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Protein

Ribonuclease UK114

Gene

Hrsp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease UK114 (EC:3.1.-.-)
Alternative name(s):
Heat-responsive protein 12
Gene namesi
Name:Hrsp12
Synonyms:Hrp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1095401. Hrsp12.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: Ensembl
  • peroxisome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 135134Ribonuclease UK114PRO_0000170309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei13 – 131N6-succinyllysineCombined sources
Modified residuei60 – 601N6-succinyllysineCombined sources
Modified residuei67 – 671N6-succinyllysineCombined sources
Modified residuei134 – 1341N6-succinyllysineCombined sources

Post-translational modificationi

Phosphorylated in vitro.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52760.
MaxQBiP52760.
PaxDbiP52760.
PeptideAtlasiP52760.
PRIDEiP52760.
TopDownProteomicsiP52760.

2D gel databases

SWISS-2DPAGEP52760.

PTM databases

iPTMnetiP52760.
PhosphoSiteiP52760.

Expressioni

Tissue specificityi

Expressed predominantly in liver and kidney. Lower levels in lung and brain.

Gene expression databases

BgeeiENSMUSG00000022323.
CleanExiMM_HRSP12.
GenevisibleiP52760. MM.

Interactioni

Protein-protein interaction databases

IntActiP52760. 6 interactions.
MINTiMINT-1869903.
STRINGi10090.ENSMUSP00000022946.

Structurei

3D structure databases

ProteinModelPortaliP52760.
SMRiP52760. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

eggNOGiKOG2317. Eukaryota.
COG0251. LUCA.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
HOVERGENiHBG003597.
InParanoidiP52760.
OMAiGSYFKEP.
OrthoDBiEOG091G0VJN.
PhylomeDBiP52760.
TreeFamiTF105775.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. RidA.
IPR019897. RidA_CS.
IPR006175. YjgF/YER057c/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIIRKVIS TTKAPAAIGP YSQAVQVDRT IYISGQVGLD PSSGQLVPGG
60 70 80 90 100
VVEEAKQALK NLGEILKAAG CDFNNVVKTT VLLADMNDFG TVNEIYKTYF
110 120 130
QGSLPARAAY QVAALPRGSR VEIEAIAVQG PFIKA
Length:135
Mass (Da):14,255
Last modified:January 23, 2007 - v3
Checksum:iDDECBFD7E03D7E25
GO

Sequence cautioni

The sequence AAA96033 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50631 mRNA. Translation: AAA96033.1. Different initiation.
BC092375 mRNA. Translation: AAH92375.1.
BC125590 mRNA. Translation: AAI25591.1.
BC125592 mRNA. Translation: AAI25593.1.
CCDSiCCDS27418.1.
RefSeqiNP_032313.2. NM_008287.3.
UniGeneiMm.491154.

Genome annotation databases

EnsembliENSMUST00000022946; ENSMUSP00000022946; ENSMUSG00000022323.
GeneIDi15473.
KEGGimmu:15473.
UCSCiuc007vlt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50631 mRNA. Translation: AAA96033.1. Different initiation.
BC092375 mRNA. Translation: AAH92375.1.
BC125590 mRNA. Translation: AAI25591.1.
BC125592 mRNA. Translation: AAI25593.1.
CCDSiCCDS27418.1.
RefSeqiNP_032313.2. NM_008287.3.
UniGeneiMm.491154.

3D structure databases

ProteinModelPortaliP52760.
SMRiP52760. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52760. 6 interactions.
MINTiMINT-1869903.
STRINGi10090.ENSMUSP00000022946.

PTM databases

iPTMnetiP52760.
PhosphoSiteiP52760.

2D gel databases

SWISS-2DPAGEP52760.

Proteomic databases

EPDiP52760.
MaxQBiP52760.
PaxDbiP52760.
PeptideAtlasiP52760.
PRIDEiP52760.
TopDownProteomicsiP52760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022946; ENSMUSP00000022946; ENSMUSG00000022323.
GeneIDi15473.
KEGGimmu:15473.
UCSCiuc007vlt.2. mouse.

Organism-specific databases

CTDi10247.
MGIiMGI:1095401. Hrsp12.

Phylogenomic databases

eggNOGiKOG2317. Eukaryota.
COG0251. LUCA.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
HOVERGENiHBG003597.
InParanoidiP52760.
OMAiGSYFKEP.
OrthoDBiEOG091G0VJN.
PhylomeDBiP52760.
TreeFamiTF105775.

Miscellaneous databases

PROiP52760.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022323.
CleanExiMM_HRSP12.
GenevisibleiP52760. MM.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. RidA.
IPR019897. RidA_CS.
IPR006175. YjgF/YER057c/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUK114_MOUSE
AccessioniPrimary (citable) accession number: P52760
Secondary accession number(s): Q569N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.