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P52804

- EFNA5_CHICK

UniProt

P52804 - EFNA5_CHICK

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Protein

Ephrin-A5

Gene

EFNA5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation By similarity. Induces growth cone collapse and repulsion of retinal ganglion cell axons.By similarity

GO - Molecular functioni

  1. chemorepellent activity Source: AgBase
  2. ephrin receptor binding Source: AgBase

GO - Biological processi

  1. brain development Source: AgBase
  2. ephrin receptor signaling pathway Source: UniProtKB
  3. negative chemotaxis Source: GOC
  4. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  5. regulation of actin cytoskeleton organization Source: UniProtKB
  6. regulation of cell-cell adhesion Source: UniProtKB
  7. regulation of focal adhesion assembly Source: UniProtKB
  8. regulation of microtubule cytoskeleton organization Source: UniProtKB
  9. regulation of Rac GTPase activity Source: UniProtKB
  10. regulation of Rho GTPase activity Source: UniProtKB
  11. retinal ganglion cell axon guidance Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A5
Alternative name(s):
EPH-related receptor tyrosine kinase ligand 7
Short name:
LERK-7
Repulsive axon guidance signal protein
Gene namesi
Name:EFNA5
Synonyms:RAGS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 203183Ephrin-A5PRO_0000008383Add
BLAST
Propeptidei204 – 22825Removed in mature formSequence AnalysisPRO_0000008384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi62 ↔ 102PROSITE-ProRule annotation
Disulfide bondi90 ↔ 151PROSITE-ProRule annotation
Lipidationi203 – 2031GPI-anchor amidated asparagineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP52804.

Expressioni

Tissue specificityi

Expressed in a graded fashion across the tectum being more strongly expressed towards the posterior pole.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000368.

Structurei

3D structure databases

ProteinModelPortaliP52804.
SMRiP52804. Positions 28-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 162134Ephrin RBDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation
Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG241965.
HOGENOMiHOG000234373.
HOVERGENiHBG051447.
InParanoidiP52804.
KOiK05462.
PhylomeDBiP52804.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR001799. Ephrin.
IPR019765. Ephrin_CS.
[Graphical view]
PANTHERiPTHR11304. PTHR11304. 1 hit.
PfamiPF00812. Ephrin. 1 hit.
[Graphical view]
PRINTSiPR01347. EPHRIN.
ProDomiPD002533. Ephrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52804-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHVEMLLLA VAALWVCVRG QEPGRKAVAD RYAVYWNSTN PRFQQGDYHI
60 70 80 90 100
DVCINDYLDV FCPHYEDSVP EDKTERYVLY MVNFDGYSSC DHISKGFKRW
110 120 130 140 150
ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYFYIS SAIPDNGRRS
160 170 180 190 200
CLKLKVFVRP ANSCMKTIGV HDRVFDVNDK VENSLEPADD TVRESAEPSR
210 220
GENAAQTPRI PIRLLATLLF LLAMLLIL
Length:228
Mass (Da):26,206
Last modified:October 1, 1996 - v1
Checksum:i56D8E4FBDECF18AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90377 mRNA. Translation: CAA62027.1.
PIRiA57084.
RefSeqiNP_990515.1. NM_205184.2.
UniGeneiGga.651.

Genome annotation databases

GeneIDi396100.
KEGGigga:396100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90377 mRNA. Translation: CAA62027.1 .
PIRi A57084.
RefSeqi NP_990515.1. NM_205184.2.
UniGenei Gga.651.

3D structure databases

ProteinModelPortali P52804.
SMRi P52804. Positions 28-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000000368.

Proteomic databases

PaxDbi P52804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396100.
KEGGi gga:396100.

Organism-specific databases

CTDi 1946.

Phylogenomic databases

eggNOGi NOG241965.
HOGENOMi HOG000234373.
HOVERGENi HBG051447.
InParanoidi P52804.
KOi K05462.
PhylomeDBi P52804.

Miscellaneous databases

NextBioi 20816158.
PROi P52804.

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR008972. Cupredoxin.
IPR001799. Ephrin.
IPR019765. Ephrin_CS.
[Graphical view ]
PANTHERi PTHR11304. PTHR11304. 1 hit.
Pfami PF00812. Ephrin. 1 hit.
[Graphical view ]
PRINTSi PR01347. EPHRIN.
ProDomi PD002533. Ephrin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases."
    Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F.
    Cell 82:359-370(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Posterior tectum.

Entry informationi

Entry nameiEFNA5_CHICK
AccessioniPrimary (citable) accession number: P52804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3