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P52815 (RM12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L12, mitochondrial

Short name=L12mt
Short name=MRP-L12
Alternative name(s):
5c5-2
Gene names
Name:MRPL12
Synonyms:RPML12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with NOA1. Ref.5

Subcellular location

Mitochondrion HAMAP-Rule MF_00368.

Sequence similarities

Belongs to the ribosomal protein L7/L12P family.

Sequence caution

The sequence AAD16894.1 differs from that shown. Reason: Frameshift at several positions.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4545Mitochondrion Potential
Chain46 – 19815339S ribosomal protein L12, mitochondrial HAMAP-Rule MF_00368
PRO_0000030458

Amino acid modifications

Modified residue1381N6-acetyllysine By similarity
Modified residue1501N6-succinyllysine By similarity
Modified residue1621N6-succinyllysine By similarity
Modified residue1781N6-succinyllysine By similarity

Natural variations

Natural variant1051S → P.
Corresponds to variant rs11546280 [ dbSNP | Ensembl ].
VAR_052001

Experimental info

Sequence conflict331A → T in CAA56249. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52815 [UniParc].

Last modified May 15, 2002. Version 2.
Checksum: 7F26BEDE9218CEF0

FASTA19821,348
        10         20         30         40         50         60 
MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY 

        70         80         90        100        110        120 
PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM GGVMSGAVPA AAAQEAVEED 

       130        140        150        160        170        180 
IPIAKERTHF TVRLTEAKPV DKVKLIKEIK NYIQGINLVQ AKKLVESLPQ EIKANVAKAE 

       190 
AEKIKAALEA VGGTVVLE 

« Hide

References

« Hide 'large scale' references
[1]"A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein."
Marty L., Fort P.
J. Biol. Chem. 271:11468-11476(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure and chromosomal localization of human mitochondrial ribosomal protein L12."
Liu J., Barnoski B.L., O'Brien T.W.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]Ma F.-R., Yan M., Zhu L.-P.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-198.
[5]"hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis."
Tang T., Zheng B., Chen S.H., Murphy A.N., Kudlicka K., Zhou H., Farquhar M.G.
J. Biol. Chem. 284:5414-5424(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NOA1.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X79865 mRNA. Translation: CAA56249.1.
AF059736 Genomic DNA. Translation: AAG32154.1.
BC002344 mRNA. Translation: AAH02344.1.
BC007497 mRNA. Translation: AAH07497.1.
AF105278 mRNA. Translation: AAD16894.1. Frameshift.
CCDSCCDS11785.1.
RefSeqNP_002940.2. NM_002949.3.
UniGeneHs.109059.

3D structure databases

ProteinModelPortalP52815.
SMRP52815. Positions 64-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112097. 59 interactions.
DIPDIP-50865N.
IntActP52815. 13 interactions.
MINTMINT-1150069.
STRING9606.ENSP00000333837.

PTM databases

PhosphoSiteP52815.

Polymorphism databases

DMDM20981709.

2D gel databases

DOSAC-COBS-2DPAGEP52815.
SWISS-2DPAGEP52815.

Proteomic databases

MaxQBP52815.
PaxDbP52815.
PeptideAtlasP52815.
PRIDEP52815.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333676; ENSP00000333837; ENSG00000262814.
GeneID6182.
KEGGhsa:6182.
UCSCuc002kbh.2. human.

Organism-specific databases

CTD6182.
GeneCardsGC17P079670.
HGNCHGNC:10378. MRPL12.
HPAHPA022853.
HPA023043.
MIM602375. gene.
neXtProtNX_P52815.
PharmGKBPA30941.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312691.
HOGENOMHOG000248814.
HOVERGENHBG001832.
InParanoidP52815.
KOK02935.
OrthoDBEOG7B5WXR.
PhylomeDBP52815.
TreeFamTF105997.

Gene expression databases

BgeeP52815.
CleanExHS_MRPL12.
GenevestigatorP52815.

Family and domain databases

Gene3D3.30.1390.10. 1 hit.
HAMAPMF_00368. Ribosomal_L7_L12.
InterProIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PANTHERPTHR11809. PTHR11809. 1 hit.
PfamPF00542. Ribosomal_L12. 1 hit.
[Graphical view]
ProDomPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
ProtoNetSearch...

Other

GeneWikiMRPL12.
GenomeRNAi6182.
NextBio24005.
PROP52815.
SOURCESearch...

Entry information

Entry nameRM12_HUMAN
AccessionPrimary (citable) accession number: P52815
Secondary accession number(s): Q969U0, Q9HCA2, Q9UQJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 15, 2002
Last modified: July 9, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM