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Protein

Zinc finger protein 134

Gene

ZNF134

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 7223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 10023C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 134
Gene namesi
Name:ZNF134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12918. ZNF134.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37506.

Polymorphism and mutation databases

BioMutaiZNF134.
DMDMi212276482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Zinc finger protein 134PRO_0000047418Add
BLAST

Proteomic databases

EPDiP52741.
MaxQBiP52741.
PaxDbiP52741.
PeptideAtlasiP52741.
PRIDEiP52741.

PTM databases

iPTMnetiP52741.
PhosphoSiteiP52741.

Expressioni

Gene expression databases

BgeeiP52741.
CleanExiHS_ZNF134.
ExpressionAtlasiP52741. baseline and differential.
GenevisibleiP52741. HS.

Organism-specific databases

HPAiHPA009064.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000379464.

Structurei

3D structure databases

ProteinModelPortaliP52741.
SMRiP52741. Positions 64-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 7223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 10023C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOVERGENiHBG018163.
InParanoidiP52741.
OMAiWTGPGCW.
PhylomeDBiP52741.
TreeFamiTF342033.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLVTAGGAW TGPGCWHEVK DEESSSEQSI SIAVSHVNTS KAGLPAQTAL
60 70 80 90 100
PCDICGPILK DILHLDEHQG THHGLKLHTC GACGRQFWFS ANLHQYQKCY
110 120 130 140 150
SIEQPLRRDK SEASIVKNCT VSKEPHPSEK PFTCKEEQKN FQATLGGCQQ
160 170 180 190 200
KAIHSKRKTH RSTESGDAFH GEQMHYKCSE CGKAFSRKDT LVQHQRIHSG
210 220 230 240 250
EKPYECSECG KAFSRKATLV QHQRIHTGER PYECSECGKT FSRKDNLTQH
260 270 280 290 300
KRIHTGEMPY KCNECGKYFS HHSNLIVHQR VHNGARPYKC SDCGKVFRHK
310 320 330 340 350
STLVQHESIH TGENPYDCSD CGKSFGHKYT LIKHQRIHTE SKPFECIECG
360 370 380 390 400
KFFSRSSDYI AHQRVHTGER PFVCSKCGKD FIRTSHLVRH QRVHTGERPY
410 420
ECSECGKAYS LSSHLNRHQK VHTAGRL
Length:427
Mass (Da):48,480
Last modified:November 4, 2008 - v2
Checksum:iAADF3DD519F12712
GO
Isoform 2 (identifier: P52741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MTLVTAGGAW...ACGRQFWFSA → MWGMWETILVQC

Show »
Length:348
Mass (Da):40,297
Checksum:iE0941AD233EC8670
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301I → T.
Corresponds to variant rs10414451 [ dbSNP | Ensembl ].
VAR_052771
Natural varianti46 – 461A → T.
Corresponds to variant rs10413455 [ dbSNP | Ensembl ].
VAR_052772
Natural varianti207 – 2071S → R.
Corresponds to variant rs34034473 [ dbSNP | Ensembl ].
VAR_052773

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9191MTLVT…FWFSA → MWGMWETILVQC in isoform 2. 1 PublicationVSP_035666Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09412 mRNA. Translation: AAC50253.1.
AK291763 mRNA. Translation: BAF84452.1.
AC003682 Genomic DNA. Translation: AAC24610.1.
CH471135 Genomic DNA. Translation: EAW72518.1.
BC112294 mRNA. Translation: AAI12295.1.
BC113410 mRNA. Translation: AAI13411.1.
CCDSiCCDS42638.1. [P52741-1]
PIRiI38599.
RefSeqiNP_003426.3. NM_003435.4. [P52741-1]
XP_011507179.1. XM_011508877.1. [P52741-1]
UniGeneiHs.469694.

Genome annotation databases

EnsembliENST00000396161; ENSP00000379464; ENSG00000213762. [P52741-1]
ENST00000622676; ENSP00000481521; ENSG00000213762. [P52741-2]
GeneIDi7693.
KEGGihsa:7693.
UCSCiuc002qpn.3. human. [P52741-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09412 mRNA. Translation: AAC50253.1.
AK291763 mRNA. Translation: BAF84452.1.
AC003682 Genomic DNA. Translation: AAC24610.1.
CH471135 Genomic DNA. Translation: EAW72518.1.
BC112294 mRNA. Translation: AAI12295.1.
BC113410 mRNA. Translation: AAI13411.1.
CCDSiCCDS42638.1. [P52741-1]
PIRiI38599.
RefSeqiNP_003426.3. NM_003435.4. [P52741-1]
XP_011507179.1. XM_011508877.1. [P52741-1]
UniGeneiHs.469694.

3D structure databases

ProteinModelPortaliP52741.
SMRiP52741. Positions 64-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000379464.

PTM databases

iPTMnetiP52741.
PhosphoSiteiP52741.

Polymorphism and mutation databases

BioMutaiZNF134.
DMDMi212276482.

Proteomic databases

EPDiP52741.
MaxQBiP52741.
PaxDbiP52741.
PeptideAtlasiP52741.
PRIDEiP52741.

Protocols and materials databases

DNASUi7693.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396161; ENSP00000379464; ENSG00000213762. [P52741-1]
ENST00000622676; ENSP00000481521; ENSG00000213762. [P52741-2]
GeneIDi7693.
KEGGihsa:7693.
UCSCiuc002qpn.3. human. [P52741-1]

Organism-specific databases

CTDi7693.
GeneCardsiZNF134.
HGNCiHGNC:12918. ZNF134.
HPAiHPA009064.
MIMi604076. gene.
neXtProtiNX_P52741.
PharmGKBiPA37506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOVERGENiHBG018163.
InParanoidiP52741.
OMAiWTGPGCW.
PhylomeDBiP52741.
TreeFamiTF342033.

Miscellaneous databases

GenomeRNAii7693.
PROiP52741.
SOURCEiSearch...

Gene expression databases

BgeeiP52741.
CleanExiHS_ZNF134.
ExpressionAtlasiP52741. baseline and differential.
GenevisibleiP52741. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Insulinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZN134_HUMAN
AccessioniPrimary (citable) accession number: P52741
Secondary accession number(s): Q9Y4B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.