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Protein

Zinc finger protein 131

Gene

ZNF131

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 381C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 443C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 131
Gene namesi
Name:ZNF131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:12915. ZNF131.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242K → R: No effect on sumoylation; when associated with R-281 and R-289. 1 Publication1
Mutagenesisi281K → R: No effect on sumoylation; when associated with R-242 and R-281. 1 Publication1
Mutagenesisi289K → R: No effect on sumoylation; when associated with R-242 and R-281. 1 Publication1
Mutagenesisi477K → R: Small loss of sumoylation. Complete loss of CBX4 sumoylation; when associated with R-601 and R-610. 1 Publication1
Mutagenesisi601K → R: Significant loss of sumoylation. Complete loss of CBX4 sumoylation; when associated with R-477 and R-610. 1 Publication1
Mutagenesisi610K → R: No effect on sumoylation. Complete loss of CBX4 sumoylation; when associated with R-477 and R-601. 1 Publication1

Organism-specific databases

DisGeNETi7690.
OpenTargetsiENSG00000172262.
PharmGKBiPA37504.

Polymorphism and mutation databases

BioMutaiZNF131.
DMDMi85681857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474131 – 623Zinc finger protein 131Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination.2 Publications
Ubiquitinated.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP52739.
MaxQBiP52739.
PeptideAtlasiP52739.
PRIDEiP52739.

PTM databases

iPTMnetiP52739.
PhosphoSitePlusiP52739.

Expressioni

Tissue specificityi

Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.1 Publication

Gene expression databases

BgeeiENSG00000172262.
CleanExiHS_ZNF131.
ExpressionAtlasiP52739. baseline and differential.
GenevisibleiP52739. HS.

Organism-specific databases

HPAiHPA007023.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL2Q141923EBI-10213055,EBI-701903

Protein-protein interaction databases

BioGridi113485. 24 interactors.
IntActiP52739. 11 interactors.

Structurei

3D structure databases

ProteinModelPortaliP52739.
SMRiP52739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 98BTBPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 148Nuclear localization signal 11 PublicationAdd BLAST12
Motifi317 – 328Nuclear localization signal 21 PublicationAdd BLAST12

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 381C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 443C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00860000133719.
HOGENOMiHOG000294225.
HOVERGENiHBG057353.
InParanoidiP52739.
OMAiDLFHCEK.
OrthoDBiEOG091G03OI.
PhylomeDBiP52739.
TreeFamiTF331428.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR027775. C2H2_Znf_fam.
IPR011333. SKP1/BTB/POZ.
IPR027758. Zfp131.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF26. PTHR10032:SF26. 3 hits.
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52739-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA
60 70 80 90 100
VLAACSKFFY KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE
110 120 130 140 150
EANDVWKAAE FLQMLEAIKA LEVRNKENSA PLEENTTGKN EAKKRKIAET
160 170 180 190 200
SNVITESLPS AESEPVEIEV EIAEGTIEVE DEGIETLEEV ASAKQSVKYI
210 220 230 240 250
QSTGSSDDSA LALLADITSK YRQGDRKGQI KEDGCPSDPT SKQVEGIEIV
260 270 280 290 300
ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE
310 320 330 340 350
SAWKQHLNCY HLEEGGVSKK QRTGKKIHVC QYCEKQFDHF GHFKEHLRKH
360 370 380 390 400
TGEKPFECPN CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV
410 420 430 440 450
FNSWDQFKDH LVIHTGDKPN HCTLCDLWFM QGNELRRHLS DAHNISERLV
460 470 480 490 500
TEEVLSVETR VQTEPVTSMT IIEQVGKVHV LPLLQVQVDS AQVTVEQVHP
510 520 530 540 550
DLLQDSQVHD SHMSELPEQV QVSYLEVGRI QTEEGTEVHV EELHVERVNQ
560 570 580 590 600
MPVEVQTELL EADLDHVTPE IMNQEERESS QADAAEAARE DHEDAEDLET
610 620
KPTVDSEAEK AENEDRTALP VLE
Length:623
Mass (Da):71,422
Last modified:January 10, 2006 - v2
Checksum:iE2720D922A39572C
GO
Isoform 2 (identifier: P52739-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-277: Missing.

Show »
Length:589
Mass (Da):67,302
Checksum:i78E7D3CF40FF243D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148 – 151AETS → CSKA in AAC50251 (PubMed:7557990).Curated4
Sequence conflicti175 – 176GT → A in AAC50251 (PubMed:7557990).Curated2
Sequence conflicti311H → R in AK057343 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016923244 – 277Missing in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057343 mRNA. No translation available.
AK299315 mRNA. Translation: BAG61325.1.
AC106800 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW56046.1.
BC035875 mRNA. Translation: AAH35875.1.
U09410 mRNA. Translation: AAC50251.1.
CCDSiCCDS43313.1. [P52739-2]
CCDS78005.1. [P52739-1]
PIRiI38597.
RefSeqiNP_001284477.1. NM_001297548.2. [P52739-1]
NP_001317636.1. NM_001330707.1.
NP_001317637.1. NM_001330708.1.
NP_001317641.1. NM_001330712.1.
NP_001317643.1. NM_001330714.1.
NP_001317646.1. NM_001330717.1.
XP_005248420.1. XM_005248363.4. [P52739-1]
XP_016865319.1. XM_017009830.1. [P52739-1]
XP_016865327.1. XM_017009838.1.
UniGeneiHs.535804.

Genome annotation databases

EnsembliENST00000306938; ENSP00000305804; ENSG00000172262. [P52739-2]
ENST00000505606; ENSP00000423945; ENSG00000172262. [P52739-2]
ENST00000509156; ENSP00000426504; ENSG00000172262. [P52739-1]
ENST00000509634; ENSP00000421246; ENSG00000172262. [P52739-2]
GeneIDi7690.
KEGGihsa:7690.
UCSCiuc003jnk.4. human. [P52739-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057343 mRNA. No translation available.
AK299315 mRNA. Translation: BAG61325.1.
AC106800 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW56046.1.
BC035875 mRNA. Translation: AAH35875.1.
U09410 mRNA. Translation: AAC50251.1.
CCDSiCCDS43313.1. [P52739-2]
CCDS78005.1. [P52739-1]
PIRiI38597.
RefSeqiNP_001284477.1. NM_001297548.2. [P52739-1]
NP_001317636.1. NM_001330707.1.
NP_001317637.1. NM_001330708.1.
NP_001317641.1. NM_001330712.1.
NP_001317643.1. NM_001330714.1.
NP_001317646.1. NM_001330717.1.
XP_005248420.1. XM_005248363.4. [P52739-1]
XP_016865319.1. XM_017009830.1. [P52739-1]
XP_016865327.1. XM_017009838.1.
UniGeneiHs.535804.

3D structure databases

ProteinModelPortaliP52739.
SMRiP52739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113485. 24 interactors.
IntActiP52739. 11 interactors.

PTM databases

iPTMnetiP52739.
PhosphoSitePlusiP52739.

Polymorphism and mutation databases

BioMutaiZNF131.
DMDMi85681857.

Proteomic databases

EPDiP52739.
MaxQBiP52739.
PeptideAtlasiP52739.
PRIDEiP52739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306938; ENSP00000305804; ENSG00000172262. [P52739-2]
ENST00000505606; ENSP00000423945; ENSG00000172262. [P52739-2]
ENST00000509156; ENSP00000426504; ENSG00000172262. [P52739-1]
ENST00000509634; ENSP00000421246; ENSG00000172262. [P52739-2]
GeneIDi7690.
KEGGihsa:7690.
UCSCiuc003jnk.4. human. [P52739-1]

Organism-specific databases

CTDi7690.
DisGeNETi7690.
GeneCardsiZNF131.
HGNCiHGNC:12915. ZNF131.
HPAiHPA007023.
MIMi604073. gene.
neXtProtiNX_P52739.
OpenTargetsiENSG00000172262.
PharmGKBiPA37504.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00860000133719.
HOGENOMiHOG000294225.
HOVERGENiHBG057353.
InParanoidiP52739.
OMAiDLFHCEK.
OrthoDBiEOG091G03OI.
PhylomeDBiP52739.
TreeFamiTF331428.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172262-MONOMER.

Miscellaneous databases

ChiTaRSiZNF131. human.
GenomeRNAii7690.
PROiP52739.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172262.
CleanExiHS_ZNF131.
ExpressionAtlasiP52739. baseline and differential.
GenevisibleiP52739. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR027775. C2H2_Znf_fam.
IPR011333. SKP1/BTB/POZ.
IPR027758. Zfp131.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF26. PTHR10032:SF26. 3 hits.
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN131_HUMAN
AccessioniPrimary (citable) accession number: P52739
Secondary accession number(s): B4DRL3, Q6PIF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.