Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52735

- VAV2_HUMAN

UniProt

P52735 - VAV2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Guanine nucleotide exchange factor VAV2

Gene

VAV2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri523 – 57250Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: Reactome
  2. metal ion binding Source: UniProtKB-KW
  3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. apoptotic signaling pathway Source: Reactome
  3. axon guidance Source: Reactome
  4. blood coagulation Source: Reactome
  5. cell migration Source: Ensembl
  6. Fc-epsilon receptor signaling pathway Source: Reactome
  7. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  8. innate immune response Source: Reactome
  9. lamellipodium assembly Source: Ensembl
  10. neurotrophin TRK receptor signaling pathway Source: Reactome
  11. platelet activation Source: Reactome
  12. positive regulation of apoptotic process Source: Reactome
  13. positive regulation of GTPase activity Source: GOC
  14. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
  15. regulation of blood coagulation Source: UniProt
  16. regulation of gene expression Source: UniProt
  17. regulation of small GTPase mediated signal transduction Source: Reactome
  18. signal transduction Source: ProtInc
  19. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_147814. DAP12 signaling.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_1695. GPVI-mediated activation cascade.
REACT_18407. G alpha (12/13) signalling events.
REACT_22272. Signal transduction by L1.
SignaLinkiP52735.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor VAV2
Short name:
VAV-2
Gene namesi
Name:VAV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:12658. VAV2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Guanine nucleotide exchange factor VAV2PRO_0000080984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei142 – 1421Phosphotyrosine; by EGFR1 Publication
Modified residuei159 – 1591Phosphotyrosine; by EGFR1 Publication
Modified residuei172 – 1721Phosphotyrosine; by EGFR1 Publication
Modified residuei576 – 5761Phosphoserine1 Publication
Modified residuei626 – 6261Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues in response to FGR activation.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP52735.
PaxDbiP52735.
PRIDEiP52735.

PTM databases

PhosphoSiteiP52735.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiP52735.
GenevestigatoriP52735.

Organism-specific databases

HPAiHPA003224.

Interactioni

Subunit structurei

Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP By similarity. Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI1Q8IZP02EBI-297549,EBI-375446
ERBB2P046263EBI-297549,EBI-641062
GAB1Q134802EBI-297549,EBI-517684
NEK3P519563EBI-297549,EBI-476041
SH3BP2P783144EBI-297549,EBI-727062
TOM1L1O756742EBI-297549,EBI-712991

Protein-protein interaction databases

BioGridi113253. 61 interactions.
DIPiDIP-33088N.
IntActiP52735. 59 interactions.
MINTiMINT-1494337.

Structurei

Secondary structure

1
878
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi661 – 6644Combined sources
Helixi668 – 6703Combined sources
Beta strandi674 – 6774Combined sources
Helixi680 – 68910Combined sources
Beta strandi694 – 6985Combined sources
Beta strandi707 – 7126Combined sources
Beta strandi714 – 72512Combined sources
Beta strandi728 – 7314Combined sources
Beta strandi737 – 7393Combined sources
Helixi740 – 7478Combined sources
Turni752 – 7554Combined sources
Beta strandi767 – 7693Combined sources
Beta strandi819 – 8257Combined sources
Beta strandi842 – 8443Combined sources
Beta strandi847 – 8548Combined sources
Beta strandi856 – 8605Combined sources
Beta strandi863 – 8675Combined sources
Beta strandi869 – 8746Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLZNMR-A663-767[»]
2DM1NMR-A819-878[»]
2LNWNMR-A659-771[»]
2LNXNMR-A659-771[»]
ProteinModelPortaliP52735.
SMRiP52735. Positions 1-572, 589-878.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52735.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119CHPROSITE-ProRule annotationAdd
BLAST
Domaini198 – 376179DHPROSITE-ProRule annotationAdd
BLAST
Domaini405 – 512108PHPROSITE-ProRule annotationAdd
BLAST
Domaini586 – 65267SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini673 – 76795SH2PROSITE-ProRule annotationAdd
BLAST
Domaini816 – 87762SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri523 – 57250Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiNOG326494.
GeneTreeiENSGT00740000115307.
HOVERGENiHBG018066.
InParanoidiP52735.
KOiK05730.
OMAiWFAGNME.
OrthoDBiEOG73FQKZ.
PhylomeDBiP52735.
TreeFamiTF316171.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF95. PTHR22826:SF95. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P52735-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL
60 70 80 90 100
SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF
110 120 130 140 150
DVRDFGKVIS AVSRLSLHSI AQNKGIRPFP SEETTENDDD VYRSLEELAD
160 170 180 190 200
EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV QQPMIRYMQK MGMTEDDKRN
210 220 230 240 250
CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV FINLEDLIKV
260 270 280 290 300
HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL
310 320 330 340 350
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS
360 370 380 390 400
AERPERQQLK EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL
410 420 430 440 450
EEFGRPKIDG ELKVRSIVNH TKQDRYLFLF DKVVIVCKRK GYSYELKEII
460 470 480 490 500
ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY LIHLQGKQGF QFFCKTEDMK
510 520 530 540 550
RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC KMFLRGTFYQ
560 570 580 590 600
GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN
610 620 630 640 650
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC
660 670 680 690 700
PVDGRPPISR PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER
710 720 730 740 750
PAEAERFAIS IKFNDEVKHI KVVEKDNWIH ITEAKKFDSL LELVEYYQCH
760 770 780 790 800
SLKESFKQLD TTLKYPYKSR ERSASRASSR SPASCASYNF SFLSPQGLSF
810 820 830 840 850
ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG DVVRIYSRIG
860 870
GDQGWWKGET NGRIGWFPST YVEEEGIQ
Length:878
Mass (Da):101,289
Last modified:July 22, 2008 - v2
Checksum:iC186911605FD5B73
GO
Isoform 2 (identifier: P52735-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.

Show »
Length:868
Mass (Da):100,057
Checksum:i6C67C472825D2DFD
GO
Isoform 3 (identifier: P52735-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-189: Missing.
     470-474: Missing.
     783-811: Missing.

Note: Contains a phosphoserine at position 769.

Show »
Length:839
Mass (Da):97,032
Checksum:i21910D516F4A211D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411F → L in CAE45861. (PubMed:17974005)Curated
Sequence conflicti254 – 2541F → L in CAE45861. (PubMed:17974005)Curated
Sequence conflicti877 – 8771I → T in CAE45861. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti594 – 5941M → V.2 Publications
Corresponds to variant rs602990 [ dbSNP | Ensembl ].
VAR_045690

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei185 – 1895Missing in isoform 2 and isoform 3. 2 PublicationsVSP_034900
Alternative sequencei470 – 4745Missing in isoform 2 and isoform 3. 2 PublicationsVSP_034901
Alternative sequencei783 – 81129Missing in isoform 3. 2 PublicationsVSP_034902Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76992 mRNA. Translation: AAB34377.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12279.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13722.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15783.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12278.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13723.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15781.1.
AL590710, AL357934, AL445931 Genomic DNA. Translation: CAI12280.1.
AL445931, AL357934, AL590710 Genomic DNA. Translation: CAI13724.1.
AL357934, AL445931, AL590710 Genomic DNA. Translation: CAI15782.1.
CH471090 Genomic DNA. Translation: EAW88108.1.
BC033187 mRNA. Translation: AAH33187.1.
BC132965 mRNA. Translation: AAI32966.1.
BC132967 mRNA. Translation: AAI32968.1.
BX640754 mRNA. Translation: CAE45861.1.
AY563001 mRNA. Translation: AAS75591.1.
CCDSiCCDS48053.1. [P52735-1]
CCDS6979.1. [P52735-3]
PIRiI51940.
RefSeqiNP_001127870.1. NM_001134398.1. [P52735-1]
NP_003362.2. NM_003371.3. [P52735-3]
XP_005272270.1. XM_005272213.1. [P52735-2]
UniGeneiHs.369921.
Hs.689325.

Genome annotation databases

EnsembliENST00000371850; ENSP00000360916; ENSG00000160293. [P52735-1]
ENST00000371851; ENSP00000360917; ENSG00000160293. [P52735-2]
ENST00000406606; ENSP00000385362; ENSG00000160293. [P52735-3]
GeneIDi7410.
KEGGihsa:7410.
UCSCiuc004cer.3. human. [P52735-3]
uc004ces.3. human. [P52735-1]

Polymorphism databases

DMDMi212287930.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76992 mRNA. Translation: AAB34377.1 .
AL590710 , AL357934 , AL445931 Genomic DNA. Translation: CAI12279.1 .
AL445931 , AL357934 , AL590710 Genomic DNA. Translation: CAI13722.1 .
AL357934 , AL445931 , AL590710 Genomic DNA. Translation: CAI15783.1 .
AL590710 , AL357934 , AL445931 Genomic DNA. Translation: CAI12278.1 .
AL445931 , AL357934 , AL590710 Genomic DNA. Translation: CAI13723.1 .
AL357934 , AL445931 , AL590710 Genomic DNA. Translation: CAI15781.1 .
AL590710 , AL357934 , AL445931 Genomic DNA. Translation: CAI12280.1 .
AL445931 , AL357934 , AL590710 Genomic DNA. Translation: CAI13724.1 .
AL357934 , AL445931 , AL590710 Genomic DNA. Translation: CAI15782.1 .
CH471090 Genomic DNA. Translation: EAW88108.1 .
BC033187 mRNA. Translation: AAH33187.1 .
BC132965 mRNA. Translation: AAI32966.1 .
BC132967 mRNA. Translation: AAI32968.1 .
BX640754 mRNA. Translation: CAE45861.1 .
AY563001 mRNA. Translation: AAS75591.1 .
CCDSi CCDS48053.1. [P52735-1 ]
CCDS6979.1. [P52735-3 ]
PIRi I51940.
RefSeqi NP_001127870.1. NM_001134398.1. [P52735-1 ]
NP_003362.2. NM_003371.3. [P52735-3 ]
XP_005272270.1. XM_005272213.1. [P52735-2 ]
UniGenei Hs.369921.
Hs.689325.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DLZ NMR - A 663-767 [» ]
2DM1 NMR - A 819-878 [» ]
2LNW NMR - A 659-771 [» ]
2LNX NMR - A 659-771 [» ]
ProteinModelPortali P52735.
SMRi P52735. Positions 1-572, 589-878.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113253. 61 interactions.
DIPi DIP-33088N.
IntActi P52735. 59 interactions.
MINTi MINT-1494337.

PTM databases

PhosphoSitei P52735.

Polymorphism databases

DMDMi 212287930.

Proteomic databases

MaxQBi P52735.
PaxDbi P52735.
PRIDEi P52735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371850 ; ENSP00000360916 ; ENSG00000160293 . [P52735-1 ]
ENST00000371851 ; ENSP00000360917 ; ENSG00000160293 . [P52735-2 ]
ENST00000406606 ; ENSP00000385362 ; ENSG00000160293 . [P52735-3 ]
GeneIDi 7410.
KEGGi hsa:7410.
UCSCi uc004cer.3. human. [P52735-3 ]
uc004ces.3. human. [P52735-1 ]

Organism-specific databases

CTDi 7410.
GeneCardsi GC09M136627.
HGNCi HGNC:12658. VAV2.
HPAi HPA003224.
MIMi 600428. gene.
neXtProti NX_P52735.
PharmGKBi PA37281.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326494.
GeneTreei ENSGT00740000115307.
HOVERGENi HBG018066.
InParanoidi P52735.
KOi K05730.
OMAi WFAGNME.
OrthoDBi EOG73FQKZ.
PhylomeDBi P52735.
TreeFami TF316171.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_147814. DAP12 signaling.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_1695. GPVI-mediated activation cascade.
REACT_18407. G alpha (12/13) signalling events.
REACT_22272. Signal transduction by L1.
SignaLinki P52735.

Miscellaneous databases

ChiTaRSi VAV2. human.
EvolutionaryTracei P52735.
GeneWikii VAV2.
GenomeRNAii 7410.
NextBioi 29012.
PROi P52735.
SOURCEi Search...

Gene expression databases

Bgeei P52735.
Genevestigatori P52735.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view ]
PANTHERi PTHR22826:SF95. PTHR22826:SF95. 1 hit.
Pfami PF00130. C1_1. 1 hit.
PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 2 hits.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTi SM00109. C1. 1 hit.
SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1."
    Henske E.P., Short M.P., Jozwiak S., Bovey C.M., Ramlakhan S., Haines J.L., Kwiatkowski D.J.
    Ann. Hum. Genet. 59:25-37(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-594.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-594.
    Tissue: Kidney.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-878 (ISOFORM 3).
    Tissue: Rectum tumor.
  6. "Transcript variant of VAV2 gene in tumoral cell lines (FaDu, HEp2, HeLa and SiHa)."
    Mancini U.M., Tajara E.H.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 453-506 (ISOFORMS 2/3).
  7. "Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac."
    Tamas P., Solti Z., Bauer P., Illes A., Sipeki S., Bauer A., Farago A., Downward J., Buday L.
    J. Biol. Chem. 278:5163-5171(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-142; TYR-159 AND TYR-172 BY EGFR.
  8. "The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization."
    Continolo S., Baruzzi A., Majeed M., Caveggion E., Fumagalli L., Lowell C.A., Berton G.
    Exp. Cell Res. 302:253-269(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  9. "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."
    Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V.
    Mol. Endocrinol. 19:939-949(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEK3 AND PRLR.
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-626, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-769 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Solution structure of the SH2 domain and of the second SH3 domain of human protein VAV-2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 663-878.

Entry informationi

Entry nameiVAV2_HUMAN
AccessioniPrimary (citable) accession number: P52735
Secondary accession number(s): A2RUM4
, A8MQ12, B6ZDF5, Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3