SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52738

- ZN140_HUMAN

UniProt

P52738 - ZN140_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein 140

Gene
ZNF140
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1Add
BLAST
Zinc fingeri189 – 21123C2H2-type 2Add
BLAST
Zinc fingeri217 – 23923C2H2-type 3Add
BLAST
Zinc fingeri245 – 26723C2H2-type 4Add
BLAST
Zinc fingeri273 – 29523C2H2-type 5Add
BLAST
Zinc fingeri301 – 32323C2H2-type 6Add
BLAST
Zinc fingeri329 – 35123C2H2-type 7Add
BLAST
Zinc fingeri357 – 37923C2H2-type 8Add
BLAST
Zinc fingeri385 – 40723C2H2-type 9Add
BLAST
Zinc fingeri413 – 43523C2H2-type 10Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 140
Gene namesi
Name:ZNF140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:12925. ZNF140.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Zinc finger protein 140PRO_0000047423Add
BLAST

Proteomic databases

PaxDbiP52738.
PRIDEiP52738.

PTM databases

PhosphoSiteiP52738.

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

ArrayExpressiP52738.
BgeeiP52738.
CleanExiHS_ZNF140.
GenevestigatoriP52738.

Organism-specific databases

HPAiHPA048332.

Interactioni

Protein-protein interaction databases

BioGridi113493. 2 interactions.
STRINGi9606.ENSP00000347755.

Structurei

3D structure databases

ProteinModelPortaliP52738.
SMRiP52738. Positions 109-436.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1Add
BLAST
Zinc fingeri189 – 21123C2H2-type 2Add
BLAST
Zinc fingeri217 – 23923C2H2-type 3Add
BLAST
Zinc fingeri245 – 26723C2H2-type 4Add
BLAST
Zinc fingeri273 – 29523C2H2-type 5Add
BLAST
Zinc fingeri301 – 32323C2H2-type 6Add
BLAST
Zinc fingeri329 – 35123C2H2-type 7Add
BLAST
Zinc fingeri357 – 37923C2H2-type 8Add
BLAST
Zinc fingeri385 – 40723C2H2-type 9Add
BLAST
Zinc fingeri413 – 43523C2H2-type 10Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52738.
KOiK09228.
OMAiQRTHTLE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP52738.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52738-1 [UniParc]FASTAAdd to Basket

« Hide

MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS    50
KPDVVSLLEQ GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ 100
YLIMERILSQ GPVYSSFKGG WKCKDHTEML QENQGCIRKV TVSHQEALAQ 150
HMNISTVERP YGCHECGKTF GRRFSLVLHQ RTHTGEKPYA CKECGKTFSQ 200
ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT GEKPYECTEC 250
GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP 300
YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI 350
HAGEKLYECD ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL 400
ILHQRTHTGE KPYVCKVCNK SFSWSSNLAK HQRTHTLDNP YEYENSFNYH 450
SFLTEHQ 457
Length:457
Mass (Da):52,996
Last modified:September 23, 2008 - v2
Checksum:iF4FF0B7D85E03731
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti386 – 3861A → V.
Corresponds to variant rs2229373 [ dbSNP | Ensembl ].
VAR_046562

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3381F → L in AAC50262. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09368 mRNA. Translation: AAC50262.1.
AK122741 mRNA. Translation: BAG53698.1.
AC026786 Genomic DNA. No translation available.
AC073911 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54795.1.
CH471218 Genomic DNA. Translation: EAW54797.1.
BC040561 mRNA. Translation: AAH40561.1.
CCDSiCCDS9282.1.
PIRiC57785.
RefSeqiNP_003431.2. NM_003440.2.
UniGeneiHs.181552.

Genome annotation databases

EnsembliENST00000355557; ENSP00000347755; ENSG00000196387.
GeneIDi7699.
KEGGihsa:7699.
UCSCiuc001ulo.3. human.

Polymorphism databases

DMDMi206729944.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09368 mRNA. Translation: AAC50262.1 .
AK122741 mRNA. Translation: BAG53698.1 .
AC026786 Genomic DNA. No translation available.
AC073911 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54795.1 .
CH471218 Genomic DNA. Translation: EAW54797.1 .
BC040561 mRNA. Translation: AAH40561.1 .
CCDSi CCDS9282.1.
PIRi C57785.
RefSeqi NP_003431.2. NM_003440.2.
UniGenei Hs.181552.

3D structure databases

ProteinModelPortali P52738.
SMRi P52738. Positions 109-436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113493. 2 interactions.
STRINGi 9606.ENSP00000347755.

PTM databases

PhosphoSitei P52738.

Polymorphism databases

DMDMi 206729944.

Proteomic databases

PaxDbi P52738.
PRIDEi P52738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355557 ; ENSP00000347755 ; ENSG00000196387 .
GeneIDi 7699.
KEGGi hsa:7699.
UCSCi uc001ulo.3. human.

Organism-specific databases

CTDi 7699.
GeneCardsi GC12P133657.
HGNCi HGNC:12925. ZNF140.
HPAi HPA048332.
MIMi 604082. gene.
neXtProti NX_P52738.
PharmGKBi PA37512.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P52738.
KOi K09228.
OMAi QRTHTLE.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P52738.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 7699.
NextBioi 29842.
PROi P52738.
SOURCEi Search...

Gene expression databases

ArrayExpressi P52738.
Bgeei P52738.
CleanExi HS_ZNF140.
Genevestigatori P52738.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins."
    Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.
    FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.
  2. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN140_HUMAN
AccessioniPrimary (citable) accession number: P52738
Secondary accession number(s): D3DXJ3, Q8IV75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi