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P52786 (CP2J1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2J1

EC=1.14.14.1
Alternative name(s):
CYPIIJ1
Cytochrome P-450IB
Gene names
Name:CYP2J1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the N-demethylation of benzphetamine to formaldehyde.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Small intestine.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Cytochrome P450 2J1
PRO_0000051768

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P52786 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 90EEE628F0538197

FASTA50157,326
        10         20         30         40         50         60 
MVAALSSLAA ALGAGLHPKT LLLGAVAFLF FAYFLKTRRP KNYPPGPWRL PFLGNLFTLD 

        70         80         90        100        110        120 
MEKSHLQLQQ FVKKYGNLFC LDLAGKSIVI VTGLPLIKEV LVHMDQNFIN RPVPPIRERS 

       130        140        150        160        170        180 
FKKNGLIMSS GQLWKEQRRF ALMTLRNFGL GKKSLEERIQ EEARHLTEAM EKEGGQPFDA 

       190        200        210        220        230        240 
HFKINNAVSN IICSITFGER FEYHDGQFQE LLKLFDEVMY LEASMLCQLY NIFPWIMKFL 

       250        260        270        280        290        300 
PGAHQTLFSN WKKLELFVSR MLENHKKDWN PAETRDFIDA YLKEMSKYPG SATSSFNEEN 

       310        320        330        340        350        360 
LICSTLDLFL AGTETTSDMR WGLLFMALYP EIQEKVHAEI DSVIGQWQQP SMASRESLPY 

       370        380        390        400        410        420 
TNAVIHEVQR MGNILPLNVP REVTVDTTLA GYHLPKGTVV LTNLTALHKD PEEWATPDTF 

       430        440        450        460        470        480 
NPEHFLENGQ FKKKEAFIPF SIGKRACLGE QLAKSELFIF FTSLMQKFTF KPPSDEKLTL 

       490        500 
NFRMGITLSP VKHRICAIPR A 

« Hide

References

[1]"A novel species of cytochrome P-450 (P-450ib) specific for the small intestine of rabbits. cDNA cloning and its expression in COS cells."
Kikuta Y., Sogawa K., Haniu M., Kinosaki M., Kusunose E., Nojima Y., Yamamoto S., Ichihara K., Kusunose M., Fujii-Kuriyama Y.
J. Biol. Chem. 266:17821-17825(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D90405 mRNA. Translation: BAA14401.1.
PIRA40938.
RefSeqNP_001153760.1. NM_001160288.1.
UniGeneOcu.2700.

3D structure databases

ProteinModelPortalP52786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000003635.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100301544.

Organism-specific databases

CTD100301544.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2J1_RABIT
AccessionPrimary (citable) accession number: P52786
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families