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Protein

Zinc finger protein 138

Gene

ZNF138

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 262C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169938-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 138
Gene namesi
Name:ZNF138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12922. ZNF138.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7697.
OpenTargetsiENSG00000197008.
PharmGKBiPA37510.

Polymorphism and mutation databases

DMDMi152031767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474221 – 262Zinc finger protein 138Add BLAST262

Proteomic databases

PaxDbiP52744.
PeptideAtlasiP52744.
PRIDEiP52744.

PTM databases

iPTMnetiP52744.
PhosphoSitePlusiP52744.

Expressioni

Gene expression databases

BgeeiENSG00000197008.
CleanExiHS_ZNF138.
ExpressionAtlasiP52744. baseline and differential.

Organism-specific databases

HPAiCAB019323.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DHPSP493663EBI-10213071,EBI-741925
KRT40Q6A1623EBI-10213071,EBI-10171697
KRTAP10-8P604103EBI-10213071,EBI-10171774
MDFIQ997503EBI-10213071,EBI-724076
TRIM41Q8WV443EBI-10213071,EBI-725997
ZBTB8AQ96BR93EBI-10213071,EBI-742740

Protein-protein interaction databases

BioGridi113492. 7 interactors.
IntActiP52744. 6 interactors.
STRINGi9606.ENSP00000407262.

Structurei

3D structure databases

ProteinModelPortaliP52744.
SMRiP52744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 262C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST13

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52744.
PhylomeDBiP52744.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52744-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL
60 70 80 90 100
RKGCKSVDEC KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH
110 120 130 140 150
KIRHTENKHF RCKECDKSLC MLSRLTQHKK IHTRENFYKC EECGKTFNWS
160 170 180 190 200
TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI LTKHKIIRTG EKPYKCAHCG
210 220 230 240 250
KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH QIIYTGEEPY
260
KCEECGKAFN LS
Length:262
Mass (Da):30,592
Last modified:July 10, 2007 - v2
Checksum:iD2B463F0E584ACE6
GO
Isoform 2 (identifier: P52744-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKRHEMVVAKHS → MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLENYRNLVFL

Note: No experimental confirmation available.Curated
Show »
Length:293
Mass (Da):34,333
Checksum:i75A81E4094BBDD30
GO
Isoform 3 (identifier: P52744-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKRHEMVVAKHS → MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLENYRNLVFL
     13-95: ALCSRFAQDL...KYVKVMHKFS → DLITCLEQGK...CVLVLPKTFG
     96-262: Missing.

Show »
Length:126
Mass (Da):14,597
Checksum:i0E5685E757EEEBBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 23LW → KG in AAC50263 (PubMed:7557990).Curated2
Sequence conflicti67F → Y in AK055644 (PubMed:14702039).Curated1
Sequence conflicti67F → Y in BAG60499 (PubMed:14702039).Curated1
Sequence conflicti67F → Y in AAC50263 (PubMed:7557990).Curated1
Isoform 2 (identifier: P52744-2)
Sequence conflicti33M → V in BAG60499 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05739862G → E.2 PublicationsCorresponds to variant rs10949946dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449211 – 12MKRHE…VAKHS → MGPLTFMDVAIEFSLEEWQC LDTAQRNVYRHVMLENYRNL VFL in isoform 2 and isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_04744613 – 95ALCSR…MHKFS → DLITCLEQGKEPWNMKRHEM VVAKHSAVAFTYDLSGLNIL SFQSILPFVSALYVMGNRNQ CLQKHLEARNKDLCVLVLPK TFG in isoform 3. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_04744796 – 262Missing in isoform 3. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055644 mRNA. No translation available.
AK294302 mRNA. Translation: BAG57583.1.
AK298230 mRNA. Translation: BAG60499.1.
AC073349 Genomic DNA. No translation available.
U09847 mRNA. Translation: AAC50263.1.
CCDSiCCDS34645.2. [P52744-2]
CCDS55115.1. [P52744-3]
PIRiI38615.
RefSeqiNP_001153655.1. NM_001160183.2.
NP_001258566.1. NM_001271637.1.
NP_006515.2. NM_006524.3.
UniGeneiHs.184080.

Genome annotation databases

EnsembliENST00000440155; ENSP00000407262; ENSG00000197008. [P52744-2]
GeneIDi7697.
KEGGihsa:7697.
UCSCiuc011kdq.4. human. [P52744-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055644 mRNA. No translation available.
AK294302 mRNA. Translation: BAG57583.1.
AK298230 mRNA. Translation: BAG60499.1.
AC073349 Genomic DNA. No translation available.
U09847 mRNA. Translation: AAC50263.1.
CCDSiCCDS34645.2. [P52744-2]
CCDS55115.1. [P52744-3]
PIRiI38615.
RefSeqiNP_001153655.1. NM_001160183.2.
NP_001258566.1. NM_001271637.1.
NP_006515.2. NM_006524.3.
UniGeneiHs.184080.

3D structure databases

ProteinModelPortaliP52744.
SMRiP52744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113492. 7 interactors.
IntActiP52744. 6 interactors.
STRINGi9606.ENSP00000407262.

PTM databases

iPTMnetiP52744.
PhosphoSitePlusiP52744.

Polymorphism and mutation databases

DMDMi152031767.

Proteomic databases

PaxDbiP52744.
PeptideAtlasiP52744.
PRIDEiP52744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000440155; ENSP00000407262; ENSG00000197008. [P52744-2]
GeneIDi7697.
KEGGihsa:7697.
UCSCiuc011kdq.4. human. [P52744-1]

Organism-specific databases

CTDi7697.
DisGeNETi7697.
GeneCardsiZNF138.
HGNCiHGNC:12922. ZNF138.
HPAiCAB019323.
MIMi604080. gene.
neXtProtiNX_P52744.
OpenTargetsiENSG00000197008.
PharmGKBiPA37510.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52744.
PhylomeDBiP52744.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169938-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7697.
PROiP52744.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197008.
CleanExiHS_ZNF138.
ExpressionAtlasiP52744. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN138_HUMAN
AccessioniPrimary (citable) accession number: P52744
Secondary accession number(s): B4DFX2
, B4DP87, E9PHI7, E9PHK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.