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P52815

- RM12_HUMAN

UniProt

P52815 - RM12_HUMAN

Protein

39S ribosomal protein L12, mitochondrial

Gene

MRPL12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (15 May 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA binding Source: ProtInc
    3. structural constituent of ribosome Source: ProtInc

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: HGNC
    2. transcription from mitochondrial promoter Source: HGNC
    3. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L12, mitochondrial
    Short name:
    L12mt
    Short name:
    MRP-L12
    Alternative name(s):
    5c5-2
    Gene namesi
    Name:MRPL12
    Synonyms:RPML12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10378. MRPL12.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: HGNC

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30941.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
    BLAST
    Chaini46 – 19815339S ribosomal protein L12, mitochondrialPRO_0000030458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei138 – 1381N6-acetyllysineBy similarity
    Modified residuei150 – 1501N6-succinyllysineBy similarity
    Modified residuei162 – 1621N6-succinyllysineBy similarity
    Modified residuei178 – 1781N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP52815.
    PaxDbiP52815.
    PeptideAtlasiP52815.
    PRIDEiP52815.

    2D gel databases

    DOSAC-COBS-2DPAGEP52815.
    SWISS-2DPAGEP52815.

    PTM databases

    PhosphoSiteiP52815.

    Expressioni

    Gene expression databases

    BgeeiP52815.
    CleanExiHS_MRPL12.
    GenevestigatoriP52815.

    Organism-specific databases

    HPAiHPA022853.
    HPA023043.

    Interactioni

    Subunit structurei

    Interacts with NOA1.1 Publication

    Protein-protein interaction databases

    BioGridi112097. 60 interactions.
    DIPiDIP-50865N.
    IntActiP52815. 13 interactions.
    MINTiMINT-1150069.
    STRINGi9606.ENSP00000333837.

    Structurei

    3D structure databases

    ProteinModelPortaliP52815.
    SMRiP52815. Positions 64-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L7/L12P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG312691.
    HOGENOMiHOG000248814.
    HOVERGENiHBG001832.
    InParanoidiP52815.
    KOiK02935.
    OrthoDBiEOG7B5WXR.
    PhylomeDBiP52815.
    TreeFamiTF105997.

    Family and domain databases

    Gene3Di3.30.1390.10. 1 hit.
    HAMAPiMF_00368. Ribosomal_L7_L12.
    InterProiIPR000206. Ribosomal_L7/12.
    IPR014719. Ribosomal_L7/12_C/ClpS-like.
    IPR013823. Ribosomal_L7/L12_C.
    IPR008932. Ribosomal_L7/L12_oligo.
    [Graphical view]
    PANTHERiPTHR11809. PTHR11809. 1 hit.
    PfamiPF00542. Ribosomal_L12. 1 hit.
    [Graphical view]
    ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF48300. SSF48300. 1 hit.
    SSF54736. SSF54736. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52815-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG    50
    APLDNAPKEY PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM 100
    GGVMSGAVPA AAAQEAVEED IPIAKERTHF TVRLTEAKPV DKVKLIKEIK 150
    NYIQGINLVQ AKKLVESLPQ EIKANVAKAE AEKIKAALEA VGGTVVLE 198
    Length:198
    Mass (Da):21,348
    Last modified:May 15, 2002 - v2
    Checksum:i7F26BEDE9218CEF0
    GO

    Sequence cautioni

    The sequence AAD16894.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331A → T in CAA56249. (PubMed:8626705)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti105 – 1051S → P.
    Corresponds to variant rs11546280 [ dbSNP | Ensembl ].
    VAR_052001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79865 mRNA. Translation: CAA56249.1.
    AF059736 Genomic DNA. Translation: AAG32154.1.
    BC002344 mRNA. Translation: AAH02344.1.
    BC007497 mRNA. Translation: AAH07497.1.
    AF105278 mRNA. Translation: AAD16894.1. Frameshift.
    CCDSiCCDS11785.1.
    RefSeqiNP_002940.2. NM_002949.3.
    UniGeneiHs.109059.

    Genome annotation databases

    EnsembliENST00000333676; ENSP00000333837; ENSG00000262814.
    GeneIDi6182.
    KEGGihsa:6182.
    UCSCiuc002kbh.2. human.

    Polymorphism databases

    DMDMi20981709.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79865 mRNA. Translation: CAA56249.1 .
    AF059736 Genomic DNA. Translation: AAG32154.1 .
    BC002344 mRNA. Translation: AAH02344.1 .
    BC007497 mRNA. Translation: AAH07497.1 .
    AF105278 mRNA. Translation: AAD16894.1 . Frameshift.
    CCDSi CCDS11785.1.
    RefSeqi NP_002940.2. NM_002949.3.
    UniGenei Hs.109059.

    3D structure databases

    ProteinModelPortali P52815.
    SMRi P52815. Positions 64-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112097. 60 interactions.
    DIPi DIP-50865N.
    IntActi P52815. 13 interactions.
    MINTi MINT-1150069.
    STRINGi 9606.ENSP00000333837.

    PTM databases

    PhosphoSitei P52815.

    Polymorphism databases

    DMDMi 20981709.

    2D gel databases

    DOSAC-COBS-2DPAGE P52815.
    SWISS-2DPAGE P52815.

    Proteomic databases

    MaxQBi P52815.
    PaxDbi P52815.
    PeptideAtlasi P52815.
    PRIDEi P52815.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333676 ; ENSP00000333837 ; ENSG00000262814 .
    GeneIDi 6182.
    KEGGi hsa:6182.
    UCSCi uc002kbh.2. human.

    Organism-specific databases

    CTDi 6182.
    GeneCardsi GC17P079670.
    HGNCi HGNC:10378. MRPL12.
    HPAi HPA022853.
    HPA023043.
    MIMi 602375. gene.
    neXtProti NX_P52815.
    PharmGKBi PA30941.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312691.
    HOGENOMi HOG000248814.
    HOVERGENi HBG001832.
    InParanoidi P52815.
    KOi K02935.
    OrthoDBi EOG7B5WXR.
    PhylomeDBi P52815.
    TreeFami TF105997.

    Miscellaneous databases

    GeneWikii MRPL12.
    GenomeRNAii 6182.
    NextBioi 24005.
    PROi P52815.
    SOURCEi Search...

    Gene expression databases

    Bgeei P52815.
    CleanExi HS_MRPL12.
    Genevestigatori P52815.

    Family and domain databases

    Gene3Di 3.30.1390.10. 1 hit.
    HAMAPi MF_00368. Ribosomal_L7_L12.
    InterProi IPR000206. Ribosomal_L7/12.
    IPR014719. Ribosomal_L7/12_C/ClpS-like.
    IPR013823. Ribosomal_L7/L12_C.
    IPR008932. Ribosomal_L7/L12_oligo.
    [Graphical view ]
    PANTHERi PTHR11809. PTHR11809. 1 hit.
    Pfami PF00542. Ribosomal_L12. 1 hit.
    [Graphical view ]
    ProDomi PD001326. Ribosomal_L7/L12_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF48300. SSF48300. 1 hit.
    SSF54736. SSF54736. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein."
      Marty L., Fort P.
      J. Biol. Chem. 271:11468-11476(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic structure and chromosomal localization of human mitochondrial ribosomal protein L12."
      Liu J., Barnoski B.L., O'Brien T.W.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. Ma F.-R., Yan M., Zhu L.-P.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-198.
    5. "hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis."
      Tang T., Zheng B., Chen S.H., Murphy A.N., Kudlicka K., Zhou H., Farquhar M.G.
      J. Biol. Chem. 284:5414-5424(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NOA1.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM12_HUMAN
    AccessioniPrimary (citable) accession number: P52815
    Secondary accession number(s): Q969U0, Q9HCA2, Q9UQJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 15, 2002
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3