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Protein

Zinc finger protein 143

Gene

ZNF143

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri267 – 291C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri327 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri357 – 381C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri387 – 411C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri417 – 440C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription from RNA polymerase III promoter Source: ProtInc
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • snRNA transcription from RNA polymerase II promoter Source: Reactome
  • transcription from RNA polymerase III promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166478-MONOMER.
ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 143
Alternative name(s):
SPH-binding factor
Selenocysteine tRNA gene transcription-activating factor
Short name:
hStaf
Gene namesi
Name:ZNF143
Synonyms:SBF, STAF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12928. ZNF143.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7702.
OpenTargetsiENSG00000166478.
PharmGKBiPA37515.

Polymorphism and mutation databases

BioMutaiZNF143.
DMDMi229462806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474261 – 638Zinc finger protein 143Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei352PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52747.
MaxQBiP52747.
PaxDbiP52747.
PeptideAtlasiP52747.
PRIDEiP52747.

PTM databases

iPTMnetiP52747.
PhosphoSitePlusiP52747.

Expressioni

Tissue specificityi

Expressed in all tissues tested, with the strongest expression in ovary.

Gene expression databases

BgeeiENSG00000166478.
CleanExiHS_ZNF143.
ExpressionAtlasiP52747. baseline and differential.
GenevisibleiP52747. HS.

Organism-specific databases

HPAiHPA003263.

Interactioni

Subunit structurei

Interacts with CHD8.1 Publication

Protein-protein interaction databases

BioGridi113496. 6 interactors.
IntActiP52747. 22 interactors.
STRINGi9606.ENSP00000379847.

Structurei

3D structure databases

ProteinModelPortaliP52747.
SMRiP52747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri267 – 291C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri327 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri357 – 381C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri387 – 411C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri417 – 440C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiP52747.
KOiK20828.
OMAiKMQIVLQ.
OrthoDBiEOG091G0N38.
PhylomeDBiP52747.
TreeFamiTF333498.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL
60 70 80 90 100
QAVTLADGST AYIQHNSKDA KLIDGQVIQL EDGSAAYVQH VPIPKSTGDS
110 120 130 140 150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS ALQAVQLEDG TTAYIHHAVQ
160 170 180 190 200
VPQSDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSESVA
210 220 230 240 250
GTGMIGENEQ EKKMQIVLQG HATRVTAKSQ QSGEKAFRCE YDGCGKLYTT
260 270 280 290 300
AHHLKVHERS HTGDRPYQCE HAGCGKAFAT GYGLKSHVRT HTGEKPYRCS
310 320 330 340 350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP FEGCGRSFTT SNIRKVHVRT
360 370 380 390 400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE
410 420 430 440 450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ
460 470 480 490 500
EAFFEPPPGQ GEDVLKGSQI TYVTGVEGDD VVSTQVATVT QSGLSQQVTL
510 520 530 540 550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPAHDA VISSAGTHSV
560 570 580 590 600
AMVTAEGTEG EQVAIVAQDL AAFHTASSEM GHQQHSHHLV TTETRPLTLV
610 620 630
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD
Length:638
Mass (Da):68,896
Last modified:May 5, 2009 - v2
Checksum:iD149030016A6058A
GO
Isoform 2 (identifier: P52747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-69: Missing.

Show »
Length:607
Mass (Da):65,636
Checksum:i285B599E182261D6
GO
Isoform 3 (identifier: P52747-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-98: TG → R

Note: No experimental confirmation available.
Show »
Length:637
Mass (Da):68,894
Checksum:iF393F46093039A3C
GO

Sequence cautioni

The sequence AAC50266 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH20219 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF83822 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433A → V in AAH20219 (PubMed:15489334).Curated1
Sequence conflicti443T → A in AK313330 (PubMed:14702039).Curated1
Sequence conflicti590Missing in BAG59697 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061937461G → D.Corresponds to variant rs34972213dbSNPEnsembl.1
Natural variantiVAR_027254561E → Q.3 PublicationsCorresponds to variant rs10743108dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03697839 – 69Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_05510997 – 98TG → R in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291133 mRNA. Translation: BAF83822.1. Different initiation.
AK297214 mRNA. Translation: BAG59697.1.
AK313330 mRNA. No translation available.
AC127030 Genomic DNA. No translation available.
AC132192 Genomic DNA. No translation available.
BC020219 mRNA. Translation: AAH20219.1. Different initiation.
U09850 mRNA. Translation: AAC50266.1. Different initiation.
AF071771 mRNA. Translation: AAC96102.1.
CCDSiCCDS60720.1. [P52747-3]
CCDS60721.1. [P52747-2]
CCDS7799.2. [P52747-1]
PIRiI38618.
RefSeqiNP_001269585.1. NM_001282656.1. [P52747-3]
NP_001269586.1. NM_001282657.1. [P52747-2]
NP_003433.3. NM_003442.5. [P52747-1]
XP_011518651.1. XM_011520349.2. [P52747-1]
XP_016873743.1. XM_017018254.1. [P52747-3]
XP_016873744.1. XM_017018255.1. [P52747-3]
UniGeneiHs.523471.

Genome annotation databases

EnsembliENST00000396597; ENSP00000379843; ENSG00000166478. [P52747-2]
ENST00000396602; ENSP00000379847; ENSG00000166478. [P52747-1]
ENST00000396604; ENSP00000379849; ENSG00000166478. [P52747-3]
ENST00000530463; ENSP00000432154; ENSG00000166478. [P52747-3]
GeneIDi7702.
KEGGihsa:7702.
UCSCiuc001mhr.3. human. [P52747-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291133 mRNA. Translation: BAF83822.1. Different initiation.
AK297214 mRNA. Translation: BAG59697.1.
AK313330 mRNA. No translation available.
AC127030 Genomic DNA. No translation available.
AC132192 Genomic DNA. No translation available.
BC020219 mRNA. Translation: AAH20219.1. Different initiation.
U09850 mRNA. Translation: AAC50266.1. Different initiation.
AF071771 mRNA. Translation: AAC96102.1.
CCDSiCCDS60720.1. [P52747-3]
CCDS60721.1. [P52747-2]
CCDS7799.2. [P52747-1]
PIRiI38618.
RefSeqiNP_001269585.1. NM_001282656.1. [P52747-3]
NP_001269586.1. NM_001282657.1. [P52747-2]
NP_003433.3. NM_003442.5. [P52747-1]
XP_011518651.1. XM_011520349.2. [P52747-1]
XP_016873743.1. XM_017018254.1. [P52747-3]
XP_016873744.1. XM_017018255.1. [P52747-3]
UniGeneiHs.523471.

3D structure databases

ProteinModelPortaliP52747.
SMRiP52747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113496. 6 interactors.
IntActiP52747. 22 interactors.
STRINGi9606.ENSP00000379847.

PTM databases

iPTMnetiP52747.
PhosphoSitePlusiP52747.

Polymorphism and mutation databases

BioMutaiZNF143.
DMDMi229462806.

Proteomic databases

EPDiP52747.
MaxQBiP52747.
PaxDbiP52747.
PeptideAtlasiP52747.
PRIDEiP52747.

Protocols and materials databases

DNASUi7702.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396597; ENSP00000379843; ENSG00000166478. [P52747-2]
ENST00000396602; ENSP00000379847; ENSG00000166478. [P52747-1]
ENST00000396604; ENSP00000379849; ENSG00000166478. [P52747-3]
ENST00000530463; ENSP00000432154; ENSG00000166478. [P52747-3]
GeneIDi7702.
KEGGihsa:7702.
UCSCiuc001mhr.3. human. [P52747-1]

Organism-specific databases

CTDi7702.
DisGeNETi7702.
GeneCardsiZNF143.
HGNCiHGNC:12928. ZNF143.
HPAiHPA003263.
MIMi603433. gene.
neXtProtiNX_P52747.
OpenTargetsiENSG00000166478.
PharmGKBiPA37515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000118073.
HOVERGENiHBG053078.
InParanoidiP52747.
KOiK20828.
OMAiKMQIVLQ.
OrthoDBiEOG091G0N38.
PhylomeDBiP52747.
TreeFamiTF333498.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166478-MONOMER.
ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiZNF143. human.
GeneWikiiZNF143.
GenomeRNAii7702.
PROiP52747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166478.
CleanExiHS_ZNF143.
ExpressionAtlasiP52747. baseline and differential.
GenevisibleiP52747. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN143_HUMAN
AccessioniPrimary (citable) accession number: P52747
Secondary accession number(s): A8K518
, B4DLY5, E7ER34, O75559, Q8WUK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.