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P52790

- HXK3_HUMAN

UniProt

P52790 - HXK3_HUMAN

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Protein

Hexokinase-3

Gene
HK3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Enzyme regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1006ATP Reviewed prediction
Nucleotide bindingi542 – 5476ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. hexokinase activity Source: MGI
  5. hormone binding Source: Ensembl
  6. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. carbohydrate phosphorylation Source: GOC
  3. cellular glucose homeostasis Source: RefGenome
  4. glucose 6-phosphate metabolic process Source: GOC
  5. glucose transport Source: Reactome
  6. glycolytic process Source: UniProtKB-KW
  7. hexose metabolic process Source: UniProtKB-UniPathway
  8. hexose transport Source: Reactome
  9. small molecule metabolic process Source: Reactome
  10. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08548-MONOMER.
ReactomeiREACT_212. Glucose transport.
SABIO-RKP52790.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-3 (EC:2.7.1.1)
Alternative name(s):
Hexokinase type III
Short name:
HK III
Gene namesi
Name:HK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:4925. HK3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrion Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 923923Hexokinase-3PRO_0000197590Add
BLAST

Proteomic databases

MaxQBiP52790.
PaxDbiP52790.
PRIDEiP52790.

PTM databases

PhosphoSiteiP52790.

Expressioni

Gene expression databases

ArrayExpressiP52790.
BgeeiP52790.
CleanExiHS_HK3.
GenevestigatoriP52790.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi109348. 3 interactions.
IntActiP52790. 3 interactions.
STRINGi9606.ENSP00000292432.

Structurei

Secondary structure

1
923
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi480 – 4878
Helixi488 – 4903
Helixi494 – 51320
Beta strandi536 – 56631
Helixi570 – 5734
Helixi577 – 59519
Beta strandi604 – 6085
Helixi639 – 64911
Beta strandi657 – 6615
Helixi663 – 67210
Beta strandi678 – 69518
Helixi696 – 6983
Beta strandi706 – 7127
Helixi715 – 7173
Turni718 – 72710
Helixi730 – 7378
Beta strandi739 – 7413
Helixi748 – 7503
Helixi753 – 76917
Helixi774 – 7763
Helixi780 – 7834
Helixi790 – 7967
Helixi803 – 8119
Turni812 – 8143
Helixi819 – 85436
Beta strandi858 – 86710
Helixi869 – 8735
Helixi877 – 88812
Beta strandi892 – 8987
Helixi903 – 91816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HM8X-ray2.80A/B/C/D480-922[»]
ProteinModelPortaliP52790.
SMRiP52790. Positions 28-919.

Miscellaneous databases

EvolutionaryTraceiP52790.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 231204Hexokinase type-1 1Add
BLAST
Domaini237 – 475239Hexokinase type-2 1Add
BLAST
Domaini480 – 675196Hexokinase type-1 2Add
BLAST
Domaini677 – 916240Hexokinase type-2 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 488488RegulatoryAdd
BLAST
Regioni162 – 18827Glucose-binding Reviewed predictionAdd
BLAST
Regioni489 – 923435CatalyticAdd
BLAST
Regioni603 – 62927Glucose-binding Reviewed predictionAdd
BLAST

Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.

Sequence similaritiesi

Belongs to the hexokinase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiP52790.
KOiK00844.
OMAiHGTEQGD.
OrthoDBiEOG7S21X5.
PhylomeDBiP52790.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52790-1 [UniParc]FASTAAdd to Basket

« Hide

MDSIGSSGLR QGEETLSCSE EGLPGPSDSS ELVQECLQQF KVTRAQLQQI    50
QASLLGSMEQ ALRGQASPAP AVRMLPTYVG STPHGTEQGD FVVLELGATG 100
ASLRVLWVTL TGIEGHRVEP RSQEFVIPQE VMLGAGQQLF DFAAHCLSEF 150
LDAQPVNKQG LQLGFSFSFP CHQTGLDRST LISWTKGFRC SGVEGQDVVQ 200
LLRDAIRRQG AYNIDVVAVV NDTVGTMMGC EPGVRPCEVG LVVDTGTNAC 250
YMEEARHVAV LDEDRGRVCV SVEWGSFSDD GALGPVLTTF DHTLDHESLN 300
PGAQRFEKMI GGLYLGELVR LVLAHLARCG VLFGGCTSPA LLSQGSILLE 350
HVAEMEDPST GAARVHAILQ DLGLSPGASD VELVQHVCAA VCTRAAQLCA 400
AALAAVLSCL QHSREQQTLQ VAVATGGRVC ERHPRFCSVL QGTVMLLAPE 450
CDVSLIPSVD GGGRGVAMVT AVAARLAAHR RLLEETLAPF RLNHDQLAAV 500
QAQMRKAMAK GLRGEASSLR MLPTFVRATP DGSERGDFLA LDLGGTNFRV 550
LLVRVTTGVQ ITSEIYSIPE TVAQGSGQQL FDHIVDCIVD FQQKQGLSGQ 600
SLPLGFTFSF PCRQLGLDQG ILLNWTKGFK ASDCEGQDVV SLLREAITRR 650
QAVELNVVAI VNDTVGTMMS CGYEDPRCEI GLIVGTGTNA CYMEELRNVA 700
GVPGDSGRMC INMEWGAFGD DGSLAMLSTR FDASVDQASI NPGKQRFEKM 750
ISGMYLGEIV RHILLHLTSL GVLFRGQQIQ RLQTRDIFKT KFLSEIESDS 800
LALRQVRAIL EDLGLPLTSD DALMVLEVCQ AVSQRAAQLC GAGVAAVVEK 850
IRENRGLEEL AVSVGVDGTL YKLHPRFSSL VAATVRELAP RCVVTFLQSE 900
DGSGKGAALV TAVACRLAQL TRV 923
Length:923
Mass (Da):99,025
Last modified:September 23, 2008 - v2
Checksum:iDA75F2A9DBB895FF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811G → R.
Corresponds to variant rs35610191 [ dbSNP | Ensembl ].
VAR_034004
Natural varianti480 – 4801R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036186
Natural varianti499 – 4991A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036187

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771F → L in AAC50732. 1 Publication
Sequence conflicti420 – 4201Q → L in AAC50422. 1 Publication
Sequence conflicti431 – 4311E → Q in AAC50422. 1 Publication
Sequence conflicti439 – 4391V → I in AAC50422. 1 Publication
Sequence conflicti510 – 5101K → R in AAC50422. 1 Publication
Sequence conflicti512 – 5132LR → SE in AAC50422. 1 Publication
Sequence conflicti516 – 5161A → S in AAC50422. 1 Publication
Sequence conflicti519 – 5191L → S in AAC50422. 1 Publication
Sequence conflicti530 – 5312PD → LT in AAC50422. 1 Publication
Sequence conflicti577 – 5782GQ → AE in AAC50422. 1 Publication
Sequence conflicti604 – 6041L → T in AAC50422. 1 Publication
Sequence conflicti708 – 7081R → H in AAC50422. 1 Publication
Sequence conflicti718 – 7181F → L in AAC50422. 1 Publication
Sequence conflicti728 – 7281S → R in AAC50422. 1 Publication
Sequence conflicti750 – 7501M → I in AAC50422. 1 Publication
Sequence conflicti831 – 8311A → V in AAC50422. 1 Publication
Sequence conflicti836 – 8361A → P in AAC50422. 1 Publication
Sequence conflicti853 – 8531E → G in AAC50732. 1 Publication
Sequence conflicti918 – 9181A → T in AAC50422. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51333 mRNA. Translation: AAC50732.1.
CH471195 Genomic DNA. Translation: EAW85048.1.
BC028129 mRNA. Translation: AAH28129.1.
U42303 mRNA. Translation: AAC50422.1.
CCDSiCCDS4407.1.
RefSeqiNP_002106.2. NM_002115.2.
UniGeneiHs.411695.

Genome annotation databases

EnsembliENST00000292432; ENSP00000292432; ENSG00000160883.
GeneIDi3101.
KEGGihsa:3101.
UCSCiuc003mez.3. human.

Polymorphism databases

DMDMi206729871.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hexokinase entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51333 mRNA. Translation: AAC50732.1 .
CH471195 Genomic DNA. Translation: EAW85048.1 .
BC028129 mRNA. Translation: AAH28129.1 .
U42303 mRNA. Translation: AAC50422.1 .
CCDSi CCDS4407.1.
RefSeqi NP_002106.2. NM_002115.2.
UniGenei Hs.411695.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HM8 X-ray 2.80 A/B/C/D 480-922 [» ]
ProteinModelPortali P52790.
SMRi P52790. Positions 28-919.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109348. 3 interactions.
IntActi P52790. 3 interactions.
STRINGi 9606.ENSP00000292432.

Chemistry

BindingDBi P52790.
ChEMBLi CHEMBL2709.

PTM databases

PhosphoSitei P52790.

Polymorphism databases

DMDMi 206729871.

Proteomic databases

MaxQBi P52790.
PaxDbi P52790.
PRIDEi P52790.

Protocols and materials databases

DNASUi 3101.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292432 ; ENSP00000292432 ; ENSG00000160883 .
GeneIDi 3101.
KEGGi hsa:3101.
UCSCi uc003mez.3. human.

Organism-specific databases

CTDi 3101.
GeneCardsi GC05M176240.
HGNCi HGNC:4925. HK3.
MIMi 142570. gene.
neXtProti NX_P52790.
PharmGKBi PA29303.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi P52790.
KOi K00844.
OMAi HGTEQGD.
OrthoDBi EOG7S21X5.
PhylomeDBi P52790.
TreeFami TF314238.

Enzyme and pathway databases

UniPathwayi UPA00242 .
BioCyci MetaCyc:HS08548-MONOMER.
Reactomei REACT_212. Glucose transport.
SABIO-RK P52790.

Miscellaneous databases

EvolutionaryTracei P52790.
GeneWikii HK3.
GenomeRNAii 3101.
NextBioi 12311.
PROi P52790.
SOURCEi Search...

Gene expression databases

ArrayExpressi P52790.
Bgeei P52790.
CleanExi HS_HK3.
Genevestigatori P52790.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization."
    Furuta H., Nishi S., Le Beau M.M., Fernald A.A., Yano H., Bell G.I.
    Genomics 36:206-209(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  4. "Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein."
    Palma F., Agostini D., Mason P., Dacha M., Piccoli G., Biagiarelli B., Fiorani M., Stocchi V.
    Mol. Cell. Biochem. 155:23-29(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 358-923.
    Tissue: Liver.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-480 AND VAL-499.

Entry informationi

Entry nameiHXK3_HUMAN
AccessioniPrimary (citable) accession number: P52790
Secondary accession number(s): Q8N1E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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