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P52786

- CP2J1_RABIT

UniProt

P52786 - CP2J1_RABIT

Protein

Cytochrome P450 2J1

Gene

CYP2J1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the N-demethylation of benzphetamine to formaldehyde.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2J1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIJ1
    Cytochrome P-450IB
    Gene namesi
    Name:CYP2J1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cytochrome P450 2J1PRO_0000051768Add
    BLAST

    Expressioni

    Tissue specificityi

    Small intestine.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000003635.

    Structurei

    3D structure databases

    ProteinModelPortaliP52786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52786-1 [UniParc]FASTAAdd to Basket

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    MVAALSSLAA ALGAGLHPKT LLLGAVAFLF FAYFLKTRRP KNYPPGPWRL    50
    PFLGNLFTLD MEKSHLQLQQ FVKKYGNLFC LDLAGKSIVI VTGLPLIKEV 100
    LVHMDQNFIN RPVPPIRERS FKKNGLIMSS GQLWKEQRRF ALMTLRNFGL 150
    GKKSLEERIQ EEARHLTEAM EKEGGQPFDA HFKINNAVSN IICSITFGER 200
    FEYHDGQFQE LLKLFDEVMY LEASMLCQLY NIFPWIMKFL PGAHQTLFSN 250
    WKKLELFVSR MLENHKKDWN PAETRDFIDA YLKEMSKYPG SATSSFNEEN 300
    LICSTLDLFL AGTETTSDMR WGLLFMALYP EIQEKVHAEI DSVIGQWQQP 350
    SMASRESLPY TNAVIHEVQR MGNILPLNVP REVTVDTTLA GYHLPKGTVV 400
    LTNLTALHKD PEEWATPDTF NPEHFLENGQ FKKKEAFIPF SIGKRACLGE 450
    QLAKSELFIF FTSLMQKFTF KPPSDEKLTL NFRMGITLSP VKHRICAIPR 500
    A 501
    Length:501
    Mass (Da):57,326
    Last modified:January 23, 2007 - v2
    Checksum:i90EEE628F0538197
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90405 mRNA. Translation: BAA14401.1.
    PIRiA40938.
    RefSeqiNP_001153760.1. NM_001160288.1.
    UniGeneiOcu.2700.

    Genome annotation databases

    GeneIDi100301544.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90405 mRNA. Translation: BAA14401.1 .
    PIRi A40938.
    RefSeqi NP_001153760.1. NM_001160288.1.
    UniGenei Ocu.2700.

    3D structure databases

    ProteinModelPortali P52786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000003635.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100301544.

    Organism-specific databases

    CTDi 100301544.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel species of cytochrome P-450 (P-450ib) specific for the small intestine of rabbits. cDNA cloning and its expression in COS cells."
      Kikuta Y., Sogawa K., Haniu M., Kinosaki M., Kusunose E., Nojima Y., Yamamoto S., Ichihara K., Kusunose M., Fujii-Kuriyama Y.
      J. Biol. Chem. 266:17821-17825(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiCP2J1_RABIT
    AccessioniPrimary (citable) accession number: P52786
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3