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P52736 (ZN133_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 133
Alternative name(s):
Zinc finger protein 150
Gene names
Name:ZNF133
Synonyms:ZNF150
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation as a repressor.

Subcellular location

Nucleus Potential.

Tissue specificity

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.2PubMed 9278146. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FOSP011004EBI-2687350,EBI-852851

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P52736-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P52736-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 654654Zinc finger protein 133
PRO_0000047417

Regions

Domain1 – 7272KRAB
Zinc finger214 – 23623C2H2-type 1
Zinc finger242 – 26423C2H2-type 2
Zinc finger270 – 29223C2H2-type 3
Zinc finger298 – 32023C2H2-type 4
Zinc finger326 – 34823C2H2-type 5
Zinc finger354 – 37623C2H2-type 6
Zinc finger382 – 40423C2H2-type 7
Zinc finger410 – 43223C2H2-type 8
Zinc finger438 – 46023C2H2-type 9
Zinc finger466 – 48823C2H2-type 10
Zinc finger494 – 51623C2H2-type 11
Zinc finger522 – 54423C2H2-type 12
Zinc finger550 – 57223C2H2-type 13
Zinc finger578 – 60023C2H2-type 14
Zinc finger606 – 63126C2H2-type 15; atypical

Natural variations

Alternative sequence731Missing in isoform 2.
VSP_039148
Natural variant1931S → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Ref.7
Corresponds to variant rs1033545 [ dbSNP | Ensembl ].
VAR_028228
Natural variant1941G → E.
Corresponds to variant rs2228273 [ dbSNP | Ensembl ].
VAR_028229

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: CF1D47B223A6DD84

FASTA65473,388
        10         20         30         40         50         60 
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI TQLEQGKETW 

        70         80         90        100        110        120 
REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL CNHPPWIFTC LCAEGNIQPG 

       130        140        150        160        170        180 
DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG 

       190        200        210        220        230        240 
LRGVELEASP AQSGNPEETD KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK 

       250        260        270        280        290        300 
PYVCGVCEKG FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC 

       310        320        330        340        350        360 
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE EKTIVCSDCG 

       370        380        390        400        410        420 
LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH QRTHSKEKPY VCGVCGHSFS 

       430        440        450        460        470        480 
QNSTLISHRR THTGEKPYVC GVCGRGFSLK SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN 

       490        500        510        520        530        540 
LIRHQRTHSG EKPMVCGECG RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH 

       550        560        570        580        590        600 
KRKHSREKPY MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH 

       610        620        630        640        650 
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS LYSL 

« Hide

Isoform 2 [UniParc].

Checksum: 883575A9CF6CD81D
Show »

FASTA65373,317

References

« Hide 'large scale' references
[1]"Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins."
Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.
FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-193.
Tissue: Insulinoma.
[2]"Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
Tommerup N., Vissing H.
Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-193.
Tissue: Insulinoma.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-193.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-193.
Tissue: Brain.
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-193.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-193.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09366 mRNA. Translation: AAC50260.1.
BT007310 mRNA. Translation: AAP35974.1.
AK291389 mRNA. Translation: BAF84078.1.
AL049646 Genomic DNA. Translation: CAC15508.1.
AL049646 Genomic DNA. Translation: CAI21835.1.
CH471133 Genomic DNA. Translation: EAX10250.1.
CH471133 Genomic DNA. Translation: EAX10253.1.
BC001887 mRNA. Translation: AAH01887.1.
PIRA57785.
RefSeqNP_001076799.1. NM_001083330.2.
NP_001269924.1. NM_001282995.1.
NP_001269925.1. NM_001282996.1.
NP_001269926.1. NM_001282997.1.
NP_001269927.1. NM_001282998.1.
NP_001269928.1. NM_001282999.1.
NP_001269929.1. NM_001283000.1.
NP_001269930.1. NM_001283001.1.
NP_001269931.1. NM_001283002.1.
NP_001269932.1. NM_001283003.1.
NP_001269933.1. NM_001283004.1.
NP_001269934.1. NM_001283005.1.
NP_001269935.1. NM_001283006.1.
NP_001269936.1. NM_001283007.1.
NP_001269937.1. NM_001283008.1.
NP_003425.2. NM_003434.5.
XP_005260876.1. XM_005260819.1.
XP_005260877.1. XM_005260820.2.
XP_005260880.1. XM_005260823.2.
UniGeneHs.472221.

3D structure databases

ProteinModelPortalP52736.
SMRP52736. Positions 1-44, 211-627.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113487. 6 interactions.
IntActP52736. 6 interactions.
MINTMINT-8247504.
STRING9606.ENSP00000366899.

PTM databases

PhosphoSiteP52736.

Polymorphism databases

DMDM116242855.

Proteomic databases

PaxDbP52736.
PRIDEP52736.

Protocols and materials databases

DNASU7692.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316358; ENSP00000346090; ENSG00000125846. [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846. [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846. [P52736-1]
GeneID7692.
KEGGhsa:7692.
UCSCuc002wql.4. human. [P52736-2]
uc002wqm.2. human. [P52736-1]

Organism-specific databases

CTD7692.
GeneCardsGC20P018264.
HGNCHGNC:12917. ZNF133.
HPAHPA001493.
MIM604075. gene.
neXtProtNX_P52736.
PharmGKBPA134900961.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP52736.
KOK09228.
OrthoDBEOG7KSX7Q.
PhylomeDBP52736.
TreeFamTF338096.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressP52736.
BgeeP52736.
CleanExHS_ZNF133.
GenevestigatorP52736.

Family and domain databases

Gene3D3.30.160.60. 15 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF133. human.
GeneWikiZNF133.
GenomeRNAi7692.
NextBio29814.
PROP52736.
SOURCESearch...

Entry information

Entry nameZN133_HUMAN
AccessionPrimary (citable) accession number: P52736
Secondary accession number(s): A8K5S4 expand/collapse secondary AC list , Q53XU1, Q5JXV8, Q9BUV2, Q9H443
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM