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Protein

Hydrophobin-1

Gene

hfb1

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrophobin-1
Alternative name(s):
Hydrophobin I
Short name:
HFBI
Gene namesi
Name:hfb1
OrganismiHypocrea jecorina (Trichoderma reesei)
Taxonomic identifieri51453 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 226PRO_0000013519
Chaini23 – 9775Hydrophobin-1PRO_0000013520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 791 Publication
Disulfide bondi40 ↔ 701 Publication
Disulfide bondi41 ↔ 531 Publication
Disulfide bondi80 ↔ 911 Publication

Post-translational modificationi

Four disulfide bonds may be present.

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

Secondary structure

1
97
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 305Combined sources
Beta strandi37 – 459Combined sources
Turni46 – 483Combined sources
Beta strandi49 – 546Combined sources
Helixi63 – 719Combined sources
Turni72 – 743Combined sources
Beta strandi76 – 816Combined sources
Beta strandi86 – 905Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FZ6X-ray2.10A/B/C/D23-97[»]
2GVMX-ray2.30A/B/C/D23-97[»]
ProteinModelPortaliP52754.
SMRiP52754. Positions 24-95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52754.

Family & Domainsi

Sequence similaritiesi

Belongs to the cerato-ulmin hydrophobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J6WN. Eukaryota.
ENOG410ZA1T. LUCA.
OMAiKRICAES.

Family and domain databases

Gene3Di3.20.120.10. 1 hit.
InterProiIPR010636. Cerato-ulmin_hydrophobin.
[Graphical view]
PfamiPF06766. Hydrophobin_2. 1 hit.
[Graphical view]
SUPFAMiSSF101751. SSF101751. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFAIAALF AAAAVAQPLE DRSNGNGNVC PPGLFSNPQC CATQVLGLIG
60 70 80 90
LDCKVPSQNV YDGTDFRNVC AKTGAQPLCC VAPVAGQALL CQTAVGA
Length:97
Mass (Da):9,874
Last modified:October 1, 1996 - v1
Checksum:iF30907B331EC3175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68124 Genomic DNA. Translation: CAA92208.1.
PIRiS62621.
S62625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68124 Genomic DNA. Translation: CAA92208.1.
PIRiS62621.
S62625.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FZ6X-ray2.10A/B/C/D23-97[»]
2GVMX-ray2.30A/B/C/D23-97[»]
ProteinModelPortaliP52754.
SMRiP52754. Positions 24-95.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J6WN. Eukaryota.
ENOG410ZA1T. LUCA.
OMAiKRICAES.

Miscellaneous databases

EvolutionaryTraceiP52754.

Family and domain databases

Gene3Di3.20.120.10. 1 hit.
InterProiIPR010636. Cerato-ulmin_hydrophobin.
[Graphical view]
PfamiPF06766. Hydrophobin_2. 1 hit.
[Graphical view]
SUPFAMiSSF101751. SSF101751. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genetic and biochemical characterization of the Trichoderma reesei hydrophobin HFBI."
    Nakari-Setaelae T., Aro N., Kalkkinen N., Alatalo E., Penttilae M.
    Eur. J. Biochem. 235:248-255(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 68-97.
    Strain: ATCC 26921 / CBS 392.92 / QM9414.
  2. "Two crystal structures of Trichoderma reesei hydrophobin HFBI -- the structure of a protein amphiphile with and without detergent interaction."
    Hakanpaa J., Szilvay G.R., Kaljunen H., Maksimainen M., Linder M., Rouvinen J.
    Protein Sci. 15:2129-2140(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 23-97, DISULFIDE BONDS.

Entry informationi

Entry nameiHYP1_HYPJE
AccessioniPrimary (citable) accession number: P52754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.