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P52738

- ZN140_HUMAN

UniProt

P52738 - ZN140_HUMAN

Protein

Zinc finger protein 140

Gene

ZNF140

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation as a repressor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 140
    Gene namesi
    Name:ZNF140
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:12925. ZNF140.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37512.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Zinc finger protein 140PRO_0000047423Add
    BLAST

    Proteomic databases

    PaxDbiP52738.
    PRIDEiP52738.

    PTM databases

    PhosphoSiteiP52738.

    Expressioni

    Tissue specificityi

    Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

    Gene expression databases

    ArrayExpressiP52738.
    BgeeiP52738.
    CleanExiHS_ZNF140.
    GenevestigatoriP52738.

    Organism-specific databases

    HPAiHPA048332.

    Interactioni

    Protein-protein interaction databases

    BioGridi113493. 2 interactions.
    STRINGi9606.ENSP00000347755.

    Structurei

    3D structure databases

    ProteinModelPortaliP52738.
    SMRiP52738. Positions 109-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP52738.
    KOiK09228.
    OMAiQRTHTLE.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiP52738.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P52738-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS    50
    KPDVVSLLEQ GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ 100
    YLIMERILSQ GPVYSSFKGG WKCKDHTEML QENQGCIRKV TVSHQEALAQ 150
    HMNISTVERP YGCHECGKTF GRRFSLVLHQ RTHTGEKPYA CKECGKTFSQ 200
    ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT GEKPYECTEC 250
    GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP 300
    YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI 350
    HAGEKLYECD ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL 400
    ILHQRTHTGE KPYVCKVCNK SFSWSSNLAK HQRTHTLDNP YEYENSFNYH 450
    SFLTEHQ 457
    Length:457
    Mass (Da):52,996
    Last modified:September 23, 2008 - v2
    Checksum:iF4FF0B7D85E03731
    GO
    Isoform 2 (identifier: P52738-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-103: Missing.

    Show »
    Length:354
    Mass (Da):41,169
    Checksum:iA0EEAF0E30DF4A52
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti338 – 3381F → L in AAC50262. (PubMed:7649249)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti386 – 3861A → V.
    Corresponds to variant rs2229373 [ dbSNP | Ensembl ].
    VAR_046562

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 103103Missing in isoform 2. 2 PublicationsVSP_056436Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09368 mRNA. Translation: AAC50262.1.
    AK122741 mRNA. Translation: BAG53698.1.
    AK303240 mRNA. Translation: BAG64326.1.
    AC026786 Genomic DNA. No translation available.
    AC073911 Genomic DNA. No translation available.
    CH471218 Genomic DNA. Translation: EAW54795.1.
    CH471218 Genomic DNA. Translation: EAW54797.1.
    CH471218 Genomic DNA. Translation: EAW54798.1.
    BC022291 mRNA. Translation: AAH22291.1.
    BC040561 mRNA. Translation: AAH40561.1.
    CCDSiCCDS9282.1.
    PIRiC57785.
    RefSeqiNP_003431.2. NM_003440.2.
    XP_005266247.1. XM_005266190.2.
    UniGeneiHs.181552.

    Genome annotation databases

    EnsembliENST00000355557; ENSP00000347755; ENSG00000196387.
    ENST00000544426; ENSP00000445411; ENSG00000196387.
    GeneIDi7699.
    KEGGihsa:7699.
    UCSCiuc001ulo.3. human.

    Polymorphism databases

    DMDMi206729944.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09368 mRNA. Translation: AAC50262.1 .
    AK122741 mRNA. Translation: BAG53698.1 .
    AK303240 mRNA. Translation: BAG64326.1 .
    AC026786 Genomic DNA. No translation available.
    AC073911 Genomic DNA. No translation available.
    CH471218 Genomic DNA. Translation: EAW54795.1 .
    CH471218 Genomic DNA. Translation: EAW54797.1 .
    CH471218 Genomic DNA. Translation: EAW54798.1 .
    BC022291 mRNA. Translation: AAH22291.1 .
    BC040561 mRNA. Translation: AAH40561.1 .
    CCDSi CCDS9282.1.
    PIRi C57785.
    RefSeqi NP_003431.2. NM_003440.2.
    XP_005266247.1. XM_005266190.2.
    UniGenei Hs.181552.

    3D structure databases

    ProteinModelPortali P52738.
    SMRi P52738. Positions 109-436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113493. 2 interactions.
    STRINGi 9606.ENSP00000347755.

    PTM databases

    PhosphoSitei P52738.

    Polymorphism databases

    DMDMi 206729944.

    Proteomic databases

    PaxDbi P52738.
    PRIDEi P52738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355557 ; ENSP00000347755 ; ENSG00000196387 .
    ENST00000544426 ; ENSP00000445411 ; ENSG00000196387 .
    GeneIDi 7699.
    KEGGi hsa:7699.
    UCSCi uc001ulo.3. human.

    Organism-specific databases

    CTDi 7699.
    GeneCardsi GC12P133657.
    HGNCi HGNC:12925. ZNF140.
    HPAi HPA048332.
    MIMi 604082. gene.
    neXtProti NX_P52738.
    PharmGKBi PA37512.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P52738.
    KOi K09228.
    OMAi QRTHTLE.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi P52738.
    TreeFami TF337055.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 7699.
    NextBioi 29842.
    PROi P52738.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52738.
    Bgeei P52738.
    CleanExi HS_ZNF140.
    Genevestigatori P52738.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins."
      Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.
      FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Insulinoma.
    2. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
      Tommerup N., Vissing H.
      Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Insulinoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Thymus.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiZN140_HUMAN
    AccessioniPrimary (citable) accession number: P52738
    Secondary accession number(s): D3DXJ3, Q05CP6, Q8IV75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3