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Reviewed, UniProtKB/Swiss-Prot P52735 (VAV2_HUMAN)

Last modified November 25, 2008. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Guanine nucleotide exchange factor VAV2
      Short name=VAV-2
Gene names
Name: VAV2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length878 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases.

Tissue specificity

Widely expressed.

Sequence similarities

Contains 1 CH (calponin-homology) domain.

Contains 1 DH (DBL-homology) domain.

Contains 1 PH domain.

Contains 1 phorbol-ester/DAG-type zinc finger.

Contains 1 SH2 domain.

Contains 2 SH3 domains.

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P52735-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P52735-2)

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.
Isoform 3 (identifier: P52735-3)

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.
     783-811: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 878878Guanine nucleotide exchange factor VAV2
PRO_0000080984

Regions

Domain1 – 119119CH
Domain198 – 376179DH
Domain405 – 512108PH
Domain586 – 65267SH3 1
Domain673 – 76795SH2
Domain816 – 87762SH3 2
Zinc finger523 – 57250Phorbol-ester/DAG-type

Amino acid modifications

Modified residue1421Phosphotyrosine; by EGFR
Modified residue1591Phosphotyrosine; by EGFR
Modified residue1721Phosphotyrosine; by EGFR

Natural variations

Alternative sequence185 – 1895Missing in isoform 2 and isoform 3.
VSP_034900
Alternative sequence470 – 4745Missing in isoform 2 and isoform 3.
VSP_034901
Alternative sequence783 – 81129Missing in isoform 3.
VSP_034902
Natural variant5941M → V
VAR_045690

Experimental info

Sequence conflict2411F → L in CAE45861. Ref.5
Sequence conflict2541F → L in CAE45861. Ref.5
Sequence conflict8771I → T in CAE45861. Ref.5

Secondary structure

................................ 878
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: C186911605FD5B73

FASTA878101,289
        10         20         30         40         50         60 
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 

        70         80         90        100        110        120 
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 

       130        140        150        160        170        180 
AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV 

       190        200        210        220        230        240 
QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV 

       250        260        270        280        290        300 
FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL 

       310        320        330        340        350        360 
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK 

       370        380        390        400        410        420 
EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH 

       430        440        450        460        470        480 
TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY 

       490        500        510        520        530        540 
LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC 

       550        560        570        580        590        600 
KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN 

       610        620        630        640        650        660 
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR 

       670        680        690        700        710        720 
PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI 

       730        740        750        760        770        780 
KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR 

       790        800        810        820        830        840 
SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG 

       850        860        870 
DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ 

« Hide

Isoform 2 [UniParc].

Checksum: 6C67C472825D2DFD
Show »

868100,057
Isoform 3 [UniParc].

Checksum: 21910D516F4A211D
Show »

83997,032

References

« Hide 'large scale' references
[1]"Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1."
Henske E.P., Short M.P., Jozwiak S., Bovey C.M., Ramlakhan S., Haines J.L., Kwiatkowski D.J.
Ann. Hum. Genet. 59:25-37(1995) [PubMed: 7762982] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-594.
Tissue: Brain.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-594.
Tissue: Kidney.
[5]The German cDNA consortium
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-878 (ISOFORM 3).
Tissue: Rectum tumor.
[6]"Transcript variant of VAV2 gene in tumoral cell lines (FaDu, HEp2, HeLa and Siha)."
Mancini U.M., Tajara E.H.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 453-506 (ISOFORM 2/3).
[7]"Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac."
Tamas P., Solti Z., Bauer P., Illes A., Sipeki S., Bauer A., Farago A., Downward J., Buday L.
J. Biol. Chem. 278:5163-5171(2003) [PubMed: 12454019] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-142; TYR-159 AND TYR-172.
[8]"Solution structure of the SH2 domain and of the second SH3 domain of human protein VAV-2."
RIKEN structural genomics initiative (RSGI)
Submitted (APR-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 663-878.
+Additional computationally mapped references.

Cross-references

Sequence databases

S76992 mRNA. Translation: AAB34377.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12279.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13722.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15783.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12278.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13723.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15781.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12280.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13724.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15782.1.
CH471090 Genomic DNA. Translation: EAW88108.1.
BC033187 mRNA. Translation: AAH33187.1.
BC132965 mRNA. Translation: AAI32966.1.
BC132967 mRNA. Translation: AAI32968.1.
BX640754 mRNA. Translation: CAE45861.1.
AY563001 mRNA. Translation: AAS75591.1.
PIRI51940.
RefSeqNP_001127870.1.
NP_003362.2.
UniGeneHs.369921
Hs.678824
Hs.689325

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2DLZNMR-A663-767[»]
2DM1NMR-A819-878[»]
SMRP52735. Positions 1-131.
ModBaseSearch...

Protein-protein interaction databases

IntActP52735.

PTM databases

PhosphoSiteP52735.

Genome annotation databases

EnsemblENSG00000160293. Homo sapiens. [Contig view]
GeneID7410.
KEGGhsa:7410.

Organism-specific databases

H-InvDBHIX0008512.
HGNCHGNC:12658. VAV2.
HPAHPA003224.
MIM600428. gene.
PharmGKBPA37281.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP52735.

Enzyme and pathway databases