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Protein

Zinc finger protein 142

Gene

ZNF142

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 18523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 24224C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 31126C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 34025C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36624C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39524C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53625C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56724C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri573 – 59624C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1135 – 115824C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1171 – 119424C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1200 – 122223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1228 – 125124C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1257 – 128024C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1286 – 130924C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1328 – 135124C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1354 – 137724C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1380 – 140324C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1424 – 144623C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1452 – 147423C2H2-type 25PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1480 – 150223C2H2-type 26PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1508 – 153023C2H2-type 27PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1536 – 155924C2H2-type 28PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1565 – 158723C2H2-type 29PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1593 – 161523C2H2-type 30PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1621 – 164323C2H2-type 31PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 142
Alternative name(s):
HA4654
Gene namesi
Name:ZNF142
Synonyms:KIAA0236
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12927. ZNF142.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37514.

Polymorphism and mutation databases

DMDMi313104298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16871687Zinc finger protein 142PRO_0000047425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei154 – 1541PhosphoserineCombined sources
Cross-linki594 – 594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP52746.
PaxDbiP52746.
PeptideAtlasiP52746.
PRIDEiP52746.

PTM databases

iPTMnetiP52746.
PhosphoSiteiP52746.

Expressioni

Gene expression databases

BgeeiENSG00000115568.
CleanExiHS_ZNF142.
ExpressionAtlasiP52746. baseline and differential.
GenevisibleiP52746. HS.

Organism-specific databases

HPAiHPA049594.

Interactioni

Protein-protein interaction databases

BioGridi113495. 8 interactions.
IntActiP52746. 2 interactions.
STRINGi9606.ENSP00000398798.

Structurei

3D structure databases

ProteinModelPortaliP52746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 31 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 18523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 24224C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 31126C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 34025C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36624C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39524C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53625C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56724C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri573 – 59624C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1135 – 115824C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1171 – 119424C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1200 – 122223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1228 – 125124C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1257 – 128024C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1286 – 130924C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1328 – 135124C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1354 – 137724C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1380 – 140324C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1424 – 144623C2H2-type 24PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1452 – 147423C2H2-type 25PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1480 – 150223C2H2-type 26PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1508 – 153023C2H2-type 27PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1536 – 155924C2H2-type 28PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1565 – 158723C2H2-type 29PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1593 – 161523C2H2-type 30PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1621 – 164323C2H2-type 31PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125424.
HOGENOMiHOG000015350.
HOVERGENiHBG074178.
InParanoidiP52746.
OMAiCPFSCQQ.
OrthoDBiEOG091G008L.
PhylomeDBiP52746.
TreeFamiTF327469.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 36 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDPLLDSQP ASSTGEMDGL CPELLLIPPP LSNRGILGPV QSPCPSRDPA
60 70 80 90 100
PIPTEPGCLL VEATATEEGP GNMEIIVETV AGTLTPGAPG ETPAPKLPPG
110 120 130 140 150
EREPSQEAGT PLPGQETAEE ENVEKEEKSD TQKDSQKAVD KGQGAQRLEG
160 170 180 190 200
DVVSGTESLF KTHMCPECKR CFKKRTHLVE HLHLHFPDPS LQCPNCQKFF
210 220 230 240 250
TSKSKLKTHL LRELGEKAHH CPLCHYSAVE RNALNRHMAS MHEDISNFYS
260 270 280 290 300
DTYACPVCRE EFRLSQALKE HLKSHTAAAA AEPLPLRCFQ EGCSYAAPDR
310 320 330 340 350
KAFIKHLKET HGVRAVECRH HSCPMLFATA EAMEAHHKSH YAFHCPHCDF
360 370 380 390 400
ACSNKHLFRK HKKQGHPGSE ELRCTFCPFA TFNPVAYQDH VGKMHAHEKI
410 420 430 440 450
HQCPECNFAT AHKRVLIRHM LLHTGEKPHK CELCDFTCRD VSYLSKHMLT
460 470 480 490 500
HSNTKDYMCT ECGYVTKWKH YLRVHMRKHA GDLRYQCNQC SYRCHRADQL
510 520 530 540 550
SSHKLRHQGK SLMCEVCAFA CKRKYELQKH MASQHHPGTP APLYPCHYCS
560 570 580 590 600
YQSRHKQAVL SHENCKHTRL REFHCALCDY RTFSNTTLLF HKRKAHGYVP
610 620 630 640 650
GDQAWQLRYA SQEPEGAMQG PTPPPDSEPS NQLSARPEGP GHEPGTVVDP
660 670 680 690 700
SLDQALPEMS EEVNTGRQEG SEAPHGGDLG GSPSPAEVEE GSCTLHLEAL
710 720 730 740 750
GVELESVTEP PLEEVTETAP MEFRPLGLEG PDGLEGPELS SFEGIGTSDL
760 770 780 790 800
SAEENPLLEK PVSEPSTNPP SLEEAPNNWV GTFKTTPPAE TAPLPPLPES
810 820 830 840 850
ESLLKALRRQ DKEQAEALVL EGRVQMVVIQ GEGRAFRCPH CPFITRREKA
860 870 880 890 900
LNLHSRTGCQ GRREPLLCPE CGASFKQQRG LSTHLLKKCP VLLRKNKGLP
910 920 930 940 950
RPDSPIPLQP VLPGTQASED TESGKPPPAS QEAELLLPKD APLELPREPE
960 970 980 990 1000
ETEEPLATVS GSPVPPAGNS LPTEAPKKHC FDPVPPAGNS SPTEAPKKHH
1010 1020 1030 1040 1050
LDPVPPAGNS SPTEALKKHR FEQGKFHCNS CPFLCSRLSS ITSHVAEGCR
1060 1070 1080 1090 1100
GGRGGGGKRG TPQTQPDVSP LSNGDSAPPK NGSTESSSGD GDTVLVQKQK
1110 1120 1130 1140 1150
GARFSCPTCP FSCQQERALR THQIRGCPLE ESGELHCSLC PFTAPAATAL
1160 1170 1180 1190 1200
RLHQKRRHPT AAPARGPRPH LQCGDCGFTC KQSRCMQQHR RLKHEGVKPH
1210 1220 1230 1240 1250
QCPFCDFSTT RRYRLEAHQS RHTGIGRIPC SSCPQTFGTN SKLRLHRLRV
1260 1270 1280 1290 1300
HDKTPTHFCP LCDYSGYLRH DITRHVNSCH QGTPAFACSQ CEAQFSSETA
1310 1320 1330 1340 1350
LKQHALRRHP EPAQPAPGSP AETTEGPLHC SRCGLLCPSP ASLRGHTRKQ
1360 1370 1380 1390 1400
HPRLECGACQ EAFPSRLALD EHRRQQHFSH RCQLCDFAAR ERVGLVKHYL
1410 1420 1430 1440 1450
EQHEETSAAV AASDGDGDAG QPPLHCPFCD FTCRHQLVLD HHVKGHGGTR
1460 1470 1480 1490 1500
LYKCTDCAYS TKNRQKITWH SRIHTGEKPY HCHLCPYACA DPSRLKYHMR
1510 1520 1530 1540 1550
IHKEERKYLC PECGYKCKWV NQLKYHMTKH TGLKPYQCPE CEYCTNRADA
1560 1570 1580 1590 1600
LRVHQETRHR EARAFMCEQC GKAFKTRFLL RTHLRKHSEA KPYVCNVCHR
1610 1620 1630 1640 1650
AFRWAAGLRH HALTHTDRHP FFCRLCNYKA KQKFQVVKHV RRHHPDQADP
1660 1670 1680
NQGVGKDPTT PTVHLHDVQL EDPSPPAPAA PHTGPEG
Length:1,687
Mass (Da):187,880
Last modified:November 30, 2010 - v4
Checksum:i91143EAF2481B6B3
GO

Sequence cautioni

The sequence BAA13242 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti460 – 4634TECG → LKGS in AAC50265 (PubMed:15815621).Curated
Sequence conflicti541 – 5411A → S in BAA13242 (PubMed:9039502).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti751 – 7511S → G.1 Publication
Corresponds to variant rs3770214 [ dbSNP | Ensembl ].
VAR_047230
Natural varianti956 – 9561L → H.
Corresponds to variant rs3770213 [ dbSNP | Ensembl ].
VAR_047231
Natural varianti1313 – 13131A → T.
Corresponds to variant rs3821033 [ dbSNP | Ensembl ].
VAR_047232

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87073 mRNA. Translation: BAA13242.2. Different initiation.
AC012510 Genomic DNA. No translation available.
U09849 mRNA. Translation: AAC50265.1.
CCDSiCCDS42817.1.
PIRiI38617.
RefSeqiNP_001099007.1. NM_001105537.2.
XP_011510091.1. XM_011511789.2.
UniGeneiHs.657969.

Genome annotation databases

EnsembliENST00000411696; ENSP00000398798; ENSG00000115568.
ENST00000449707; ENSP00000408643; ENSG00000115568.
GeneIDi7701.
KEGGihsa:7701.
UCSCiuc002vin.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87073 mRNA. Translation: BAA13242.2. Different initiation.
AC012510 Genomic DNA. No translation available.
U09849 mRNA. Translation: AAC50265.1.
CCDSiCCDS42817.1.
PIRiI38617.
RefSeqiNP_001099007.1. NM_001105537.2.
XP_011510091.1. XM_011511789.2.
UniGeneiHs.657969.

3D structure databases

ProteinModelPortaliP52746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113495. 8 interactions.
IntActiP52746. 2 interactions.
STRINGi9606.ENSP00000398798.

PTM databases

iPTMnetiP52746.
PhosphoSiteiP52746.

Polymorphism and mutation databases

DMDMi313104298.

Proteomic databases

MaxQBiP52746.
PaxDbiP52746.
PeptideAtlasiP52746.
PRIDEiP52746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411696; ENSP00000398798; ENSG00000115568.
ENST00000449707; ENSP00000408643; ENSG00000115568.
GeneIDi7701.
KEGGihsa:7701.
UCSCiuc002vin.6. human.

Organism-specific databases

CTDi7701.
GeneCardsiZNF142.
HGNCiHGNC:12927. ZNF142.
HPAiHPA049594.
MIMi604083. gene.
neXtProtiNX_P52746.
PharmGKBiPA37514.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125424.
HOGENOMiHOG000015350.
HOVERGENiHBG074178.
InParanoidiP52746.
OMAiCPFSCQQ.
OrthoDBiEOG091G008L.
PhylomeDBiP52746.
TreeFamiTF327469.

Miscellaneous databases

ChiTaRSiZNF142. human.
GenomeRNAii7701.
PROiP52746.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115568.
CleanExiHS_ZNF142.
ExpressionAtlasiP52746. baseline and differential.
GenevisibleiP52746. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 36 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN142_HUMAN
AccessioniPrimary (citable) accession number: P52746
Secondary accession number(s): Q92510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: September 7, 2016
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.