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P52801 (EFNA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ephrin-A2
Alternative name(s):
CEK7-ligand
Short name=CEK7-L
ELF-1
EPH-related receptor tyrosine kinase ligand 6
Short name=LERK-6
Gene names
Name:Efna2
Synonyms:Elf1, Epl6, Eplg6, Lerk6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Ref.4 Ref.5

Subunit structure

Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8. Ref.4

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Sequence similarities

Belongs to the ephrin family.

Contains 1 ephrin RBD (ephrin receptor-binding) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 184164Ephrin-A2
PRO_0000008363
Propeptide185 – 20925Removed in mature form Potential
PRO_0000008364

Regions

Domain30 – 170141Ephrin RBD

Amino acid modifications

Lipidation1841GPI-anchor amidated asparagine Potential
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Disulfide bond69 ↔ 110 By similarity
Disulfide bond98 ↔ 159 By similarity

Sequences

Sequence LengthMass (Da)Tools
P52801 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F1997545F25B9ABC

FASTA20923,586
        10         20         30         40         50         60 
MAPAQRPLLP LLLLLLPLRA RNEDPARANA DRYAVYWNRS NPRFQVSAVG DGGGYTVEVS 

        70         80         90        100        110        120 
INDYLDIYCP HYGAPLPPAE RMERYILYMV NGEGHASCDH RQRGFKRWEC NRPAAPGGPL 

       130        140        150        160        170        180 
KFSEKFQLFT PFSLGFEFRP GHEYYYISAT PPNLVDRPCL RLKVYVRPTN ETLYEAPEPI 

       190        200 
FTSNSSCSGL GGCHLFLTTV PVLWSLLGS 

« Hide

References

« Hide 'large scale' references
[1]"Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases."
Cheng H.J., Flanagan J.G.
Cell 79:157-168(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster.
Tissue: Brain.
[2]"cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases."
Shao H., Lou L., Pandey A., Verderame M.F., Siever D.A., Dixit V.M.
J. Biol. Chem. 270:3467-3470(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb.
[4]"The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands."
Park S., Sanchez M.P.
Oncogene 14:533-542(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN EPHA8 ACTIVATION, INTERACTION WITH EPHA8.
[5]"Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis."
Irie N., Takada Y., Watanabe Y., Matsuzaki Y., Naruse C., Asano M., Iwakura Y., Suda T., Matsuo K.
J. Biol. Chem. 284:14637-14644(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN BONE REMODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14941 mRNA. Translation: AAA53636.1.
U14752 mRNA. Translation: AAA68520.1.
BC048697 mRNA. Translation: AAH48697.1.
CCDSCCDS24013.1.
PIRA54984.
RefSeqNP_031935.3. NM_007909.3.
UniGeneMm.1478.

3D structure databases

ProteinModelPortalP52801.
SMRP52801. Positions 29-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000003154.

PTM databases

PhosphoSiteP52801.

Proteomic databases

PaxDbP52801.
PRIDEP52801.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003154; ENSMUSP00000003154; ENSMUSG00000003070.
GeneID13637.
KEGGmmu:13637.
UCSCuc007gcg.2. mouse.

Organism-specific databases

CTD1943.
MGIMGI:102707. Efna2.

Phylogenomic databases

eggNOGNOG252953.
GeneTreeENSGT00390000015107.
HOGENOMHOG000234373.
HOVERGENHBG051447.
InParanoidP52801.
KOK05462.
OMACSSPGGC.
OrthoDBEOG70W3FD.
PhylomeDBP52801.

Gene expression databases

BgeeP52801.
CleanExMM_EFNA2.
MM_ELF1.
GenevestigatorP52801.

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR008972. Cupredoxin.
IPR001799. Ephrin.
IPR019765. Ephrin_CS.
[Graphical view]
PANTHERPTHR11304. PTHR11304. 1 hit.
PfamPF00812. Ephrin. 1 hit.
[Graphical view]
PRINTSPR01347. EPHRIN.
ProDomPD002533. Ephrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF49503. SSF49503. 1 hit.
PROSITEPS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284324.
PROP52801.
SOURCESearch...

Entry information

Entry nameEFNA2_MOUSE
AccessionPrimary (citable) accession number: P52801
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot