Reviewed, UniProtKB/Swiss-Prot P52823 (STC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Stanniocalcin-1
      Short name=STC-1

Gene names

Name:	STC1
Synonyms:	STC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.
Sequence similarities	Belongs to the stanniocalcin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Ref.2 Traceable author statement. Source: ProtInc cell-cell signaling Ref.2 Traceable author statement. Source: ProtInc cellular calcium ion homeostasis Ref.2 Traceable author statement. Source: ProtInc response to nutrient Ref.2 Traceable author statement. Source: ProtInc
Molecular function	hormone activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17
	Propeptide	18 – 33	16	Potential		PRO_0000033297
	Chain	34 – 247	214	Stanniocalcin-1		PRO_0000033298
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Disulfide bond	45 ↔ 59		By similarity
	Disulfide bond	54 ↔ 74		By similarity
	Disulfide bond	65 ↔ 114		By similarity
	Disulfide bond	98 ↔ 128		By similarity
	Disulfide bond	135 ↔ 170		By similarity
	Disulfide bond	202		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52823-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 1E4A8BD861B49AED	FASTA	247	27,621
	10 20 30 40 50 60 MLQNSAVLLV LVISASATHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL QVGCGAFACL 70 80 90 100 110 120 ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGVTSKVFLA IRRCSTFQRM 130 140 150 160 170 180 IAEVQEECYS KLNVCSIAKR NPEAITEVVQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD 190 200 210 220 230 240 SLMEKIGPNM ASLFHILQTD HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEEDSPSHIK RTSHESA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human cDNA highly homologous to the fish hormone stanniocalcin." Chang A.C.-M., Janosi J., Hulsbeek M., de Jong D., Jeffrey K.J., Noble J.R., Reddel R.R. Mol. Cell. Endocrinol. 112:241-247(1995) [PubMed: 7489828] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fibrosarcoma and Lung carcinoma.
[2]	"Human stanniocalcin: a possible hormonal regulator of mineral metabolism." Olsen H.S., Cepeda M.A., Zhang Q.-Q., Rosen C.A., Vozzolo B.L., Wagner G.F. Proc. Natl. Acad. Sci. U.S.A. 93:1792-1796(1996) [PubMed: 8700837] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal lung.
[3]	"Characterization of the human stanniocalcin 1 gene." Jeffrey K.J., Reddel R.R. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-32.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U25997 mRNA. Translation: AAC09472.1. U46768 mRNA. Translation: AAA88903.1. AF242179 Genomic DNA. Translation: AAL79522.1. BC029044 mRNA. Translation: AAH29044.1.
RefSeq	NP_003146.1.
UniGene	Hs.25590
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000159167. Homo sapiens. [Contig view]
GeneID	6781.
KEGG	hsa:6781.
Organism-specific databases
H-InvDB	HIX0007390.
HGNC	HGNC:11373. STC1.
MIM	601185. gene.
PharmGKB	PA36190.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P52823.
HOVERGEN	P52823.
Gene expression databases
ArrayExpress	P52823.
CleanEx	HS_STC1.
GermOnline	ENSG00000159167. Homo sapiens.
Family and domain databases
InterPro	IPR004978. Stanniocalcin. [Graphical view]
PANTHER	PTHR11245. Stanniocalcin. 1 hit.
Pfam	PF03298. Stanniocalcin. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P52823.
NextBio	26480.
SOURCE	Search...

Entry information

Entry name

STC1_HUMAN

Accession

Primary (citable) accession number: P52823

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 4, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)