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P52726 (MT_OREMO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Metallothionein
PRO_0000197298

Regions

Region1 – 2828Beta
Region29 – 6032Alpha

Sites

Metal binding41Divalent metal cation; cluster B
Metal binding61Divalent metal cation; cluster B
Metal binding121Divalent metal cation; cluster B
Metal binding141Divalent metal cation; cluster B
Metal binding181Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding231Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding281Divalent metal cation; cluster B
Metal binding321Divalent metal cation; cluster A
Metal binding331Divalent metal cation; cluster A
Metal binding351Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding401Divalent metal cation; cluster A
Metal binding431Divalent metal cation; cluster A
Metal binding471Divalent metal cation; cluster A
Metal binding491Divalent metal cation; cluster A
Metal binding541Divalent metal cation; cluster A
Metal binding581Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A

Experimental info

Sequence conflict191S → T in AAP14678. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P52726 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: BB33448F3563A01D

FASTA606,021
        10         20         30         40         50         60 
MDPCECAKTG TCNCGGSCSC TKCSCKSCKK SCCDCCPSGC SKCASGCVCK GKTCDTSCCQ 

« Hide

References

[1]"PCR-cloning of goldfish and tilapia metallothionein complementary DNAs."
Chan K.M.
Biochem. Biophys. Res. Commun. 205:368-374(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Tilapia metallothionein genes: PCR-cloning and gene regulation studies in vitro."
Cheung P.L., Lam K.L., Chan K.M.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75042 mRNA. Translation: AAB32778.1.
AY257202 Genomic DNA. Translation: AAP14678.1.
PIRJC2420.

3D structure databases

ProteinModelPortalP52726.
SMRP52726. Positions 2-29, 31-60.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT_OREMO
AccessionPrimary (citable) accession number: P52726
Secondary accession number(s): Q7ZZP8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries