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Protein

Ephrin-A4

Gene

EFNA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB
  • transmembrane-ephrin receptor activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
SignaLinkiP52798
SIGNORiP52798

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A4
Alternative name(s):
EPH-related receptor tyrosine kinase ligand 4
Short name:
LERK-4
Gene namesi
Name:EFNA4
Synonyms:EPLG4, LERK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000243364.7
HGNCiHGNC:3224 EFNA4
MIMi601380 gene
neXtProtiNX_P52798

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1945
OpenTargetsiENSG00000243364
PharmGKBiPA27659

Polymorphism and mutation databases

BioMutaiEFNA4
DMDMi1706672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000000837326 – 170Ephrin-A4Add BLAST145
PropeptideiPRO_0000008374171 – 201Removed in mature formSequence analysisAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi58 ↔ 99PROSITE-ProRule annotation
Disulfide bondi86 ↔ 144PROSITE-ProRule annotation
Lipidationi170GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP52798
PeptideAtlasiP52798
PRIDEiP52798
ProteomicsDBi56536
56537 [P52798-2]

PTM databases

iPTMnetiP52798
PhosphoSitePlusiP52798

Expressioni

Tissue specificityi

Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.

Gene expression databases

BgeeiENSG00000243364
CleanExiHS_EFNA4
GenevisibleiP52798 HS

Organism-specific databases

HPAiCAB021350
HPA064952

Interactioni

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108265, 3 interactors
DIPiDIP-48295N
IntActiP52798, 2 interactors
STRINGi9606.ENSP00000414378

Structurei

3D structure databases

ProteinModelPortaliP52798
SMRiP52798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 155Ephrin RBDPROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiP52798
KOiK05462
OMAiCCKESKS
OrthoDBiEOG091G0K52
PhylomeDBiP52798

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52798-1) [UniParc]FASTAAdd to basket
Also known as: GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLPLLRTV LWAAFLGSPL RGGSSLRHVV YWNSSNPRLL RGDAVVELGL
60 70 80 90 100
NDYLDIVCPH YEGPGPPEGP ETFALYMVDW PGYESCQAEG PRAYKRWVCS
110 120 130 140 150
LPFGHVQFSE KIQRFTPFSL GFEFLPGETY YYISVPTPES SGQCLRLQVS
160 170 180 190 200
VCCKERKSES AHPVGSPGES GTSGWRGGDT PSPLCLLLLL LLLILRLLRI

L
Length:201
Mass (Da):22,386
Last modified:October 1, 1996 - v1
Checksum:iABE8D5443A9AF28D
GO
Isoform 2 (identifier: P52798-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     157-201: KSESAHPVGS...LLILRLLRIL → NLPSHPKEPE...VPIQTDKMEH

Show »
Length:193
Mass (Da):21,699
Checksum:iD0817324CC728EF5
GO
Isoform 3 (identifier: P52798-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-201: KSESAHPVGS...LLILRLLRIL → RARVLPRSPG...LAGACPLITG

Note: Gene prediction based on EST data.
Show »
Length:207
Mass (Da):22,584
Checksum:i67767F6020B4530B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001448157 – 201KSESA…LLRIL → NLPSHPKEPESSQDPLEEEG SLLPALGVPIQTDKMEH in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_046707157 – 201KSESA…LLRIL → RARVLPRSPGGGGIPAACTG GANSDRQDGALMGEIRGSEV TLAGACPLITG in isoform 3. CuratedAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14188 mRNA Translation: AAC50079.1
AJ006352 mRNA Translation: CAA06992.1
AJ006353 mRNA Translation: CAA06993.1
CR533569 mRNA Translation: CAG38600.1
AL691442 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53138.1
CH471121 Genomic DNA Translation: EAW53139.1
BC107483 mRNA Translation: AAI07484.1
CCDSiCCDS1089.1 [P52798-1]
CCDS41407.1 [P52798-2]
CCDS44237.1 [P52798-3]
PIRiI38850
RefSeqiNP_005218.1, NM_005227.2 [P52798-1]
NP_872631.1, NM_182689.1 [P52798-3]
NP_872632.2, NM_182690.2 [P52798-2]
UniGeneiHs.449913
Hs.639422

Genome annotation databases

EnsembliENST00000359751; ENSP00000352789; ENSG00000243364 [P52798-2]
ENST00000368409; ENSP00000357394; ENSG00000243364 [P52798-1]
ENST00000427683; ENSP00000414378; ENSG00000243364 [P52798-3]
GeneIDi1945
KEGGihsa:1945
UCSCiuc001fhc.4 human [P52798-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEFNA4_HUMAN
AccessioniPrimary (citable) accession number: P52798
Secondary accession number(s): C9JHJ8
, G3XAK2, O95457, Q5SR71, Q6FI57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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