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Protein

Ribonuclease UK114

Gene

Hrsp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease UK114 (EC:3.1.-.-)
Alternative name(s):
Heat-responsive protein 12
Gene namesi
Name:Hrsp12
Synonyms:Hrp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1095401. Hrsp12.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: Ensembl
  • peroxisome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 135134Ribonuclease UK114PRO_0000170309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei13 – 131N6-succinyllysineCombined sources
Modified residuei60 – 601N6-succinyllysineCombined sources
Modified residuei67 – 671N6-succinyllysineCombined sources
Modified residuei134 – 1341N6-succinyllysineCombined sources

Post-translational modificationi

Phosphorylated in vitro.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52760.
MaxQBiP52760.
PaxDbiP52760.
PRIDEiP52760.
TopDownProteomicsiP52760.

2D gel databases

SWISS-2DPAGEP52760.

PTM databases

iPTMnetiP52760.
PhosphoSiteiP52760.

Expressioni

Tissue specificityi

Expressed predominantly in liver and kidney. Lower levels in lung and brain.

Gene expression databases

BgeeiP52760.
CleanExiMM_HRSP12.
GenevisibleiP52760. MM.

Interactioni

Protein-protein interaction databases

IntActiP52760. 6 interactions.
MINTiMINT-1869903.
STRINGi10090.ENSMUSP00000022946.

Structurei

3D structure databases

ProteinModelPortaliP52760.
SMRiP52760. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

eggNOGiKOG2317. Eukaryota.
COG0251. LUCA.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
HOVERGENiHBG003597.
InParanoidiP52760.
OMAiGSYFKEP.
OrthoDBiEOG75F4G2.
PhylomeDBiP52760.
TreeFamiTF105775.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. RidA.
IPR019897. RidA_CS.
IPR006175. YjgF/YER057c/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIIRKVIS TTKAPAAIGP YSQAVQVDRT IYISGQVGLD PSSGQLVPGG
60 70 80 90 100
VVEEAKQALK NLGEILKAAG CDFNNVVKTT VLLADMNDFG TVNEIYKTYF
110 120 130
QGSLPARAAY QVAALPRGSR VEIEAIAVQG PFIKA
Length:135
Mass (Da):14,255
Last modified:January 23, 2007 - v3
Checksum:iDDECBFD7E03D7E25
GO

Sequence cautioni

The sequence AAA96033.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50631 mRNA. Translation: AAA96033.1. Different initiation.
BC092375 mRNA. Translation: AAH92375.1.
BC125590 mRNA. Translation: AAI25591.1.
BC125592 mRNA. Translation: AAI25593.1.
CCDSiCCDS27418.1.
RefSeqiNP_032313.2. NM_008287.3.
UniGeneiMm.491154.

Genome annotation databases

EnsembliENSMUST00000022946; ENSMUSP00000022946; ENSMUSG00000022323.
GeneIDi15473.
KEGGimmu:15473.
UCSCiuc007vlt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50631 mRNA. Translation: AAA96033.1. Different initiation.
BC092375 mRNA. Translation: AAH92375.1.
BC125590 mRNA. Translation: AAI25591.1.
BC125592 mRNA. Translation: AAI25593.1.
CCDSiCCDS27418.1.
RefSeqiNP_032313.2. NM_008287.3.
UniGeneiMm.491154.

3D structure databases

ProteinModelPortaliP52760.
SMRiP52760. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52760. 6 interactions.
MINTiMINT-1869903.
STRINGi10090.ENSMUSP00000022946.

PTM databases

iPTMnetiP52760.
PhosphoSiteiP52760.

2D gel databases

SWISS-2DPAGEP52760.

Proteomic databases

EPDiP52760.
MaxQBiP52760.
PaxDbiP52760.
PRIDEiP52760.
TopDownProteomicsiP52760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022946; ENSMUSP00000022946; ENSMUSG00000022323.
GeneIDi15473.
KEGGimmu:15473.
UCSCiuc007vlt.2. mouse.

Organism-specific databases

CTDi10247.
MGIiMGI:1095401. Hrsp12.

Phylogenomic databases

eggNOGiKOG2317. Eukaryota.
COG0251. LUCA.
GeneTreeiENSGT00420000029792.
HOGENOMiHOG000267215.
HOVERGENiHBG003597.
InParanoidiP52760.
OMAiGSYFKEP.
OrthoDBiEOG75F4G2.
PhylomeDBiP52760.
TreeFamiTF105775.

Miscellaneous databases

NextBioi288314.
PROiP52760.
SOURCEiSearch...

Gene expression databases

BgeeiP52760.
CleanExiMM_HRSP12.
GenevisibleiP52760. MM.

Family and domain databases

Gene3Di3.30.1330.40. 1 hit.
InterProiIPR013813. Endoribo_LPSP/chorism_mut-like.
IPR006056. RidA.
IPR019897. RidA_CS.
IPR006175. YjgF/YER057c/UK114.
[Graphical view]
PANTHERiPTHR11803. PTHR11803. 1 hit.
PfamiPF01042. Ribonuc_L-PSP. 1 hit.
[Graphical view]
SUPFAMiSSF55298. SSF55298. 1 hit.
TIGRFAMsiTIGR00004. TIGR00004. 1 hit.
PROSITEiPS01094. UPF0076. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hrp12, a novel heat-responsive, tissue-specific, phosphorylated protein isolated from mouse liver."
    Samuel S.J., Tzung S.P., Cohen S.A.
    Hepatology 25:1213-1222(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-13; LYS-60; LYS-67 AND LYS-134, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUK114_MOUSE
AccessioniPrimary (citable) accession number: P52760
Secondary accession number(s): Q569N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.