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Protein

Zinc finger protein 133

Gene

ZNF133

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation as a repressor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 23623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 63126C2H2-type 15; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 133
Alternative name(s):
Zinc finger protein 150
Gene namesi
Name:ZNF133
Synonyms:ZNF150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:12917. ZNF133.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134900961.

Polymorphism and mutation databases

DMDMi116242855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Zinc finger protein 133PRO_0000047417Add
BLAST

Proteomic databases

PaxDbiP52736.
PRIDEiP52736.

PTM databases

PhosphoSiteiP52736.

Expressioni

Tissue specificityi

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiP52736.
CleanExiHS_ZNF133.
ExpressionAtlasiP52736. baseline and differential.
GenevisibleiP52736. HS.

Organism-specific databases

HPAiHPA001493.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FOSP011004EBI-2687350,EBI-852851
KRTAP10-7P604093EBI-2687350,EBI-10172290

Protein-protein interaction databases

BioGridi113487. 7 interactions.
IntActiP52736. 7 interactions.
MINTiMINT-8247504.
STRINGi9606.ENSP00000366899.

Structurei

3D structure databases

ProteinModelPortaliP52736.
SMRiP52736. Positions 1-44, 216-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7272KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 23623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 63126C2H2-type 15; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52736.
KOiK09228.
OMAiKHSREKP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP52736.
TreeFamiTF338096.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P52736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI
60 70 80 90 100
TQLEQGKETW REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL
110 120 130 140 150
CNHPPWIFTC LCAEGNIQPG DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG
160 170 180 190 200
AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG LRGVELEASP AQSGNPEETD
210 220 230 240 250
KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK PYVCGVCEKG
260 270 280 290 300
FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC
310 320 330 340 350
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE
360 370 380 390 400
EKTIVCSDCG LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH
410 420 430 440 450
QRTHSKEKPY VCGVCGHSFS QNSTLISHRR THTGEKPYVC GVCGRGFSLK
460 470 480 490 500
SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN LIRHQRTHSG EKPMVCGECG
510 520 530 540 550
RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH KRKHSREKPY
560 570 580 590 600
MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH
610 620 630 640 650
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS

LYSL
Length:654
Mass (Da):73,388
Last modified:October 17, 2006 - v2
Checksum:iCF1D47B223A6DD84
GO
Isoform 2 (identifier: P52736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Missing.

Show »
Length:653
Mass (Da):73,317
Checksum:i883575A9CF6CD81D
GO
Isoform 3 (identifier: P52736-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):62,460
Checksum:iDE76B50A05C5C9FD
GO
Isoform 4 (identifier: P52736-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MAFRDVAVDF...EKKCSPATCP → MCNGRKTVL

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):66,027
Checksum:i794B47D25C80881D
GO
Isoform 5 (identifier: P52736-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAHM

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):73,728
Checksum:iF7B081A6F912B039
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281N → S in BAG58259 (PubMed:14702039).Curated
Sequence conflicti363 – 3631F → Y in BAG58430 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931S → T.6 Publications
Corresponds to variant rs1033545 [ dbSNP | Ensembl ].
VAR_028228
Natural varianti194 – 1941G → E.
Corresponds to variant rs2228273 [ dbSNP | Ensembl ].
VAR_028229

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9595Missing in isoform 3. 1 PublicationVSP_055021Add
BLAST
Alternative sequencei1 – 7272MAFRD…PATCP → MCNGRKTVL in isoform 4. 1 PublicationVSP_055022Add
BLAST
Alternative sequencei1 – 11M → MAHM in isoform 5. 1 PublicationVSP_055023
Alternative sequencei73 – 731Missing in isoform 2. 3 PublicationsVSP_039148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09366 mRNA. Translation: AAC50260.1.
BT007310 mRNA. Translation: AAP35974.1.
AK291389 mRNA. Translation: BAF84078.1.
AK295273 mRNA. Translation: BAG58259.1.
AK295513 mRNA. Translation: BAG58430.1.
AK316386 mRNA. Translation: BAH14757.1.
AL049646 Genomic DNA. Translation: CAC15508.1.
AL049646 Genomic DNA. Translation: CAI21835.1.
CH471133 Genomic DNA. Translation: EAX10250.1.
CH471133 Genomic DNA. Translation: EAX10251.1.
CH471133 Genomic DNA. Translation: EAX10252.1.
CH471133 Genomic DNA. Translation: EAX10253.1.
BC001887 mRNA. Translation: AAH01887.1.
CCDSiCCDS13134.1. [P52736-2]
CCDS63234.1. [P52736-1]
CCDS63235.1. [P52736-4]
PIRiA57785.
RefSeqiNP_001076799.1. NM_001083330.2.
NP_001269924.1. NM_001282995.1.
NP_001269925.1. NM_001282996.1.
NP_001269926.1. NM_001282997.1.
NP_001269927.1. NM_001282998.1.
NP_001269928.1. NM_001282999.1.
NP_001269929.1. NM_001283000.1.
NP_001269930.1. NM_001283001.1.
NP_001269931.1. NM_001283002.1.
NP_001269932.1. NM_001283003.1.
NP_001269933.1. NM_001283004.1.
NP_001269934.1. NM_001283005.1.
NP_001269935.1. NM_001283006.1.
NP_001269936.1. NM_001283007.1.
NP_001269937.1. NM_001283008.1.
NP_003425.2. NM_003434.5.
XP_005260876.1. XM_005260819.1. [P52736-1]
XP_005260877.1. XM_005260820.3. [P52736-1]
XP_005260880.1. XM_005260823.3. [P52736-1]
XP_006723680.1. XM_006723617.2. [P52736-4]
UniGeneiHs.472221.

Genome annotation databases

EnsembliENST00000316358; ENSP00000346090; ENSG00000125846. [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846. [P52736-2]
ENST00000396026; ENSP00000400897; ENSG00000125846. [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846. [P52736-1]
ENST00000402618; ENSP00000385279; ENSG00000125846. [P52736-4]
ENST00000622607; ENSP00000481326; ENSG00000125846. [P52736-1]
ENST00000628216; ENSP00000487315; ENSG00000125846. [P52736-5]
ENST00000630056; ENSP00000485741; ENSG00000125846. [P52736-3]
GeneIDi7692.
KEGGihsa:7692.
UCSCiuc002wql.4. human. [P52736-2]
uc002wqm.2. human. [P52736-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09366 mRNA. Translation: AAC50260.1.
BT007310 mRNA. Translation: AAP35974.1.
AK291389 mRNA. Translation: BAF84078.1.
AK295273 mRNA. Translation: BAG58259.1.
AK295513 mRNA. Translation: BAG58430.1.
AK316386 mRNA. Translation: BAH14757.1.
AL049646 Genomic DNA. Translation: CAC15508.1.
AL049646 Genomic DNA. Translation: CAI21835.1.
CH471133 Genomic DNA. Translation: EAX10250.1.
CH471133 Genomic DNA. Translation: EAX10251.1.
CH471133 Genomic DNA. Translation: EAX10252.1.
CH471133 Genomic DNA. Translation: EAX10253.1.
BC001887 mRNA. Translation: AAH01887.1.
CCDSiCCDS13134.1. [P52736-2]
CCDS63234.1. [P52736-1]
CCDS63235.1. [P52736-4]
PIRiA57785.
RefSeqiNP_001076799.1. NM_001083330.2.
NP_001269924.1. NM_001282995.1.
NP_001269925.1. NM_001282996.1.
NP_001269926.1. NM_001282997.1.
NP_001269927.1. NM_001282998.1.
NP_001269928.1. NM_001282999.1.
NP_001269929.1. NM_001283000.1.
NP_001269930.1. NM_001283001.1.
NP_001269931.1. NM_001283002.1.
NP_001269932.1. NM_001283003.1.
NP_001269933.1. NM_001283004.1.
NP_001269934.1. NM_001283005.1.
NP_001269935.1. NM_001283006.1.
NP_001269936.1. NM_001283007.1.
NP_001269937.1. NM_001283008.1.
NP_003425.2. NM_003434.5.
XP_005260876.1. XM_005260819.1. [P52736-1]
XP_005260877.1. XM_005260820.3. [P52736-1]
XP_005260880.1. XM_005260823.3. [P52736-1]
XP_006723680.1. XM_006723617.2. [P52736-4]
UniGeneiHs.472221.

3D structure databases

ProteinModelPortaliP52736.
SMRiP52736. Positions 1-44, 216-627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113487. 7 interactions.
IntActiP52736. 7 interactions.
MINTiMINT-8247504.
STRINGi9606.ENSP00000366899.

PTM databases

PhosphoSiteiP52736.

Polymorphism and mutation databases

DMDMi116242855.

Proteomic databases

PaxDbiP52736.
PRIDEiP52736.

Protocols and materials databases

DNASUi7692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316358; ENSP00000346090; ENSG00000125846. [P52736-1]
ENST00000377671; ENSP00000366899; ENSG00000125846. [P52736-2]
ENST00000396026; ENSP00000400897; ENSG00000125846. [P52736-2]
ENST00000401790; ENSP00000383945; ENSG00000125846. [P52736-1]
ENST00000402618; ENSP00000385279; ENSG00000125846. [P52736-4]
ENST00000622607; ENSP00000481326; ENSG00000125846. [P52736-1]
ENST00000628216; ENSP00000487315; ENSG00000125846. [P52736-5]
ENST00000630056; ENSP00000485741; ENSG00000125846. [P52736-3]
GeneIDi7692.
KEGGihsa:7692.
UCSCiuc002wql.4. human. [P52736-2]
uc002wqm.2. human. [P52736-1]

Organism-specific databases

CTDi7692.
GeneCardsiGC20P018264.
HGNCiHGNC:12917. ZNF133.
HPAiHPA001493.
MIMi604075. gene.
neXtProtiNX_P52736.
PharmGKBiPA134900961.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063157.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP52736.
KOiK09228.
OMAiKHSREKP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP52736.
TreeFamiTF338096.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF133. human.
GeneWikiiZNF133.
GenomeRNAii7692.
NextBioi29814.
PROiP52736.
SOURCEiSearch...

Gene expression databases

BgeeiP52736.
CleanExiHS_ZNF133.
ExpressionAtlasiP52736. baseline and differential.
GenevisibleiP52736. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins."
    Vissing H., Meyer W.-K., Aagaard L., Tommerup N., Thiesen H.-J.
    FEBS Lett. 369:153-157(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-193.
    Tissue: Insulinoma.
  2. "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders."
    Tommerup N., Vissing H.
    Genomics 27:259-264(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-193.
    Tissue: Insulinoma.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-193.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), VARIANT THR-193.
    Tissue: Brain, Caudate nucleus, Hippocampus and Testis.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-193.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-193.
    Tissue: Lung.

Entry informationi

Entry nameiZN133_HUMAN
AccessioniPrimary (citable) accession number: P52736
Secondary accession number(s): A8K5S4
, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.