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Protein

60S ribosomal protein L5-A

Gene

rpl501

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

Miscellaneous

There are two genes for L5 in S.pombe.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SPO-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SPO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5-A
Gene namesi
Name:rpl501
Synonyms:rpl5a
ORF Names:SPAC3H5.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H5.12c
PomBaseiSPAC3H5.12c rpl501

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001314521 – 29460S ribosomal protein L5-AAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine1 Publication1
Modified residuei12Phosphotyrosine1 Publication1
Modified residuei81Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP52822
PaxDbiP52822
PRIDEiP52822

PTM databases

iPTMnetiP52822

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU).By similarity

Protein-protein interaction databases

BioGridi2800561 interactor.
IntActiP52822 1 interactor.
MINTiP52822
STRINGi4896.SPAC3H5.12c.1

Structurei

3D structure databases

ProteinModelPortaliP52822
SMRiP52822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000105947
InParanoidiP52822
KOiK02932
OMAiMAHGPRY
OrthoDBiEOG092C44EY
PhylomeDBiP52822

Family and domain databases

HAMAPiMF_01337_A Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485 Rbsml_L5_euk/L18_arc
IPR025607 Rbsml_L5e/L18P_C
PANTHERiPTHR23410 PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204 Ribosomal_L18_c, 1 hit
PF17144 Ribosomal_L5e, 1 hit
PRINTSiPR00058 RIBOSOMALL5

Sequencei

Sequence statusi: Complete.

P52822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIKAVKSS PYFSRYQTKY RRRREGKTDY YARKRLIAQA KNKYNAPKYR
60 70 80 90 100
LVVRFSNRFV TCQIVSSRVN GDYVLAHAHS SELPRYGIKW GLANWTAAYA
110 120 130 140 150
TGLLVARRAL AKVGLADKYE GVTEPEGEFE LTEAIEDGPR PFKVFLDVGL
160 170 180 190 200
KRTSTGSRVF GAMKGASDGG LFIPHSPNRF PGFDIETEEL DDETLRKYIY
210 220 230 240 250
GGHVAEYMEM LIDDDEERYQ KQFSGLIADG IESDQLEDIY AEAYAKIRED
260 270 280 290
PSFQKSGKDA AAFKAESLKH TQRKLTAEER KERFNAKVIE AGRA
Length:294
Mass (Da):33,460
Last modified:July 15, 1998 - v2
Checksum:iCA72FE578EB3E35F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Missing in AAB05674 (PubMed:8626719).Curated1
Sequence conflicti28T → I in AAB05674 (PubMed:8626719).Curated1
Sequence conflicti223F → S in AAB05674 (PubMed:8626719).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48270 Genomic DNA Translation: AAB05674.1
CU329670 Genomic DNA Translation: CAB16596.1
PIRiT38758
RefSeqiNP_594180.1, NM_001019604.2

Genome annotation databases

EnsemblFungiiSPAC3H5.12c.1; SPAC3H5.12c.1:pep; SPAC3H5.12c
GeneIDi2543642
KEGGispo:SPAC3H5.12c

Similar proteinsi

Entry informationi

Entry nameiRL5A_SCHPO
AccessioniPrimary (citable) accession number: P52822
Secondary accession number(s): O14153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome