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P52786

- CP2J1_RABIT

UniProt

P52786 - CP2J1_RABIT

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Protein

Cytochrome P450 2J1

Gene

CYP2J1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the N-demethylation of benzphetamine to formaldehyde.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J1 (EC:1.14.14.1)
Alternative name(s):
CYPIIJ1
Cytochrome P-450IB
Gene namesi
Name:CYP2J1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 2J1PRO_0000051768Add
BLAST

Expressioni

Tissue specificityi

Small intestine.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003635.

Structurei

3D structure databases

ProteinModelPortaliP52786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP52786.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52786-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAALSSLAA ALGAGLHPKT LLLGAVAFLF FAYFLKTRRP KNYPPGPWRL
60 70 80 90 100
PFLGNLFTLD MEKSHLQLQQ FVKKYGNLFC LDLAGKSIVI VTGLPLIKEV
110 120 130 140 150
LVHMDQNFIN RPVPPIRERS FKKNGLIMSS GQLWKEQRRF ALMTLRNFGL
160 170 180 190 200
GKKSLEERIQ EEARHLTEAM EKEGGQPFDA HFKINNAVSN IICSITFGER
210 220 230 240 250
FEYHDGQFQE LLKLFDEVMY LEASMLCQLY NIFPWIMKFL PGAHQTLFSN
260 270 280 290 300
WKKLELFVSR MLENHKKDWN PAETRDFIDA YLKEMSKYPG SATSSFNEEN
310 320 330 340 350
LICSTLDLFL AGTETTSDMR WGLLFMALYP EIQEKVHAEI DSVIGQWQQP
360 370 380 390 400
SMASRESLPY TNAVIHEVQR MGNILPLNVP REVTVDTTLA GYHLPKGTVV
410 420 430 440 450
LTNLTALHKD PEEWATPDTF NPEHFLENGQ FKKKEAFIPF SIGKRACLGE
460 470 480 490 500
QLAKSELFIF FTSLMQKFTF KPPSDEKLTL NFRMGITLSP VKHRICAIPR

A
Length:501
Mass (Da):57,326
Last modified:January 23, 2007 - v2
Checksum:i90EEE628F0538197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90405 mRNA. Translation: BAA14401.1.
PIRiA40938.
RefSeqiNP_001153760.1. NM_001160288.1.
UniGeneiOcu.2700.

Genome annotation databases

GeneIDi100301544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90405 mRNA. Translation: BAA14401.1 .
PIRi A40938.
RefSeqi NP_001153760.1. NM_001160288.1.
UniGenei Ocu.2700.

3D structure databases

ProteinModelPortali P52786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000003635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100301544.

Organism-specific databases

CTDi 100301544.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P52786.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel species of cytochrome P-450 (P-450ib) specific for the small intestine of rabbits. cDNA cloning and its expression in COS cells."
    Kikuta Y., Sogawa K., Haniu M., Kinosaki M., Kusunose E., Nojima Y., Yamamoto S., Ichihara K., Kusunose M., Fujii-Kuriyama Y.
    J. Biol. Chem. 266:17821-17825(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiCP2J1_RABIT
AccessioniPrimary (citable) accession number: P52786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3