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Protein

Zinc finger protein 140

Gene

ZNF140

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 140
Gene namesi
Name:ZNF140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196387.9
HGNCiHGNC:12925 ZNF140
MIMi604082 gene
neXtProtiNX_P52738

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7699
OpenTargetsiENSG00000196387
PharmGKBiPA37512

Polymorphism and mutation databases

BioMutaiZNF140
DMDMi206729944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474231 – 457Zinc finger protein 140Add BLAST457

Proteomic databases

EPDiP52738
PaxDbiP52738
PeptideAtlasiP52738
PRIDEiP52738
ProteomicsDBi56511

PTM databases

iPTMnetiP52738
PhosphoSitePlusiP52738

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000196387
CleanExiHS_ZNF140
ExpressionAtlasiP52738 baseline and differential
GenevisibleiP52738 HS

Organism-specific databases

HPAiHPA048332

Interactioni

Protein-protein interaction databases

BioGridi113493, 4 interactors
IntActiP52738, 1 interactor
STRINGi9606.ENSP00000347755

Structurei

3D structure databases

ProteinModelPortaliP52738
SMRiP52738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri189 – 211C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP52738
KOiK09228
OMAiSKAFRCH
OrthoDBiEOG091G02KC
PhylomeDBiP52738
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52738-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS
60 70 80 90 100
KPDVVSLLEQ GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ
110 120 130 140 150
YLIMERILSQ GPVYSSFKGG WKCKDHTEML QENQGCIRKV TVSHQEALAQ
160 170 180 190 200
HMNISTVERP YGCHECGKTF GRRFSLVLHQ RTHTGEKPYA CKECGKTFSQ
210 220 230 240 250
ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT GEKPYECTEC
260 270 280 290 300
GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP
310 320 330 340 350
YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI
360 370 380 390 400
HAGEKLYECD ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL
410 420 430 440 450
ILHQRTHTGE KPYVCKVCNK SFSWSSNLAK HQRTHTLDNP YEYENSFNYH

SFLTEHQ
Length:457
Mass (Da):52,996
Last modified:September 23, 2008 - v2
Checksum:iF4FF0B7D85E03731
GO
Isoform 2 (identifier: P52738-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:354
Mass (Da):41,169
Checksum:iA0EEAF0E30DF4A52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338F → L in AAC50262 (PubMed:7649249).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046562386A → V. Corresponds to variant dbSNP:rs2229373Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564361 – 103Missing in isoform 2. 2 PublicationsAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09368 mRNA Translation: AAC50262.1
AK122741 mRNA Translation: BAG53698.1
AK303240 mRNA Translation: BAG64326.1
AC026786 Genomic DNA No translation available.
AC073911 Genomic DNA No translation available.
CH471218 Genomic DNA Translation: EAW54795.1
CH471218 Genomic DNA Translation: EAW54797.1
CH471218 Genomic DNA Translation: EAW54798.1
BC022291 mRNA Translation: AAH22291.1
BC040561 mRNA Translation: AAH40561.1
CCDSiCCDS73550.1 [P52738-2]
CCDS9282.1 [P52738-1]
PIRiC57785
RefSeqiNP_001287705.1, NM_001300776.1 [P52738-2]
NP_001287706.1, NM_001300777.1
NP_001287707.1, NM_001300778.1 [P52738-2]
NP_003431.2, NM_003440.3 [P52738-1]
XP_011533137.1, XM_011534835.2 [P52738-1]
XP_011533142.1, XM_011534840.2 [P52738-2]
XP_016875413.1, XM_017019924.1 [P52738-2]
XP_016875414.1, XM_017019925.1 [P52738-2]
UniGeneiHs.181552

Genome annotation databases

EnsembliENST00000355557; ENSP00000347755; ENSG00000196387 [P52738-1]
ENST00000544426; ENSP00000445411; ENSG00000196387 [P52738-2]
GeneIDi7699
KEGGihsa:7699
UCSCiuc001ulo.4 human [P52738-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN140_HUMAN
AccessioniPrimary (citable) accession number: P52738
Secondary accession number(s): D3DXJ3, Q05CP6, Q8IV75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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