Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L22

Gene

rpl-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Gene namesi
Name:rpl-22
ORF Names:C27A2.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC27A2.2a; CE04102; WBGene00004434; rpl-22.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002155082 – 13060S ribosomal protein L22Add BLAST129

Proteomic databases

EPDiP52819.
PaxDbiP52819.
PeptideAtlasiP52819.
PRIDEiP52819.

PTM databases

iPTMnetiP52819.

Expressioni

Gene expression databases

BgeeiWBGene00004434.

Interactioni

Protein-protein interaction databases

BioGridi39224. 1 interactor.
IntActiP52819. 1 interactor.
STRINGi6239.C27A2.2a.3.

Structurei

3D structure databases

ProteinModelPortaliP52819.
SMRiP52819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434. Eukaryota.
ENOG4111UVJ. LUCA.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
InParanoidiP52819.
KOiK02891.
OMAiQVGRMKN.
OrthoDBiEOG091G0POE.
PhylomeDBiP52819.

Family and domain databases

InterProiView protein in InterPro
IPR002671. Ribosomal_L22e.
PANTHERiPTHR10064. PTHR10064. 1 hit.
PfamiView protein in Pfam
PF01776. Ribosomal_L22e. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P52819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPKPHAKSA KKALRKKKVH LKFNVECKNP VEDGILRIED LEAFLNEKIK
60 70 80 90 100
VNGKTGHLAA NNVKVEVAKS KVSVVSEVPF SKRYLKYLTK KYLKRNSLRD
110 120 130
WLRVVAVNKN TYEVRYFHIN DGEDAGSDHE
Length:130
Mass (Da):14,946
Last modified:January 23, 2007 - v3
Checksum:i9E2244161D88759F
GO
Isoform b (identifier: P52819-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-53: EAFLNEKIKVNG → SIEFPSLSQDQA
     54-130: Missing.

Note: No experimental confirmation available.
Show »
Length:53
Mass (Da):6,013
Checksum:i8E9F9A6316D88015
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02136542 – 53EAFLN…IKVNG → SIEFPSLSQDQA in isoform b. CuratedAdd BLAST12
Alternative sequenceiVSP_02136654 – 130Missing in isoform b. CuratedAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080349 Genomic DNA. Translation: CCD63067.1.
FO080349 Genomic DNA. Translation: CCD63068.1.
PIRiT15648.
RefSeqiNP_494932.1. NM_062531.5. [P52819-1]
UniGeneiCel.8253.

Genome annotation databases

EnsemblMetazoaiC27A2.2a; C27A2.2a; WBGene00004434. [P52819-1]
GeneIDi173873.
KEGGicel:CELE_C27A2.2.
UCSCiC27A2.2a.1. c. elegans. [P52819-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL22_CAEEL
AccessioniPrimary (citable) accession number: P52819
Secondary accession number(s): P85027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families