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Protein

FYVE, RhoGEF and PH domain-containing protein 1

Gene

Fgd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri729 – 789FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 1
Alternative name(s):
Faciogenital dysplasia 1 protein homolog
Rho/Rac guanine nucleotide exchange factor FGD1
Short name:
Rho/Rac GEF
Zinc finger FYVE domain-containing protein 3
Gene namesi
Name:Fgd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:104566 Fgd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi159P → A: Abolishes binding to DBNL. 1 Publication1
Mutagenesisi162P → A: Abolishes binding to DBNL. 1 Publication1
Mutagenesisi164K → E: No effect on binding to DBNL. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809411 – 960FYVE, RhoGEF and PH domain-containing protein 1Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei710PhosphothreonineCombined sources1
Modified residuei714PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP52734
PaxDbiP52734
PRIDEiP52734

PTM databases

iPTMnetiP52734
PhosphoSitePlusiP52734

Expressioni

Gene expression databases

BgeeiENSMUSG00000025265
CleanExiMM_FGD1
ExpressionAtlasiP52734 baseline and differential
GenevisibleiP52734 MM

Interactioni

Subunit structurei

Interacts with DBNL/ABP1 and CTTN. Binds CDC42 (By similarity). May interact with CCPG1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199637, 2 interactors
IntActiP52734, 2 interactors
MINTiP52734
STRINGi10090.ENSMUSP00000026296

Structurei

3D structure databases

ProteinModelPortaliP52734
SMRiP52734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini372 – 560DHPROSITE-ProRule annotationAdd BLAST189
Domaini589 – 688PH 1PROSITE-ProRule annotationAdd BLAST100
Domaini820 – 920PH 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 187SH3-bindingSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 330Pro-richAdd BLAST324

Domaini

The DH domain is involved in interaction with CCPG1.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri729 – 789FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00890000139342
HOGENOMiHOG000220866
HOVERGENiHBG007506
InParanoidiP52734
KOiK05720
OMAiLVNTWTE
OrthoDBiEOG091G03FU
TreeFamiTF316247

Family and domain databases

CDDicd01219 PH1_FGD1, 1 hit
cd13236 PH2_FGD1-4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035941 FGD1-4_PH2
IPR035939 FGD1_PH1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

P52734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGHRVPGGP GPSDPERSAA NTPGAAPLAC ADSDPGALEP GLPVSRGSGT
60 70 80 90 100
ALGGPLDPQF VGPSDASLGA PPSSRVLPCG PSPQHHRALR FSYHLEGSQP
110 120 130 140 150
RPGLHQGNRI LVKSLSLDPG QSLEPHPEGP QRLRSDPGPP TEIPGPRPSP
160 170 180 190 200
LKRAPGPKPQ VPPKPSYLQM PRVLPPPEPI PPPPSRPLPA DPRVAKGLVP
210 220 230 240 250
RAEASTSSAA VSSLIEKFER EPVIVASDRP APGPCPVPPE PAMLPQPPPQ
260 270 280 290 300
PTGSQLPEGE ASRCLFLLAP GPRDGEKVPN RDSGIDSISS PSNSEETCFV
310 320 330 340 350
SDDGPPIHSL CPGPPALASM PVALADPHRP GSQEVDSDLE EEEEEEEEEK
360 370 380 390 400
EREIPVPPME RQESVELTVQ QKVFHIANEL LQTEKAYVSR LHLLDQVFCA
410 420 430 440 450
RLLEEARNRS SFPADVVHGI FSNICSIYCF HQQFLLPELE KRMEEWDRYP
460 470 480 490 500
RIGDILQKLA PFLKMYGEYV KNFDRAVELV NTWTERSTQF KVIIHEVQKE
510 520 530 540 550
EACGNLTLQH HMLEPVQRIP RYELLLKDYL LKLPHGSPDS KDAQKSLELI
560 570 580 590 600
ATAAEHSNAA IRKMERMHKL LKVYELLGGE EDIVSPTKEL IKEGHILKLS
610 620 630 640 650
AKNGTTQDRY LILFNDRLLY CVPRLRLLGQ KFSVRARIDV DGMELKESSN
660 670 680 690 700
LNMPRTFLVS GKQRSLELQA RTEEEKKDWV QAINSTLLKH EQTLETFKLL
710 720 730 740 750
NSTNRDDEDT PPNSPNVDLG KRAPTPIREK EVTMCMRCQE PFNSITKRRH
760 770 780 790 800
HCKACGHVVC GKCSEFRARL IYDNNRSNRV CTDCYVALHG APGSSPACSQ
810 820 830 840 850
HTPQRRRSIL EKQASVAAEN SVICSFLHYM EKGGKGWHKA WFVVPENEPL
860 870 880 890 900
VLYIYGAPQD VKAQRSLPLI GFEVGPPEAG ERPDRRHVFK ITQSHLSWYF
910 920 930 940 950
SPETEELQRR WMAVLGRAGR GDTFCPGPTL SEDKEMEETP VAASGATAEP
960
PEASQTRDKT
Length:960
Mass (Da):106,365
Last modified:July 27, 2011 - v2
Checksum:iE3E489BA2F3AE056
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti504G → R in AAA96001 (PubMed:8535076).Curated1
Sequence conflicti633S → T in AAA96001 (PubMed:8535076).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22325 mRNA Translation: AAA96001.1
AL805937 Genomic DNA No translation available.
BC011462 mRNA Translation: AAH11462.1
CCDSiCCDS30467.1
RefSeqiNP_032027.2, NM_008001.4
UniGeneiMm.475704
Mm.8142

Genome annotation databases

EnsembliENSMUST00000026296; ENSMUSP00000026296; ENSMUSG00000025265
GeneIDi14163
KEGGimmu:14163
UCSCiuc009uow.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFGD1_MOUSE
AccessioniPrimary (citable) accession number: P52734
Secondary accession number(s): Q921L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health