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Protein

Zinc finger protein 131

Gene

ZNF131

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 381C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 443C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 131
Gene namesi
Name:ZNF131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000172262.11
HGNCiHGNC:12915 ZNF131
MIMi604073 gene
neXtProtiNX_P52739

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242K → R: No effect on sumoylation; when associated with R-281 and R-289. 1 Publication1
Mutagenesisi281K → R: No effect on sumoylation; when associated with R-242 and R-281. 1 Publication1
Mutagenesisi289K → R: No effect on sumoylation; when associated with R-242 and R-281. 1 Publication1
Mutagenesisi477K → R: Small loss of sumoylation. Complete loss of CBX4 sumoylation; when associated with R-601 and R-610. 1 Publication1
Mutagenesisi601K → R: Significant loss of sumoylation. Complete loss of CBX4 sumoylation; when associated with R-477 and R-610. 1 Publication1
Mutagenesisi610K → R: No effect on sumoylation. Complete loss of CBX4 sumoylation; when associated with R-477 and R-601. 1 Publication1

Organism-specific databases

DisGeNETi7690
OpenTargetsiENSG00000172262
PharmGKBiPA37504

Polymorphism and mutation databases

BioMutaiZNF131
DMDMi85681857

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474131 – 623Zinc finger protein 131Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination.2 Publications
Ubiquitinated.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP52739
MaxQBiP52739
PeptideAtlasiP52739
PRIDEiP52739

PTM databases

iPTMnetiP52739
PhosphoSitePlusiP52739

Expressioni

Tissue specificityi

Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.1 Publication

Gene expression databases

BgeeiENSG00000172262
CleanExiHS_ZNF131
ExpressionAtlasiP52739 baseline and differential
GenevisibleiP52739 HS

Organism-specific databases

HPAiHPA007023
HPA027748
HPA074630

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL2Q141925EBI-10213055,EBI-701903

Protein-protein interaction databases

BioGridi113485, 84 interactors
IntActiP52739, 11 interactors
MINTiP52739

Structurei

3D structure databases

ProteinModelPortaliP52739
SMRiP52739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 98BTBPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 148Nuclear localization signal 11 PublicationAdd BLAST12
Motifi317 – 328Nuclear localization signal 21 PublicationAdd BLAST12

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 381C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 443C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00910000144063
HOGENOMiHOG000294225
HOVERGENiHBG057353
InParanoidiP52739
OMAiDLFHCEK
OrthoDBiEOG091G03OI
PhylomeDBiP52739
TreeFamiTF331428

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR027758 Zfp131
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44722 PTHR44722, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52739-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA
60 70 80 90 100
VLAACSKFFY KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE
110 120 130 140 150
EANDVWKAAE FLQMLEAIKA LEVRNKENSA PLEENTTGKN EAKKRKIAET
160 170 180 190 200
SNVITESLPS AESEPVEIEV EIAEGTIEVE DEGIETLEEV ASAKQSVKYI
210 220 230 240 250
QSTGSSDDSA LALLADITSK YRQGDRKGQI KEDGCPSDPT SKQVEGIEIV
260 270 280 290 300
ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE
310 320 330 340 350
SAWKQHLNCY HLEEGGVSKK QRTGKKIHVC QYCEKQFDHF GHFKEHLRKH
360 370 380 390 400
TGEKPFECPN CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV
410 420 430 440 450
FNSWDQFKDH LVIHTGDKPN HCTLCDLWFM QGNELRRHLS DAHNISERLV
460 470 480 490 500
TEEVLSVETR VQTEPVTSMT IIEQVGKVHV LPLLQVQVDS AQVTVEQVHP
510 520 530 540 550
DLLQDSQVHD SHMSELPEQV QVSYLEVGRI QTEEGTEVHV EELHVERVNQ
560 570 580 590 600
MPVEVQTELL EADLDHVTPE IMNQEERESS QADAAEAARE DHEDAEDLET
610 620
KPTVDSEAEK AENEDRTALP VLE
Length:623
Mass (Da):71,422
Last modified:January 10, 2006 - v2
Checksum:iE2720D922A39572C
GO
Isoform 2 (identifier: P52739-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-277: Missing.

Show »
Length:589
Mass (Da):67,302
Checksum:i78E7D3CF40FF243D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148 – 151AETS → CSKA in AAC50251 (PubMed:7557990).Curated4
Sequence conflicti175 – 176GT → A in AAC50251 (PubMed:7557990).Curated2
Sequence conflicti311H → R in AK057343 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016923244 – 277Missing in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057343 mRNA No translation available.
AK299315 mRNA Translation: BAG61325.1
AC106800 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW56046.1
BC035875 mRNA Translation: AAH35875.1
U09410 mRNA Translation: AAC50251.1
CCDSiCCDS43313.1 [P52739-2]
CCDS78005.1 [P52739-1]
PIRiI38597
RefSeqiNP_001284477.1, NM_001297548.2 [P52739-1]
NP_001317636.1, NM_001330707.1 [P52739-1]
NP_001317637.1, NM_001330708.1 [P52739-1]
NP_001317641.1, NM_001330712.1 [P52739-1]
NP_001317643.1, NM_001330714.1 [P52739-1]
NP_001317646.1, NM_001330717.1
XP_005248420.1, XM_005248363.4 [P52739-1]
XP_016865319.1, XM_017009830.1 [P52739-1]
XP_016865327.1, XM_017009838.1
UniGeneiHs.535804

Genome annotation databases

EnsembliENST00000306938; ENSP00000305804; ENSG00000172262 [P52739-2]
ENST00000505606; ENSP00000423945; ENSG00000172262 [P52739-2]
ENST00000509156; ENSP00000426504; ENSG00000172262 [P52739-1]
ENST00000509634; ENSP00000421246; ENSG00000172262 [P52739-2]
GeneIDi7690
KEGGihsa:7690
UCSCiuc003jnk.4 human [P52739-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN131_HUMAN
AccessioniPrimary (citable) accession number: P52739
Secondary accession number(s): B4DRL3, Q6PIF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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