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Protein

Putative zinc finger protein 137

Gene

ZNF137P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 9423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 137
Alternative name(s):
Zinc finger protein 137 pseudogene
Gene namesi
Name:ZNF137P
Synonyms:ZNF137
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:12921. ZNF137P.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Putative zinc finger protein 137PRO_0000047421Add
BLAST

Proteomic databases

PaxDbiP52743.
PRIDEiP52743.

PTM databases

PhosphoSiteiP52743.

Expressioni

Gene expression databases

GenevestigatoriP52743.

Structurei

3D structure databases

ProteinModelPortaliP52743.
SMRiP52743. Positions 23-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 9423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12223C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiP52743.
PhylomeDBiP52743.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52743-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVARFLVEK HTLHVIIDFI LSKVSNQQSN LAQHQRVYTG EKPYKCNEWG
60 70 80 90 100
KALSGKSSLF YHQAIHGVGK LCKCNDCHKV FSNATTIANH WRIHNEDRSY
110 120 130 140 150
KCNKCGKIFR HRSYLAVYQR THTGEKPYKY HDCGKVFSQA SSYAKHRRIH
160 170 180 190 200
TGEKPHKCDD CGKVLTSRSH LIRHQRIHTG QKSYKCLKCG KVFSLWALHA

EHQKIHF
Length:207
Mass (Da):24,115
Last modified:October 1, 1996 - v1
Checksum:i44581FE39D47AA7A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121R → Q.
Corresponds to variant rs7250969 [ dbSNP | Ensembl ].
VAR_033556
Natural varianti181 – 1811Q → H.
Corresponds to variant rs1802617 [ dbSNP | Ensembl ].
VAR_012025

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09414 mRNA. Translation: AAC50255.1.
AC022150 Genomic DNA. No translation available.
BC110456 mRNA. No translation available.
PIRiI38602.
UniGeneiHs.373648.

Polymorphism databases

DMDMi1731413.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09414 mRNA. Translation: AAC50255.1.
AC022150 Genomic DNA. No translation available.
BC110456 mRNA. No translation available.
PIRiI38602.
UniGeneiHs.373648.

3D structure databases

ProteinModelPortaliP52743.
SMRiP52743. Positions 23-206.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP52743.

Polymorphism databases

DMDMi1731413.

Proteomic databases

PaxDbiP52743.
PRIDEiP52743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC19P053099.
HGNCiHGNC:12921. ZNF137P.
MIMi604079. gene.
neXtProtiNX_P52743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiP52743.
PhylomeDBiP52743.

Miscellaneous databases

PROiP52743.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP52743.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZN137_HUMAN
AccessioniPrimary (citable) accession number: P52743
Secondary accession number(s): Q2TBC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious CDS prediction. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.