ID   ZN137_HUMAN             Reviewed;         207 AA.
AC   P52743; Q2TBC7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 149.
DE   RecName: Full=Putative zinc finger protein 137;
DE   AltName: Full=Zinc finger protein 137 pseudogene;
GN   Name=ZNF137P; Synonyms=ZNF137;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Insulinoma;
RX   PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA   Tommerup N., Vissing H.;
RT   "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT   identify putative candidate genes for developmental and malignant
RT   disorders.";
RL   Genomics 27:259-264(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious CDS prediction. May be produced at very
CC       low levels due to a premature stop codon in the mRNA, leading to
CC       nonsense-mediated mRNA decay. {ECO:0000305}.
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DR   EMBL; U09414; AAC50255.1; -; mRNA.
DR   EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC110456; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; I38602; I38602.
DR   AlphaFoldDB; P52743; -.
DR   SMR; P52743; -.
DR   iPTMnet; P52743; -.
DR   PhosphoSitePlus; P52743; -.
DR   BioMuta; HGNC:12921; -.
DR   DMDM; 1731413; -.
DR   jPOST; P52743; -.
DR   MassIVE; P52743; -.
DR   MaxQB; P52743; -.
DR   PeptideAtlas; P52743; -.
DR   ProteomicsDB; 56519; -.
DR   AGR; HGNC:12921; -.
DR   GeneCards; ZNF137P; -.
DR   HGNC; HGNC:12921; ZNF137P.
DR   MIM; 604079; gene.
DR   neXtProt; NX_P52743; -.
DR   InParanoid; P52743; -.
DR   PhylomeDB; P52743; -.
DR   PathwayCommons; P52743; -.
DR   Pharos; P52743; Tdark.
DR   PRO; PR:P52743; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P52743; Protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24399:SF69; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR   PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   5: Uncertain;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..207
FT                   /note="Putative zinc finger protein 137"
FT                   /id="PRO_0000047421"
FT   ZN_FING         72..94
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         100..122
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         128..150
FT                   /note="C2H2-type 3; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         156..178
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         184..206
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         112
FT                   /note="R -> Q (in dbSNP:rs7250969)"
FT                   /id="VAR_033556"
FT   VARIANT         181
FT                   /note="Q -> H (in dbSNP:rs1802617)"
FT                   /id="VAR_012025"
SQ   SEQUENCE   207 AA;  24115 MW;  44581FE39D47AA7A CRC64;
     MNVARFLVEK HTLHVIIDFI LSKVSNQQSN LAQHQRVYTG EKPYKCNEWG KALSGKSSLF
     YHQAIHGVGK LCKCNDCHKV FSNATTIANH WRIHNEDRSY KCNKCGKIFR HRSYLAVYQR
     THTGEKPYKY HDCGKVFSQA SSYAKHRRIH TGEKPHKCDD CGKVLTSRSH LIRHQRIHTG
     QKSYKCLKCG KVFSLWALHA EHQKIHF
//