Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P52801

- EFNA2_MOUSE

UniProt

P52801 - EFNA2_MOUSE

Protein

Ephrin-A2

Gene

Efna2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.2 Publications

    GO - Molecular functioni

    1. ephrin receptor binding Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. axon guidance Source: RefGenome
    2. bone remodeling Source: UniProtKB
    3. ephrin receptor signaling pathway Source: UniProtKB
    4. olfactory bulb development Source: Ensembl
    5. osteoclast differentiation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin-A2
    Alternative name(s):
    CEK7-ligand
    Short name:
    CEK7-L
    ELF-1
    EPH-related receptor tyrosine kinase ligand 6
    Short name:
    LERK-6
    Gene namesi
    Name:Efna2
    Synonyms:Elf1, Epl6, Eplg6, Lerk6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:102707. Efna2.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. neuromuscular junction Source: Ensembl
    3. perikaryon Source: Ensembl
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 184164Ephrin-A2PRO_0000008363Add
    BLAST
    Propeptidei185 – 20925Removed in mature formSequence AnalysisPRO_0000008364Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi69 ↔ 110PROSITE-ProRule annotation
    Disulfide bondi98 ↔ 159PROSITE-ProRule annotation
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Lipidationi184 – 1841GPI-anchor amidated asparagineSequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiP52801.
    PRIDEiP52801.

    PTM databases

    PhosphoSiteiP52801.

    Expressioni

    Gene expression databases

    BgeeiP52801.
    CleanExiMM_EFNA2.
    MM_ELF1.
    GenevestigatoriP52801.

    Interactioni

    Subunit structurei

    Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000003154.

    Structurei

    3D structure databases

    ProteinModelPortaliP52801.
    SMRiP52801. Positions 29-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 170141Ephrin RBDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ephrin family.PROSITE-ProRule annotation
    Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG252953.
    GeneTreeiENSGT00390000015107.
    HOGENOMiHOG000234373.
    HOVERGENiHBG051447.
    InParanoidiP52801.
    KOiK05462.
    OMAiCSSPGGC.
    OrthoDBiEOG70W3FD.
    PhylomeDBiP52801.

    Family and domain databases

    Gene3Di2.60.40.420. 1 hit.
    InterProiIPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view]
    PANTHERiPTHR11304. PTHR11304. 1 hit.
    PfamiPF00812. Ephrin. 1 hit.
    [Graphical view]
    PRINTSiPR01347. EPHRIN.
    ProDomiPD002533. Ephrin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52801-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPAQRPLLP LLLLLLPLRA RNEDPARANA DRYAVYWNRS NPRFQVSAVG    50
    DGGGYTVEVS INDYLDIYCP HYGAPLPPAE RMERYILYMV NGEGHASCDH 100
    RQRGFKRWEC NRPAAPGGPL KFSEKFQLFT PFSLGFEFRP GHEYYYISAT 150
    PPNLVDRPCL RLKVYVRPTN ETLYEAPEPI FTSNSSCSGL GGCHLFLTTV 200
    PVLWSLLGS 209
    Length:209
    Mass (Da):23,586
    Last modified:October 1, 1996 - v1
    Checksum:iF1997545F25B9ABC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14941 mRNA. Translation: AAA53636.1.
    U14752 mRNA. Translation: AAA68520.1.
    BC048697 mRNA. Translation: AAH48697.1.
    CCDSiCCDS24013.1.
    PIRiA54984.
    RefSeqiNP_031935.3. NM_007909.3.
    UniGeneiMm.1478.

    Genome annotation databases

    EnsembliENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070.
    GeneIDi13637.
    KEGGimmu:13637.
    UCSCiuc007gcg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14941 mRNA. Translation: AAA53636.1 .
    U14752 mRNA. Translation: AAA68520.1 .
    BC048697 mRNA. Translation: AAH48697.1 .
    CCDSi CCDS24013.1.
    PIRi A54984.
    RefSeqi NP_031935.3. NM_007909.3.
    UniGenei Mm.1478.

    3D structure databases

    ProteinModelPortali P52801.
    SMRi P52801. Positions 29-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000003154.

    PTM databases

    PhosphoSitei P52801.

    Proteomic databases

    PaxDbi P52801.
    PRIDEi P52801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003154 ; ENSMUSP00000003154 ; ENSMUSG00000003070 .
    GeneIDi 13637.
    KEGGi mmu:13637.
    UCSCi uc007gcg.2. mouse.

    Organism-specific databases

    CTDi 1943.
    MGIi MGI:102707. Efna2.

    Phylogenomic databases

    eggNOGi NOG252953.
    GeneTreei ENSGT00390000015107.
    HOGENOMi HOG000234373.
    HOVERGENi HBG051447.
    InParanoidi P52801.
    KOi K05462.
    OMAi CSSPGGC.
    OrthoDBi EOG70W3FD.
    PhylomeDBi P52801.

    Miscellaneous databases

    NextBioi 284324.
    PROi P52801.
    SOURCEi Search...

    Gene expression databases

    Bgeei P52801.
    CleanExi MM_EFNA2.
    MM_ELF1.
    Genevestigatori P52801.

    Family and domain databases

    Gene3Di 2.60.40.420. 1 hit.
    InterProi IPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view ]
    PANTHERi PTHR11304. PTHR11304. 1 hit.
    Pfami PF00812. Ephrin. 1 hit.
    [Graphical view ]
    PRINTSi PR01347. EPHRIN.
    ProDomi PD002533. Ephrin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    PROSITEi PS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases."
      Cheng H.J., Flanagan J.G.
      Cell 79:157-168(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Brain.
    2. "cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases."
      Shao H., Lou L., Pandey A., Verderame M.F., Siever D.A., Dixit V.M.
      J. Biol. Chem. 270:3467-3470(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.
    4. "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands."
      Park S., Sanchez M.P.
      Oncogene 14:533-542(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EPHA8 ACTIVATION, INTERACTION WITH EPHA8.
    5. "Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis."
      Irie N., Takada Y., Watanabe Y., Matsuzaki Y., Naruse C., Asano M., Iwakura Y., Suda T., Matsuo K.
      J. Biol. Chem. 284:14637-14644(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN BONE REMODELING.

    Entry informationi

    Entry nameiEFNA2_MOUSE
    AccessioniPrimary (citable) accession number: P52801
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3