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Protein

Beta-chimaerin

Gene

CHN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.

Enzyme regulationi

In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 264Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • GTPase activator activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106069-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
SignaLinkiP52757.
SIGNORiP52757.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-chimaerin
Alternative name(s):
Beta-chimerin
Rho GTPase-activating protein 3
Gene namesi
Name:CHN2
Synonyms:ARHGAP3, BCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1944. CHN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1124.
OpenTargetsiENSG00000106069.
PharmGKBiPA26474.

Chemistry databases

ChEMBLiCHEMBL4504.

Polymorphism and mutation databases

BioMutaiCHN2.
DMDMi2506455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566971 – 468Beta-chimaerinAdd BLAST468

Proteomic databases

PaxDbiP52757.
PeptideAtlasiP52757.
PRIDEiP52757.

PTM databases

iPTMnetiP52757.
PhosphoSitePlusiP52757.

Expressioni

Tissue specificityi

Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas.

Gene expression databases

BgeeiENSG00000106069.
CleanExiHS_CHN2.
ExpressionAtlasiP52757. baseline and differential.
GenevisibleiP52757. HS.

Organism-specific databases

HPAiHPA018989.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK2O436394EBI-714925,EBI-713635
RAC1P630004EBI-714925,EBI-413628

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi107548. 9 interactors.
IntActiP52757. 10 interactors.
MINTiMINT-1420866.
STRINGi9606.ENSP00000222792.

Chemistry databases

BindingDBiP52757.

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 36Combined sources8
Beta strandi58 – 63Combined sources6
Helixi66 – 73Combined sources8
Beta strandi79 – 84Combined sources6
Beta strandi86 – 88Combined sources3
Beta strandi92 – 98Combined sources7
Beta strandi101 – 104Combined sources4
Beta strandi108 – 114Combined sources7
Beta strandi116 – 118Combined sources3
Helixi125 – 138Combined sources14
Helixi141 – 146Combined sources6
Helixi153 – 155Combined sources3
Beta strandi156 – 161Combined sources6
Turni229 – 231Combined sources3
Turni237 – 240Combined sources4
Beta strandi246 – 248Combined sources3
Helixi255 – 257Combined sources3
Turni266 – 269Combined sources4
Helixi279 – 286Combined sources8
Helixi292 – 303Combined sources12
Beta strandi306 – 308Combined sources3
Turni309 – 313Combined sources5
Helixi318 – 328Combined sources11
Turni331 – 334Combined sources4
Beta strandi339 – 342Combined sources4
Helixi346 – 358Combined sources13
Helixi369 – 373Combined sources5
Turni374 – 377Combined sources4
Helixi381 – 392Combined sources12
Helixi397 – 405Combined sources9
Turni406 – 410Combined sources5
Helixi411 – 414Combined sources4
Turni415 – 419Combined sources5
Helixi424 – 431Combined sources8
Turni432 – 434Combined sources3
Helixi445 – 448Combined sources4
Helixi450 – 462Combined sources13
Helixi464 – 467Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XA6X-ray3.20A7-468[»]
ProteinModelPortaliP52757.
SMRiP52757.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52757.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 127SH2PROSITE-ProRule annotationAdd BLAST69
Domaini277 – 468Rho-GAPPROSITE-ProRule annotationAdd BLAST192

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 264Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

SH2 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
ENOG410YM3I. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000231926.
HOVERGENiHBG080489.
InParanoidiP52757.
KOiK20630.
OMAiIICPGEV.
OrthoDBiEOG091G0834.
PhylomeDBiP52757.
TreeFamiTF342052.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR017356. CHN1/CHN2.
IPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF038015. N-chimaerin. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta-2 (identifier: P52757-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASSNSSLS GSSVSSDAEE YQPPIWKSYL YQLQQEAPRP KRIICPREVE
60 70 80 90 100
NRPKYYGREF HGIISREQAD ELLGGVEGAY ILRESQRQPG CYTLALRFGN
110 120 130 140 150
QTLNYRLFHD GKHFVGEKRF ESIHDLVTDG LITLYIETKA AEYISKMTTN
160 170 180 190 200
PIYEHIGYAT LLREKVSRRL SRSKNEPRKT NVTHEEHTAV EKISSLVRRA
210 220 230 240 250
ALTHNDNHFN YEKTHNFKVH TFRGPHWCEY CANFMWGLIA QGVRCSDCGL
260 270 280 290 300
NVHKQCSKHV PNDCQPDLKR IKKVYCCDLT TLVKAHNTQR PMVVDICIRE
310 320 330 340 350
IEARGLKSEG LYRVSGFTEH IEDVKMAFDR DGEKADISAN VYPDINIITG
360 370 380 390 400
ALKLYFRDLP IPVITYDTYS KFIDAAKISN ADERLEAVHE VLMLLPPAHY
410 420 430 440 450
ETLRYLMIHL KKVTMNEKDN FMNAENLGIV FGPTLMRPPE DSTLTTLHDM
460
RYQKLIVQIL IENEDVLF
Length:468
Mass (Da):53,924
Last modified:November 1, 1997 - v2
Checksum:i63254958E0B5804C
GO
Isoform Beta-1 (identifier: P52757-2)
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: P52757-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MAASSNSSLS...REVENRPKYY → MFSEELWLEN...PPLKLFACSQ
     57-192: Missing.

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):38,178
Checksum:i7A2B5C42F1769425
GO
Isoform 4 (identifier: P52757-4) [UniParc]FASTAAdd to basket
Also known as: B1-CHNdel ex7p

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQE → MFSEELWLENEKKCAVVRKSKQGRKRQELLAVAFGV
     37-217: Missing.

Show »
Length:287
Mass (Da):33,053
Checksum:i919FF9A301706C6E
GO
Isoform 5 (identifier: P52757-5) [UniParc]FASTAAdd to basket
Also known as: B1-CHNdel ex9

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MAASSNSSLS...REVENRPKYY → MFSEELWLEN...PPLKLFACSQ
     57-192: Missing.
     247-304: Missing.

Show »
Length:274
Mass (Da):31,518
Checksum:i4216F583B958B41F
GO
Isoform 6 (identifier: P52757-6) [UniParc]FASTAAdd to basket
Also known as: B1-CHNdel ex7p,11

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQE → MFSEELWLENEKKCAVVRKSKQGRKRQELLAVAFGV
     37-217: Missing.
     331-377: DGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAK → E

Show »
Length:241
Mass (Da):27,951
Checksum:iD1E415379991433D
GO
Isoform 7 (identifier: P52757-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MAASSNSSLS...REVENRPKYY → MFSEELWLEN...PPLKLFACSQ
     57-192: Missing.
     331-377: DGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAK → E

Show »
Length:286
Mass (Da):33,075
Checksum:i8831F1DAC250619E
GO
Isoform 8 (identifier: P52757-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-192: Missing.

Show »
Length:324
Mass (Da):37,199
Checksum:i9E131257B687487F
GO
Isoform Beta-3 (identifier: P52757-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MAASSNSSLSGSSVS → MTQTHRAKSA...FADGLHSSCT

Show »
Length:543
Mass (Da):62,441
Checksum:i5EDA9330E0F66530
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 6MAASSN → MRLL in AAA16836 (PubMed:8175705).Curated6
Sequence conflicti1 – 6MAASSN → MRLL in AAA19191 (PubMed:8175705).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022118204H → R.1 PublicationCorresponds to variant rs3750103dbSNPEnsembl.1
Natural variantiVAR_049136438P → S.Corresponds to variant rs34971642dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462711 – 56MAASS…RPKYY → MFSEELWLENEKKCAVVRKS KQGRKRQELLAVAFGVKVGV KGGFLWPPLKLFACSQ in isoform 3, isoform 5 and isoform 7. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_0476001 – 36MAASS…QLQQE → MFSEELWLENEKKCAVVRKS KQGRKRQELLAVAFGV in isoform 4 and isoform 6. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_0536791 – 15MAASS…GSSVS → MTQTHRAKSASSCPNLLVPE TWPHQVSASHAGRSKQPQGG ILKINEEHRRGAIQDLLASP GFTFGKRVVFDSHCLKRQHT FADGLHSSCT in isoform Beta-3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_04760137 – 217Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST181
Alternative sequenceiVSP_05332349 – 192Missing in isoform 8. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_04627257 – 192Missing in isoform 3, isoform 5 and isoform 7. 2 PublicationsAdd BLAST136
Alternative sequenceiVSP_047602247 – 304Missing in isoform 5. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_047603331 – 377DGEKA…IDAAK → E in isoform 6 and isoform 7. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29126 mRNA. Translation: AAA19191.1.
U07223 mRNA. Translation: AAA16836.1.
U28926 mRNA. Translation: AAA86528.1.
EU732752 mRNA. Translation: ACF04989.1.
EU732753 mRNA. Translation: ACF04990.1.
EU732754 mRNA. Translation: ACF04991.1.
EU732758 mRNA. Translation: ACF04995.1.
EU732762 mRNA. Translation: ACF04999.1.
GQ924106 mRNA. Translation: ADK47390.1.
AK026415 mRNA. No translation available.
AK313021 mRNA. Translation: BAG35856.1.
AK316030 mRNA. Translation: BAH14401.1.
AC004417 Genomic DNA. Translation: AAC06177.1.
AC004593 Genomic DNA. No translation available.
AC005232 Genomic DNA. No translation available.
AC007096 Genomic DNA. No translation available.
AC007255 Genomic DNA. Translation: AAS07498.1.
CH236948 Genomic DNA. Translation: EAL24205.1.
CH471073 Genomic DNA. Translation: EAW93919.1.
BC112155 mRNA. Translation: AAI12156.1.
CCDSiCCDS47566.1. [P52757-3]
CCDS5420.1. [P52757-1]
CCDS78219.1. [P52757-5]
PIRiA53764.
RefSeqiNP_001035025.1. NM_001039936.2. [P52757-3]
NP_001279998.1. NM_001293069.1. [P52757-9]
NP_001279999.1. NM_001293070.1.
NP_001280000.1. NM_001293071.1.
NP_001280002.1. NM_001293073.1. [P52757-4]
NP_001280004.1. NM_001293075.1. [P52757-6]
NP_001280005.1. NM_001293076.1. [P52757-5]
NP_001280006.1. NM_001293077.1.
NP_001280007.1. NM_001293078.1.
NP_001280008.1. NM_001293079.1.
NP_001280009.1. NM_001293080.1. [P52757-7]
NP_004058.1. NM_004067.3. [P52757-1]
UniGeneiHs.654611.
Hs.710429.
Hs.734596.

Genome annotation databases

EnsembliENST00000222792; ENSP00000222792; ENSG00000106069. [P52757-1]
ENST00000412711; ENSP00000486515; ENSG00000106069. [P52757-3]
ENST00000421775; ENSP00000394284; ENSG00000106069. [P52757-5]
GeneIDi1124.
KEGGihsa:1124.
UCSCiuc003szz.4. human. [P52757-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29126 mRNA. Translation: AAA19191.1.
U07223 mRNA. Translation: AAA16836.1.
U28926 mRNA. Translation: AAA86528.1.
EU732752 mRNA. Translation: ACF04989.1.
EU732753 mRNA. Translation: ACF04990.1.
EU732754 mRNA. Translation: ACF04991.1.
EU732758 mRNA. Translation: ACF04995.1.
EU732762 mRNA. Translation: ACF04999.1.
GQ924106 mRNA. Translation: ADK47390.1.
AK026415 mRNA. No translation available.
AK313021 mRNA. Translation: BAG35856.1.
AK316030 mRNA. Translation: BAH14401.1.
AC004417 Genomic DNA. Translation: AAC06177.1.
AC004593 Genomic DNA. No translation available.
AC005232 Genomic DNA. No translation available.
AC007096 Genomic DNA. No translation available.
AC007255 Genomic DNA. Translation: AAS07498.1.
CH236948 Genomic DNA. Translation: EAL24205.1.
CH471073 Genomic DNA. Translation: EAW93919.1.
BC112155 mRNA. Translation: AAI12156.1.
CCDSiCCDS47566.1. [P52757-3]
CCDS5420.1. [P52757-1]
CCDS78219.1. [P52757-5]
PIRiA53764.
RefSeqiNP_001035025.1. NM_001039936.2. [P52757-3]
NP_001279998.1. NM_001293069.1. [P52757-9]
NP_001279999.1. NM_001293070.1.
NP_001280000.1. NM_001293071.1.
NP_001280002.1. NM_001293073.1. [P52757-4]
NP_001280004.1. NM_001293075.1. [P52757-6]
NP_001280005.1. NM_001293076.1. [P52757-5]
NP_001280006.1. NM_001293077.1.
NP_001280007.1. NM_001293078.1.
NP_001280008.1. NM_001293079.1.
NP_001280009.1. NM_001293080.1. [P52757-7]
NP_004058.1. NM_004067.3. [P52757-1]
UniGeneiHs.654611.
Hs.710429.
Hs.734596.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XA6X-ray3.20A7-468[»]
ProteinModelPortaliP52757.
SMRiP52757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107548. 9 interactors.
IntActiP52757. 10 interactors.
MINTiMINT-1420866.
STRINGi9606.ENSP00000222792.

Chemistry databases

BindingDBiP52757.
ChEMBLiCHEMBL4504.

PTM databases

iPTMnetiP52757.
PhosphoSitePlusiP52757.

Polymorphism and mutation databases

BioMutaiCHN2.
DMDMi2506455.

Proteomic databases

PaxDbiP52757.
PeptideAtlasiP52757.
PRIDEiP52757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222792; ENSP00000222792; ENSG00000106069. [P52757-1]
ENST00000412711; ENSP00000486515; ENSG00000106069. [P52757-3]
ENST00000421775; ENSP00000394284; ENSG00000106069. [P52757-5]
GeneIDi1124.
KEGGihsa:1124.
UCSCiuc003szz.4. human. [P52757-1]

Organism-specific databases

CTDi1124.
DisGeNETi1124.
GeneCardsiCHN2.
HGNCiHGNC:1944. CHN2.
HPAiHPA018989.
MIMi602857. gene.
neXtProtiNX_P52757.
OpenTargetsiENSG00000106069.
PharmGKBiPA26474.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
ENOG410YM3I. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000231926.
HOVERGENiHBG080489.
InParanoidiP52757.
KOiK20630.
OMAiIICPGEV.
OrthoDBiEOG091G0834.
PhylomeDBiP52757.
TreeFamiTF342052.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106069-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
SignaLinkiP52757.
SIGNORiP52757.

Miscellaneous databases

ChiTaRSiCHN2. human.
EvolutionaryTraceiP52757.
GeneWikiiChimerin_2.
GenomeRNAii1124.
PROiP52757.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106069.
CleanExiHS_CHN2.
ExpressionAtlasiP52757. baseline and differential.
GenevisibleiP52757. HS.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR017356. CHN1/CHN2.
IPR020454. DAG/PE-bd.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF038015. N-chimaerin. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIO_HUMAN
AccessioniPrimary (citable) accession number: P52757
Secondary accession number(s): A4D1A2
, B3VCF1, B3VCF2, B3VCF3, B3VCF7, B3VCG1, C9J7B0, E9PGE0, F8QPL9, Q2M203, Q75MM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 173 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.