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Protein

39S ribosomal protein L12, mitochondrial

Gene

MRPL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. structural constituent of ribosome Source: ProtInc

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. positive regulation of transcription, DNA-templated Source: HGNC
  7. transcription from mitochondrial promoter Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L12, mitochondrial
Short name:
L12mt
Short name:
MRP-L12
Alternative name(s):
5c5-2
Gene namesi
Name:MRPL12
Synonyms:RPML12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10378. MRPL12.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial large ribosomal subunit Source: UniProtKB
  3. mitochondrion Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
BLAST
Chaini46 – 19815339S ribosomal protein L12, mitochondrialPRO_0000030458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei138 – 1381N6-acetyllysineBy similarity
Modified residuei150 – 1501N6-succinyllysineBy similarity
Modified residuei162 – 1621N6-succinyllysineBy similarity
Modified residuei178 – 1781N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP52815.
PaxDbiP52815.
PeptideAtlasiP52815.
PRIDEiP52815.

2D gel databases

DOSAC-COBS-2DPAGEP52815.
SWISS-2DPAGEP52815.

PTM databases

PhosphoSiteiP52815.

Expressioni

Gene expression databases

BgeeiP52815.
CleanExiHS_MRPL12.
ExpressionAtlasiP52815. baseline and differential.
GenevestigatoriP52815.

Organism-specific databases

HPAiHPA022853.
HPA023043.

Interactioni

Subunit structurei

Interacts with NOA1.1 Publication

Protein-protein interaction databases

BioGridi112097. 61 interactions.
DIPiDIP-50865N.
IntActiP52815. 13 interactions.
MINTiMINT-1150069.
STRINGi9606.ENSP00000333837.

Structurei

3D structure databases

ProteinModelPortaliP52815.
SMRiP52815. Positions 64-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7/L12P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG312691.
GeneTreeiENSGT00390000000190.
HOGENOMiHOG000248814.
HOVERGENiHBG001832.
InParanoidiP52815.
KOiK02935.
OrthoDBiEOG7B5WXR.
PhylomeDBiP52815.
TreeFamiTF105997.

Family and domain databases

Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12.
InterProiIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PANTHERiPTHR11809. PTHR11809. 1 hit.
PfamiPF00542. Ribosomal_L12. 1 hit.
[Graphical view]
ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG
60 70 80 90 100
APLDNAPKEY PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM
110 120 130 140 150
GGVMSGAVPA AAAQEAVEED IPIAKERTHF TVRLTEAKPV DKVKLIKEIK
160 170 180 190
NYIQGINLVQ AKKLVESLPQ EIKANVAKAE AEKIKAALEA VGGTVVLE
Length:198
Mass (Da):21,348
Last modified:May 15, 2002 - v2
Checksum:i7F26BEDE9218CEF0
GO

Sequence cautioni

The sequence AAD16894.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331A → T in CAA56249 (PubMed:8626705).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051S → P.
Corresponds to variant rs11546280 [ dbSNP | Ensembl ].
VAR_052001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79865 mRNA. Translation: CAA56249.1.
AF059736 Genomic DNA. Translation: AAG32154.1.
BC002344 mRNA. Translation: AAH02344.1.
BC007497 mRNA. Translation: AAH07497.1.
AF105278 mRNA. Translation: AAD16894.1. Frameshift.
CCDSiCCDS11785.1.
RefSeqiNP_002940.2. NM_002949.3.
UniGeneiHs.109059.

Genome annotation databases

EnsembliENST00000333676; ENSP00000333837; ENSG00000262814.
GeneIDi6182.
KEGGihsa:6182.
UCSCiuc002kbh.2. human.

Polymorphism databases

DMDMi20981709.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79865 mRNA. Translation: CAA56249.1.
AF059736 Genomic DNA. Translation: AAG32154.1.
BC002344 mRNA. Translation: AAH02344.1.
BC007497 mRNA. Translation: AAH07497.1.
AF105278 mRNA. Translation: AAD16894.1. Frameshift.
CCDSiCCDS11785.1.
RefSeqiNP_002940.2. NM_002949.3.
UniGeneiHs.109059.

3D structure databases

ProteinModelPortaliP52815.
SMRiP52815. Positions 64-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112097. 61 interactions.
DIPiDIP-50865N.
IntActiP52815. 13 interactions.
MINTiMINT-1150069.
STRINGi9606.ENSP00000333837.

PTM databases

PhosphoSiteiP52815.

Polymorphism databases

DMDMi20981709.

2D gel databases

DOSAC-COBS-2DPAGEP52815.
SWISS-2DPAGEP52815.

Proteomic databases

MaxQBiP52815.
PaxDbiP52815.
PeptideAtlasiP52815.
PRIDEiP52815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333676; ENSP00000333837; ENSG00000262814.
GeneIDi6182.
KEGGihsa:6182.
UCSCiuc002kbh.2. human.

Organism-specific databases

CTDi6182.
GeneCardsiGC17P079670.
HGNCiHGNC:10378. MRPL12.
HPAiHPA022853.
HPA023043.
MIMi602375. gene.
neXtProtiNX_P52815.
PharmGKBiPA30941.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312691.
GeneTreeiENSGT00390000000190.
HOGENOMiHOG000248814.
HOVERGENiHBG001832.
InParanoidiP52815.
KOiK02935.
OrthoDBiEOG7B5WXR.
PhylomeDBiP52815.
TreeFamiTF105997.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPL12. human.
GeneWikiiMRPL12.
GenomeRNAii6182.
NextBioi24005.
PROiP52815.
SOURCEiSearch...

Gene expression databases

BgeeiP52815.
CleanExiHS_MRPL12.
ExpressionAtlasiP52815. baseline and differential.
GenevestigatoriP52815.

Family and domain databases

Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12.
InterProiIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PANTHERiPTHR11809. PTHR11809. 1 hit.
PfamiPF00542. Ribosomal_L12. 1 hit.
[Graphical view]
ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein."
    Marty L., Fort P.
    J. Biol. Chem. 271:11468-11476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure and chromosomal localization of human mitochondrial ribosomal protein L12."
    Liu J., Barnoski B.L., O'Brien T.W.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. Ma F.-R., Yan M., Zhu L.-P.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-198.
  5. "hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis."
    Tang T., Zheng B., Chen S.H., Murphy A.N., Kudlicka K., Zhou H., Farquhar M.G.
    J. Biol. Chem. 284:5414-5424(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NOA1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM12_HUMAN
AccessioniPrimary (citable) accession number: P52815
Secondary accession number(s): Q969U0, Q9HCA2, Q9UQJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 15, 2002
Last modified: March 4, 2015
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.