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Protein

Zinc finger protein 133

Gene

ZNF133

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 631C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 133
Alternative name(s):
Zinc finger protein 150
Gene namesi
Name:ZNF133
Synonyms:ZNF150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:12917. ZNF133.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7692.
OpenTargetsiENSG00000125846.
PharmGKBiPA134900961.

Polymorphism and mutation databases

DMDMi116242855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474171 – 654Zinc finger protein 133Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki506Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki618Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP52736.
PaxDbiP52736.
PeptideAtlasiP52736.
PRIDEiP52736.

PTM databases

iPTMnetiP52736.
PhosphoSitePlusiP52736.

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000125846.
CleanExiHS_ZNF133.
ExpressionAtlasiP52736. baseline and differential.
GenevisibleiP52736. HS.

Organism-specific databases

HPAiHPA001493.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113487. 26 interactors.
IntActiP52736. 7 interactors.
MINTiMINT-8247504.
STRINGi9606.ENSP00000366899.

Structurei

3D structure databases

ProteinModelPortaliP52736.
SMRiP52736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 236C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 631C2H2-type 15; atypicalPROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52736.
KOiK09228.
PhylomeDBiP52736.
TreeFamiTF338096.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI
60 70 80 90 100
TQLEQGKETW REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL
110 120 130 140 150
CNHPPWIFTC LCAEGNIQPG DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG
160 170 180 190 200
AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG LRGVELEASP AQSGNPEETD
210 220 230 240 250
KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK PYVCGVCEKG
260 270 280 290 300
FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC
310 320 330 340 350
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE
360 370 380 390 400
EKTIVCSDCG LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH
410 420 430 440 450
QRTHSKEKPY VCGVCGHSFS QNSTLISHRR THTGEKPYVC GVCGRGFSLK
460 470 480 490 500
SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN LIRHQRTHSG EKPMVCGECG
510 520 530 540 550
RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH KRKHSREKPY
560 570 580 590 600
MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH
610 620 630 640 650
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS

LYSL
Length:654
Mass (Da):73,388
Last modified:October 17, 2006 - v2
Checksum:iCF1D47B223A6DD84
GO
Isoform 2 (identifier: P52736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Show »
Length:653
Mass (Da):73,317
Checksum:i883575A9CF6CD81D
GO
Isoform 3 (identifier: P52736-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):62,460
Checksum:iDE76B50A05C5C9FD
GO
Isoform 4 (identifier: P52736-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MAFRDVAVDF...EKKCSPATCP → MCNGRKTVL

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):66,027
Checksum:i794B47D25C80881D
GO
Isoform 5 (identifier: P52736-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAHM

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):73,728
Checksum:iF7B081A6F912B039
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228N → S in BAG58259 (PubMed:14702039).Curated1
Sequence conflicti363F → Y in BAG58430 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028228193S → T6 PublicationsCorresponds to variant dbSNP:rs1033545Ensembl.1
Natural variantiVAR_028229194G → E. Corresponds to variant dbSNP:rs2228273Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550211 – 95Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0550221 – 72MAFRD…PATCP → MCNGRKTVL in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0550231M → MAHM in isoform 5. 1 Publication1
Alternative sequenceiVSP_03914873Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09366 mRNA. Translation: AAC50260.1.
BT007310 mRNA. Translation: AAP35974.1.
AK291389 mRNA. Translation: BAF84078.1.
AK295273 mRNA. Translation: BAG58259.1.
AK295513 mRNA. Translation: BAG58430.1.
AK316386 mRNA. Translation: BAH14757.1.
AL049646 Genomic DNA. Translation: CAC15508.1.
AL049646 Genomic DNA. Translation: CAI21835.1.
CH471133 Genomic DNA. Translation: EAX10250.1.
CH471133 Genomic DNA. Translation: EAX10251.1.
CH471133 Genomic DNA. Translation: EAX10252.1.
CH471133 Genomic DNA. Translation: EAX10253.1.
BC001887 mRNA. Translation: AAH01887.1.
CCDSiCCDS13134.1. [P52736-2]
CCDS63233.1. [P52736-5]
CCDS63234.1. [P52736-1]
CCDS63235.1. [P52736-4]
PIRiA57785.
RefSeqiNP_001076799.1. NM_001083330.2.
NP_001269924.1. NM_001282995.1.
NP_001269925.1. NM_001282996.1.
NP_001269926.1. NM_001282997.1.
NP_001269927.1. NM_001282998.1.
NP_001269928.1. NM_001282999.1.
NP_001269929.1. NM_001283000.1.
NP_001269930.1. NM_001283001.1.
NP_001269931.1. NM_001283002.1.
NP_001269932.1. NM_001283003.1.
NP_001269933.1. NM_001283004.1.
NP_001269934.1. NM_001283005.1.
NP_001269935.1. NM_001283006.1.
NP_001269936.1. NM_001283007.1.
NP_001269937.1. NM_001283008.1.
NP_003425.2. NM_003434.5.
XP_005260876.1. XM_005260819.1. [P52736-1]
XP_005260877.1. XM_005260820.4. [P52736-1]
XP_011527638.1. XM_011529336.1. [P52736-1]
XP_011527639.1. XM_011529337.1. [P52736-1]
XP_011527640.1. XM_011529338.2. [P52736-1]
XP_011527641.1. XM_011529339.1. [P52736-1]
XP_016883530.1. XM_017028041.1. [P52736-5]
XP_016883531.1. XM_017028042.1. [P52736-5]
XP_016883533.1. XM_017028044.1. [P52736-1]
XP_016883534.1. XM_017028045.1. [P52736-1]
XP_016883535.1. XM_017028046.1. [P52736-1]
XP_016883536.1. XM_017028047.1. [P52736-1]
XP_016883537.1. XM_017028048.1. [P52736-1]
XP_016883538.1. XM_017028049.1. [P52736-2]
XP_016883539.1. XM_017028050.1. [P52736-2]
XP_016883540.1. XM_017028051.1. [P52736-2]
XP_016883541.1. XM_017028052.1. [P52736-2]
XP_016883542.1. XM_017028053.1. [P52736-2]
XP_016883543.1. XM_017028054.1. [P52736-2]
XP_016883544.1. XM_017028055.1. [P52736-4]
XP_016883545.1. XM_017028056.1. [P52736-4]
XP_016883546.1. XM_017028057.1. [P52736-4]
UniGeneiHs.472221.

Genome annotation databases

EnsembliENST00000316358; ENSP00000346090; ENSG00000125846. [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846. [P52736-2]
ENST00000396026; ENSP00000400897; ENSG00000125846. [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846. [P52736-1]
ENST00000402618; ENSP00000385279; ENSG00000125846. [P52736-4]
ENST00000622607; ENSP00000481326; ENSG00000125846. [P52736-1]
ENST00000628216; ENSP00000487315; ENSG00000125846. [P52736-5]
ENST00000630056; ENSP00000485741; ENSG00000125846. [P52736-3]
GeneIDi7692.
KEGGihsa:7692.
UCSCiuc002wql.6. human. [P52736-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN133_HUMAN
AccessioniPrimary (citable) accession number: P52736
Secondary accession number(s): A8K5S4
, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: August 30, 2017
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families