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Protein

Zinc finger protein 138

Gene

ZNF138

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 262C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 138
Gene namesi
Name:ZNF138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197008.9
HGNCiHGNC:12922 ZNF138
MIMi604080 gene
neXtProtiNX_P52744

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7697
OpenTargetsiENSG00000197008
PharmGKBiPA37510

Polymorphism and mutation databases

DMDMi152031767

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474221 – 262Zinc finger protein 138Add BLAST262

Proteomic databases

PaxDbiP52744
PeptideAtlasiP52744
PRIDEiP52744

PTM databases

iPTMnetiP52744
PhosphoSitePlusiP52744

Expressioni

Gene expression databases

BgeeiENSG00000197008
CleanExiHS_ZNF138
ExpressionAtlasiP52744 baseline and differential

Organism-specific databases

HPAiHPA077435

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1134928 interactors.
IntActiP52744 11 interactors.
STRINGi9606.ENSP00000407262

Structurei

3D structure databases

ProteinModelPortaliP52744
SMRiP52744
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 262C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST13

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP52744
PhylomeDBiP52744
TreeFamiTF342117

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52744-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL
60 70 80 90 100
RKGCKSVDEC KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH
110 120 130 140 150
KIRHTENKHF RCKECDKSLC MLSRLTQHKK IHTRENFYKC EECGKTFNWS
160 170 180 190 200
TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI LTKHKIIRTG EKPYKCAHCG
210 220 230 240 250
KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH QIIYTGEEPY
260
KCEECGKAFN LS
Length:262
Mass (Da):30,592
Last modified:July 10, 2007 - v2
Checksum:iD2B463F0E584ACE6
GO
Isoform 2 (identifier: P52744-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKRHEMVVAKHS → MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLENYRNLVFL

Note: No experimental confirmation available.Curated
Show »
Length:293
Mass (Da):34,333
Checksum:i75A81E4094BBDD30
GO
Isoform 3 (identifier: P52744-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKRHEMVVAKHS → MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLENYRNLVFL
     13-95: ALCSRFAQDL...KYVKVMHKFS → DLITCLEQGK...CVLVLPKTFG
     96-262: Missing.

Show »
Length:126
Mass (Da):14,597
Checksum:i0E5685E757EEEBBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 23LW → KG in AAC50263 (PubMed:7557990).Curated2
Sequence conflicti67F → Y in AK055644 (PubMed:14702039).Curated1
Sequence conflicti67F → Y in BAG60499 (PubMed:14702039).Curated1
Sequence conflicti67F → Y in AAC50263 (PubMed:7557990).Curated1
Isoform 2 (identifier: P52744-2)
Sequence conflicti33M → V in BAG60499 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05739862G → E2 PublicationsCorresponds to variant dbSNP:rs10949946Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449211 – 12MKRHE…VAKHS → MGPLTFMDVAIEFSLEEWQC LDTAQRNVYRHVMLENYRNL VFL in isoform 2 and isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_04744613 – 95ALCSR…MHKFS → DLITCLEQGKEPWNMKRHEM VVAKHSAVAFTYDLSGLNIL SFQSILPFVSALYVMGNRNQ CLQKHLEARNKDLCVLVLPK TFG in isoform 3. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_04744796 – 262Missing in isoform 3. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055644 mRNA No translation available.
AK294302 mRNA Translation: BAG57583.1
AK298230 mRNA Translation: BAG60499.1
AC073349 Genomic DNA No translation available.
U09847 mRNA Translation: AAC50263.1
CCDSiCCDS34645.2 [P52744-2]
CCDS55115.1 [P52744-3]
PIRiI38615
RefSeqiNP_001153655.1, NM_001160183.2
NP_001258566.1, NM_001271637.1
NP_006515.2, NM_006524.3
UniGeneiHs.184080

Genome annotation databases

EnsembliENST00000440155; ENSP00000407262; ENSG00000197008 [P52744-2]
GeneIDi7697
KEGGihsa:7697
UCSCiuc011kdq.4 human [P52744-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN138_HUMAN
AccessioniPrimary (citable) accession number: P52744
Secondary accession number(s): B4DFX2
, B4DP87, E9PHI7, E9PHK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome