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Protein

Zinc finger protein 136

Gene

ZNF136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 136
Gene namesi
Name:ZNF136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196646.11.
HGNCiHGNC:12920. ZNF136.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196646.
PharmGKBiPA37508.

Polymorphism and mutation databases

BioMutaiZNF136.
DMDMi1731412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474201 – 540Zinc finger protein 136Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP52737.
PaxDbiP52737.
PeptideAtlasiP52737.
PRIDEiP52737.

PTM databases

iPTMnetiP52737.
PhosphoSitePlusiP52737.

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000196646.
CleanExiHS_ZNF136.
ExpressionAtlasiP52737. baseline and differential.
GenevisibleiP52737. HS.

Organism-specific databases

HPAiHPA054120.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113490. 15 interactors.
IntActiP52737. 6 interactors.
STRINGi9606.ENSP00000344162.

Structurei

3D structure databases

ProteinModelPortaliP52737.
SMRiP52737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 90KRABPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52737.
KOiK09228.
OMAiKCMWESL.
OrthoDBiEOG091G02KC.
PhylomeDBiP52737.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.

Sequencei

Sequence statusi: Complete.

P52737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVAFEDVD VNFTQEEWAL LDPSQKNLYR DVMWETMRNL ASIGKKWKDQ
60 70 80 90 100
NIKDHYKHRG RNLRSHMLER LYQTKDGSQR GGIFSQFANQ NLSKKIPGVK
110 120 130 140 150
LCESIVYGEV SMGQSSLNRH IKDHSGHEPK EYQEYGEKPD TRNQCWKPFS
160 170 180 190 200
SHHSFRTHEI IHTGEKLYDC KECGKTFFSL KRIRRHIITH SGYTPYKCKV
210 220 230 240 250
CGKAFDYPSR FRTHERSHTG EKPYECQECG KAFTCITSVR RHMIKHTGDG
260 270 280 290 300
PYKCKVCGKP FHSLSSFQVH ERIHTGEKPF KCKQCGKAFS CSPTLRIHER
310 320 330 340 350
THTGEKPYEC KQCGKAFSYL PSLRLHERIH TGEKPFVCKQ CGKAFRSAST
360 370 380 390 400
FQIHERTHTG EKPYECKECG EAFSCIPSMR RHMIKHTGEG PYKCKVCGKP
410 420 430 440 450
FHSLSPFRIH ERTHTGEKPY VCKHCGKAFV SSTSIRIHER THTGEKPYEC
460 470 480 490 500
KQCGKAFSYL NSFRTHEMIH TGEKPFECKR CGKAFRSSSS FRLHERTHTG
510 520 530 540
QKPYHCKECG KAYSCRASFQ RHMLTHAEDG PPYKCMWESL
Length:540
Mass (Da):62,784
Last modified:October 1, 1996 - v1
Checksum:i313297AB22F62952
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033555107Y → C. Corresponds to variant dbSNP:rs10425995Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09367 mRNA. Translation: AAC50261.1.
BC006421 mRNA. Translation: AAH06421.1.
CCDSiCCDS32916.1.
PIRiB57785.
RefSeqiNP_001334942.1. NM_001348013.1.
NP_001334943.1. NM_001348014.1.
NP_003428.1. NM_003437.4.
UniGeneiHs.479874.
Hs.627287.

Genome annotation databases

EnsembliENST00000343979; ENSP00000344162; ENSG00000196646.
GeneIDi7695.
KEGGihsa:7695.
UCSCiuc002mti.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN136_HUMAN
AccessioniPrimary (citable) accession number: P52737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families