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Protein

Zinc finger protein 135

Gene

ZNF135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.1 Publication

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cytoskeleton organization Source: UniProtKB
  • regulation of cell morphogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 135
Alternative name(s):
Zinc finger protein 61
Zinc finger protein 78-like 1
Gene namesi
Name:ZNF135
Synonyms:ZNF61, ZNF78L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000176293.19
HGNCiHGNC:12919 ZNF135
MIMi604077 gene
neXtProtiNX_P52742

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176293
PharmGKBiPA37507

Polymorphism and mutation databases

BioMutaiZNF135
DMDMi296453071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474191 – 658Zinc finger protein 135Add BLAST658

Proteomic databases

EPDiP52742
PaxDbiP52742
PeptideAtlasiP52742
PRIDEiP52742

PTM databases

iPTMnetiP52742
PhosphoSitePlusiP52742

Expressioni

Gene expression databases

BgeeiENSG00000176293
CleanExiHS_ZNF135
ExpressionAtlasiP52742 baseline and differential
GenevisibleiP52742 HS

Organism-specific databases

HPAiHPA006961

Interactioni

Protein-protein interaction databases

BioGridi1134896 interactors.
IntActiP52742 11 interactors.
MINTiP52742
STRINGi9606.ENSP00000441410

Structurei

3D structure databases

ProteinModelPortaliP52742
SMRiP52742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144021
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP52742
KOiK09228
OMAiQWQRNGF
OrthoDBiEOG091G02KC
PhylomeDBiP52742
TreeFamiTF350822

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52742-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPGVRVSTD PEQVTFEDVV VGFSQEEWGQ LKPAQRTLYR DVMLDTFRLL
60 70 80 90 100
VSVGHWLPKP NVISLLEQEA ELWAVESRLP QGVYPDLETR PKVKLSVLKQ
110 120 130 140 150
GISEEISNSV ILVERFLWDG LWYCRGEDTE GHWEWSCESL ESLAVPVAFT
160 170 180 190 200
PVKTPVLEQW QRNGFGENIS LNPDLPHQPM TPERQSPHTW GTRGKREKPD
210 220 230 240 250
LNVLQKTCVK EKPYKCQECG KAFSHSSALI EHHRTHTGER PYECHECLKG
260 270 280 290 300
FRNSSALTKH QRIHTGEKPY KCTQCGRTFN QIAPLIQHQR THTGEKPYEC
310 320 330 340 350
SECGKSFSFR SSFSQHERTH TGEKPYECSE CGKAFRQSIH LTQHLRIHTG
360 370 380 390 400
EKPYQCGECG KAFSHSSSLT KHQRIHTGEK PYECHECGKA FTQITPLIQH
410 420 430 440 450
QRTHTGEKPY ECGECGKAFS QSTLLTEHRR IHTGEKPYGC NECGKTFSHS
460 470 480 490 500
SSLSQHERTH TGEKPYECSQ CGKAFRQSTH LTQHQRIHTG EKPYECNDCG
510 520 530 540 550
KAFSHSSSLT KHQRIHTGEK PYECNQCGRA FSQLAPLIQH QRIHTGEKPY
560 570 580 590 600
ECNQCGRAFS QSSLLIEHQR IHTKEKPYGC NECGKSFSHS SSLSQHERTH
610 620 630 640 650
TGEKPYECHD CGKSFRQSTH LTQHRRIHTG EKPYACRDCG KAFTHSSSLT

KHQRTHTG
Length:658
Mass (Da):75,261
Last modified:May 18, 2010 - v3
Checksum:iED6A4FB042CB3CE5
GO
Isoform 2 (identifier: P52742-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MTPGVRVSTDP → MELGSRRRSVGCRCRGLCLAVRR
     359-638: Missing.

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):44,822
Checksum:iCD54463064CF737B
GO
Isoform 3 (identifier: P52742-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-85: P → PEIKGHFQFLLLS

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:670
Mass (Da):76,675
Checksum:iE070433AD8D6C9A5
GO
Isoform 4 (identifier: P52742-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MTPGVRVSTDP → MELGSRRRSVGCRCRGLCLAVRR
     85-85: P → PEIKGHFQFLLLS

Note: Gene prediction based on EST data.
Show »
Length:682
Mass (Da):78,151
Checksum:iC4D2B1A44B70570B
GO

Sequence cautioni

The sequence AAC50254 differs from that shown. Reason: Frameshift at positions 207, 558 and 563.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166G → R in AAC50254 (PubMed:7557990).Curated1
Sequence conflicti247C → F in BAG58141 (PubMed:14702039).Curated1
Sequence conflicti308S → C in BAG58141 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05277422G → D2 PublicationsCorresponds to variant dbSNP:rs1469087Ensembl.1
Natural variantiVAR_052775507S → L. Corresponds to variant dbSNP:rs2228277Ensembl.1
Natural variantiVAR_052776517T → A. Corresponds to variant dbSNP:rs2228278Ensembl.1
Natural variantiVAR_052777579G → R. Corresponds to variant dbSNP:rs2228279Ensembl.1
Natural variantiVAR_052778592S → L. Corresponds to variant dbSNP:rs2228275Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460731 – 11MTPGVRVSTDP → MELGSRRRSVGCRCRGLCLA VRR in isoform 2 and isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04670685P → PEIKGHFQFLLLS in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_046074359 – 638Missing in isoform 2. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098011 mRNA Translation: BAC05214.1
AK295110 mRNA Translation: BAG58141.1
AC008751 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72553.1
BC046434 mRNA Translation: AAH46434.1
U09413 mRNA Translation: AAC50254.1 Frameshift.
CCDSiCCDS12970.2 [P52742-3]
CCDS54329.1 [P52742-4]
CCDS54330.1 [P52742-2]
CCDS74471.1 [P52742-1]
PIRiI38600
RefSeqiNP_001158001.1, NM_001164529.1
NP_001158002.1, NM_001164530.1 [P52742-2]
NP_001276330.1, NM_001289401.1 [P52742-1]
NP_001276331.1, NM_001289402.1
NP_003427.3, NM_003436.3 [P52742-3]
NP_009065.1, NM_007134.1 [P52742-4]
XP_006723425.1, XM_006723362.3 [P52742-3]
XP_006723426.1, XM_006723363.3 [P52742-3]
XP_016882729.1, XM_017027240.1 [P52742-1]
UniGeneiHs.85863

Genome annotation databases

EnsembliENST00000313434; ENSP00000321406; ENSG00000176293 [P52742-1]
ENST00000359978; ENSP00000369437; ENSG00000176293 [P52742-2]
ENST00000401053; ENSP00000441410; ENSG00000176293 [P52742-4]
ENST00000511556; ENSP00000422074; ENSG00000176293 [P52742-3]
GeneIDi7694
KEGGihsa:7694
UCSCiuc002qrd.3 human [P52742-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN135_HUMAN
AccessioniPrimary (citable) accession number: P52742
Secondary accession number(s): B4DHH9
, E9PEV2, F5GYY9, I3L0B3, Q5U5L3, Q8N1I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome