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Protein

2-iminobutanoate/2-iminopropanoate deaminase

Gene

Rida

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.By similarity
May also function as an endoribonuclease, cleaving mRNA phosphodiester bonds of single-stranded RNA (By similarity). Thereby, may inhibit protein translation (By similarity).By similarity

Catalytic activityi

2-iminobutanoate + H2O = 2-oxobutanoate + NH3.By similarity
2-iminopropanoate + H2O = pyruvate + NH3.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-8849175 Threonine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
2-iminobutanoate/2-iminopropanoate deaminaseBy similarity (EC:3.5.99.10By similarity)
Alternative name(s):
Heat-responsive protein 121 Publication
Reactive intermediate imine deaminase A homologImported
Translation inhibitor L-PSP ribonucleaseBy similarity (EC:3.1.-.-By similarity)
Gene namesi
Name:RidaImported
Synonyms:Hrp121 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1095401 Rida

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001703092 – 1352-iminobutanoate/2-iminopropanoate deaminaseAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei13N6-succinyllysineCombined sources1
Modified residuei60N6-succinyllysineCombined sources1
Modified residuei67N6-succinyllysineCombined sources1
Modified residuei134N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52760
MaxQBiP52760
PaxDbiP52760
PeptideAtlasiP52760
PRIDEiP52760
TopDownProteomicsiP52760

2D gel databases

SWISS-2DPAGEiP52760

PTM databases

iPTMnetiP52760
PhosphoSitePlusiP52760
SwissPalmiP52760

Expressioni

Tissue specificityi

Expressed predominantly in liver and kidney. Lower levels in lung and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000022323
CleanExiMM_HRSP12
GenevisibleiP52760 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP52760, 6 interactors
MINTiP52760
STRINGi10090.ENSMUSP00000022946

Structurei

3D structure databases

ProteinModelPortaliP52760
SMRiP52760
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RutC family.Curated

Phylogenomic databases

eggNOGiKOG2317 Eukaryota
COG0251 LUCA
GeneTreeiENSGT00420000029792
HOGENOMiHOG000267215
HOVERGENiHBG003597
InParanoidiP52760
KOiK09022
OMAiGSYFKEP
OrthoDBiEOG091G0VJN
PhylomeDBiP52760
TreeFamiTF105775

Family and domain databases

Gene3Di3.30.1330.40, 1 hit
InterProiView protein in InterPro
IPR006056 RidA
IPR019897 RidA_CS
IPR035959 RutC-like_sf
IPR006175 YjgF/YER057c/UK114
PANTHERiPTHR11803 PTHR11803, 1 hit
PfamiView protein in Pfam
PF01042 Ribonuc_L-PSP, 1 hit
SUPFAMiSSF55298 SSF55298, 1 hit
TIGRFAMsiTIGR00004 TIGR00004, 1 hit
PROSITEiView protein in PROSITE
PS01094 UPF0076, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIIRKVIS TTKAPAAIGP YSQAVQVDRT IYISGQVGLD PSSGQLVPGG
60 70 80 90 100
VVEEAKQALK NLGEILKAAG CDFNNVVKTT VLLADMNDFG TVNEIYKTYF
110 120 130
QGSLPARAAY QVAALPRGSR VEIEAIAVQG PFIKA
Length:135
Mass (Da):14,255
Last modified:January 23, 2007 - v3
Checksum:iDDECBFD7E03D7E25
GO

Sequence cautioni

The sequence AAA96033 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50631 mRNA Translation: AAA96033.1 Different initiation.
BC092375 mRNA Translation: AAH92375.1
BC125590 mRNA Translation: AAI25591.1
BC125592 mRNA Translation: AAI25593.1
CCDSiCCDS27418.1
RefSeqiNP_032313.2, NM_008287.3
UniGeneiMm.491154

Genome annotation databases

EnsembliENSMUST00000022946; ENSMUSP00000022946; ENSMUSG00000022323
GeneIDi15473
KEGGimmu:15473
UCSCiuc007vlt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRIDA_MOUSE
AccessioniPrimary (citable) accession number: P52760
Secondary accession number(s): Q569N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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