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Protein

Zinc finger protein 136

Gene

ZNF136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 136
Gene namesi
Name:ZNF136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12920. ZNF136.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37508.

Polymorphism and mutation databases

BioMutaiZNF136.
DMDMi1731412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Zinc finger protein 136PRO_0000047420Add
BLAST

Proteomic databases

MaxQBiP52737.
PaxDbiP52737.
PRIDEiP52737.

PTM databases

iPTMnetiP52737.
PhosphoSiteiP52737.

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiP52737.
CleanExiHS_ZNF136.
ExpressionAtlasiP52737. baseline and differential.
GenevisibleiP52737. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952734EBI-749129,EBI-748961
CEP70Q8NHQ15EBI-749129,EBI-739624
MDFIQ997507EBI-749129,EBI-724076
MTUS2Q5JR594EBI-749129,EBI-742948

Protein-protein interaction databases

BioGridi113490. 8 interactions.
IntActiP52737. 4 interactions.
STRINGi9606.ENSP00000344162.

Structurei

3D structure databases

ProteinModelPortaliP52737.
SMRiP52737. Positions 4-54, 136-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 9087KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52737.
KOiK09228.
OMAiFSCIPSM.
PhylomeDBiP52737.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVAFEDVD VNFTQEEWAL LDPSQKNLYR DVMWETMRNL ASIGKKWKDQ
60 70 80 90 100
NIKDHYKHRG RNLRSHMLER LYQTKDGSQR GGIFSQFANQ NLSKKIPGVK
110 120 130 140 150
LCESIVYGEV SMGQSSLNRH IKDHSGHEPK EYQEYGEKPD TRNQCWKPFS
160 170 180 190 200
SHHSFRTHEI IHTGEKLYDC KECGKTFFSL KRIRRHIITH SGYTPYKCKV
210 220 230 240 250
CGKAFDYPSR FRTHERSHTG EKPYECQECG KAFTCITSVR RHMIKHTGDG
260 270 280 290 300
PYKCKVCGKP FHSLSSFQVH ERIHTGEKPF KCKQCGKAFS CSPTLRIHER
310 320 330 340 350
THTGEKPYEC KQCGKAFSYL PSLRLHERIH TGEKPFVCKQ CGKAFRSAST
360 370 380 390 400
FQIHERTHTG EKPYECKECG EAFSCIPSMR RHMIKHTGEG PYKCKVCGKP
410 420 430 440 450
FHSLSPFRIH ERTHTGEKPY VCKHCGKAFV SSTSIRIHER THTGEKPYEC
460 470 480 490 500
KQCGKAFSYL NSFRTHEMIH TGEKPFECKR CGKAFRSSSS FRLHERTHTG
510 520 530 540
QKPYHCKECG KAYSCRASFQ RHMLTHAEDG PPYKCMWESL
Length:540
Mass (Da):62,784
Last modified:October 1, 1996 - v1
Checksum:i313297AB22F62952
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071Y → C.
Corresponds to variant rs10425995 [ dbSNP | Ensembl ].
VAR_033555

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09367 mRNA. Translation: AAC50261.1.
BC006421 mRNA. Translation: AAH06421.1.
CCDSiCCDS32916.1.
PIRiB57785.
RefSeqiNP_003428.1. NM_003437.3.
UniGeneiHs.479874.

Genome annotation databases

EnsembliENST00000343979; ENSP00000344162; ENSG00000196646.
GeneIDi7695.
KEGGihsa:7695.
UCSCiuc002mti.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09367 mRNA. Translation: AAC50261.1.
BC006421 mRNA. Translation: AAH06421.1.
CCDSiCCDS32916.1.
PIRiB57785.
RefSeqiNP_003428.1. NM_003437.3.
UniGeneiHs.479874.

3D structure databases

ProteinModelPortaliP52737.
SMRiP52737. Positions 4-54, 136-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113490. 8 interactions.
IntActiP52737. 4 interactions.
STRINGi9606.ENSP00000344162.

PTM databases

iPTMnetiP52737.
PhosphoSiteiP52737.

Polymorphism and mutation databases

BioMutaiZNF136.
DMDMi1731412.

Proteomic databases

MaxQBiP52737.
PaxDbiP52737.
PRIDEiP52737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343979; ENSP00000344162; ENSG00000196646.
GeneIDi7695.
KEGGihsa:7695.
UCSCiuc002mti.4. human.

Organism-specific databases

CTDi7695.
GeneCardsiZNF136.
HGNCiHGNC:12920. ZNF136.
MIMi604078. gene.
neXtProtiNX_P52737.
PharmGKBiPA37508.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52737.
KOiK09228.
OMAiFSCIPSM.
PhylomeDBiP52737.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7695.
PROiP52737.
SOURCEiSearch...

Gene expression databases

BgeeiP52737.
CleanExiHS_ZNF136.
ExpressionAtlasiP52737. baseline and differential.
GenevisibleiP52737. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins."
    Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.
    FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.
  2. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiZN136_HUMAN
AccessioniPrimary (citable) accession number: P52737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.