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Protein

Zinc finger protein 132

Gene

ZNF132

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131849-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 132
Gene namesi
Name:ZNF132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12916. ZNF132.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7691.
OpenTargetsiENSG00000131849.
PharmGKBiPA37505.

Polymorphism and mutation databases

BioMutaiZNF132.
DMDMi212276481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474161 – 706Zinc finger protein 132Add BLAST706

Proteomic databases

MaxQBiP52740.
PaxDbiP52740.
PeptideAtlasiP52740.
PRIDEiP52740.

PTM databases

iPTMnetiP52740.
PhosphoSitePlusiP52740.

Expressioni

Gene expression databases

BgeeiENSG00000131849.
CleanExiHS_ZNF132.
GenevisibleiP52740. HS.

Organism-specific databases

HPAiHPA008726.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254166.

Structurei

3D structure databases

ProteinModelPortaliP52740.
SMRiP52740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 121KRABPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri655 – 677C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri683 – 705C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52740.
KOiK09228.
OMAiRERTYEC.
OrthoDBiEOG091G02KC.
PhylomeDBiP52740.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPSPQVLM GLPALLMGPA QHTSWPCGSA VPTLKSMVTF EDVAVYFSQE
60 70 80 90 100
EWELLDAAQR HLYHSVMLEN LELVTSLGSW HGVEGEGAHP KQNVSVEVLQ
110 120 130 140 150
VRIPNADPST KKANSCDMCG PFLKDILHLA EHQGTQSEEK PYTCGACGRD
160 170 180 190 200
FWLNANLHQH QKEHSGGKPF RWYKDRDALM KSSKVHLSEN PFTCREGGKV
210 220 230 240 250
ILGSCDLLQL QAVDSGQKPY SNLGQLPEVC TTQKLFECSN CGKAFLKSST
260 270 280 290 300
LPNHLRTHSE EIPFTCPTGG NFLEEKSILG NKKFHTGEIP HVCKECGKAF
310 320 330 340 350
SHSSKLRKHQ KFHTEVKYYE CIACGKTFNH KLTFVHHQRI HSGERPYECD
360 370 380 390 400
ECGKAFSNRS HLIRHEKVHT GERPFECLKC GRAFSQSSNF LRHQKVHTQV
410 420 430 440 450
RPYECSQCGK SFSRSSALIQ HWRVHTGERP YECSECGRAF NNNSNLAQHQ
460 470 480 490 500
KVHTGERPFE CSECGRDFSQ SSHLLRHQKV HTGERPFECC DCGKAFSNSS
510 520 530 540 550
TLIQHQKVHT GQRPYECSEC RKSFSRSSSL IQHWRIHTGE KPYECSECGK
560 570 580 590 600
AFAHSSTLIE HWRVHTKERP YECNECGKFF SQNSILIKHQ KVHTGEKPYK
610 620 630 640 650
CSECGKFFSR KSSLICHWRV HTGERPYECS ECGRAFSSNS HLVRHQRVHT
660 670 680 690 700
QERPYECIQC GKAFSERSTL VRHQKVHTRE RTYECSQCGK LFSHLCNLAQ

HKKIHT
Length:706
Mass (Da):80,623
Last modified:November 4, 2008 - v2
Checksum:i7C74CEF0C0701AC3
GO
Isoform 2 (identifier: P52740-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Show »
Length:589
Mass (Da):67,889
Checksum:iCB27322EEFC6E4CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047229203G → D.Corresponds to variant rs1122955dbSNPEnsembl.1
Natural variantiVAR_012024252P → L.Corresponds to variant rs1465789dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356651 – 117Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09411 mRNA. Translation: AAC50252.1.
AC012313 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72591.1.
BC109107 mRNA. Translation: AAI09108.1.
BC109108 mRNA. Translation: AAI09109.1.
CCDSiCCDS12980.1. [P52740-1]
PIRiI38598.
RefSeqiNP_003424.3. NM_003433.3. [P52740-1]
UniGeneiHs.156169.

Genome annotation databases

EnsembliENST00000254166; ENSP00000254166; ENSG00000131849. [P52740-1]
GeneIDi7691.
KEGGihsa:7691.
UCSCiuc002qst.4. human. [P52740-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09411 mRNA. Translation: AAC50252.1.
AC012313 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72591.1.
BC109107 mRNA. Translation: AAI09108.1.
BC109108 mRNA. Translation: AAI09109.1.
CCDSiCCDS12980.1. [P52740-1]
PIRiI38598.
RefSeqiNP_003424.3. NM_003433.3. [P52740-1]
UniGeneiHs.156169.

3D structure databases

ProteinModelPortaliP52740.
SMRiP52740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000254166.

PTM databases

iPTMnetiP52740.
PhosphoSitePlusiP52740.

Polymorphism and mutation databases

BioMutaiZNF132.
DMDMi212276481.

Proteomic databases

MaxQBiP52740.
PaxDbiP52740.
PeptideAtlasiP52740.
PRIDEiP52740.

Protocols and materials databases

DNASUi7691.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254166; ENSP00000254166; ENSG00000131849. [P52740-1]
GeneIDi7691.
KEGGihsa:7691.
UCSCiuc002qst.4. human. [P52740-1]

Organism-specific databases

CTDi7691.
DisGeNETi7691.
GeneCardsiZNF132.
HGNCiHGNC:12916. ZNF132.
HPAiHPA008726.
MIMi604074. gene.
neXtProtiNX_P52740.
OpenTargetsiENSG00000131849.
PharmGKBiPA37505.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52740.
KOiK09228.
OMAiRERTYEC.
OrthoDBiEOG091G02KC.
PhylomeDBiP52740.
TreeFamiTF339848.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131849-MONOMER.

Miscellaneous databases

ChiTaRSiZNF132. human.
GenomeRNAii7691.
PROiP52740.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131849.
CleanExiHS_ZNF132.
GenevisibleiP52740. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN132_HUMAN
AccessioniPrimary (citable) accession number: P52740
Secondary accession number(s): Q32MI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.