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P52738

- ZN140_HUMAN

UniProt

P52738 - ZN140_HUMAN

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Protein

Zinc finger protein 140

Gene

ZNF140

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 140
Gene namesi
Name:ZNF140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:12925. ZNF140.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Zinc finger protein 140PRO_0000047423Add
BLAST

Proteomic databases

PaxDbiP52738.
PRIDEiP52738.

PTM databases

PhosphoSiteiP52738.

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiP52738.
CleanExiHS_ZNF140.
ExpressionAtlasiP52738. baseline and differential.
GenevestigatoriP52738.

Organism-specific databases

HPAiHPA048332.

Interactioni

Protein-protein interaction databases

BioGridi113493. 3 interactions.
STRINGi9606.ENSP00000347755.

Structurei

3D structure databases

ProteinModelPortaliP52738.
SMRiP52738. Positions 109-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119035.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52738.
KOiK09228.
OMAiQRTHTLE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP52738.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P52738-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS
60 70 80 90 100
KPDVVSLLEQ GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ
110 120 130 140 150
YLIMERILSQ GPVYSSFKGG WKCKDHTEML QENQGCIRKV TVSHQEALAQ
160 170 180 190 200
HMNISTVERP YGCHECGKTF GRRFSLVLHQ RTHTGEKPYA CKECGKTFSQ
210 220 230 240 250
ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT GEKPYECTEC
260 270 280 290 300
GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP
310 320 330 340 350
YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI
360 370 380 390 400
HAGEKLYECD ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL
410 420 430 440 450
ILHQRTHTGE KPYVCKVCNK SFSWSSNLAK HQRTHTLDNP YEYENSFNYH

SFLTEHQ
Length:457
Mass (Da):52,996
Last modified:September 23, 2008 - v2
Checksum:iF4FF0B7D85E03731
GO
Isoform 2 (identifier: P52738-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:354
Mass (Da):41,169
Checksum:iA0EEAF0E30DF4A52
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3381F → L in AAC50262. (PubMed:7649249)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti386 – 3861A → V.
Corresponds to variant rs2229373 [ dbSNP | Ensembl ].
VAR_046562

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103Missing in isoform 2. 2 PublicationsVSP_056436Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09368 mRNA. Translation: AAC50262.1.
AK122741 mRNA. Translation: BAG53698.1.
AK303240 mRNA. Translation: BAG64326.1.
AC026786 Genomic DNA. No translation available.
AC073911 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54795.1.
CH471218 Genomic DNA. Translation: EAW54797.1.
CH471218 Genomic DNA. Translation: EAW54798.1.
BC022291 mRNA. Translation: AAH22291.1.
BC040561 mRNA. Translation: AAH40561.1.
CCDSiCCDS9282.1. [P52738-1]
PIRiC57785.
RefSeqiNP_003431.2. NM_003440.3.
UniGeneiHs.181552.

Genome annotation databases

EnsembliENST00000355557; ENSP00000347755; ENSG00000196387. [P52738-1]
ENST00000544426; ENSP00000445411; ENSG00000196387. [P52738-2]
GeneIDi7699.
KEGGihsa:7699.
UCSCiuc001ulo.3. human. [P52738-1]

Polymorphism databases

DMDMi206729944.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09368 mRNA. Translation: AAC50262.1 .
AK122741 mRNA. Translation: BAG53698.1 .
AK303240 mRNA. Translation: BAG64326.1 .
AC026786 Genomic DNA. No translation available.
AC073911 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54795.1 .
CH471218 Genomic DNA. Translation: EAW54797.1 .
CH471218 Genomic DNA. Translation: EAW54798.1 .
BC022291 mRNA. Translation: AAH22291.1 .
BC040561 mRNA. Translation: AAH40561.1 .
CCDSi CCDS9282.1. [P52738-1 ]
PIRi C57785.
RefSeqi NP_003431.2. NM_003440.3.
UniGenei Hs.181552.

3D structure databases

ProteinModelPortali P52738.
SMRi P52738. Positions 109-436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113493. 3 interactions.
STRINGi 9606.ENSP00000347755.

PTM databases

PhosphoSitei P52738.

Polymorphism databases

DMDMi 206729944.

Proteomic databases

PaxDbi P52738.
PRIDEi P52738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355557 ; ENSP00000347755 ; ENSG00000196387 . [P52738-1 ]
ENST00000544426 ; ENSP00000445411 ; ENSG00000196387 . [P52738-2 ]
GeneIDi 7699.
KEGGi hsa:7699.
UCSCi uc001ulo.3. human. [P52738-1 ]

Organism-specific databases

CTDi 7699.
GeneCardsi GC12P133657.
HGNCi HGNC:12925. ZNF140.
HPAi HPA048332.
MIMi 604082. gene.
neXtProti NX_P52738.
PharmGKBi PA37512.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119035.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P52738.
KOi K09228.
OMAi QRTHTLE.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P52738.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 7699.
NextBioi 29842.
PROi P52738.
SOURCEi Search...

Gene expression databases

Bgeei P52738.
CleanExi HS_ZNF140.
ExpressionAtlasi P52738. baseline and differential.
Genevestigatori P52738.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins."
    Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.
    FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Insulinoma.
  2. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Insulinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thymus.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiZN140_HUMAN
AccessioniPrimary (citable) accession number: P52738
Secondary accession number(s): D3DXJ3, Q05CP6, Q8IV75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3