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P52804

- EFNA5_CHICK

UniProt

P52804 - EFNA5_CHICK

Protein

Ephrin-A5

Gene

EFNA5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation By similarity. Induces growth cone collapse and repulsion of retinal ganglion cell axons.By similarity

    GO - Molecular functioni

    1. chemorepellent activity Source: AgBase
    2. ephrin receptor binding Source: AgBase

    GO - Biological processi

    1. brain development Source: AgBase
    2. ephrin receptor signaling pathway Source: UniProtKB
    3. negative chemotaxis Source: GOC
    4. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    5. regulation of actin cytoskeleton organization Source: UniProtKB
    6. regulation of cell-cell adhesion Source: UniProtKB
    7. regulation of focal adhesion assembly Source: UniProtKB
    8. regulation of microtubule cytoskeleton organization Source: UniProtKB
    9. regulation of Rac GTPase activity Source: UniProtKB
    10. regulation of Rho GTPase activity Source: UniProtKB
    11. retinal ganglion cell axon guidance Source: AgBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin-A5
    Alternative name(s):
    EPH-related receptor tyrosine kinase ligand 7
    Short name:
    LERK-7
    Repulsive axon guidance signal protein
    Gene namesi
    Name:EFNA5
    Synonyms:RAGS
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 203183Ephrin-A5PRO_0000008383Add
    BLAST
    Propeptidei204 – 22825Removed in mature formSequence AnalysisPRO_0000008384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi62 ↔ 102PROSITE-ProRule annotation
    Disulfide bondi90 ↔ 151PROSITE-ProRule annotation
    Lipidationi203 – 2031GPI-anchor amidated asparagineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiP52804.

    Expressioni

    Tissue specificityi

    Expressed in a graded fashion across the tectum being more strongly expressed towards the posterior pole.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000000368.

    Structurei

    3D structure databases

    ProteinModelPortaliP52804.
    SMRiP52804. Positions 28-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 162134Ephrin RBDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ephrin family.PROSITE-ProRule annotation
    Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG241965.
    HOGENOMiHOG000234373.
    HOVERGENiHBG051447.
    InParanoidiP52804.
    KOiK05462.
    PhylomeDBiP52804.

    Family and domain databases

    Gene3Di2.60.40.420. 1 hit.
    InterProiIPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view]
    PANTHERiPTHR11304. PTHR11304. 1 hit.
    PfamiPF00812. Ephrin. 1 hit.
    [Graphical view]
    PRINTSiPR01347. EPHRIN.
    ProDomiPD002533. Ephrin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52804-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPHVEMLLLA VAALWVCVRG QEPGRKAVAD RYAVYWNSTN PRFQQGDYHI    50
    DVCINDYLDV FCPHYEDSVP EDKTERYVLY MVNFDGYSSC DHISKGFKRW 100
    ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYFYIS SAIPDNGRRS 150
    CLKLKVFVRP ANSCMKTIGV HDRVFDVNDK VENSLEPADD TVRESAEPSR 200
    GENAAQTPRI PIRLLATLLF LLAMLLIL 228
    Length:228
    Mass (Da):26,206
    Last modified:October 1, 1996 - v1
    Checksum:i56D8E4FBDECF18AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90377 mRNA. Translation: CAA62027.1.
    PIRiA57084.
    RefSeqiNP_990515.1. NM_205184.2.
    UniGeneiGga.651.

    Genome annotation databases

    GeneIDi396100.
    KEGGigga:396100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90377 mRNA. Translation: CAA62027.1 .
    PIRi A57084.
    RefSeqi NP_990515.1. NM_205184.2.
    UniGenei Gga.651.

    3D structure databases

    ProteinModelPortali P52804.
    SMRi P52804. Positions 28-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000000368.

    Proteomic databases

    PaxDbi P52804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396100.
    KEGGi gga:396100.

    Organism-specific databases

    CTDi 1946.

    Phylogenomic databases

    eggNOGi NOG241965.
    HOGENOMi HOG000234373.
    HOVERGENi HBG051447.
    InParanoidi P52804.
    KOi K05462.
    PhylomeDBi P52804.

    Miscellaneous databases

    NextBioi 20816158.
    PROi P52804.

    Family and domain databases

    Gene3Di 2.60.40.420. 1 hit.
    InterProi IPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view ]
    PANTHERi PTHR11304. PTHR11304. 1 hit.
    Pfami PF00812. Ephrin. 1 hit.
    [Graphical view ]
    PRINTSi PR01347. EPHRIN.
    ProDomi PD002533. Ephrin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    PROSITEi PS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases."
      Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F.
      Cell 82:359-370(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Posterior tectum.

    Entry informationi

    Entry nameiEFNA5_CHICK
    AccessioniPrimary (citable) accession number: P52804
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3