P52736 (ZN133_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 133

Alternative name(s):
Zinc finger protein 150

Gene names

Name:	ZNF133
Synonyms:	ZNF150

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	654 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation as a repressor.
Subcellular location	Nucleus Potential.
Tissue specificity	Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Traceable author statement Ref.2PubMed 9278146. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FOS	P01100	4	EBI-2687350,EBI-852851

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P52736-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P52736-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 654	654	Zinc finger protein 133		PRO_0000047417
Regions
	Domain	1 – 72	72	KRAB
	Zinc finger	214 – 236	23	C2H2-type 1
	Zinc finger	242 – 264	23	C2H2-type 2
	Zinc finger	270 – 292	23	C2H2-type 3
	Zinc finger	298 – 320	23	C2H2-type 4
	Zinc finger	326 – 348	23	C2H2-type 5
	Zinc finger	354 – 376	23	C2H2-type 6
	Zinc finger	382 – 404	23	C2H2-type 7
	Zinc finger	410 – 432	23	C2H2-type 8
	Zinc finger	438 – 460	23	C2H2-type 9
	Zinc finger	466 – 488	23	C2H2-type 10
	Zinc finger	494 – 516	23	C2H2-type 11
	Zinc finger	522 – 544	23	C2H2-type 12
	Zinc finger	550 – 572	23	C2H2-type 13
	Zinc finger	578 – 600	23	C2H2-type 14
	Zinc finger	606 – 631	26	C2H2-type 15; atypical
Natural variations
	Alternative sequence	73	1	Missing in isoform 2.		VSP_039148
	Natural variant	193	1	S → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.7 Corresponds to variant rs1033545 [ dbSNP | Ensembl ].		VAR_028228
	Natural variant	194	1	G → E. Corresponds to variant rs2228273 [ dbSNP | Ensembl ].		VAR_028229

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: CF1D47B223A6DD84	FASTA	654	73,388
	10 20 30 40 50 60 MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI TQLEQGKETW 70 80 90 100 110 120 REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL CNHPPWIFTC LCAEGNIQPG 130 140 150 160 170 180 DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG 190 200 210 220 230 240 LRGVELEASP AQSGNPEETD KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK 250 260 270 280 290 300 PYVCGVCEKG FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC 310 320 330 340 350 360 SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE EKTIVCSDCG 370 380 390 400 410 420 LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH QRTHSKEKPY VCGVCGHSFS 430 440 450 460 470 480 QNSTLISHRR THTGEKPYVC GVCGRGFSLK SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN 490 500 510 520 530 540 LIRHQRTHSG EKPMVCGECG RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH 550 560 570 580 590 600 KRKHSREKPY MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH 610 620 630 640 650 TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS LYSL
	Isoform 2 [UniParc]. Checksum: 883575A9CF6CD81D	FASTA	653	73,317
	10 20 30 40 50 60 MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI TQLEQGKETW 70 80 90 100 110 120 REEKKCSPAT CPDPEPELYL DPFCPPGFSS QKFPMQHVLC NHPPWIFTCL CAEGNIQPGD 130 140 150 160 170 180 PGPGDQEKQQ QASEGRPWSD QAEGPEGEGA MPLFGRTKKR TLGAFSRPPQ RQPVSSRNGL 190 200 210 220 230 240 RGVELEASPA QSGNPEETDK LLKRIEVLGF GTVNCGECGL SFSKMTNLLS HQRIHSGEKP 250 260 270 280 290 300 YVCGVCEKGF SLKKSLARHQ KAHSGEKPIV CRECGRGFNR KSTLIIHERT HSGEKPYMCS 310 320 330 340 350 360 ECGRGFSQKS NLIIHQRTHS GEKPYVCREC GKGFSQKSAV VRHQRTHLEE KTIVCSDCGL 370 380 390 400 410 420 GFSDRSNLIS HQRTHSGEKP YACKECGRCF RQRTTLVNHQ RTHSKEKPYV CGVCGHSFSQ 430 440 450 460 470 480 NSTLISHRRT HTGEKPYVCG VCGRGFSLKS HLNRHQNIHS GEKPIVCKDC GRGFSQQSNL 490 500 510 520 530 540 IRHQRTHSGE KPMVCGECGR GFSQKSNLVA HQRTHSGERP YVCRECGRGF SHQAGLIRHK 550 560 570 580 590 600 RKHSREKPYM CRQCGLGFGN KSALITHKRA HSEEKPCVCR ECGQGFLQKS HLTLHQMTHT 610 620 630 640 650 GEKPYVCKTC GRGFSLKSHL SRHRKTTSVH HRLPVQPDPE PCAGQPSDSL YSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins." Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J. FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-193. Tissue: Insulinoma.
[2]	"Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders." Tommerup N., Vissing H. Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-193. Tissue: Insulinoma.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-193.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-193. Tissue: Brain.
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-193.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-193. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09366 mRNA. Translation: AAC50260.1. BT007310 mRNA. Translation: AAP35974.1. AK291389 mRNA. Translation: BAF84078.1. AL049646 Genomic DNA. Translation: CAC15508.1. AL049646 Genomic DNA. Translation: CAI21835.1. CH471133 Genomic DNA. Translation: EAX10250.1. CH471133 Genomic DNA. Translation: EAX10253.1. BC001887 mRNA. Translation: AAH01887.1.
IPI	IPI00797700. IPI00942217.
PIR	A57785.
RefSeq	NP_001076799.1. NM_001083330.1. NP_003425.2. NM_003434.4.
UniGene	Hs.472221.
3D structure databases
ProteinModelPortal	P52736.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52736. 2 interactions.
MINT	MINT-8247504.
STRING	9606.ENSP00000366899.
PTM databases
PhosphoSite	P52736.
Polymorphism databases
DMDM	116242855.
Proteomic databases
PaxDb	P52736.
PRIDE	P52736.
Protocols and materials databases
DNASU	7692.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316358; ENSP00000346090; ENSG00000125846. ENST00000377671; ENSP00000366899; ENSG00000125846. ENST00000401790; ENSP00000383945; ENSG00000125846.
GeneID	7692.
KEGG	hsa:7692.
UCSC	uc002wql.4. human. uc002wqm.2. human.
Organism-specific databases
CTD	7692.
GeneCards	GC20P018264.
HGNC	HGNC:12917. ZNF133.
HPA	HPA001493.
MIM	604075. gene.
neXtProt	NX_P52736.
PharmGKB	PA134900961.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P52736.
KO	K09228.
OrthoDB	EOG476JZM.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P52736.
Bgee	P52736.
CleanEx	HS_ZNF133.
Genevestigator	P52736.
GermOnline	ENSG00000125846. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 15 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 14 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF133. human.
GenomeRNAi	7692.
NextBio	29814.
SOURCE	Search...

Entry information

Entry name

ZN133_HUMAN

Accession

Primary (citable) accession number: P52736
Secondary accession number(s): A8K5S4 , Q53XU1, Q5JXV8, Q9BUV2, Q9H443

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 17, 2006
Last modified:	May 29, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.