similarity
Disulfide bondi135 ↔ 170By similarity
Disulfide bondi202 – 202InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP52823.
PaxDbiP52823.
PRIDEiP52823.

PTM databases

iPTMnetiP52823.
PhosphoSiteiP52823.

Expressioni

Tissue specificityi

Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.

Gene expression databases

BgeeiP52823.
CleanExiHS_STC1.
ExpressionAtlasiP52823. baseline and differential.
GenevisibleiP52823. HS.

Organism-specific databases

HPAiCAB018625.
HPA023918.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000290271.

Structurei

3D structure databases

ProteinModelPortaliP52823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH10. Eukaryota.
ENOG410YPCI. LUCA.
GeneTreeiENSGT00390000005989.
HOGENOMiHOG000008670.
HOVERGENiHBG003575.
InParanoidiP52823.
OMAiHDICKSF.
OrthoDBiEOG76T9S0.
PhylomeDBiP52823.
TreeFamiTF324693.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 1 hit.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52823-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQNSAVLLV LVISASATHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL
60 70 80 90 100
QVGCGAFACL ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA
110 120 130 140 150
NGVTSKVFLA IRRCSTFQRM IAEVQEECYS KLNVCSIAKR NPEAITEVVQ
160 170 180 190 200
LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD SLMEKIGPNM ASLFHILQTD
210 220 230 240
HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEEDSPSHIK RTSHESA
Length:247
Mass (Da):27,621
Last modified:October 1, 1996 - v1
Checksum:i1E4A8BD861B49AED
GO
Isoform 2 (identifier: P52823-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,487
Checksum:iA1B21E4E6608DC8A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. 1 PublicationVSP_057169Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25997 mRNA. Translation: AAC09472.1.
U46768 mRNA. Translation: AAA88903.1.
AF242179 Genomic DNA. Translation: AAL79522.1.
AK297734 mRNA. Translation: BAG60084.1.
AC012119 Genomic DNA. No translation available.
BC029044 mRNA. Translation: AAH29044.1.
AF098463 Genomic DNA. Translation: AAC97949.1.
CCDSiCCDS6043.1. [P52823-1]
RefSeqiNP_003146.1. NM_003155.2. [P52823-1]
UniGeneiHs.25590.

Genome annotation databases

EnsembliENST00000290271; ENSP00000290271; ENSG00000159167. [P52823-1]
ENST00000524323; ENSP00000427932; ENSG00000159167. [P52823-2]
GeneIDi6781.
KEGGihsa:6781.
UCSCiuc003xdw.2. human. [P52823-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25997 mRNA. Translation: AAC09472.1.
U46768 mRNA. Translation: AAA88903.1.
AF242179 Genomic DNA. Translation: AAL79522.1.
AK297734 mRNA. Translation: BAG60084.1.
AC012119 Genomic DNA. No translation available.
BC029044 mRNA. Translation: AAH29044.1.
AF098463 Genomic DNA. Translation: AAC97949.1.
CCDSiCCDS6043.1. [P52823-1]
RefSeqiNP_003146.1. NM_003155.2. [P52823-1]
UniGeneiHs.25590.

3D structure databases

ProteinModelPortaliP52823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000290271.

PTM databases

iPTMnetiP52823.
PhosphoSiteiP52823.

Polymorphism and mutation databases

BioMutaiSTC1.
DMDMi1706175.

Proteomic databases

MaxQBiP52823.
PaxDbiP52823.
PRIDEiP52823.

Protocols and materials databases

DNASUi6781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290271; ENSP00000290271; ENSG00000159167. [P52823-1]
ENST00000524323; ENSP00000427932; ENSG00000159167. [P52823-2]
GeneIDi6781.
KEGGihsa:6781.
UCSCiuc003xdw.2. human. [P52823-1]

Organism-specific databases

CTDi6781.
GeneCardsiSTC1.
HGNCiHGNC:11373. STC1.
HPAiCAB018625.
HPA023918.
MIMi601185. gene.
neXtProtiNX_P52823.
PharmGKBiPA36190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH10. Eukaryota.
ENOG410YPCI. LUCA.
GeneTreeiENSGT00390000005989.
HOGENOMiHOG000008670.
HOVERGENiHBG003575.
InParanoidiP52823.
OMAiHDICKSF.
OrthoDBiEOG76T9S0.
PhylomeDBiP52823.
TreeFamiTF324693.

Miscellaneous databases

ChiTaRSiSTC1. human.
GeneWikiiSTC1.
GenomeRNAii6781.
NextBioi26480.
PROiP52823.
SOURCEiSearch...

Gene expression databases

BgeeiP52823.
CleanExiHS_STC1.
ExpressionAtlasiP52823. baseline and differential.
GenevisibleiP52823. HS.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 1 hit.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human cDNA highly homologous to the fish hormone stanniocalcin."
    Chang A.C.-M., Janosi J., Hulsbeek M., de Jong D., Jeffrey K.J., Noble J.R., Reddel R.R.
    Mol. Cell. Endocrinol. 112:241-247(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fibrosarcoma and Lung carcinoma.
  2. "Human stanniocalcin: a possible hormonal regulator of mineral metabolism."
    Olsen H.S., Cepeda M.A., Zhang Q.-Q., Rosen C.A., Vozzolo B.L., Wagner G.F.
    Proc. Natl. Acad. Sci. U.S.A. 93:1792-1796(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal lung.
  3. "Characterization of the human stanniocalcin 1 gene."
    Jeffrey K.J., Reddel R.R.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon, Kidney and Stomach.
  7. "Comparative analysis of mammalian stanniocalcin genes."
    Varghese R., Wong C.K., Deol H., Wagner G.F., DiMattia G.E.
    Endocrinology 139:4714-4725(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-32.

Entry informationi

Entry nameiSTC1_HUMAN
AccessioniPrimary (citable) accession number: P52823
Secondary accession number(s): B4DN22, Q71UE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.