Reviewed, UniProtKB/Swiss-Prot P52793 (EFNA1_MOUSE)

Names and origin

Protein names

Recommended name:
    Ephrin-A1
Alternative name(s):
    EPH-related receptor tyrosine kinase ligand 1
      Short name=LERK-1
    Immediate early response protein B61

Gene names

Name:	Efna1
Synonyms:	Epgl1, Epl1, Lerk1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subunit structure	Binds to the receptor tyrosine kinases EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Sequence similarities	Belongs to the ephrin family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Biological process	activation of MAPK activity Inferred from direct assay. Source: MGI ephrin receptor signaling pathway Inferred from direct assay. Source: MGI neuron differentiation Inferred from direct assay. Source: MGI regulation of axonogenesis Inferred from direct assay. Source: MGI
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 182	165	Ephrin-A1		PRO_0000008355
	Propeptide	183 – 205	23	Removed in mature form Potential		PRO_0000008356
Amino acid modifications
	Lipidation	182	1	GPI-anchor amidated serine Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 92		By similarity
Experimental info
	Sequence conflict	74	1	H → Y in BAA07344. Ref.1
	Sequence conflict	79	1	A → T Ref.1
	Sequence conflict	81	1	Q → E Ref.1
	Sequence conflict	91	1	N → K in BAA07344. Ref.1
	Sequence conflict	94	1	R → Q in BAA07344. Ref.1
	Sequence conflict	112	1	T → S in BAA07344. Ref.1
	Sequence conflict	115	1	I → T in BAA07344. Ref.1
	Sequence conflict	138	1	S → T in BAA07344. Ref.1
	Sequence conflict	154	1	N → S Ref.1
	Sequence conflict	156	1	Q → H Ref.1
	Sequence conflict	159	1	V → A Ref.1
	Sequence conflict	181	1	Y → H in BAA07344. Ref.1
	Sequence conflict	204	1	S → T in BAA07344. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P52793-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 5A8F3A6E2091E868	FASTA	205	23,802
	10 20 30 40 50 60 MEFLWAPLLG LCCSLAAADR HIVFWNSSNP KFREEDYTVH VQLNDYLDII CPHYEDDSVA 70 80 90 100 110 120 DAAMERYTLY MVEHQEYVAC QPQSKDQVRW NCNRPSAKHG PEKLSEKFQR FTPFILGKEF 130 140 150 160 170 180 KEGHSYYYIS KPIYHQESQC LKLKVTVNGK ITHNPQAHVN PQEKRLQADD PEVQVLHSIG 190 200 YSAAPRLFPL VWAVLLLPLL LLQSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis." Takahashi H., Ikeda T. Oncogene 11:879-883(1995) [PubMed: 7675446] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR.
[2]	Morris J.C., Ciarletta A., Morris G.E., Giannotti J., Caruso A., Hammett D.J., Finnerty H., Turner K., Wood C.R. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis." Flenniken A.M., Gale N.W., Yancopoulos G.D., Wilkinson D.G. Dev. Biol. 179:382-401(1996) [PubMed: 8903354] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D38146 mRNA. Translation: BAA07344.1. U26188 mRNA. Translation: AAA67563.1. U90662 mRNA. Translation: AAB50237.1. BC002046 mRNA. Translation: AAH02046.1.
IPI	IPI00130752.
UniGene	Mm.15675
3D structure databases
HSSP	HSSP built from PDB template 1KGY based on UniProtKB P52800.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000027954. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:103236. Efna1.
Phylogenomic databases
HOGENOM	P52793.
HOVERGEN	P52793.
OMA	P52793. HSYYYIS.
Gene expression databases
ArrayExpress	P52793.
Bgee	P52793.
CleanEx	MM_EFNA1.
GermOnline	ENSMUSG00000027954. Mus musculus.
Family and domain databases
InterPro	IPR008972. Cupredoxin. IPR001799. Ephrin. IPR019765. Ephrin_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.420. Cupredoxin. 1 hit.
PANTHER	PTHR11304. Ephrin. 1 hit.
Pfam	PF00812. Ephrin. 1 hit. [Graphical view]
PRINTS	PR01347. EPHRIN.
ProDom	PD002533. Ephrin. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01299. EPHRIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

EFNA1_MOUSE

Accession

Primary (citable) accession number: P52793
Secondary accession number(s): P97331

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)