P52744 (ZN138_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 138

Gene names

Name:

ZNF138

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation as a repressor.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement Ref.3. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.3. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P52744-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P52744-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKRHEMVVAKHS → MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLENYRNLVFL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Zinc finger protein 138		PRO_0000047422
Regions
	Zinc finger	110 – 132	23	C2H2-type 1
	Zinc finger	138 – 160	23	C2H2-type 2; degenerate
	Zinc finger	166 – 188	23	C2H2-type 3; degenerate
	Zinc finger	194 – 216	23	C2H2-type 4
	Zinc finger	222 – 244	23	C2H2-type 5; degenerate
	Zinc finger	250 – 262	13	C2H2-type 6; degenerate
Natural variations
	Alternative sequence	1 – 12	12	MKRHE…VAKHS → MGPLTFMDVAIEFSLEEWQC LDTAQRNVYRHVMLENYRNL VFL in isoform 2.		VSP_044921
	Natural variant	62	1	G → E. Ref.1 Ref.3 Corresponds to variant rs10949946 [ dbSNP | Ensembl ].		VAR_057398
Experimental info
	Sequence conflict	22 – 23	2	LW → KG in AAC50263. Ref.3
	Sequence conflict	67	1	F → Y in AK055644. Ref.1
	Sequence conflict	67	1	F → Y in BAG60499. Ref.1
	Sequence conflict	67	1	F → Y in AAC50263. Ref.3
Isoform 2:
	Sequence conflict	33	1	M → V in BAG60499. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: D2B463F0E584ACE6	FASTA	262	30,592
	10 20 30 40 50 60 MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL RKGCKSVDEC 70 80 90 100 110 120 KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH KIRHTENKHF RCKECDKSLC 130 140 150 160 170 180 MLSRLTQHKK IHTRENFYKC EECGKTFNWS TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI 190 200 210 220 230 240 LTKHKIIRTG EKPYKCAHCG KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH 250 260 QIIYTGEEPY KCEECGKAFN LS
	Isoform 2 [UniParc]. Checksum: 75A81E4094BBDD30	FASTA	293	34,333
	10 20 30 40 50 60 MGPLTFMDVA IEFSLEEWQC LDTAQRNVYR HVMLENYRNL VFLALCSRFA QDLWLEQNIK 70 80 90 100 110 120 DSFQKVTLSR YGKYGHKNLQ LRKGCKSVDE CKGHQGGFNG LNQCLKITTS KIFQCNKYVK 130 140 150 160 170 180 VMHKFSNSNR HKIRHTENKH FRCKECDKSL CMLSRLTQHK KIHTRENFYK CEECGKTFNW 190 200 210 220 230 240 STNLSKPKKI HTGEKPYKCE VCGKAFHQSS ILTKHKIIRT GEKPYKCAHC GKAFKQSSHL 250 260 270 280 290 TRHKIIHTEE KPYKCEQCGK VFKQSPTLTK HQIIYTGEEP YKCEECGKAF NLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLU-62.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders." Tommerup N., Vissing H. Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-260 (ISOFORM 1), VARIANT GLU-62. Tissue: Insulinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055644 mRNA. No translation available. AK298230 mRNA. Translation: BAG60499.1. AC073349 Genomic DNA. No translation available. U09847 mRNA. Translation: AAC50263.1.
IPI	IPI00377099. IPI00926871.
PIR	I38615.
RefSeq	NP_001153655.1. NM_001160183.2. NP_001258566.1. NM_001271637.1. NP_006515.2. NM_006524.3.
UniGene	Hs.184080.
3D structure databases
ProteinModelPortal	P52744.
ModBase	Search...
PTM databases
PhosphoSite	P52744.
Polymorphism databases
DMDM	152031767.
Proteomic databases
PaxDb	P52744.
PRIDE	P52744.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359735; ENSP00000352770; ENSG00000197008. ENST00000397136; ENSP00000380325; ENSG00000197008. ENST00000440155; ENSP00000407262; ENSG00000197008.
GeneID	7697.
KEGG	hsa:7697.
UCSC	uc003ttg.3. human.
Organism-specific databases
GeneCards	GC07P064254.
HGNC	HGNC:12922. ZNF138.
MIM	604080. gene.
neXtProt	NX_P52744.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P52744.
PhylomeDB	P52744.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P52744.
Bgee	P52744.
CleanEx	HS_ZNF138.
Genevestigator	P52744.
GermOnline	ENSG00000197008. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 6 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	29838.
SOURCE	Search...

Entry information

Entry name

ZN138_HUMAN

Accession

Primary (citable) accession number: P52744
Secondary accession number(s): B4DP87, E9PHI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.