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P52787 (IF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastric intrinsic factor
Alternative name(s):
Intrinsic factor
Short name=IF
Short name=INF
Gene names
Name:Gif
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis By similarity.

Subunit structure

Interacts with CUBN (via CUB domains) By similarity.

Subcellular location

Secreted.

Tissue specificity

Gastric mucosa.

Sequence similarities

Belongs to the eukaryotic cobalamin transport proteins family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 417399Gastric intrinsic factor
PRO_0000005559

Regions

Region365 – 3706Cobalamin binding By similarity
Region386 – 39510Cobalamin binding By similarity

Sites

Binding site1711Cobalamin By similarity
Binding site2221Cobalamin By similarity
Binding site2701Cobalamin By similarity

Amino acid modifications

Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential
Disulfide bond26 ↔ 246 By similarity
Disulfide bond103 ↔ 288 By similarity
Disulfide bond143 ↔ 182 By similarity

Experimental info

Sequence conflict861D → N in AAA37881. Ref.1
Sequence conflict861D → N in AAA37882. Ref.1
Sequence conflict1561R → A in AAA37881. Ref.1
Sequence conflict1561R → A in AAA37882. Ref.1
Sequence conflict3271L → P in AAA37881. Ref.1
Sequence conflict3271L → P in AAA37882. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52787 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: BF38663EFC90F34A

FASTA41745,497
        10         20         30         40         50         60 
MAWLTLYLLS VLWAVAGTST RAQSSCSVPP DQQPWVDGLQ ALMENSVTDS DFPNPSILIA 

        70         80         90        100        110        120 
MNLAGAYNVE AQKLLTYQLM ASDSADLTSG QLALTVMALT SSCRDPGSKV STLLKKMENW 

       130        140        150        160        170        180 
SPSSPGAESS AFYGPGLAIL ALCQKSSEAT LPIAVRFAKT LMMEPSPFNV DTGAVATLAL 

       190        200        210        220        230        240 
TCMYNKIPVG SQENYRDLFG QALKAIVEKI SLRIKADGII GDIYSTGLAM QALSVTPEQP 

       250        260        270        280        290        300 
TKKWDCEKTM HTILNEIKQG KFQNPMSIAQ ILPSLKGKTY LDVPQVTCGP DHEVPPTLTD 

       310        320        330        340        350        360 
YPTPVPTSVS NITVIYTINN QLRGVDLLFN VTIEVSVKSG SVLLAVLEEA QRKNSMFKFE 

       370        380        390        400        410 
TTMTSWGLIV SSINNIAENV NHKTYWEFLS GKTPLDEGVA YYIPFNHEHI TANFTQY

« Hide

References

« Hide 'large scale' references
[1]"Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units."
Lorenz R.G., Gordon J.I.
J. Biol. Chem. 268:26559-26570(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: BALB/c.
Tissue: Stomach.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cecum.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L24192 Genomic DNA. Translation: AAA37881.1.
L24191 mRNA. Translation: AAA37882.1.
AK078933 mRNA. Translation: BAC37468.1.
CH466534 Genomic DNA. Translation: EDL41439.1.
BC118519 mRNA. Translation: AAI18520.1.
IPIIPI00387294.
PIRA49684.
RefSeqNP_032144.2. NM_008118.3.
UniGeneMm.456.

3D structure databases

ProteinModelPortalP52787.
SMRP52787. Positions 25-417.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025585.

PTM databases

PhosphoSiteP52787.

Proteomic databases

PRIDEP52787.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025585; ENSMUSP00000025585; ENSMUSG00000024682.
GeneID14603.
KEGGmmu:14603.
UCSCuc008gsw.1. mouse.

Organism-specific databases

CTD2694.
MGIMGI:1202394. Gif.

Phylogenomic databases

eggNOGNOG254667.
GeneTreeENSGT00530000063370.
HOGENOMHOG000013214.
HOVERGENHBG006133.
InParanoidQ8C5C1.
KOK14615.
OMANLAGAYN.
OrthoDBEOG4VX258.

Gene expression databases

BgeeP52787.
CleanExMM_GIF.
GenevestigatorP52787.
GermOnlineENSMUSG00000024682. Mus musculus.

Family and domain databases

InterProIPR002157. Cbl-bd_transpt_euk.
[Graphical view]
PANTHERPTHR10559. PTHR10559. 1 hit.
PfamPF01122. Cobalamin_bind. 1 hit.
[Graphical view]
PROSITEPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286384.
SOURCESearch...

Entry information

Entry nameIF_MOUSE
AccessionPrimary (citable) accession number: P52787
Secondary accession number(s): Q8C5C1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 3, 2009
Last modified: April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents