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P52789

- HXK2_HUMAN

UniProt

P52789 - HXK2_HUMAN

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Protein
Hexokinase-2
Gene
HK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Enzyme regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301ATP 1 By similarity
Binding sitei209 – 2091Glucose-6-phosphate 1
Binding sitei232 – 2321Glucose-6-phosphate 1
Binding sitei235 – 2351Substrate 1
Binding sitei260 – 2601Substrate 1
Binding sitei449 – 4491Glucose-6-phosphate 1
Binding sitei558 – 5581ATP Reviewed prediction
Binding sitei657 – 6571Glucose-6-phosphate 2
Binding sitei680 – 6801ATP 2 By similarity
Binding sitei680 – 6801Glucose-6-phosphate 2
Binding sitei708 – 7081Substrate 2
Binding sitei897 – 8971Glucose-6-phosphate 2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 896ATP 1 Reviewed prediction
Nucleotide bindingi425 – 4262ATP 1 By similarity
Nucleotide bindingi532 – 5376ATP 2 By similarity
Nucleotide bindingi747 – 7482ATP 2 By similarity
Nucleotide bindingi784 – 7885ATP 2 By similarity
Nucleotide bindingi863 – 8675ATP 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. glucose binding Source: Ensembl
  5. hexokinase activity Source: ProtInc
  6. mannokinase activity Source: RefGenome

GO - Biological processi

  1. apoptotic mitochondrial changes Source: MGI
  2. carbohydrate metabolic process Source: Reactome
  3. cellular glucose homeostasis Source: RefGenome
  4. glucose 6-phosphate metabolic process Source: GOC
  5. glucose metabolic process Source: Ensembl
  6. glucose transport Source: Reactome
  7. glycolytic process Source: RefGenome
  8. hexose transport Source: Reactome
  9. lactation Source: Ensembl
  10. regulation of glucose import Source: Ensembl
  11. small molecule metabolic process Source: Reactome
  12. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08399-MONOMER.
ReactomeiREACT_212. Glucose transport.
SABIO-RKP52789.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-2 (EC:2.7.1.1)
Alternative name(s):
Hexokinase type II
Short name:
HK II
Muscle form hexokinase
Gene namesi
Name:HK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4923. HK2.

Subcellular locationi

Mitochondrion outer membrane By similarity
Note: Its hydrophobic N-terminal sequence may be involved in membrane binding By similarity.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrial outer membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 917917Hexokinase-2
PRO_0000197587Add
BLAST

Proteomic databases

MaxQBiP52789.
PaxDbiP52789.
PeptideAtlasiP52789.
PRIDEiP52789.

PTM databases

PhosphoSiteiP52789.

Expressioni

Tissue specificityi

Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.

Gene expression databases

ArrayExpressiP52789.
BgeeiP52789.
CleanExiHS_HK2.
GenevestigatoriP52789.

Organism-specific databases

HPAiHPA028587.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi109346. 22 interactions.
DIPiDIP-50110N.
IntActiP52789. 4 interactions.
MINTiMINT-1461614.
STRINGi9606.ENSP00000290573.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 257
Helixi27 – 293
Helixi33 – 5119
Turni53 – 553
Helixi56 – 583
Beta strandi78 – 9720
Beta strandi106 – 1127
Helixi116 – 1194
Helixi123 – 14119
Beta strandi148 – 1547
Helixi185 – 19410
Beta strandi201 – 2077
Helixi209 – 21810
Beta strandi224 – 24118
Helixi242 – 2443
Beta strandi252 – 2587
Helixi261 – 2633
Turni264 – 2674
Turni269 – 2735
Helixi276 – 2838
Beta strandi285 – 2873
Helixi292 – 2954
Turni299 – 3013
Helixi302 – 31514
Helixi320 – 3223
Helixi326 – 3294
Helixi336 – 3449
Beta strandi345 – 3473
Helixi348 – 35811
Helixi365 – 40137
Beta strandi404 – 41310
Helixi415 – 4195
Beta strandi420 – 4223
Helixi423 – 43412
Beta strandi438 – 4447
Helixi449 – 47426
Helixi475 – 4773
Helixi481 – 49919
Helixi501 – 5044
Beta strandi527 – 53610
Beta strandi539 – 5457
Beta strandi553 – 5597
Helixi564 – 5685
Helixi571 – 58818
Beta strandi597 – 6026
Beta strandi606 – 6105
Beta strandi613 – 6164
Helixi633 – 64210
Beta strandi650 – 6556
Helixi657 – 66610
Beta strandi672 – 68918
Turni690 – 6923
Beta strandi699 – 7068
Helixi709 – 7113
Turni712 – 7154
Turni717 – 7215
Helixi724 – 7318
Beta strandi733 – 7353
Helixi742 – 7443
Turni747 – 7493
Helixi750 – 76314
Helixi768 – 7703
Turni774 – 7763
Helixi785 – 7884
Turni789 – 7913
Helixi797 – 80610
Helixi813 – 84836
Beta strandi852 – 86110
Helixi863 – 8675
Helixi871 – 88212
Beta strandi886 – 8927
Helixi897 – 91115

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NZTX-ray2.45A/B17-916[»]
ProteinModelPortaliP52789.
SMRiP52789. Positions 17-913.

Miscellaneous databases

EvolutionaryTraceiP52789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 221205Hexokinase type-1 1
Add
BLAST
Domaini223 – 462240Hexokinase type-2 1
Add
BLAST
Domaini465 – 669205Hexokinase type-1 2
Add
BLAST
Domaini671 – 910240Hexokinase type-2 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1212Hydrophobic
Add
BLAST
Regioni13 – 475463Regulatory
Add
BLAST
Regioni84 – 885Glucose-6-phosphate 1 binding
Regioni155 – 1562Substrate 1 binding
Regioni172 – 1732Substrate 1 binding
Regioni208 – 2092Substrate 1 binding
Regioni291 – 2944Substrate 1 binding
Regioni413 – 4153Glucose-6-phosphate 1 binding
Regioni476 – 917442Catalytic
Add
BLAST
Regioni532 – 5365Glucose-6-phosphate 2 binding
Regioni603 – 6042Substrate 2 binding
Regioni620 – 6212Substrate 2 binding
Regioni656 – 6572Substrate 2 binding
Regioni682 – 6832Substrate 2 binding
Regioni739 – 7424Substrate 2 binding
Regioni861 – 8633Glucose-6-phosphate 2 binding

Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.

Sequence similaritiesi

Belongs to the hexokinase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiP52789.
KOiK00844.
OMAiHHLGLES.
OrthoDBiEOG7S21X5.
PhylomeDBiP52789.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52789-1 [UniParc]FASTAAdd to Basket

« Hide

MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG    50
LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN 100
GLQKVEMENQ IYAIPEDIMR GSGTQLFDHI AECLANFMDK LQIKDKKLPL 150
GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV EGRDVVALIR KAIQRRGDFD 200
IDIVAVVNDT VGTMMTCGYD DHNCEIGLIV GTGSNACYME EMRHIDMVEG 250
DEGRMCINME WGAFGDDGSL NDIRTEFDQE IDMGSLNPGK QLFEKMISGM 300
YMGELVRLIL VKMAKEELLF GGKLSPELLN TGRFETKDIS DIEGEKDGIR 350
KAREVLMRLG LDPTQEDCVA THRICQIVST RSASLCAATL AAVLQRIKEN 400
KGEERLRSTI GVDGSVYKKH PHFAKRLHKT VRRLVPGCDV RFLRSEDGSG 450
KGAAMVTAVA YRLADQHRAR QKTLEHLQLS HDQLLEVKRR MKVEMERGLS 500
KETHASAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV LLVRVRNGKW 550
GGVEMHNKIY AIPQEVMHGT GDELFDHIVQ CIADFLEYMG MKGVSLPLGF 600
TFSFPCQQNS LDESILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD 650
VVAVVNDTVG TMMTCGFEDP HCEVGLIVGT GSNACYMEEM RNVELVEGEE 700
GRMCVNMEWG AFGDNGCLDD FRTEFDVAVD ELSLNPGKQR FEKMISGMYL 750
GEIVRNILID FTKRGLLFRG RISERLKTRG IFETKFLSQI ESDCLALLQV 800
RAILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA VVDRIRENRG 850
LDALKVTVGV DGTLYKLHPH FAKVMHETVK DLAPKCDVSF LQSEDGSGKG 900
AALITAVACR IREAGQR 917
Length:917
Mass (Da):102,380
Last modified:December 7, 2004 - v2
Checksum:iF17CE1938CF13880
GO

Polymorphismi

Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421Q → H Does not affect activity. 4 Publications
Corresponds to variant rs2229621 [ dbSNP | Ensembl ].
VAR_003691
Natural varianti148 – 1481L → F.1 Publication
VAR_010577
Natural varianti274 – 2741R → C.1 Publication
Corresponds to variant rs28363006 [ dbSNP | Ensembl ].
VAR_020504
Natural varianti314 – 3141A → P.1 Publication
Corresponds to variant rs28363015 [ dbSNP | Ensembl ].
VAR_020505
Natural varianti314 – 3141A → V.1 Publication
VAR_010578
Natural varianti331 – 3311T → I.1 Publication
Corresponds to variant rs28363016 [ dbSNP | Ensembl ].
VAR_020506
Natural varianti353 – 3531R → C.1 Publication
Corresponds to variant rs61748096 [ dbSNP | Ensembl ].
VAR_010579
Natural varianti387 – 3871A → S.1 Publication
Corresponds to variant rs28363029 [ dbSNP | Ensembl ].
VAR_020507
Natural varianti497 – 4971R → Q.1 Publication
Corresponds to variant rs2229625 [ dbSNP | Ensembl ].
VAR_010580
Natural varianti775 – 7751R → Q.1 Publication
Corresponds to variant rs185927605 [ dbSNP | Ensembl ].
VAR_010581
Natural varianti801 – 8011R → Q.1 Publication
Corresponds to variant rs28363057 [ dbSNP | Ensembl ].
VAR_020508
Natural varianti844 – 8441R → K.2 Publications
Corresponds to variant rs2229629 [ dbSNP | Ensembl ].
VAR_010582
Natural varianti881 – 8811D → N.1 Publication
Corresponds to variant rs28363065 [ dbSNP | Ensembl ].
VAR_020509

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti803 – 8031I → T in CAA86511. 1 Publication
Sequence conflicti870 – 8701Missing in CAA86476. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46376 mRNA. Translation: CAA86511.1.
Z46354
, Z46355, Z46604, Z46356, Z46357, Z46358, Z46359, Z46360, Z46361, Z46362, Z46363, Z46364, Z46365, Z46366, Z46367, Z46368, Z46369 Genomic DNA. Translation: CAA86476.2.
AF148513 mRNA. Translation: AAD30174.1.
AY623118 Genomic DNA. Translation: AAT38114.1.
CH471053 Genomic DNA. Translation: EAW99601.1.
CH471053 Genomic DNA. Translation: EAW99602.1.
BC021116 mRNA. Translation: AAH21116.1.
BC064369 mRNA. Translation: AAH64369.1.
D25412 Genomic DNA. Translation: BAA04999.1.
CCDSiCCDS1956.1.
PIRiS48809. JC2025.
RefSeqiNP_000180.2. NM_000189.4.
UniGeneiHs.406266.
Hs.591588.

Genome annotation databases

EnsembliENST00000290573; ENSP00000290573; ENSG00000159399.
GeneIDi3099.
KEGGihsa:3099.
UCSCiuc002snd.3. human.

Polymorphism databases

DMDMi56405344.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Hexokinase entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46376 mRNA. Translation: CAA86511.1 .
Z46354
, Z46355 , Z46604 , Z46356 , Z46357 , Z46358 , Z46359 , Z46360 , Z46361 , Z46362 , Z46363 , Z46364 , Z46365 , Z46366 , Z46367 , Z46368 , Z46369 Genomic DNA. Translation: CAA86476.2 .
AF148513 mRNA. Translation: AAD30174.1 .
AY623118 Genomic DNA. Translation: AAT38114.1 .
CH471053 Genomic DNA. Translation: EAW99601.1 .
CH471053 Genomic DNA. Translation: EAW99602.1 .
BC021116 mRNA. Translation: AAH21116.1 .
BC064369 mRNA. Translation: AAH64369.1 .
D25412 Genomic DNA. Translation: BAA04999.1 .
CCDSi CCDS1956.1.
PIRi S48809. JC2025.
RefSeqi NP_000180.2. NM_000189.4.
UniGenei Hs.406266.
Hs.591588.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NZT X-ray 2.45 A/B 17-916 [» ]
ProteinModelPortali P52789.
SMRi P52789. Positions 17-913.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109346. 22 interactions.
DIPi DIP-50110N.
IntActi P52789. 4 interactions.
MINTi MINT-1461614.
STRINGi 9606.ENSP00000290573.

Chemistry

BindingDBi P52789.
ChEMBLi CHEMBL2640.

PTM databases

PhosphoSitei P52789.

Polymorphism databases

DMDMi 56405344.

Proteomic databases

MaxQBi P52789.
PaxDbi P52789.
PeptideAtlasi P52789.
PRIDEi P52789.

Protocols and materials databases

DNASUi 3099.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290573 ; ENSP00000290573 ; ENSG00000159399 .
GeneIDi 3099.
KEGGi hsa:3099.
UCSCi uc002snd.3. human.

Organism-specific databases

CTDi 3099.
GeneCardsi GC02P075059.
H-InvDB HIX0030207.
HGNCi HGNC:4923. HK2.
HPAi HPA028587.
MIMi 601125. gene.
neXtProti NX_P52789.
PharmGKBi PA29301.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi P52789.
KOi K00844.
OMAi HHLGLES.
OrthoDBi EOG7S21X5.
PhylomeDBi P52789.
TreeFami TF314238.

Enzyme and pathway databases

UniPathwayi UPA00242 .
BioCyci MetaCyc:HS08399-MONOMER.
Reactomei REACT_212. Glucose transport.
SABIO-RK P52789.

Miscellaneous databases

EvolutionaryTracei P52789.
GeneWikii HK2.
GenomeRNAii 3099.
NextBioi 12305.
PROi P52789.
SOURCEi Search...

Gene expression databases

ArrayExpressi P52789.
Bgeei P52789.
CleanExi HS_HK2.
Genevestigatori P52789.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human hexokinase II: sequence and homology to other hexokinases."
    Deeb S.S., Malkki M., Laakso M.
    Biochem. Biophys. Res. Commun. 197:68-74(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity."
    Lehto M., Huang X., Davis E.M., Le Beau M.M., Laurila E., Eriksson K.F., Bell G.I., Groop L.C.
    Diabetologia 38:1466-1474(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-142.
    Tissue: Blood, Muscle and Placenta.
  3. Malkki M., Heikkinen S., Deeb S.S., Laakso M.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  4. NIEHS SNPs program
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-142; CYS-274; PRO-314; ILE-331; SER-387; GLN-801; LYS-844 AND ASN-881.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.
  7. "Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines."
    Shinohara Y., Yamamoto K., Kogure K., Ichihara J., Terada H.
    Cancer Lett. 82:27-32(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 614-739.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystal structure of human hexokinase II."
    Structural genomics consortium (SGC)
    Submitted (DEC-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 17-916 IN COMPLEX WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE.
  10. "Amino acid substitutions in hexokinase II among patients with NIDDM."
    Laakso M., Malkki M., Deeb S.S.
    Diabetes 44:330-334(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-314; CYS-353 AND GLN-775.
  11. "Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution."
    Vidal-Puig A., Printz R.L., Stratton I.M., Granner D.K., Moller D.E.
    Diabetes 44:340-346(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HIS-142.
  12. "Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity."
    Echwald S.M., Bjoerbaek C., Hansen T., Clausen J.O., Vestergaard H., Zierath J.R., Printz R.L., Granner D.K., Pedersen O.
    Diabetes 44:347-353(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-142; PHE-148; GLN-497 AND LYS-844.

Entry informationi

Entry nameiHXK2_HUMAN
AccessioniPrimary (citable) accession number: P52789
Secondary accession number(s): D6W5J2, Q8WU87, Q9UN82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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