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Protein

Zinc finger protein 132

Gene

ZNF132

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 132
Gene namesi
Name:ZNF132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000131849.10
HGNCiHGNC:12916 ZNF132
MIMi604074 gene
neXtProtiNX_P52740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7691
OpenTargetsiENSG00000131849
PharmGKBiPA37505

Polymorphism and mutation databases

BioMutaiZNF132
DMDMi212276481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474161 – 706Zinc finger protein 132Add BLAST706

Proteomic databases

EPDiP52740
MaxQBiP52740
PaxDbiP52740
PeptideAtlasiP52740
PRIDEiP52740

PTM databases

iPTMnetiP52740
PhosphoSitePlusiP52740

Expressioni

Gene expression databases

BgeeiENSG00000131849
CleanExiHS_ZNF132
ExpressionAtlasiP52740 baseline and differential
GenevisibleiP52740 HS

Organism-specific databases

HPAiHPA008726

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254166

Structurei

3D structure databases

ProteinModelPortaliP52740
SMRiP52740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 121KRABPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP52740
KOiK09228
OMAiRERTYEC
OrthoDBiEOG091G02KC
PhylomeDBiP52740
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPSPQVLM GLPALLMGPA QHTSWPCGSA VPTLKSMVTF EDVAVYFSQE
60 70 80 90 100
EWELLDAAQR HLYHSVMLEN LELVTSLGSW HGVEGEGAHP KQNVSVEVLQ
110 120 130 140 150
VRIPNADPST KKANSCDMCG PFLKDILHLA EHQGTQSEEK PYTCGACGRD
160 170 180 190 200
FWLNANLHQH QKEHSGGKPF RWYKDRDALM KSSKVHLSEN PFTCREGGKV
210 220 230 240 250
ILGSCDLLQL QAVDSGQKPY SNLGQLPEVC TTQKLFECSN CGKAFLKSST
260 270 280 290 300
LPNHLRTHSE EIPFTCPTGG NFLEEKSILG NKKFHTGEIP HVCKECGKAF
310 320 330 340 350
SHSSKLRKHQ KFHTEVKYYE CIACGKTFNH KLTFVHHQRI HSGERPYECD
360 370 380 390 400
ECGKAFSNRS HLIRHEKVHT GERPFECLKC GRAFSQSSNF LRHQKVHTQV
410 420 430 440 450
RPYECSQCGK SFSRSSALIQ HWRVHTGERP YECSECGRAF NNNSNLAQHQ
460 470 480 490 500
KVHTGERPFE CSECGRDFSQ SSHLLRHQKV HTGERPFECC DCGKAFSNSS
510 520 530 540 550
TLIQHQKVHT GQRPYECSEC RKSFSRSSSL IQHWRIHTGE KPYECSECGK
560 570 580 590 600
AFAHSSTLIE HWRVHTKERP YECNECGKFF SQNSILIKHQ KVHTGEKPYK
610 620 630 640 650
CSECGKFFSR KSSLICHWRV HTGERPYECS ECGRAFSSNS HLVRHQRVHT
660 670 680 690 700
QERPYECIQC GKAFSERSTL VRHQKVHTRE RTYECSQCGK LFSHLCNLAQ

HKKIHT
Length:706
Mass (Da):80,623
Last modified:November 4, 2008 - v2
Checksum:i7C74CEF0C0701AC3
GO
Isoform 2 (identifier: P52740-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Show »
Length:589
Mass (Da):67,889
Checksum:iCB27322EEFC6E4CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047229203G → D. Corresponds to variant dbSNP:rs1122955Ensembl.1
Natural variantiVAR_012024252P → L. Corresponds to variant dbSNP:rs1465789Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356651 – 117Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09411 mRNA Translation: AAC50252.1
AC012313 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72591.1
BC109107 mRNA Translation: AAI09108.1
BC109108 mRNA Translation: AAI09109.1
CCDSiCCDS12980.1 [P52740-1]
PIRiI38598
RefSeqiNP_003424.3, NM_003433.3 [P52740-1]
UniGeneiHs.156169

Genome annotation databases

EnsembliENST00000254166; ENSP00000254166; ENSG00000131849 [P52740-1]
GeneIDi7691
KEGGihsa:7691
UCSCiuc002qst.4 human [P52740-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN132_HUMAN
AccessioniPrimary (citable) accession number: P52740
Secondary accession number(s): Q32MI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: February 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome