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P52735

- VAV2_HUMAN

UniProt

P52735 - VAV2_HUMAN

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Protein
Guanine nucleotide exchange factor VAV2
Gene
VAV2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri523 – 57250Phorbol-ester/DAG-type
Add
BLAST

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  2. guanyl-nucleotide exchange factor activity Source: Reactome
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  3. angiogenesis Source: UniProtKB-KW
  4. apoptotic signaling pathway Source: Reactome
  5. axon guidance Source: Reactome
  6. blood coagulation Source: Reactome
  7. cell migration Source: Ensembl
  8. innate immune response Source: Reactome
  9. lamellipodium assembly Source: Ensembl
  10. neurotrophin TRK receptor signaling pathway Source: Reactome
  11. platelet activation Source: Reactome
  12. positive regulation of apoptotic process Source: Reactome
  13. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
  14. regulation of GTPase activity Source: GOC
  15. regulation of blood coagulation Source: UniProt
  16. regulation of gene expression Source: UniProt
  17. regulation of small GTPase mediated signal transduction Source: Reactome
  18. signal transduction Source: ProtInc
  19. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_147814. DAP12 signaling.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_1695. GPVI-mediated activation cascade.
REACT_18407. G alpha (12/13) signalling events.
REACT_22272. Signal transduction by L1.
SignaLinkiP52735.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor VAV2
Short name:
VAV-2
Gene namesi
Name:VAV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:12658. VAV2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Guanine nucleotide exchange factor VAV2
PRO_0000080984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei142 – 1421Phosphotyrosine; by EGFR1 Publication
Modified residuei159 – 1591Phosphotyrosine; by EGFR1 Publication
Modified residuei172 – 1721Phosphotyrosine; by EGFR1 Publication
Modified residuei576 – 5761Phosphoserine1 Publication
Modified residuei626 – 6261Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues in response to FGR activation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP52735.
PaxDbiP52735.
PRIDEiP52735.

PTM databases

PhosphoSiteiP52735.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiP52735.
GenevestigatoriP52735.

Organism-specific databases

HPAiHPA003224.

Interactioni

Subunit structurei

Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP By similarity. Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI1Q8IZP02EBI-297549,EBI-375446
ERBB2P046263EBI-297549,EBI-641062
GAB1Q134802EBI-297549,EBI-517684
NEK3P519563EBI-297549,EBI-476041
SH3BP2P783144EBI-297549,EBI-727062
TOM1L1O756742EBI-297549,EBI-712991

Protein-protein interaction databases

BioGridi113253. 61 interactions.
DIPiDIP-33088N.
IntActiP52735. 59 interactions.
MINTiMINT-1494337.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi661 – 6644
Helixi668 – 6703
Beta strandi674 – 6774
Helixi680 – 68910
Beta strandi694 – 6985
Beta strandi707 – 7126
Beta strandi714 – 72512
Beta strandi728 – 7314
Beta strandi737 – 7393
Helixi740 – 7478
Turni752 – 7554
Beta strandi767 – 7693
Beta strandi819 – 8257
Beta strandi842 – 8443
Beta strandi847 – 8548
Beta strandi856 – 8605
Beta strandi863 – 8675
Beta strandi869 – 8746

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLZNMR-A663-767[»]
2DM1NMR-A819-878[»]
2LNWNMR-A659-771[»]
2LNXNMR-A659-771[»]
ProteinModelPortaliP52735.
SMRiP52735. Positions 1-572, 589-878.

Miscellaneous databases

EvolutionaryTraceiP52735.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119CH
Add
BLAST
Domaini198 – 376179DH
Add
BLAST
Domaini405 – 512108PH
Add
BLAST
Domaini586 – 65267SH3 1
Add
BLAST
Domaini673 – 76795SH2
Add
BLAST
Domaini816 – 87762SH3 2
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH2 domain.
Contains 2 SH3 domains.

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiNOG326494.
HOVERGENiHBG018066.
InParanoidiP52735.
KOiK05730.
OMAiWFAGNME.
OrthoDBiEOG73FQKZ.
PhylomeDBiP52735.
TreeFamiTF316171.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF95. PTHR22826:SF95. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P52735-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL    50
SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF 100
DVRDFGKVIS AVSRLSLHSI AQNKGIRPFP SEETTENDDD VYRSLEELAD 150
EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV QQPMIRYMQK MGMTEDDKRN 200
CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV FINLEDLIKV 250
HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL 300
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS 350
AERPERQQLK EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL 400
EEFGRPKIDG ELKVRSIVNH TKQDRYLFLF DKVVIVCKRK GYSYELKEII 450
ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY LIHLQGKQGF QFFCKTEDMK 500
RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC KMFLRGTFYQ 550
GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN 600
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC 650
PVDGRPPISR PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER 700
PAEAERFAIS IKFNDEVKHI KVVEKDNWIH ITEAKKFDSL LELVEYYQCH 750
SLKESFKQLD TTLKYPYKSR ERSASRASSR SPASCASYNF SFLSPQGLSF 800
ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG DVVRIYSRIG 850
GDQGWWKGET NGRIGWFPST YVEEEGIQ 878
Length:878
Mass (Da):101,289
Last modified:July 22, 2008 - v2
Checksum:iC186911605FD5B73
GO
Isoform 2 (identifier: P52735-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.

Show »
Length:868
Mass (Da):100,057
Checksum:i6C67C472825D2DFD
GO
Isoform 3 (identifier: P52735-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.
     783-811: Missing.

Note: Contains a phosphoserine at position 769.

Show »
Length:839
Mass (Da):97,032
Checksum:i21910D516F4A211D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti594 – 5941M → V.2 Publications
Corresponds to variant rs602990 [ dbSNP | Ensembl ].
VAR_045690

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei185 – 1895Missing in isoform 2 and isoform 3.
VSP_034900
Alternative sequencei470 – 4745Missing in isoform 2 and isoform 3.
VSP_034901
Alternative sequencei783 – 81129Missing in isoform 3.
VSP_034902Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411F → L in CAE45861. 1 Publication
Sequence conflicti254 – 2541F → L in CAE45861. 1 Publication
Sequence conflicti877 – 8771I → T in CAE45861. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76992 mRNA. Translation: AAB34377.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12279.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13722.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15783.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12278.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13723.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15781.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12280.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13724.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15782.1.
CH471090 Genomic DNA. Translation: EAW88108.1.
BC033187 mRNA. Translation: AAH33187.1.
BC132965 mRNA. Translation: AAI32966.1.
BC132967 mRNA. Translation: AAI32968.1.
BX640754 mRNA. Translation: CAE45861.1.
AY563001 mRNA. Translation: AAS75591.1.
CCDSiCCDS48053.1. [P52735-1]
CCDS6979.1. [P52735-3]
PIRiI51940.
RefSeqiNP_001127870.1. NM_001134398.1. [P52735-1]
NP_003362.2. NM_003371.3. [P52735-3]
XP_005272270.1. XM_005272213.1. [P52735-2]
UniGeneiHs.369921.
Hs.689325.

Genome annotation databases

EnsembliENST00000371850; ENSP00000360916; ENSG00000160293. [P52735-1]
ENST00000371851; ENSP00000360917; ENSG00000160293. [P52735-2]
ENST00000406606; ENSP00000385362; ENSG00000160293. [P52735-3]
GeneIDi7410.
KEGGihsa:7410.
UCSCiuc004cer.3. human. [P52735-3]
uc004ces.3. human. [P52735-1]

Polymorphism databases

DMDMi212287930.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76992 mRNA. Translation: AAB34377.1 .
AL590710 , AL357934 , AL445931 Genomic DNA. Translation: CAI12279.1 .
AL445931 , AL357934 , AL590710 Genomic DNA. Translation: CAI13722.1 .
AL357934 , AL445931 , AL590710 Genomic DNA. Translation: CAI15783.1 .
AL590710 , AL357934 , AL445931 Genomic DNA. Translation: CAI12278.1 .
AL445931 , AL357934 , AL590710 Genomic DNA. Translation: CAI13723.1 .
AL357934 , AL445931 , AL590710 Genomic DNA. Translation: CAI15781.1 .
AL590710 , AL357934 , AL445931 Genomic DNA. Translation: CAI12280.1 .
AL445931 , AL357934 , AL590710 Genomic DNA. Translation: CAI13724.1 .
AL357934 , AL445931 , AL590710 Genomic DNA. Translation: CAI15782.1 .
CH471090 Genomic DNA. Translation: EAW88108.1 .
BC033187 mRNA. Translation: AAH33187.1 .
BC132965 mRNA. Translation: AAI32966.1 .
BC132967 mRNA. Translation: AAI32968.1 .
BX640754 mRNA. Translation: CAE45861.1 .
AY563001 mRNA. Translation: AAS75591.1 .
CCDSi CCDS48053.1. [P52735-1 ]
CCDS6979.1. [P52735-3 ]
PIRi I51940.
RefSeqi NP_001127870.1. NM_001134398.1. [P52735-1 ]
NP_003362.2. NM_003371.3. [P52735-3 ]
XP_005272270.1. XM_005272213.1. [P52735-2 ]
UniGenei Hs.369921.
Hs.689325.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DLZ NMR - A 663-767 [» ]
2DM1 NMR - A 819-878 [» ]
2LNW NMR - A 659-771 [» ]
2LNX NMR - A 659-771 [» ]
ProteinModelPortali P52735.
SMRi P52735. Positions 1-572, 589-878.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113253. 61 interactions.
DIPi DIP-33088N.
IntActi P52735. 59 interactions.
MINTi MINT-1494337.

PTM databases

PhosphoSitei P52735.

Polymorphism databases

DMDMi 212287930.

Proteomic databases

MaxQBi P52735.
PaxDbi P52735.
PRIDEi P52735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371850 ; ENSP00000360916 ; ENSG00000160293 . [P52735-1 ]
ENST00000371851 ; ENSP00000360917 ; ENSG00000160293 . [P52735-2 ]
ENST00000406606 ; ENSP00000385362 ; ENSG00000160293 . [P52735-3 ]
GeneIDi 7410.
KEGGi hsa:7410.
UCSCi uc004cer.3. human. [P52735-3 ]
uc004ces.3. human. [P52735-1 ]

Organism-specific databases

CTDi 7410.
GeneCardsi GC09M136627.
HGNCi HGNC:12658. VAV2.
HPAi HPA003224.
MIMi 600428. gene.
neXtProti NX_P52735.
PharmGKBi PA37281.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326494.
HOVERGENi HBG018066.
InParanoidi P52735.
KOi K05730.
OMAi WFAGNME.
OrthoDBi EOG73FQKZ.
PhylomeDBi P52735.
TreeFami TF316171.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_147814. DAP12 signaling.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_1695. GPVI-mediated activation cascade.
REACT_18407. G alpha (12/13) signalling events.
REACT_22272. Signal transduction by L1.
SignaLinki P52735.

Miscellaneous databases

ChiTaRSi VAV2. human.
EvolutionaryTracei P52735.
GeneWikii VAV2.
GenomeRNAii 7410.
NextBioi 29012.
PROi P52735.
SOURCEi Search...

Gene expression databases

Bgeei P52735.
Genevestigatori P52735.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view ]
PANTHERi PTHR22826:SF95. PTHR22826:SF95. 1 hit.
Pfami PF00130. C1_1. 1 hit.
PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTi SM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1."
    Henske E.P., Short M.P., Jozwiak S., Bovey C.M., Ramlakhan S., Haines J.L., Kwiatkowski D.J.
    Ann. Hum. Genet. 59:25-37(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-594.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-594.
    Tissue: Kidney.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-878 (ISOFORM 3).
    Tissue: Rectum tumor.
  6. "Transcript variant of VAV2 gene in tumoral cell lines (FaDu, HEp2, HeLa and SiHa)."
    Mancini U.M., Tajara E.H.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 453-506 (ISOFORMS 2/3).
  7. "Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac."
    Tamas P., Solti Z., Bauer P., Illes A., Sipeki S., Bauer A., Farago A., Downward J., Buday L.
    J. Biol. Chem. 278:5163-5171(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-142; TYR-159 AND TYR-172 BY EGFR.
  8. "The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization."
    Continolo S., Baruzzi A., Majeed M., Caveggion E., Fumagalli L., Lowell C.A., Berton G.
    Exp. Cell Res. 302:253-269(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  9. "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."
    Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V.
    Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEK3 AND PRLR.
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-626, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-769 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Solution structure of the SH2 domain and of the second SH3 domain of human protein VAV-2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 663-878.

Entry informationi

Entry nameiVAV2_HUMAN
AccessioniPrimary (citable) accession number: P52735
Secondary accession number(s): A2RUM4
, A8MQ12, B6ZDF5, Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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